Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis.

Jingwei Xu, Charles F Ericson, Yun-Wei Lien, Florentine U N Rutaganira, Fabian Eisenstein, Miki Feldmüller, Nicole King, Martin Pilhofer

March 2022 Nat Microbiol

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The overall tone reflects high interest and recognition of the study's significance, with examples like references to cryoelectron microscopy, structural features, and potential applications. Words such as 'important,' 'exciting,' and mentions of the research 'revealing' new nanomachines contribute to the perception of meaningful scientific progress and potential impact.

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Discussions highlight potential applications in microbiology and biotechnology, suggesting users see this research as having meaningful influence.

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Posts referencing the article

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Structural Analysis of Extracellular Contractile Injection System in Marine Bacterium

Structural Analysis of Extracellular Contractile Injection System in Marine Bacterium

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Structural Analysis of Extracellular Contractile Injection System in Marine Bacterium

Structural Analysis of Extracellular Contractile Injection System in Marine Bacterium

This study explores a novel extracellular contractile injection system in Algoriphagus machipongonensis, revealing unique structural features and key components identified through cryoelectron microscopy and genetic analysis, advancing understanding of CIS functions and potential applications.

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April 5, 2022

24 views

Helical Symmetry in Extracellular Contractile Injection Systems

Helical Symmetry in Extracellular Contractile Injection Systems

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Cyclic C6 Symmetry in Protein Structures Explained

Cyclic C6 Symmetry in Protein Structures Explained

This video explores the cyclic C6 symmetry in a complex protein structure with 48 monomers and a total weight of 227,545 kDa. It highlights structural features and biological significance, providing insights into protein assembly and function.

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April 5, 2022

12 views

  • HungryMicrobe
    @hungrymicrobe (Twitter)

    Publisher Correction: Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis https://t.co/plT6DKipsp
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    April 4, 2022

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  • BactSecretionPapers
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    Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis. #T6SS https://t.co/sQFrAqfuJG
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    February 16, 2022

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  • NobuoMaita
    @nob_mai (Twitter)

    7AEB etc. Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis Nature, 2022
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    February 15, 2022

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    Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis https://t.co/2CIO9fCEHo
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    February 15, 2022

  • NobuoMaita
    @nob_mai (Twitter)

    Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis. Nat Microbiol (2022). https://t.co/YhnkIrF2Fp
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    February 14, 2022

  • Ryo Yokoyama
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    Back to back; Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis https://t.co/kOp611vFXt
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    February 14, 2022

  • Charles Ericson
    @CharlesFEricson (Twitter)

    RT @NatureMicrobiol: OUT NOW: Identification and structure of an extracellular contractile injection system from the marine bacterium Algor…
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    RT @NatureMicrobiol: OUT NOW: Identification and structure of an extracellular contractile injection system from the marine bacterium Algor…
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  • Chuck Smallwood, PhD
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    RT @NatureMicrobiol: OUT NOW: Identification and structure of an extracellular contractile injection system from the marine bacterium Algor…
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    RT @NatureMicrobiol: OUT NOW: Identification and structure of an extracellular contractile injection system from the marine bacterium Algor…
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  • Nature Microbiology
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    OUT NOW: Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis. By Martin Pilhofer & colleagues. @xujw_thu @CharlesFEricson @PilhoferLab @ETH_en @ETH_DBIOL #cryoET #cryoEM https://t.co/yZH6qFfb7n
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    February 14, 2022

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  • Panagiotis Sarris
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    Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis. https://t.co/L8QaQE97Ht
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    February 14, 2022

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Abstract Synopsis

  • The study explores a new type of extracellular contractile injection system (eCIS) in the marine bacterium Algoriphagus machipongonensis, showing it functions similarly to other CISs but with unique structural features.
  • Using cryoelectron microscopy and genetic tools, researchers identified key structural components like a cap adaptor, a tube lumen plug, and a baseplate cage, which are essential for the system's assembly, cargo loading, and activity.
  • The detailed atomic model reveals evolutionary hotspots that can help in understanding CIS functions and potentially reengineering these nanomachines for applications in microbiology and biotechnology.