Overall, the discussions reflect strong support and interest in the article, with examples like references to '89% efficacy,' comments on the importance of early treatment within 3 days, and debates on study design and sample size. The tone is analytical and supportive, emphasizing the significance of the findings in improving COVID-19 management.
AgreementModerate agreement
Most comments support the positive findings of the publication, highlighting efficacy and safety, indicating general consensus.
InterestHigh interest
There is high curiosity about the study results and implications, with many referencing specific data and studies.
EngagementHigh engagement
Discussions delve into detailed analysis, comparisons with other studies, and questions about methodology.
ImpactHigh impact
The social discussions acknowledge the potential influence of the research on treatment practices and public health policies.
Jun 17, 2022 · 128 likes · 27 shares · 66,965 followersView post →
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jvipondmd
@jvipondmd · X
Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the control arm. https://t.co/NqB9nGRyhB
Jan 20, 2024 · 95 likes · 10 shares · 48,202 followersView post →
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jvipondmd
@jvipondmd · X
The blog starts with Hammond (2022), the original NEJM trial that started it all.
https://t.co/kOXdQVp2UY
Zero deaths vs. 7 for placebo.
NNT of 17 for combination of hosp/death. Not bad!
7/ https://t.co/Jw71Gm8K9A
Feb 22, 2024 · 39 likes · 2 shares · 48,202 followersView post →
FY
Fizz-DI@比較と使い分け-KOJIMA Yushi
@Fizz_DI · X
重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi: 10.1056/NEJMoa2118542. Online ahead of print. PMID:35172054
https://t.co/QkU9yx2Vmn
Feb 17, 2022 · 28 likes · 11 shares · 34,633 followersView post →
M無
Mugen UJIIE (氏家 無限)
@carpe_diem0820 · X
パキロビッドの臨床研究報告
Covid-19発症者にニルマトレルビルとリトナビルの併用で、重症化リスクを89%低減
安全性の明らかな懸念はなしも下記は増加
味覚障害(5.6% vs. 0.3%)
下痢 (3.1% vs. 1.6%)
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19
https://t.co/aus9I3BGmK https://t.co/agyGwnA3oy https://t.co/PteaAamicR
Feb 18, 2022 · 26 likes · 11 shares · 12,357 followersView post →
The Omicron variant of SARS-CoV-2 exhibits less efficient replication and cell fusion activity compared to the Delta variant, particularly in TMPRSS2-expressing cells. It primarily uses the endocytic pathway for…
This week, John Mandrola MD examines statin intolerance and the impact of new medications like finerenone on chronic kidney disease in type 2 diabetes. He discusses the effectiveness of finerenone in reducing…
@grok @Ja_vajos @JanTakje_II @RichelTheo @Theo_Roy33 They are not replicated if they are flawed.
Allowing dosing to start beyond day 3 as a design (not sub group) means it is flawed.
Per the following Paxlovid study "dosing within 3 days of symptoms"
Replicate Design or it is flawed.
https://t.co/3SDoT1uOFL
@real_seeking @tunackr2020 @redpilldispensr Paxlovids approval started with a double blinded study if over 2000 patients
https://t.co/lQftW39i08 https://t.co/Ve6n3eiuS5
@OliveJenkins911 @thehealthb0t Treatment of symptomatic Covid-19 with nirmatrelvir plus ritonavir resulted in a risk of progression to severe Covid-19 that was 89% lower.
Source- New England Journal of Medicine https://t.co/6LCeL7R8Eu
@dr_francisco79 Aqui: https://t.co/QcHVYFJtO5
O senhor deveria perceber a diferença nas populações/recomendações. Poderia estudar um pouco mais em vez de perder tempo discutindo com IA em rede social ou processando quem faz piada.
@C_A_G0101 @MeMeDocMa @nicolasberrod @pimp_renelle @nathanpsmad oui, et non. EPIC-HR est ici: https://t.co/nlfMbzRB9S comme dit ci dessus, le nirmatrelvir REDUIT LA MORTALITE! OUI! Mais, chez des patients non vaccinés recrutés en 2021. L'autre étude ci dessus, randomisée inclue des patients de fin 2021 juqu'en juillet 22 à 50% vaccinés
Jan 26, 2025 · 2 likes · 8,978 followersView post →
FS
Fred Stalder
@sudokuvariante · X
Please remind us how antivirals should be used: within 5 days after symptom onset. https://t.co/Cy41eb2ZqJ https://t.co/O4YxHPBoZR
and that it failed when the treatment is delayed https://t.co/1hWdPB8H5c https://t.co/pJQLsMK1Uo
2/2
Dec 25, 2024 · 21 likes · 4,781 followersView post →
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SeekingRealTruth
@real_seeking · X
@LedenUnor @craigbyren @ElipieMegan @HeatherEHeying @AndrewEcker829 Paxlovid
Dosing every 12 hours for 5 days
Treated within 3 days after symptom onset
ALSO: Started 5 days of symptoms but had to extract 3 days max to pass
https://t.co/3SDoT1uOFL
@Indig0star @WhiteL_o_t_u_s @sudokuvariante @LoLoWarn @Lavisjuste1 @Apoo52105617 P.S. Pour en rajouter une couche sur à quel point l'argument du "80 events c'était pas assez pour publier
Dans l'essai du Paxlovid, qui a carrément donné lieu à une AMM (vous conviendrez que les AMM sont plus difficiles à avoir que les publications) https://t.co/rIOoSfDe4q 4/n https://t.co/IwyAvfqsKu
Nov 11, 2024 · 2 likes · 2,780 followersView post →
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SeekingRealTruth
@real_seeking · X
@dr_jon_l @yeahnaa333 @donkerwater Paxlovid
Dosing every 12 hours for 5 days
Treated within 3 days after symptom onset
ALSO: Started 5 days of symptoms but had to extract 3 days max to pass
https://t.co/3SDoT1ugQd
@dr_jon_l @jamesamcgee @ZombiApocolypse Paxlovid
Dosing every 12 hours for 5 days
Treated within 3 days after symptom onset
ALSO: Started 5 days of symptoms but had to extract 3 days max to pass
https://t.co/3SDoT1ugQd
@nicolafiore Google is full of links to studies about the clinical trials of Paxlovid. It's been taken by hundreds of thousands of people. If you don't want to take it, fine whatever, but some of us need to in order to survive a SARS infection.
https://t.co/6bKUhWGz2V
RT @LoLoWarn: @jmdogne alors qu'il est efficace chez les personnes à risque en précoce.
https://t.co/ySKZJWFuZD
Aug 24, 2024 · 2 shares · 1,267 followersView post →
PF
Pr fentedelynx
@Olivierfente · X
RT @LoLoWarn: @jmdogne alors qu'il est efficace chez les personnes à risque en précoce.
https://t.co/ySKZJWFuZD
Aug 24, 2024 · 2 shares · 16,802 followersView post →
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LoLo aka Laurent
@LoLoWarn · X
@jmdogne alors qu'il est efficace chez les personnes à risque en précoce.
https://t.co/ySKZJWFuZD
Aug 23, 2024 · 5 likes · 2 shares · 2,883 followersView post →
DF
Dr Judy VaccinePLUS - Novavax JN1 Feb 25
@JudyandHuahua · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Aug 20, 2024 · 10 shares · 2,591 followersView post →
EM
Ed Belongia MD
@belongia.bsky.social · Bluesky
Paxlovid does not shorten duration of illness but greatly reduces severe illness in high risk patents. It is under prescribed for older adults and other high risk groups.
pubmed.ncbi.nlm.nih.gov/35172054/
@fluidloading @tim_riggins330 @voks45 @JeanKev_Apeupre @lonnibesancon @RChabriet Et non, tu connais les règles de l’EBM, l’avis d’expert ça vaut rien face à un rct chez des personnes à risque. Encore une fois tu fais de l’EBM à géométrie variable.
https://t.co/ySKZJWFuZD https://t.co/6gRnqJY9Ut
Aug 5, 2024 · 2 likes · 2,883 followersView post →
Voici deux bons exemples pour le remdesivir et le paxlovid dont les deux études portent sur du soins précoce et personnes à risques (Merci Karine)
https://t.co/ySKZJWFuZD
https://t.co/gNiJX4QCD1 https://t.co/eHwqbeZeWR
Jun 29, 2024 · 20 likes · 2,883 followersView post →
う
うん、
@wai201303 · X
RT @black_kghp: https://t.co/R8VJcrldKN
Jun 26, 2024 · 7 shares · 229 followersView post →
@lebon80 @CitizenXSci @EricBillyFR @sudokuvariante 2246 personnes pour le paxlovid.
https://t.co/eHuUFmkswO
En UNE SEULE étude, pas en 50. Donc biiien plus significatif que tes 1500 personnes.
@BradBanko @DrPaulOffit That is not true, it is based on gold standard DBRCT but it is VERY carefully curated one! actually so curated that all subsequent stuies were not allowed! https://t.co/uvBcTAFkgn "Pfizer has denied access to Paxlovid for independent RCTs Ledford" https://t.co/iNFENWLnsg
@I_am_Steele @AlyssaDAMinIt @Anne_Gee_2923 @DrEtiquette @ZaleskiLuke Paxlovid
Dosing every 12 hours for 5 days
Treated within 3 days after symptom onset
ALSO: Started 5 days of symptoms but had to extract 3 days max to pass
https://t.co/3SDoT1ugQd
Apr 24, 2024 · 1 like · 1 share · 173 followersView post →
JG
Joel Grossman
@JoelGrossmanMD · X
@anish_koka @shycollie Not going to come at you with anecdotal success stories but what is your criticism of this?
https://t.co/Ffn1Q2dH0b
@Debunk_the_Funk @TheChiefNerd Paxlovid was only over indicated to work in unvaccinated adults at high risk of severe COVID-19 who had not been infected
https://t.co/cCxgSAreUy
By the time the FDA authorized paxlovid for use in the US in late 2021
https://t.co/KWeEXcThYo
Combined seroprevalence from https://t.co/i93BS4MPDV
@ryanbeed @Cornholio2024 @cbeckj @MB05076 @LaceyForostoski @villagerssn @ThomMohr @PeaceLillie33 @RaggetteU @Iwontsubmit @HealthFreedomLA Didn’t take much time for this one.
@mauri_perez El ensayo original de paxlovid fue positivo, por muy poco y con endpoint blando, pero positivo.
El tema era ver qué psaba en vacunados y post exposición.
https://t.co/DGDHgdB5Kj
@catturd2 Also, a 2022 study showed 20 hospitalizations & 7 deaths in the placebo group with 3 hospitalizations & 0 deaths in the group that received
So this obviously decreases hospitalizations & death, but keep cherry pick the results for your ignorant MAGA base
https://t.co/TvbQAi20wl
@Debunk_the_Funk @TheChiefNerd This is the study stating the 89% relative risk. Different patient population that the one Nerd is presenting.
Not overly impressed with this one as the incidence was small in both groups and the absolute risk reduction is small.
https://t.co/0GIETKc97e
@MaxDelvallee @NEJM Et précision de taille @MaxDelvallee , il se pourrait sur cette étude l’administration du paxlovid soit un poil trop tardif comparé à l’étude pivot du pax (non hosp) alors qu’ici ils sont hospitalisé et pour une grande partie au moins sous oxygène
https://t.co/ySKZJWFuZD
@KinseyKat1 @ryanbeed @PeaceLillie33 @LaceyForostoski @Iwontsubmit @HealthFreedomLA Since he seems reluctant to show the study I will link it here so people can look at the whole picture.
Look at the actual percentages and not just the RR.
I am also suspicious of the 13 deaths in placebo group with none in the trial arm.
https://t.co/0GIETKc97e
@CraigKellyPHON 1/ Craig, I know you don't read peer reviewed papers, but here's a double-blind, randomized, controlled trial of Paxlovid published in February 2022, when the participants would have had the Delta variant (Omicron appeared Dec. 2021) It was effective. https://t.co/wn9vN8zHK8 https://t.co/tXTu5fMzqj
@fluidloading bah voici donc l'etude de #Pfizer en personne (pas facile à trouver je dois dire)
89% d'efficacité qui disent!!
du coup pfizer ment... ou c'est toi?
https://t.co/Masf2E4loO https://t.co/zXFykgpiqE
@AstorAaron @Rando8715401 The results of EPIC-HR have been known for a long time. That study was published two years ago. https://t.co/GkY7LTzZT1
Apr 4, 2024 · 1 like · 43,373 followersView post →
JM
Jake Scott, MD
@jakescottMD · X
@zeynep @simoj_ Of course EPIC-HR was a trial, but it only included unvaccinated people and didn’t include a sufficient number of immunocompromised patients to make any meaningful conclusions.
And I’ve never claimed that observational evidence is zero evidence.
https://t.co/otD8fksCex https://t.co/9pFlr1tEHR
Pour référence le bénéfice existait en 2022 pour les patients à hauts risques. Avec l’évolution de l’immunité en population et des variants moins létaux à voir si cela perdure
https://t.co/wsq79oZfiH
Apr 4, 2024 · 1 like · 18,240 followersView post →
EB
Eric Billy
@EricBillyFR · X
@think_fungus On a les info pour high risk.
https://t.co/wsq79oZfiH
@docdu16 Cela peut dépendre du niveau de risque.
Ça ne présente peut-être plus de bénéfice aujourd’hui car l’immunité de la population a évolué, phénomène de moisson, virus moins létal car variant/clade différent, etc .
https://t.co/wsq79oZfiH
Bénéfique chez les patients à risque (DOI: 10.1056/NEJMoa2118542), le nirmatrelvir/ritonavir perd son intérêt dans les populations à faible risque (DOI: 10.1056/NEJMoa2309003).
Le bénéfice -risque d'un médicament dépend plus du patient et de l'indication que du médicament https://t.co/kkgNTnwO3U https://t.co/1uH7bOhMO0
Die RCT zu Paxlovid (links) ist ein schönes Statement. Nicht für Paxlovid, sondern für die Impfung, wenn man sie im Kontext der EPIC-HR-Studie liest (rechts).
https://t.co/Sg1Loh65i3
https://t.co/o0XmiWme2G https://t.co/mWizHde04x
@Universal_Ken @Amy_Walker20 @Melchizedek1972 @LymeScience @MdBreathe @myedpillus Paxlovid
Dosing every 12 hours for 5 days
Treated within 3 days after symptom onset
ALSO: Started 5 days of symptoms but had to extract 3 days max to pass
https://t.co/3SDoT1ugQd
@BHater2022 @DanishTechGuy @yay_its_james Link to specific tweet that do "thorough debunking"
Yes sample size is small, and patient selection is biased in wrong direction (low risk/mild), what do you think would be p-value if it was 3x larger size and patients at risk selection like here? https://t.co/uvBcTAFkgn
RT @jvipondmd: The blog starts with Hammond (2022), the original NEJM trial that started it all.
https://t.co/kOXdQVp2UY
Zero deaths vs. 7…
Feb 23, 2024 · 2 shares · 1,135 followersView post →
SJ
Sandy J
@SandyHi2244 · X
RT @jvipondmd: The blog starts with Hammond (2022), the original NEJM trial that started it all.
https://t.co/kOXdQVp2UY
Zero deaths vs. 7…
Feb 22, 2024 · 2 shares · 7,331 followersView post →
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jvipondmd
@jvipondmd · X
The blog starts with Hammond (2022), the original NEJM trial that started it all.
https://t.co/kOXdQVp2UY
Zero deaths vs. 7 for placebo.
NNT of 17 for combination of hosp/death. Not bad!
7/ https://t.co/Jw71Gm8K9A
Feb 22, 2024 · 39 likes · 2 shares · 48,202 followersView post →
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SeekingRealTruth
@real_seeking · X
@DocDeezWhat @SummnaS @BGatesIsaPyscho Paxlovid
Dosing every 12 hours for 5 days
Treated within 3 days after symptom onset
https://t.co/3SDoT1ugQd
@DrSuneelDhand No, the COVID drug Paxlovid is not dangerous and ineffective. Several studies show Paxlovid reduces COVID mortality and is safe https://t.co/GGqYlJX6pq https://t.co/ZpccmhCa6w
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 22, 2024 · 10 shares · 7,435 followersView post →
M
Michael
@chacotocub3 · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 21, 2024 · 10 shares · 260 followersView post →
AW
Alexis White
@AJWite · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 21, 2024 · 10 shares · 1,897 followersView post →
D
Diana
@Diana79929170 · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 21, 2024 · 10 shares · 836 followersView post →
NO
Nels Olsen
@yegnho · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 21, 2024 · 10 shares · 622 followersView post →
V
Venilia
@Venilia13 · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 20, 2024 · 10 shares · 277 followersView post →
CC
Carol ❤️Cookies
@CarolPe64837759 · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 20, 2024 · 10 shares · 841 followersView post →
AF
Anti-Fascist
@JeSuisPrestLvt · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 20, 2024 · 10 shares · 696 followersView post →
NI
nb_covid_info
@nb_covid_info · X
RT @jvipondmd: Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the…
Jan 20, 2024 · 10 shares · 8,270 followersView post →
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jvipondmd
@jvipondmd · X
Study 1: 89% RRR (6% ARR or NNT of 17) in bad outcomes (hospitalization/death). zero deaths in the active arm, vs. 13 in the control arm. https://t.co/NqB9nGRyhB
Jan 20, 2024 · 95 likes · 10 shares · 48,202 followersView post →
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safedr
@safedr4 · X
RT @jvipondmd: A reminder that the paxlovid arm had zero (ZERO!) deaths compared to 13 in the placebo arm.
for high risk patients. https:/…
A reminder that the paxlovid arm had zero (ZERO!) deaths compared to 13 in the placebo arm.
for high risk patients. https://t.co/NqB9nGRyhB
Jan 20, 2024 · 4 likes · 1 share · 48,202 followersView post →
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DrGadh
@Gadhzilla · X
@DCDoc33 Paxlovid is milquetoast (weak). Read the NEJM article below. The NHS of the UK just dumped it after wasting 2B. Low dose lithium is powerful, and safer (read the second paper, mine) but Big Pharma would prefer it remain unknown.
https://t.co/lDZXLFiOSY
https://t.co/g6TIrPEvgQ
@masimaux @sudokuvariante @boulware_dr The fact that this IVM study was done on very healthy-low risk (and is used as doesn't work argument) and PAX one on at high-risk patients tells you about study design bias from author! https://t.co/uvBcTAFkgn it is amazing that you see benefit despite bias regardless!
@a_huss1 @ingomar_gutmann "Eligible patients were required to be at least 18 years old; to have confirmed SARS-CoV-2 infection and symptom onset no more than 5 days before randomization, with at least one sign or symptom of Covid-19 on the day of randomization"
https://t.co/dCpTNogMps https://t.co/0H7pxekJJP
Dec 23, 2023 · 17 likes · 1,064 followersView post →
@domstadtmedicus naja, es gibt eine Zulassungsstudie.
https://t.co/rvJtSEB9QA
wir haben ja auch keine dauerhaften Studien zu Antibiotikagabe bei Infekten.
Paxlovid ist zugelassen und sollte Indikationsgerecht eingesetzt werden. Ich gebe es häufig/biete es häufig an. Nicht jeder will es.
@TBkowski @medexit ...bo albo też nie czytali, albo nie zrozumieli, albo wybrali sobie z tego to, co im pasowało pod tezę.
tu jest podział, którego nie widzą - na hosp. i zgony. ba. jest nawet na wiek (<65 i >65), oraz czas rozp. leczenia (<3d i >3d) [2/n]
https://t.co/3k7xImm22t
May 20, 2023 · 2 likes · 1,178 followersView post →
ǤX
Ǥợɲƶąḽǫ ≈ ∫ϕx∂x✍
@MGClaros · X
En un ensayo doble ciego, aleatorizado, controlado, con adultos sintomáticos, no vacunados y no hospitalizados, y alto riesgo de COVID-19 grave, el uso de nirmatrelvir más ritonavir redujo incidencia de hospitalización o muerte por esta enfermedad
https://t.co/N3d6BLLQ1t
@Ltdantheman76 @simoncynicsays @Anymous84861064 @kevinnbass @US_FDA BS argument, it will not reach stat sig. BY DESIGN! Compare it with this one: https://t.co/uvBcTAFS5V Very carefully crafted (look at numbers 4x more, exclusions trough the roof, number of centers used is insane), now do the stat.for those # maintaining OR p goes to 0.000x
@Jeannemarie1309 @Sq178kin @Beerussamarange @bitchwitch1969 @bonnesante73 @nicorlando1980 @SahabiaAli @Titithebest4 https://t.co/C8szn3Baqe
De rien. Mais t’as pas le niveau
Nov 15, 2022 · 27 shares · 1,796 followersView post →
LO
Luis Del Carpio Orantes
@CarpioOrantes23 · X
Tuvimos la dicha de participar en el grupo de investigadores de este antiviral especifico contra COVID-19, sumando armas al arsenal anti pandemia https://t.co/TNkEw4ib4B https://t.co/As9GpaJJkF
@Christian_NDBy ...aber doch in nem zweiten Arm auch bis zu 5 Tage nach Symptombeginn überprüft und einen Effekt gezeigt. Das ist ja schon ne Hausnummer bei SARS-CoV-2 und würde ich als "späte Einnahme" gelten lassen. https://t.co/C47vQ5z8Yj https://t.co/4wakDrkHax
@JSanders174 @RI2APAC @LEPfedup @GovDanMcKee .@GovDanMcKee is at high risk for COVID-19 complications by virtue of his age; keep in mind that approximately 60% of the US population has at least one high-risk factor.
https://t.co/Wzy2WsRD0e
@dokhollidays @Kirsche16473791 @a_usem @GieslerIris @Karl_Lauterbach @US_FDA Problematik bzgl Rebound ist bereits Thema einiger Studien, siehe zB: ▶️ https://t.co/Xc005nzVKz ▶️ Hier finden sich des Weiteren div Studien: https://t.co/nYhHylSxDj
Ach so, Ursprungsstudie für die Notfall-EUA 12/21: https://t.co/p5fVy16fiT
= 1120 Patienten bekamen Paxlovid, 3/
Aug 5, 2022 · 2 likes · 1,538 followersView post →
TT
The Rounds Table
@roundstable · X
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 was examined in an article by Hammond et al. in NEJM.
Read more here:
https://t.co/ysUTBDXTzB
Jun 30, 2022 · 27 shares · 2,019 followersView post →
ニ
ニューロドクター乱夢
@hichachu · X
1. Hammond J, Leister-Tebbe H, Gardner A, Abreu P, Bao W, Wisemandle W, et al. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with COVID-19. New Engl J Med 2022; 386(15): 1397-1408.
https://t.co/0NL1LE5N7O
Jun 17, 2022 · 128 likes · 27 shares · 66,965 followersView post →
JM
James Heilman, MD
@WikiDocJames · X
@BC_Irma_Stretch The trial is here published in the NEJM. https://t.co/byQgBoWESA Yah 6% of people report a crappy metallic taste. Lot of meds don't taste great. I have been recommended people wear proper masks for more than two years... Best
Jun 6, 2022 · 2 likes · 9,019 followersView post →
KF
Kat Timberlake, PharmD, FCSHP
@KatTPharmD · X
RT @CarlosdelRio7: Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 https://t.co/9UMpBEgtNL Finally the Paxlovid stud…
May 31, 2022 · 25 shares · 832 followersView post →
DL
Dr. Juan Martínez Lozano
@DrJuanMartnezL1 · X
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/U1fT40xaYm
@Northofwestward @EricTopol That's the SR study (standard risk) the original study is the HR study (high risk)
This is the original trial:
https://t.co/TrtlDk9w9S
Risk for progression to severe COVID-19 lower with nirmatrelvir + ritonavir
https://t.co/cQC38PAuJJ
https://t.co/zrJumTDd7x
https://t.co/Mk6PmiQQ5T https://t.co/Ua9QMYa5pX
RT @MIDCUSA: Lots of discussion regarding Paxlovid rebound. Nirmatrelvir is a Mpro protease inhibitor. Does mutation of Mpro explain the re…
May 17, 2022 · 2 shares · 429 followersView post →
MC
Metro Infectious Disease Consultants
@MIDCUSA · X
Lots of discussion regarding Paxlovid rebound. Nirmatrelvir is a Mpro protease inhibitor. Does mutation of Mpro explain the relapse? https://t.co/5HWAZkAmU4 had 731 matched samples with no association between Mpro mutation and Rx failure. #paxlovidrebound https://t.co/lAgkHB6wNg
May 17, 2022 · 6 likes · 2 shares · 2,329 followersView post →
AF
Abillo Fon
@abillofon · X
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/ppZCEraQUQ
In der Zulassungsstudie (https://t.co/kT75SkvMJH) führte dies zu einer Reduktion schwerer bzw. tödlicher Covid-19-Verläufe um ca. 88 %. Falls diese Therapie wegen Kontraindikationen oder Wechselwirkungen nicht angewendet werden kann, gibt es dazu noch mehrere Alternativen.
10/12
4) HAMMOND, Jennifer et al.. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19. The New England Journal of Medicine, v.386, n.15, p.1397-1408, 2022. Disponível em: <https://t.co/cEHyyc33rM>.
Paxlovid es el tratamiento de elección vs SARS Cov2, aún no está disponible en México. ¿Habremos de llegar a las 800 mil defunciones para que se disponga de él?
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/iSZz3PW33b
パクスロビド(日本名パキロビッドパック)の第2/3相臨床試験(治験)結果 日本語版Abstract
高リスクの入院していない成人 Covid-19 患者に対する経口ニルマトレルビル
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19
J. Hammond and Others
https://t.co/yHnKnflHNQ
These are impressive results. I'd expect the ARR would be a lot less in a vaccinated/previously exposed population but still...
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/A8k54vK4JE
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/6ciuqrX5uB
The US Pharmaceutical and Biotech industries and their scientific staffs have produced both vaccines and treatments in a record time to suppress the COVID epidemic.
@heidi_monkkonen @lasleh @hsfi Tehoa, jos aloitus 1-3vrk sisällä. Ei enää 4-5pv kuluttua!
In the planned interim analysis of patients treated within 3 days after symptom onset the incidence of Covid-19-related hospitalization or death by day 28 was lower
https://t.co/iIV7oN7ECI
2/
@DrJacksonCork discussed the NEJM oral nirmatrelvir study: https://t.co/SgGWdd2Sfl
Hopefully some of you were able to join the @IDJClub last night as well for a deeper dive! Can scroll thru #IDJClub for more!
ファイザーの経口薬(日本での販売名パキロビッド)の治験論文
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/89qTVWKSU1
Feb 26, 2022 · 1 like · 1,366 followersView post →
JO
James William Owens
@Willard1951 · X
@NoDictatorship9 @nuhope2022 @tomsirolimus @mhunt081266 @F250Roush @PLHartungRN @sammy44231 @zeetubes @AndrewLazarus4 @Monstercoyliar @ogilville1 @SkepticalMutant @MatthewNewell67 @BrexitMyArse @mcfunny @AbsoluteGnosis @raouldukeerik @JimeeLiberty @TonyBaduy @volpiranyas @provaxtexan @IdunsDaughter @KayVonPaul @Alex_on_A14 @NoMisinfoToday @DbootyNabber @doom37455413 @richykirsh @kath2cats @jtmayes3 @doritmi @ninawowp @MarkTho29550016 @xfirgaming @ConsequentialBr @lewbloch @tatsandfats @JonathanHannah @SallyJiggles @andylumm @3dogrunner @MagnoliaHoney2 @CHSdoctor @chimera414 @Nockit1 @skepticalprune @LandonNTooke @SeamusMacSuibh1 @Fannyi5 @jallen1315 doi = digital object identifier
It's the link to a paper
Such as the one I used for the very recent paper on the protease inhibitor clinical trial
https://t.co/92pUebewQi
@F250Roush @PLHartungRN @NoDictatorship9 @jtmayes3 @sammy44231 @tomsirolimus @mhunt081266 @zeetubes @AndrewLazarus4 @Monstercoyliar @ogilville1 @SkepticalMutant @MatthewNewell67 @BrexitMyArse @mcfunny @nuhope2022 @AbsoluteGnosis @raouldukeerik @JimeeLiberty @TonyBaduy @volpiranyas @provaxtexan @IdunsDaughter @KayVonPaul @Alex_on_A14 @NoMisinfoToday @DbootyNabber @doom37455413 @richykirsh @kath2cats @doritmi @ninawowp @MarkTho29550016 @xfirgaming @ConsequentialBr @lewbloch @tatsandfats @JonathanHannah @SallyJiggles @andylumm @3dogrunner @MagnoliaHoney2 @CHSdoctor @chimera414 @Nockit1 @skepticalprune @LandonNTooke @SeamusMacSuibh1 @Fannyi5 @jallen1315 Yes, specific protease inhibitor as COVID makes a very large proto-protein which must be cleaved into functional pieces for the virus to replicate
Yes, needs to be given early in infection
Data look good https://t.co/Xl7EEQDEWU
And NEJM early
@CVimmunology @Hartmann_KE I guess this is what I get for being behind on NEJM: Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/p7wDVP8dkq
Some good news for early treatment of vulnerable individuals with COVID infections
Hammond et al "Oral Nirmatrelvir for high-risk, nonhospitalized adults with Covid-19" NEJM early online 2022
https://t.co/92pUebewQi
#medtwitter How excited should we get? Will this 1. help 2. anytime soon?
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/cUEJF9UJpR
RT @carpe_diem0820: パキロビッドの臨床研究報告
Covid-19発症者にニルマトレルビルとリトナビルの併用で、重症化リスクを89%低減
安全性の明らかな懸念はなしも下記は増加
味覚障害(5.6% vs. 0.3%)
下痢 (3.1% vs. 1.6%)
Or…
Feb 18, 2022 · 11 shares · 947 followersView post →
M
msj
@1007wtnb · X
RT @carpe_diem0820: パキロビッドの臨床研究報告
Covid-19発症者にニルマトレルビルとリトナビルの併用で、重症化リスクを89%低減
安全性の明らかな懸念はなしも下記は増加
味覚障害(5.6% vs. 0.3%)
下痢 (3.1% vs. 1.6%)
Or…
Feb 18, 2022 · 11 shares · 875 followersView post →
感
感染少尉
@racketandmd · X
RT @carpe_diem0820: パキロビッドの臨床研究報告
Covid-19発症者にニルマトレルビルとリトナビルの併用で、重症化リスクを89%低減
安全性の明らかな懸念はなしも下記は増加
味覚障害(5.6% vs. 0.3%)
下痢 (3.1% vs. 1.6%)
Or…
Feb 18, 2022 · 11 shares · 181 followersView post →
M無
Mugen UJIIE (氏家 無限)
@carpe_diem0820 · X
パキロビッドの臨床研究報告
Covid-19発症者にニルマトレルビルとリトナビルの併用で、重症化リスクを89%低減
安全性の明らかな懸念はなしも下記は増加
味覚障害(5.6% vs. 0.3%)
下痢 (3.1% vs. 1.6%)
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19
https://t.co/aus9I3BGmK https://t.co/agyGwnA3oy https://t.co/PteaAamicR
Feb 18, 2022 · 26 likes · 11 shares · 12,357 followersView post →
I
Interasma
@Interasma · X
RT @Aller_MD: Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 | NEJM https://t.co/BEgRe7K8PY
Feb 18, 2022 · 4 shares · 2,448 followersView post →
あ
あのにます
@god812eternityk · X
RT @Fizz_DI: 重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi…
Feb 17, 2022 · 11 shares · 109 followersView post →
TK
T.kimura
@jjcrazydiamond · X
RT @Fizz_DI: 重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi…
Feb 17, 2022 · 11 shares · 1,371 followersView post →
コ
コロナ
@jdTPPfL6mabrB09 · X
RT @Fizz_DI: 重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi…
Feb 17, 2022 · 11 shares · 16 followersView post →
MH
mariko hashimoto
@017charu · X
RT @Fizz_DI: 重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi…
Feb 17, 2022 · 11 shares · 162 followersView post →
青
青島周一
@syuichiao89 · X
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 https://t.co/zKBIx3jmlG
Feb 17, 2022 · 1 like · 8,599 followersView post →
メ薬
メディカルトリビューン編集部(薬剤情報担当)
@pharmatribune · X
RT @Fizz_DI: 重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi…
Feb 17, 2022 · 11 shares · 2,917 followersView post →
みM
みずはら mizuhara
@gibbous_leo · X
RT @Fizz_DI: 重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi…
Feb 17, 2022 · 11 shares · 1,427 followersView post →
T
ted跡地
@rody0708 · X
RT @Fizz_DI: 重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi…
Feb 17, 2022 · 11 shares · 148 followersView post →
春回
春から研修医@ワクチン7回接種済
@igakusei_covid · X
RT @Fizz_DI: 重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi…
Feb 17, 2022 · 11 shares · 80 followersView post →
FY
Fizz-DI@比較と使い分け-KOJIMA Yushi
@Fizz_DI · X
重症化リスクのあるCOVID-19患者に対する「パキロビッド:ニルマトレルビル300mg+リトナビル100mg」の5日間投与は、プラセボに比べ、28日間の入院または死亡を88.9%抑制。
N Engl J Med . 2022 Feb 16. doi: 10.1056/NEJMoa2118542. Online ahead of print. PMID:35172054
https://t.co/QkU9yx2Vmn
Feb 17, 2022 · 28 likes · 11 shares · 34,633 followersView post →
T
Нара Без Эффекта | TikTok
TikTok
... 10.1056/NEJMoa2118542 НЕпоказательные работы. Арбидол - мало регистрированных серий и мета-анализов; суммарно доказательность неоднородна — мета-анализы не ...
... 10.1056/NEJMoa2118542 НЕпоказательные работы. Арбидол - мало регистрированных серий и мета-анализов; суммарно доказательность неоднородна — мета-анализы не ...
org/doi/full/10.1056/NEJMoa2118542 SC DHEC Evusheld Antibody Treatment for COVID-19 High-risk Groups Vanderbilt University Medical Center Antibodies ...
Nirmatrelvir/Ritonavir Reduces Risk of Hospitalization in At-Risk ...
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... 10.1056/NEJMoa2118542?articleTools=true. Editor's Note: Dr. Ebell is deputy editor for evidence-based medicine for AFP and cofounder and editor-in-chief of ...