Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-Linked Glycosylation.

Aron Gyorgypal, Shishir P S Chundawat

May 2022 Anal Chem

Synopsis of Social media discussions

The discussions convey strong support and curiosity about the innovative platform, exemplified by comments like 'creating monitoring toolkit to speed production' and highlighting its coverage in prominent publications. The tone emphasizes the technological advancement and potential for industrial impact, with words like 'speed' and 'automated' indicating excitement about its practical applications and importance in therapeutics manufacturing.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of the research, especially highlighting its potential to improve biomanufacturing processes, with comments referencing the system's benefits and support from funding agencies.

I
Interest
 High level of interest

The posts demonstrate high interest, with mentions of the platform being featured on covers, its role in speeding production, and its innovative approach, indicating enthusiasm and curiosity among readers.

E
Engagement
 Moderate level of engagement

Several posts delve into technical aspects, such as the automated monitoring and its applications in therapeutic glycoprotein production, showing a moderate level of detailed engagement.

I
Impact
 Moderate level of impact

Given the focus on accelerating biologic drug production and enhancing quality control, the discussions suggest the publication could have a meaningful impact on biopharmaceutical manufacturing.

Social Mentions

YouTube

3 Videos

Facebook

2 Posts

Twitter

15 Posts

News

11 Articles

Metrics

Video Views

509

Total Likes

12

Extended Reach

1,171,351

Social Features

31

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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Share CHO Cell research papers JP

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  • Absurd
    @qualityisarul3 (Twitter)

    RT @physorg_com: Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https:…
    view full post

    May 27, 2022

    3

  • NP AGARWAL世界一フォローを目指しますAiming best in world.
    @np_grwl (Twitter)

    RT @physorg_com: Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https:…
    view full post

    May 24, 2022

    3

  • Chundawat Lab @ Rutgers University
    @ChundawatLab (Twitter)

    RT @an_chem: Work from the @sps_chundawat lab is featured on the cover of our latest issue! Check out their integrated platform, N-GLYcanyz…
    view full post

    May 23, 2022

    4

  • SOE Chem & Biochem RU
    @ChemE_RU (Twitter)

    RT @an_chem: Work from the @sps_chundawat lab is featured on the cover of our latest issue! Check out their integrated platform, N-GLYcanyz…
    view full post

    May 23, 2022

    4

  • Shishir Chundawat
    @sps_chundawat (Twitter)

    RT @an_chem: Work from the @sps_chundawat lab is featured on the cover of our latest issue! Check out their integrated platform, N-GLYcanyz…
    view full post

    May 23, 2022

    4

  • Friv
    @Julius_LeoXXVI (Twitter)

    RT @an_chem: Work from the @sps_chundawat lab is featured on the cover of our latest issue! Check out their integrated platform, N-GLYcanyz…
    view full post

    May 23, 2022

    4

  • SOE Chem & Biochem RU
    @ChemE_RU (Twitter)

    RT @sps_chundawat: Aron’s paper highlighting this process analytical technology to enable therapeutic glycoproteins production was publishe…
    view full post

    May 18, 2022

    1

  • Shishir Chundawat
    @sps_chundawat (Twitter)

    Aron’s paper highlighting this process analytical technology to enable therapeutic glycoproteins production was published as a cover article in ACS Analytical Chemistry this week (https://t.co/qYZQHYrc9F). Special thanks to the @US_FDA for funding this research! @ACSPublications
    view full post

    May 18, 2022

    1

    1

  • Phys.org Chemistry
    @physorg_chem (Twitter)

    RT @physorg_com: Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https:…
    view full post

    May 18, 2022

    3

  • Phys.org
    @physorg_com (Twitter)

    Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https://t.co/Neai90MOId
    view full post

    May 18, 2022

    4

    3

  • Aron Gyorgypal, PhD
    @A_Gyorgypal (Twitter)

    Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-Linked Glycosylation https://t.co/CguGbsCSGD
    view full post

    April 8, 2022

  • Aishwarya Kanchi Ranganath
    @aishwaryakanchi (Twitter)

    RT @biorxivpreprint: An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation http…
    view full post

    November 15, 2021

    2

  • glycopreprint
    @glycopreprint (Twitter)

    An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation https://t.co/sOpsxhRfqA #glycotime
    view full post

    November 15, 2021

    2

  • Aron Gyorgypal, PhD
    @A_Gyorgypal (Twitter)

    RT @biorxivpreprint: An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation http…
    view full post

    November 15, 2021

    2

  • bioRxiv
    @biorxivpreprint (Twitter)

    An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation https://t.co/si9qcd4sCK #bioRxiv
    view full post

    November 14, 2021

    2

    2

Abstract Synopsis

  • The development of the NGLYcanyzer system enables rapid, automated online monitoring of monoclonal antibody (mAb) glycosylation during biomanufacturing, enhancing process understanding and quality control in continuous production.
  • The system integrates mAb sampling, deglycosylation, glycan labeling with fluorescent dyes, and glycan analysis within 3 hours, using advanced chromatography techniques and optimized fluorescent labeling methods to improve detection sensitivity.
  • Implementation of this platform at upstream bioreactors allows real-time, near-instantaneous monitoring of glycosylation patterns in biologics like Trastuzumab, supporting more efficient and flexible biomanufacturing processes aligned with regulatory expectations.