Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Yi Zhu, Jim Kirkland & colleagues https://t.co/NLcmDt9KM5 https://t.co/nohY0VL5KD
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.
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Mar 2022 – Nov 2023Where it's discussed
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X / Twitter38 posts
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News22 articles
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Reddit9 posts
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Blogs6 articles
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YouTube2 videos
AI synopsis
What people are saying
These discussions reflect a highly engaged and optimistic view of the research, with many emphasizing the therapeutic potential of senolytics to increase Klotho levels and combat aging. Phrases like 'promise,' 'translational potential,' and references to 'mechanistic insights' illustrate both the scientific interest and perceived importance of the findings, especially in the context of developing anti-aging interventions.
Most discussions agree on the promising nature of the research, emphasizing that senolytic drugs can restore key aging-related proteins. Words like 'restore' and 'potential' indicate positive alignment with the findings.
The discussions show high curiosity and relevance, with posts highlighting the translational and therapeutic potential of the research, such as references to 'clinical translation' and 'mechanistic insights.'
Several posts delve into specific details, including mechanisms (e.g., 'senescence cell secretome') and implications for aging and disease, indicating deep engagement.
There’s a consensus that this research could have a high impact on aging and regenerative medicine, supported by enthusiastic phrases describing it as a 'game changer' or 'promising avenue.'
Abstract in brief
- The study shows that senescent cells produce factors like activin A and IL-1 that decrease Klotho levels, which are protective in aging and disease.
- Using senolytic drugs like Dasatinib plus Quercetin (DQ), researchers can eliminate senescent cells, leading to increased Klotho levels in both mice and humans.
- Boosting Klotho through senolytics has therapeutic potential for age-related diseases, as it can counteract the negative effects caused by senescent cells.]
Top posts
Most liked on X and BlueskyScientists, including @marissa_schafer, @MayoClinic found that #senescence cell secretome ⬇️ Klotho and that senolytics ⬆️ Klotho. @eBioMedicine Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/wPze3LrK8m
Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/NLcmDt9KM5 https://t.co/5VPopeokqs https://t.co/ZnztQQ6uCR
Klotho spins the thread of life in Greek mythology. Klotho is also the name of an essential endogenous rejuvenation factor. Selective removal of senescent cells (i.e., senolytic treatment) increased Klotho in mice and humans. https://t.co/IBHWeMSgEb
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/Lo6Uh1DRA9
Senolytics increase urine Klotho in humans. SASP factors are inversely correlated with urine Klotho. Kirkland @MayoClinic https://t.co/A6q92DXXZ5 @_MIA_Portugal
All mentions
Key Breakthroughs in Longevity Research: Insights from 2022
What a year 2022 has been for longevity research. This video discusses crucial findings including the effects of old blood on young mice and how senolytic drugs can mitigate these impacts. Join us in exploring the…
Senolytics and Klotho: Restoring Longevity Proteins in Aging and Disease
Orally active senolytics restore Klotho levels in mice and humans. This video explores how senescent cells decrease Klotho, a protective protein, and how drugs like Dasatinib plus Quercetin can eliminate these cells to…
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/dg8zyDQ8uL
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/rT8XC2bjH1
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/JGcvXUIRB8 https://t.co/X6HUOnAZ2J https://t.co/0EICjaqhvh
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/JGcvXUZUD8 https://t.co/QFWoZhd6Mj
RT @PeptideScience: Orally-active, clinically-translatable #senolytics restore α-Klotho in mice and humans “α-#Klotho is a #geroprotective…
Orally-active, clinically-translatable #senolytics restore α-Klotho in mice and humans “α-#Klotho is a #geroprotective #protein that can attenuate or alleviate deleterious changes with #ageing and #disease.” #Aging #AlphaKlotho #Senolytic #Senescence https://t.co/XT5kLqVcIo
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans #longevity #CODIS https://t.co/3bGYLwSsFL
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/DcJ5dQvb1H
RT @BigDataNova: Klotho and Aging. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/kL0UI…
Klotho and Aging. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/kL0UIkvRyN
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/rfV7FmfPHy
RT @agingdoc1: Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t…
Senolytics increase urine Klotho in humans. SASP factors are inversely correlated with urine Klotho. Kirkland @MayoClinic https://t.co/A6q92DXXZ5 @_MIA_Portugal
The authors of "Orally-active, clinically-translatable senolytics…" (https://t.co/bnrhe6v2aF) included RRIDs in their paper! We appreciate the author's support of reproducibility. #methodsmatter #STMpublishing
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/JGcvXUIRB8 To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAzN5D https://t.co/Sw8UbalWKl https://t.co/ujJwFcZlBD https://t.co/FA8rkC5Za7 https://t.co/TerzwxRcXz
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/D6mClISczA #ICSA #senescence #senolytics
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans. Thus, clearing senescent cells restores α-Klotho, potentially opening a novel, translationally-feasible avenue for developing orally-active small molecule. https://t.co/U7wviVNR1U
Klotho spins the thread of life in Greek mythology. Klotho is also the name of an essential endogenous rejuvenation factor. Selective removal of senescent cells (i.e., senolytic treatment) increased Klotho in mice and humans. https://t.co/IBHWeMSgEb
RT @nnhooten: Scientists, including @marissa_schafer, @MayoClinic found that #senescence cell secretome ⬇️ Klotho and that senolytics ⬆️ Kl…
RT @nnhooten: Scientists, including @marissa_schafer, @MayoClinic found that #senescence cell secretome ⬇️ Klotho and that senolytics ⬆️ Kl…
Scientists, including @marissa_schafer, @MayoClinic found that #senescence cell secretome ⬇️ Klotho and that senolytics ⬆️ Klotho. @eBioMedicine Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/wPze3LrK8m
RT @agingdoc1: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Yi Zhu, Jim Kirkland & colleagues ht…
RT @agingdoc1: Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t…
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans. α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. https://t.co/U7wviVNR1U
RT @agingdoc1: Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t…
Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/NLcmDt9KM5 https://t.co/5VPopeokqs https://t.co/ZnztQQ6uCR
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/1Z3Ycxh2rO
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/4BaIoqQXu7 https://t.co/z9dZdz3ljg
RT @LivingForever8: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/S47KEfOFk0
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/S47KEfOFk0
RT @sminaev2015: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/Lo6Uh1DR…
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/evmAF3Ncsw 美国研究人员发布在《eBioMedicine》的研究发现,口服活性、临床可转化的抗衰老药物可以增加小鼠和人类的 α-Klotho。
RT @agingdoc1: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Yi Zhu, Jim Kirkland & colleagues ht…
RT @sminaev2015: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/Lo6Uh1DR…
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/Lo6Uh1DRA9
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Yi Zhu, Jim Kirkland & colleagues https://t.co/NLcmDt9KM5 https://t.co/nohY0VL5KD
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - https://t.co/F7WSyh6Gd5
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/WFtXCBBlHb