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Br J Cancer September 2022 PMID 35383278

The STING pathway: Therapeutic vulnerabilities in ovarian cancer.

Noor Shakfa, Deyang Li, Sarah Nersesian, Juliette Wilson-Sanchez, Madhuri Koti

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Mentions

7
Peak: 5 in Jul 2022
across 2 sources since Apr 2022

Extended reach

6,605
potential audience

Total likes

11

Video views

36

Mentions per month

Apr 2022 – Jul 2022

Where it's discussed

  • X / Twitter6 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions primarily consist of promotional posts and references to the publication, with phrases like 'explores the paper' and 'read for free,' indicating a focus on dissemination rather than detailed critique. The tone is neutral and informational, which aligns with the moderate interest and engagement scores seen here.

AgreementNeither agree nor disagree

The discussions show neutral or mixed reactions, with some appreciation but no strong consensus or disagreement.

InterestModerate interest

While there's some curiosity about the paper's content, the discussions are relatively brief and lack deep curiosity.

EngagementModerate engagement

The posts mainly promote the material without in-depth critique or exploration, indicating moderate engagement.

ImpactNeutral impact

The collective discussion seems to have limited influence on broader discourse or practice, mostly sharing links and summaries.

Abstract in brief

  • Ovarian cancer, especially high-grade serous ovarian carcinoma (HGSC), is a leading cause of death among gynecologic cancers, with most patients developing resistance to traditional treatments, despite initial responsiveness.
  • Although tumors show high immune cell infiltration and markers of immune activity, many patients don't benefit from immunotherapies, partly because of tumor heterogeneity and complex changes in the tumor immune environment.
  • The cGAS-STING pathway, involved in immune response activation, is being studied as a promising therapeutic target; activating this pathway could boost immune-mediated tumor destruction and improve treatment outcomes when combined with existing therapies like chemotherapy.
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Top posts

Most liked on X and Bluesky
Queen's Ovarian Cancer Club
@quovclub · X

We are very pleased to present our third YouTube video, which explores the paper "The STING pathway: Therapeutic vulnerabilities in ovarian cancer" by Shakfa et al. Subscribe to our channel to see more ovarian cancer content! https://t.co/nPFWubESun

Jul 12, 2022 · 8 likes · 3 shares · 70 followers View post →
British Journal of Cancer
@BrJCancer · X

The STING pathway: Therapeutic vulnerabilities in ovarian cancer Read for free using #SharedIt: https://t.co/qw1OiNUYun #Ovariancancer #Tumourimmunology https://t.co/iNG8PhXXH0

Apr 20, 2022 · 1 like · 1 share · 3,620 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @BrJCancer: The STING pathway: Therapeutic vulnerabilities in ovarian cancer Read for free using #SharedIt: https://t.co/qw1OiNUYun #O…

Apr 20, 2022 · 1 share · 1,324 followers View post →
ojobile innocent
@OjobileInnocent · X

RT @quovclub: We are very pleased to present our third YouTube video, which explores the paper "The STING pathway: Therapeutic vulnerabilit…

Jul 17, 2022 · 3 shares · 1,074 followers View post →
Noor Shakfa, PhD
@NoorShakfa · X

RT @quovclub: We are very pleased to present our third YouTube video, which explores the paper "The STING pathway: Therapeutic vulnerabilit…

Jul 17, 2022 · 3 shares · 452 followers View post →
Beatrice Lu
@BeatriceLu8 · X

RT @quovclub: We are very pleased to present our third YouTube video, which explores the paper "The STING pathway: Therapeutic vulnerabilit…

Jul 13, 2022 · 3 shares · 1 followers View post →

All mentions

Noor Shakfa, PhD
@NoorShakfa · X

RT @quovclub: We are very pleased to present our third YouTube video, which explores the paper "The STING pathway: Therapeutic vulnerabilit…

Jul 17, 2022 · 3 shares · 452 followers View post →
ojobile innocent
@OjobileInnocent · X

RT @quovclub: We are very pleased to present our third YouTube video, which explores the paper "The STING pathway: Therapeutic vulnerabilit…

Jul 17, 2022 · 3 shares · 1,074 followers View post →
Beatrice Lu
@BeatriceLu8 · X

RT @quovclub: We are very pleased to present our third YouTube video, which explores the paper "The STING pathway: Therapeutic vulnerabilit…

Jul 13, 2022 · 3 shares · 1 followers View post →
Queen's Ovarian Cancer Club
@quovclub · X

We are very pleased to present our third YouTube video, which explores the paper "The STING pathway: Therapeutic vulnerabilities in ovarian cancer" by Shakfa et al. Subscribe to our channel to see more ovarian cancer content! https://t.co/nPFWubESun

Jul 12, 2022 · 8 likes · 3 shares · 70 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @BrJCancer: The STING pathway: Therapeutic vulnerabilities in ovarian cancer Read for free using #SharedIt: https://t.co/qw1OiNUYun #O…

Apr 20, 2022 · 1 share · 1,324 followers View post →
British Journal of Cancer
@BrJCancer · X

The STING pathway: Therapeutic vulnerabilities in ovarian cancer Read for free using #SharedIt: https://t.co/qw1OiNUYun #Ovariancancer #Tumourimmunology https://t.co/iNG8PhXXH0

Apr 20, 2022 · 1 like · 1 share · 3,620 followers View post →