JCI Insight March 2022 PMID 35143420

Cilia proteins are biomarkers of altered flow in the vasculature.

Ankan Gupta, Karthikeyan Thirugnanam, Madhan Thamilarasan, Ashraf M Mohieldin, Hadeel T Zedan, Shubhangi Prabhudesai, Meghan R Griffin, Andrew D Spearman, Amy Pan, Sean P Palecek, Huseyin C Yalcin, Surya M Nauli, Kevin R Rarick, Rahima Zennadi, Ramani Ramchandran

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Mentions

Peak: 2 in Feb 2022

across 3 sources since Feb 2022

Extended reach

84,542

potential audience

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Video views

1,001

Mentions per month

Feb 2022 – Aug 2022

Where it's discussed

X / Twitter5 posts
News2 articles
YouTube1 videos

AI synopsis

What people are saying

The discussions reflect general agreement and moderate interest, with mentions of how shear stress causes cilia disassembly and how ciliary proteins can serve as indicators, supported by phrases like 'can be tracked in fluids' and 'biomarkers of altered flow.' The tone remains informative and somewhat optimistic without deep technical debate, demonstrating a basic engagement with the potential implications of the research.

AgreementModerate agreement

Most discussions acknowledge the significance of cilia proteins as biomarkers, indicating general agreement with the publication’s findings.

InterestModerate interest

The discussions show a moderate level of curiosity about the biological mechanisms and implications, but do not delve deeply into detailed methodology or broader impact.

EngagementModerate engagement

Participants demonstrate a basic understanding by referencing shear stress and cilia disassembly, showing some engagement, though not extensively exploring applications.

ImpactModerate impact

The conversations suggest recognition of the potential diagnostic and clinical importance of these biomarkers but stop short of asserting transformative changes.

Abstract in brief

Cilia proteins are released into the bloodstream when endothelial cells (ECs) experience changes in shear stress, especially during high-flow conditions, and this release is associated with the loss of cilia from the cell surface.
Experiments using human cells and zebrafish models demonstrated that increased shear stress leads to deciliation and the presence of ciliary proteins in circulation, which can serve as indicators of vascular flow alterations and endothelial damage.
In sickle cell disease patients, elevated levels of ciliary proteins in blood and on red blood cells suggest that these proteins can act as biomarkers for endothelial injury and may be linked to increased reactive oxygen species (ROS), offering potential diagnostic insights.]

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Cilia Proteins as Biomarkers of Blood Flow Changes and Vascular Health

Cilia proteins are released into the bloodstream during shear stress-induced endothelial damage. Dr. Ramani Ramchandran's team explores these proteins as biomarkers for vascular flow alterations and endothelial injury…

Researchpod · Aug 31, 2022 1,001 views

Andrew Frankstine

@frankstine_a · X

RT @JCI_insight: Cilia proteins are biomarkers of altered flow in the vasculature: https://t.co/wiPgQXUWYZ @MedicalCollege #VascularBiolog…

Apr 7, 2022 · 1 share · 405 followers View post →

JCI insight

@JCI_insight · X

Cilia proteins are biomarkers of altered flow in the vasculature: https://t.co/wiPgQXUWYZ @MedicalCollege #VascularBiology https://t.co/D1y4W7TZhn

Apr 1, 2022 · 3 likes · 1 share · 39,980 followers View post →

JCI insight

@JCI_insight · X

Mar 23, 2022 · 1 like · 39,980 followers View post →

القطاع الصحي QU Health Sector

@QU_Health · X

To read more please visit the link below: https://t.co/S7ZcLMkaHH https://t.co/Jp2r2JAgiu

Feb 17, 2022 · 2,008 followers View post →

Cilia Papers

@cilia_biblios · X

Cilia proteins are biomarkers of altered flow in the vasculature https://t.co/Z2oKvgJWUE https://t.co/YZDIju9dh9

Feb 10, 2022 · 1,165 followers View post →