Mol Cancer February 2022 PMID 35151318

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance.

Chen Zhang, Xinyin Liu, Shidai Jin, Yi Chen, Renhua Guo

Mentions

16
Peak: 5 in Oct 2023
across 3 sources since Feb 2022

Extended reach

43,595
potential audience

Total likes

23

Video views

83

Mentions per month

Feb 2022 – Apr 2025

Where it's discussed

  • X / Twitter12 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The discussions demonstrate a positive outlook on ferroptosis as a novel approach to overcoming drug resistance, with phrases like 'great importance in #cancer' and 'a promising strategy,' indicating high interest and perceived significance. Some comments delve into specific mechanisms such as GPX4 and p53, illustrating engagement with the biological details, but overall, the tone is exploratory rather than deeply technical, suggesting moderate impact awareness.

AgreementModerate agreement

Most discussions recognize ferroptosis as a promising and relevant mechanism in cancer therapy, showing overall support for the publication's premise.

InterestHigh interest

The discussions indicate high interest, with mentions of ferroptosis's importance and potential in overcoming drug resistance, engaging the audience’s curiosity.

EngagementModerate engagement

While some comments reference specific biological mechanisms and suggest a desire to understand ferroptosis better, the overall depth remains moderate, showing interest but limited detailed analysis.

ImpactModerate impact

Participants perceive ferroptosis as a significant strategy in developing new cancer treatments, reflecting awareness of its potential to influence future therapies.

Abstract in brief

  • Ferroptosis is a unique form of cell death that depends on iron and is different from other types like apoptosis, necrosis, and autophagy, and it plays an important role in stopping tumor growth.
  • Since drug resistance is a major obstacle in cancer treatment, recent studies show that inducing ferroptosis can help overcome this resistance and improve the effectiveness of therapies such as chemotherapy, targeted therapy, and immunotherapy.
  • The review explores how understanding and controlling ferroptosis might be a promising strategy for reversing cancer drug resistance, although there are still challenges to be addressed before it can be widely applied in treatments.]

Top posts

Most liked on X and Bluesky
Dr. Thomas Ichim
@exosome · X

So much to learn…ferroptosis is a type of cell death that depends on iron and is of great importance in #cancer. https://t.co/IYuVnvWKM2.

Oct 8, 2023 · 20 likes · 4 shares · 33,094 followers View post →
Todd McKenzie
@ToddEBear · X

"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance | Molecular Cancer | Full Text" https://t.co/9ETnCWB7af.

Nov 26, 2022 · 1 like · 2,282 followers View post →
C V
@ClaudioLondon7 · X

@PaulGradenwitz @tnseyfried https://t.co/s5ZJvEDWp2.

Apr 13, 2025 · 1 like · 1 share · 535 followers View post →
Cankay Koryak
@CankayKoryak · X

"... renal cell carcinoma is particularly susceptible to ferroptosis... (GPX4) as a central regulator of ferroptosis.. protecting against excessive lipid peroxidation... inactivation of the p53 tumor suppression.. associated with ferroptosis suppression" https://t.co/OTCjbEiMpx.

Feb 29, 2024 · 3,071 followers View post →
Conserv1023
@Conserv1023 · X

RT @exosome: So much to learn…ferroptosis is a type of cell death that depends on iron and is of great importance in #cancer. https://t.co…

Oct 9, 2023 · 4 shares · 1,553 followers View post →
ETERNAL
@RWyoral · X

RT @exosome: So much to learn…ferroptosis is a type of cell death that depends on iron and is of great importance in #cancer. https://t.co…

Oct 8, 2023 · 4 shares · 896 followers View post →

All mentions

Diego A.R. ⚯͛
@AngelesRomD · X

RT @ClaudioLondon7: @PaulGradenwitz @tnseyfried https://t.co/s5ZJvEDWp2.

Apr 13, 2025 · 1 share · 87 followers View post →
C V
@ClaudioLondon7 · X

@PaulGradenwitz @tnseyfried https://t.co/s5ZJvEDWp2.

Apr 13, 2025 · 1 like · 1 share · 535 followers View post →
Cankay Koryak
@CankayKoryak · X

"... renal cell carcinoma is particularly susceptible to ferroptosis... (GPX4) as a central regulator of ferroptosis.. protecting against excessive lipid peroxidation... inactivation of the p53 tumor suppression.. associated with ferroptosis suppression" https://t.co/OTCjbEiMpx.

Feb 29, 2024 · 3,071 followers View post →
Conserv1023
@Conserv1023 · X

RT @exosome: So much to learn…ferroptosis is a type of cell death that depends on iron and is of great importance in #cancer. https://t.co…

Oct 9, 2023 · 4 shares · 1,553 followers View post →
BillOckham
@BillOccham0 · X

RT @exosome: So much to learn…ferroptosis is a type of cell death that depends on iron and is of great importance in #cancer. https://t.co…

Oct 8, 2023 · 4 shares · 588 followers View post →
Negawatts are best
@JoelTH · X

RT @exosome: So much to learn…ferroptosis is a type of cell death that depends on iron and is of great importance in #cancer. https://t.co…

Oct 8, 2023 · 4 shares · 558 followers View post →
ETERNAL
@RWyoral · X

RT @exosome: So much to learn…ferroptosis is a type of cell death that depends on iron and is of great importance in #cancer. https://t.co…

Oct 8, 2023 · 4 shares · 896 followers View post →
Dr. Thomas Ichim
@exosome · X

So much to learn…ferroptosis is a type of cell death that depends on iron and is of great importance in #cancer. https://t.co/IYuVnvWKM2.

Oct 8, 2023 · 20 likes · 4 shares · 33,094 followers View post →
Ava Cross
@avacro86 · X

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance | Molecular Cancer | Full Text https://t.co/XWaypo20Ar

Dec 29, 2022 · 225 followers View post →
Todd McKenzie
@ToddEBear · X

"Ferroptosis in cancer therapy: a novel approach to reversing drug resistance | Molecular Cancer | Full Text" https://t.co/9ETnCWB7af.

Nov 26, 2022 · 1 like · 2,282 followers View post →
IronBiologyBot
@IronBiologyBot · X

RT @IronBiologyBot: Paper alert: Ferroptosis in cancer therapy: a novel approach to reversing drug resistance https://t.co/SwodDxQRye #Iro…

Feb 14, 2022 · 1 share · 288 followers View post →
IronBiologyBot
@IronBiologyBot · X

Paper alert: Ferroptosis in cancer therapy: a novel approach to reversing drug resistance https://t.co/SwodDxQRye #IronBiology #BioIron #Iron

Feb 14, 2022 · 1 share · 288 followers View post →