Anal Chem May 2022 PMID 35385654

Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-Linked Glycosylation.

Aron Gyorgypal, Shishir P S Chundawat

Mentions

31
Peak: 10 in May 2022
across 4 sources since Nov 2021

Extended reach

1,171,351
potential audience

Total likes

12

Video views

509

Mentions per month

Nov 2021 – Oct 2025

Where it's discussed

  • X / Twitter15 posts
  • News11 articles
  • YouTube3 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions convey strong support and curiosity about the innovative platform, exemplified by comments like 'creating monitoring toolkit to speed production' and highlighting its coverage in prominent publications. The tone emphasizes the technological advancement and potential for industrial impact, with words like 'speed' and 'automated' indicating excitement about its practical applications and importance in therapeutics manufacturing.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, especially highlighting its potential to improve biomanufacturing processes, with comments referencing the system's benefits and support from funding agencies.

InterestHigh interest

The posts demonstrate high interest, with mentions of the platform being featured on covers, its role in speeding production, and its innovative approach, indicating enthusiasm and curiosity among readers.

EngagementModerate engagement

Several posts delve into technical aspects, such as the automated monitoring and its applications in therapeutic glycoprotein production, showing a moderate level of detailed engagement.

ImpactModerate impact

Given the focus on accelerating biologic drug production and enhancing quality control, the discussions suggest the publication could have a meaningful impact on biopharmaceutical manufacturing.

Abstract in brief

  • The development of the NGLYcanyzer system enables rapid, automated online monitoring of monoclonal antibody (mAb) glycosylation during biomanufacturing, enhancing process understanding and quality control in continuous production.
  • The system integrates mAb sampling, deglycosylation, glycan labeling with fluorescent dyes, and glycan analysis within 3 hours, using advanced chromatography techniques and optimized fluorescent labeling methods to improve detection sensitivity.
  • Implementation of this platform at upstream bioreactors allows real-time, near-instantaneous monitoring of glycosylation patterns in biologics like Trastuzumab, supporting more efficient and flexible biomanufacturing processes aligned with regulatory expectations.

Top posts

Most liked on X and Bluesky
Phys.org
@physorg_com · X

Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https://t.co/Neai90MOId

May 18, 2022 · 4 likes · 3 shares · 1,020,500 followers View post →
bioRxiv
@biorxivpreprint · X

An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation https://t.co/si9qcd4sCK #bioRxiv

Nov 14, 2021 · 2 likes · 2 shares · 137,929 followers View post →
glycopreprint
@glycopreprint · X

An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation https://t.co/sOpsxhRfqA #glycotime

Nov 15, 2021 · 2 likes · 1,352 followers View post →
Shishir Chundawat
@sps_chundawat · X

Aron’s paper highlighting this process analytical technology to enable therapeutic glycoproteins production was published as a cover article in ACS Analytical Chemistry this week (https://t.co/qYZQHYrc9F). Special thanks to the @US_FDA for funding this research! @ACSPublications

May 18, 2022 · 1 like · 1 share · 280 followers View post →
Phys.org Chemistry
@physorg_chem · X

RT @physorg_com: Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https:…

May 18, 2022 · 3 shares · 7,142 followers View post →
NP AGARWAL世界一フォローを目指しますAiming best in world.
@np_grwl · X

RT @physorg_com: Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https:…

May 24, 2022 · 3 shares · 1,787 followers View post →

All mentions

Absurd
@qualityisarul3 · X

RT @physorg_com: Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https:…

May 27, 2022 · 3 shares · 278 followers View post →
NP AGARWAL世界一フォローを目指しますAiming best in world.
@np_grwl · X

RT @physorg_com: Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https:…

May 24, 2022 · 3 shares · 1,787 followers View post →
Chundawat Lab @ Rutgers University
@ChundawatLab · X

RT @an_chem: Work from the @sps_chundawat lab is featured on the cover of our latest issue! Check out their integrated platform, N-GLYcanyz…

May 23, 2022 · 4 shares · 24 followers View post →
SOE Chem & Biochem RU
@ChemE_RU · X

RT @an_chem: Work from the @sps_chundawat lab is featured on the cover of our latest issue! Check out their integrated platform, N-GLYcanyz…

May 23, 2022 · 4 shares · 121 followers View post →
Shishir Chundawat
@sps_chundawat · X

RT @an_chem: Work from the @sps_chundawat lab is featured on the cover of our latest issue! Check out their integrated platform, N-GLYcanyz…

May 23, 2022 · 4 shares · 280 followers View post →
Friv
@Julius_LeoXXVI · X

RT @an_chem: Work from the @sps_chundawat lab is featured on the cover of our latest issue! Check out their integrated platform, N-GLYcanyz…

May 23, 2022 · 4 shares · 822 followers View post →
SOE Chem & Biochem RU
@ChemE_RU · X

RT @sps_chundawat: Aron’s paper highlighting this process analytical technology to enable therapeutic glycoproteins production was publishe…

May 18, 2022 · 1 share · 121 followers View post →
Shishir Chundawat
@sps_chundawat · X

Aron’s paper highlighting this process analytical technology to enable therapeutic glycoproteins production was published as a cover article in ACS Analytical Chemistry this week (https://t.co/qYZQHYrc9F). Special thanks to the @US_FDA for funding this research! @ACSPublications

May 18, 2022 · 1 like · 1 share · 280 followers View post →
Phys.org Chemistry
@physorg_chem · X

RT @physorg_com: Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https:…

May 18, 2022 · 3 shares · 7,142 followers View post →
Phys.org
@physorg_com · X

Engineering team creates monitoring toolkit to speed production of biologic drugs @RutgersU https://t.co/qMRyp3RYE7 https://t.co/Neai90MOId

May 18, 2022 · 4 likes · 3 shares · 1,020,500 followers View post →
Aron Gyorgypal, PhD
@A_Gyorgypal · X

Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-Linked Glycosylation https://t.co/CguGbsCSGD

Apr 8, 2022 · 13 followers View post →
Aishwarya Kanchi Ranganath
@aishwaryakanchi · X

RT @biorxivpreprint: An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation http…

Nov 15, 2021 · 2 shares · 109 followers View post →
glycopreprint
@glycopreprint · X

An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation https://t.co/sOpsxhRfqA #glycotime

Nov 15, 2021 · 2 likes · 1,352 followers View post →
Aron Gyorgypal, PhD
@A_Gyorgypal · X

RT @biorxivpreprint: An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation http…

Nov 15, 2021 · 2 shares · 13 followers View post →
bioRxiv
@biorxivpreprint · X

An Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-linked Glycosylation https://t.co/si9qcd4sCK #bioRxiv

Nov 14, 2021 · 2 likes · 2 shares · 137,929 followers View post →