Nat Commun March 2022 PMID 35273146

Improved prediction of protein-protein interactions using AlphaFold2.

Patrick Bryant, Gabriele Pozzati, Arne Elofsson

Mentions

58
Peak: 21 in Sep 2021
across 4 sources since Sep 2021

Extended reach

248,956
potential audience

Total likes

159

Video views

249

Mentions per month

Sep 2021 – Aug 2023

Where it's discussed

  • X / Twitter50 posts
  • News3 articles
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The collective discussions reflect a highly positive stance, with many posts emphasizing the novel use of AlphaFold2, its success in identifying protein interactions, and its potential to transform research, as exemplified by statements like 'received 33,244 downloads' and descriptions of methodological advancements, demonstrating both enthusiasm and recognition of significant scientific impact.

AgreementStrong agreement

Most discussions highlight the significance and innovative aspects of using AlphaFold2 for predicting protein interactions, showing strong support.

InterestHigh interest

The widespread sharing, mention of download numbers, and discussions of implications demonstrate high curiosity and engagement from the community.

EngagementModerate engagement

Many posts reference specific methodological improvements and potential applications, indicating active participation, though some are more promotional.

ImpactHigh impact

The emphasis on the method’s ability to identify a large portion of true interactions with low false positives suggests the community perceives considerable scientific and practical impact.

Abstract in brief

  • The study explores using AlphaFold2, a highly accurate protein structure prediction tool, to model heterodimeric protein complexes, addressing a key challenge in understanding protein functions.
  • The researchers optimized the AlphaFold2 protocol with better multiple sequence alignments, successfully generating acceptable quality models for 63% of protein dimers, and developed a function to predict the quality of these models based on interface data.
  • By leveraging predicted DockQ scores, the method can effectively distinguish interacting from noninteracting proteins, identifying 51% of all true interacting pairs at a low false positive rate of 1%.]

Top posts

Most liked on X and Bluesky
bioRxiv
@biorxivpreprint · X

Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https://t.co/nBynW20ltD #bioRxiv

Sep 15, 2021 · 55 likes · 16 shares · 136,866 followers View post →
Arne Elofsson @arneelof.bsky.social
@arneelof · X

#MyOAarticle "Improved prediction of protein-protein interactions using AlphaFold2" received 33,244 downloads since its publication! Access the article here: https://t.co/FtlJUxaMs7

Feb 13, 2023 · 29 likes · 7 shares · 2,568 followers View post →
Arne Elofsson @arneelof.bsky.social
@arneelof · X

Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZsnRSHiu

Jan 20, 2022 · 29 likes · 7 shares · 2,568 followers View post →
jlsteenwyk
@jlsteenwyk · X

In the article 'Improved prediction of protein-protein interactions using AlphaFold2,' authors report the ability to identify 51% of all interacting pairs at 1% FPR #science #alphafold #biology #protein #Chemistry https://t.co/3XfboODoi9

Feb 13, 2023 · 26 likes · 4 shares · 4,673 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https://t.co/5CPnR1Sr4B #biorxiv_bioinfo

Sep 15, 2021 · 11 likes · 2 shares · 18,047 followers View post →
NobuoMaita
@nob_mai · X

Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/zPPkt1AHug

Mar 10, 2022 · 5 likes · 1,076 followers View post →

All mentions

Ryoma Takeshima
@RyomaTakeshima · X

RT @jlsteenwyk: In the article 'Improved prediction of protein-protein interactions using AlphaFold2,' authors report the ability to identi…

Feb 14, 2023 · 4 shares · 186 followers View post →
Ilnam Kang
@ilnam_kang · X

RT @jlsteenwyk: In the article 'Improved prediction of protein-protein interactions using AlphaFold2,' authors report the ability to identi…

Feb 13, 2023 · 4 shares · 235 followers View post →
T Tian
@gdsttian · X

RT @arneelof: #MyOAarticle "Improved prediction of protein-protein interactions using AlphaFold2" received 33,244 downloads since its publi…

Feb 13, 2023 · 7 shares · 139 followers View post →
Li Chuin Chong
@lichuin_chong · X

RT @arneelof: #MyOAarticle "Improved prediction of protein-protein interactions using AlphaFold2" received 33,244 downloads since its publi…

Feb 13, 2023 · 7 shares · 74 followers View post →
Philipp Peslalz
@PhilippPeslalz · X

RT @arneelof: #MyOAarticle "Improved prediction of protein-protein interactions using AlphaFold2" received 33,244 downloads since its publi…

Feb 13, 2023 · 7 shares · 170 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @jlsteenwyk: In the article 'Improved prediction of protein-protein interactions using AlphaFold2,' authors report the ability to identi…

Feb 13, 2023 · 4 shares · 8,157 followers View post →
priya joseph
@ayirpelle · X

RT @arneelof: #MyOAarticle "Improved prediction of protein-protein interactions using AlphaFold2" received 33,244 downloads since its publi…

Feb 13, 2023 · 7 shares · 4,902 followers View post →
Kausthubh R
@kausthubh_r · X

RT @jlsteenwyk: In the article 'Improved prediction of protein-protein interactions using AlphaFold2,' authors report the ability to identi…

Feb 13, 2023 · 4 shares · 661 followers View post →
jlsteenwyk
@jlsteenwyk · X

In the article 'Improved prediction of protein-protein interactions using AlphaFold2,' authors report the ability to identify 51% of all interacting pairs at 1% FPR #science #alphafold #biology #protein #Chemistry https://t.co/3XfboODoi9

Feb 13, 2023 · 26 likes · 4 shares · 4,673 followers View post →
Emerson
@emergmoreira · X

RT @arneelof: #MyOAarticle "Improved prediction of protein-protein interactions using AlphaFold2" received 33,244 downloads since its publi…

Feb 13, 2023 · 7 shares · 192 followers View post →
tyler
@tyler19079389 · X

RT @arneelof: #MyOAarticle "Improved prediction of protein-protein interactions using AlphaFold2" received 33,244 downloads since its publi…

Feb 13, 2023 · 7 shares · 27 followers View post →
Arne Elofsson @arneelof.bsky.social
@arneelof · X

#MyOAarticle "Improved prediction of protein-protein interactions using AlphaFold2" received 33,244 downloads since its publication! Access the article here: https://t.co/FtlJUxaMs7

Feb 13, 2023 · 29 likes · 7 shares · 2,568 followers View post →
diegB
@diegB4 · X

@GLim2016 @DeepMind We use this method https://t.co/VFU86lpz97

Aug 31, 2022 · 1 like · 146 followers View post →
Codon Magazine
@codonmag · X

Improved prediction of protein-protein interactions using AlphaFold2 | Nature Communications https://t.co/STeXWpEQ9s #AI #biology

Mar 14, 2022 · 152 followers View post →
isplab
@isplab1 · X

"Improved prediction of protein-protein interactions using AlphaFold2" — Read it on @ResearchGate: https://t.co/RhUSUjtGf5

Mar 13, 2022 · 6 followers View post →
Martin Mayta
@MartinMayta2 · X

https://t.co/7gfwH7uyim

Mar 13, 2022 · 214 followers View post →
Tominaga K. (tomiken)
@pacyc1841 · X

» Improved prediction of protein-protein interactions using AlphaFold2 | Nature Communications https://t.co/NySybWK8mc

Mar 11, 2022 · 855 followers View post →
Amar Singh
@DrSinghAmar · X

Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/RNx3HFSfbr

Mar 10, 2022 · 123 followers View post →
NobuoMaita
@nob_mai · X

Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/zPPkt1AHug

Mar 10, 2022 · 5 likes · 1,076 followers View post →
Martín González Buitrón
@tinchoGB · X

RT @arneelof: Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZ…

Jan 22, 2022 · 7 shares · 56 followers View post →
SBG-UNQ
@SbgUnq · X

RT @arneelof: Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZ…

Jan 21, 2022 · 7 shares · 303 followers View post →
Kozo Tomita Lab: RNA Biology
@RnaLaboratory · X

RT @arneelof: Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZ…

Jan 21, 2022 · 7 shares · 403 followers View post →
Juvenal Yosa
@El_Dryosa · X

RT @arneelof: Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZ…

Jan 21, 2022 · 7 shares · 610 followers View post →
Elodie Laine
@LaineElodie · X

RT @arneelof: Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZ…

Jan 21, 2022 · 7 shares · 518 followers View post →
Supakorn Pongpakdee
@SupakornPongpa1 · X

RT @arneelof: Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZ…

Jan 20, 2022 · 7 shares · 62 followers View post →
Abhiman Saraswathi
@abhimans · X

RT @arneelof: Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZ…

Jan 20, 2022 · 7 shares · 245 followers View post →
Arne Elofsson @arneelof.bsky.social
@arneelof · X

Read this #preprint on @researchsquare: Improved prediction of protein-protein interactions using AlphaFold2 https://t.co/1VZsnRSHiu

Jan 20, 2022 · 29 likes · 7 shares · 2,568 followers View post →
CompChemBio Bot
@CompChemBioBot · X

RT @SeqComplete: #BioIT #BioInformatics Improved prediction of protein-protein interactions using AlphaFold2 [NEW RESULTS] https://t.co/E4s…

Dec 16, 2021 · 1 share · 2,762 followers View post →
SeqComplete
@SeqComplete · X

#BioIT #BioInformatics Improved prediction of protein-protein interactions using AlphaFold2 [NEW RESULTS] https://t.co/E4sI1LoQCr

Dec 16, 2021 · 1 like · 1 share · 4,412 followers View post →
Darin S. Lory
@unixgod · X

Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments #alphafold #alphafold2 https://t.co/Z37lcGRUiK

Sep 26, 2021 · 2 likes · 1,598 followers View post →
Xuan Yang
@Born1984Yang · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 16, 2021 · 16 shares · 87 followers View post →
Glenn Werneburg, MD PhD
@gwerneburg · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 16, 2021 · 16 shares · 1,064 followers View post →
PromisingPreprints
@PromPreprint · X

Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https://t.co/kdQebwGdOR

Sep 16, 2021 · 3,312 followers View post →
Juan C. Opazo
@opazolab · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 16, 2021 · 16 shares · 1,670 followers View post →
Kristian Frandsen
@KrFrandsen · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 16, 2021 · 16 shares · 969 followers View post →
Helio Rocha
@_elioRocha · X

#bioRxiv Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments #bioinfo https://t.co/h36nVPebJN

Sep 16, 2021 · 609 followers View post →
Peter Phan
@Castlereagh88 · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 16, 2021 · 16 shares · 1,628 followers View post →
Amar Singh
@DrSinghAmar · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 16, 2021 · 16 shares · 123 followers View post →
Roland Dunbrack
@RolandDunbrack · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 16, 2021 · 16 shares · 4,214 followers View post →
Ximing XU
@Biocheming · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 16 shares · 339 followers View post →
Hamim Zafar
@Quasarzafar · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 16 shares · 551 followers View post →
summer2016
@ShengqianXia11 · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 16 shares · 255 followers View post →
Alessandro Liquori
@Aless_Liquori · X

RT @biorxiv_bioinfo: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 2 shares · 143 followers View post →
Anshul Kundaje (anshulkundaje@bluesky)
@anshulkundaje · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 16 shares · 26,792 followers View post →
Howard Salis
@hsalis · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 16 shares · 4,118 followers View post →
io
@io_1337 · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 16 shares · 2,791 followers View post →
Kato
@oxkawaka · X

RT @biorxivpreprint: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 16 shares · 5,814 followers View post →
やまを
@levinthal_prdx · X

RT @biorxiv_bioinfo: Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https:…

Sep 15, 2021 · 2 shares · 477 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https://t.co/5CPnR1Sr4B #biorxiv_bioinfo

Sep 15, 2021 · 11 likes · 2 shares · 18,047 followers View post →
bioRxiv
@biorxivpreprint · X

Improved prediction of protein-protein interactions using AlphaFold2 and extended multiple-sequence alignments https://t.co/nBynW20ltD #bioRxiv

Sep 15, 2021 · 55 likes · 16 shares · 136,866 followers View post →