March 2022 PMID 35292270

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.

Yi Zhu, Larissa G P Langhi Prata, Erin O Wissler Gerdes, Jair Machado Espindola Netto, Tamar Pirtskhalava, Nino Giorgadze, Utkarsh Tripathi, Christina L Inman, Kurt O Johnson, Ailing Xue, Allyson K Palmer, Tingjun Chen, Kalli Schaefer, Jamie N Justice, Anoop M Nambiar

Mentions

77
Peak: 26 in Mar 2022
across 5 sources since Mar 2022

Extended reach

378,107
potential audience

Total likes

2,166

Video views

74,318

Mentions per month

Mar 2022 – Nov 2023

Where it's discussed

  • X / Twitter38 posts
  • News22 articles
  • Reddit9 posts
  • Blogs6 articles
  • YouTube2 videos

AI synopsis

What people are saying

These discussions reflect a highly engaged and optimistic view of the research, with many emphasizing the therapeutic potential of senolytics to increase Klotho levels and combat aging. Phrases like 'promise,' 'translational potential,' and references to 'mechanistic insights' illustrate both the scientific interest and perceived importance of the findings, especially in the context of developing anti-aging interventions.

AgreementModerate agreement

Most discussions agree on the promising nature of the research, emphasizing that senolytic drugs can restore key aging-related proteins. Words like 'restore' and 'potential' indicate positive alignment with the findings.

InterestHigh interest

The discussions show high curiosity and relevance, with posts highlighting the translational and therapeutic potential of the research, such as references to 'clinical translation' and 'mechanistic insights.'

EngagementHigh engagement

Several posts delve into specific details, including mechanisms (e.g., 'senescence cell secretome') and implications for aging and disease, indicating deep engagement.

ImpactHigh impact

There’s a consensus that this research could have a high impact on aging and regenerative medicine, supported by enthusiastic phrases describing it as a 'game changer' or 'promising avenue.'

Abstract in brief

  • The study shows that senescent cells produce factors like activin A and IL-1 that decrease Klotho levels, which are protective in aging and disease.
  • Using senolytic drugs like Dasatinib plus Quercetin (DQ), researchers can eliminate senescent cells, leading to increased Klotho levels in both mice and humans.
  • Boosting Klotho through senolytics has therapeutic potential for age-related diseases, as it can counteract the negative effects caused by senescent cells.]

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Yi Zhu, Jim Kirkland & colleagues https://t.co/NLcmDt9KM5 https://t.co/nohY0VL5KD

Mar 13, 2022 · 14 likes · 2 shares · 41,809 followers View post →
Nikki Noren Hooten
@nnhooten · X

Scientists, including @marissa_schafer, @MayoClinic found that #senescence cell secretome ⬇️ Klotho and that senolytics ⬆️ Klotho. @eBioMedicine Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/wPze3LrK8m

Mar 17, 2022 · 12 likes · 2 shares · 1,321 followers View post →
Agingdoc
@agingdoc1 · X

Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/NLcmDt9KM5 https://t.co/5VPopeokqs https://t.co/ZnztQQ6uCR

Mar 15, 2022 · 7 likes · 4 shares · 41,809 followers View post →
quadrascope
@quadrascope · X

Klotho spins the thread of life in Greek mythology. Klotho is also the name of an essential endogenous rejuvenation factor. Selective removal of senescent cells (i.e., senolytic treatment) increased Klotho in mice and humans. https://t.co/IBHWeMSgEb

Mar 22, 2022 · 4 likes · 95 followers View post →
Sergey Minaev
@sminaev2015 · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/Lo6Uh1DRA9

Mar 14, 2022 · 3 likes · 2 shares · 31,501 followers View post →
David Weinkove
@dweinkove · X

Senolytics increase urine Klotho in humans. SASP factors are inversely correlated with urine Klotho. Kirkland @MayoClinic https://t.co/A6q92DXXZ5 @_MIA_Portugal

Apr 7, 2022 · 3 likes · 1 share · 2,347 followers View post →

All mentions

john morley
@drjohnmorley · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/dg8zyDQ8uL

Nov 20, 2023 · 8,309 followers View post →
Denize Logoscracia
@Denizelogos · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/rT8XC2bjH1

Dec 19, 2022 · 772 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/JGcvXUIRB8 https://t.co/X6HUOnAZ2J https://t.co/0EICjaqhvh

Nov 5, 2022 · 883 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/JGcvXUZUD8 https://t.co/QFWoZhd6Mj

Nov 3, 2022 · 883 followers View post →
DNA&RNA Universe
@DNA_RNA_Uni · X

RT @PeptideScience: Orally-active, clinically-translatable #senolytics restore α-Klotho in mice and humans “α-#Klotho is a #geroprotective…

Oct 21, 2022 · 1 share · 39,332 followers View post →
Peptide Sciences
@PeptideScience · X

Orally-active, clinically-translatable #senolytics restore α-Klotho in mice and humans “α-#Klotho is a #geroprotective #protein that can attenuate or alleviate deleterious changes with #ageing and #disease.” #Aging #AlphaKlotho #Senolytic #Senescence https://t.co/XT5kLqVcIo

Oct 15, 2022 · 2 likes · 1 share · 6,633 followers View post →
NOMIX
@NOMIX_AI · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans #longevity #CODIS https://t.co/3bGYLwSsFL

Aug 5, 2022 · 596 followers View post →
Brent Segal
@bsegal73 · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/DcJ5dQvb1H

Aug 4, 2022 · 829 followers View post →
Michael Nova MD
@BigDataNova · X

RT @BigDataNova: Klotho and Aging. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/kL0UI…

Jul 15, 2022 · 1 share · 1,061 followers View post →
Michael Nova MD
@BigDataNova · X

Klotho and Aging. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/kL0UIkvRyN

Jul 14, 2022 · 1 like · 1 share · 1,061 followers View post →
CogniSphere
@jorgensenmc1 · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/rfV7FmfPHy

Jul 5, 2022 · 820 followers View post →
Agingdoc
@agingdoc1 · X

RT @agingdoc1: Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t…

May 30, 2022 · 4 shares · 41,809 followers View post →
David Weinkove
@dweinkove · X

Senolytics increase urine Klotho in humans. SASP factors are inversely correlated with urine Klotho. Kirkland @MayoClinic https://t.co/A6q92DXXZ5 @_MIA_Portugal

Apr 7, 2022 · 3 likes · 1 share · 2,347 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Orally-active, clinically-translatable senolytics…" (https://t.co/bnrhe6v2aF) included RRIDs in their paper! We appreciate the author's support of reproducibility. #methodsmatter #STMpublishing

Mar 27, 2022 · 161 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/JGcvXUIRB8 To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAzN5D https://t.co/Sw8UbalWKl https://t.co/ujJwFcZlBD https://t.co/FA8rkC5Za7 https://t.co/TerzwxRcXz

Mar 26, 2022 · 883 followers View post →
Romuald Binet
@RomualdBinet · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/D6mClISczA #ICSA #senescence #senolytics

Mar 24, 2022 · 216 followers View post →
Orlando_uy
@Orlando_uy · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans. Thus, clearing senescent cells restores α-Klotho, potentially opening a novel, translationally-feasible avenue for developing orally-active small molecule. https://t.co/U7wviVNR1U

Mar 23, 2022 · 2 likes · 694 followers View post →
quadrascope
@quadrascope · X

Klotho spins the thread of life in Greek mythology. Klotho is also the name of an essential endogenous rejuvenation factor. Selective removal of senescent cells (i.e., senolytic treatment) increased Klotho in mice and humans. https://t.co/IBHWeMSgEb

Mar 22, 2022 · 4 likes · 95 followers View post →
eBioMedicine – The Lancet Discovery Science
@eBioMedicine · X

RT @nnhooten: Scientists, including @marissa_schafer, @MayoClinic found that #senescence cell secretome ⬇️ Klotho and that senolytics ⬆️ Kl…

Mar 17, 2022 · 2 shares · 10,097 followers View post →
Matthew S. Alexander
@Matt_Muscle_Guy · X

RT @nnhooten: Scientists, including @marissa_schafer, @MayoClinic found that #senescence cell secretome ⬇️ Klotho and that senolytics ⬆️ Kl…

Mar 17, 2022 · 2 shares · 5,465 followers View post →
Nikki Noren Hooten
@nnhooten · X

Scientists, including @marissa_schafer, @MayoClinic found that #senescence cell secretome ⬇️ Klotho and that senolytics ⬆️ Klotho. @eBioMedicine Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/wPze3LrK8m

Mar 17, 2022 · 12 likes · 2 shares · 1,321 followers View post →
The Longevity Forum
@Longevity_Forum · X

RT @agingdoc1: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Yi Zhu, Jim Kirkland & colleagues ht…

Mar 17, 2022 · 2 shares · 3,224 followers View post →
Sir Knight Mark Anthony Davis MBA
@MysticMark7777 · X

RT @agingdoc1: Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t…

Mar 16, 2022 · 4 shares · 2,157 followers View post →
Orlando_uy
@Orlando_uy · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans. α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. https://t.co/U7wviVNR1U

Mar 16, 2022 · 1 like · 694 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @agingdoc1: Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t…

Mar 15, 2022 · 4 shares · 547 followers View post →
Agingdoc
@agingdoc1 · X

Better quality image from: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/NLcmDt9KM5 https://t.co/5VPopeokqs https://t.co/ZnztQQ6uCR

Mar 15, 2022 · 7 likes · 4 shares · 41,809 followers View post →
Chris Alton
@enfiniti27 · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/1Z3Ycxh2rO

Mar 14, 2022 · 1 like · 39 followers View post →
Nutriop Longevity
@nutriop · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/4BaIoqQXu7 https://t.co/z9dZdz3ljg

Mar 14, 2022 · 80 followers View post →
AntiAgify - Science will set you free
@AntiAgify · X

RT @LivingForever8: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/S47KEfOFk0

Mar 14, 2022 · 1 share · 1,350 followers View post →
Living Forever
@LivingForever8 · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/S47KEfOFk0

Mar 14, 2022 · 1 like · 1 share · 417 followers View post →
Sergey Minaev
@sminaev2015 · X

RT @sminaev2015: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/Lo6Uh1DR…

Mar 14, 2022 · 2 shares · 31,501 followers View post →
TimePie (focus on anti-aging science)
@TimePieChina · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/evmAF3Ncsw 美国研究人员发布在《eBioMedicine》的研究发现,口服活性、临床可转化的抗衰老药物可以增加小鼠和人类的 α-Klotho。

Mar 14, 2022 · 701 followers View post →
Carlos Colmenero
@colme99 · X

RT @agingdoc1: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Yi Zhu, Jim Kirkland & colleagues ht…

Mar 14, 2022 · 2 shares · 77 followers View post →
DiannDerecho
@DiannDerecho · X

RT @sminaev2015: Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/Lo6Uh1DR…

Mar 14, 2022 · 2 shares · 3,214 followers View post →
Sergey Minaev
@sminaev2015 · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - eBioMedicine https://t.co/Lo6Uh1DRA9

Mar 14, 2022 · 3 likes · 2 shares · 31,501 followers View post →
Agingdoc
@agingdoc1 · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Yi Zhu, Jim Kirkland & colleagues https://t.co/NLcmDt9KM5 https://t.co/nohY0VL5KD

Mar 13, 2022 · 14 likes · 2 shares · 41,809 followers View post →
Ken Gusler
@kgusler · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans - https://t.co/F7WSyh6Gd5

Mar 13, 2022 · 20,018 followers View post →
James Debate
@James_Debate · X

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans https://t.co/WFtXCBBlHb

Mar 13, 2022 · 303 followers View post →