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Comput Struct Biotechnol J March 2022 PMID 35386099

Network-based stage-specific drug repurposing for Alzheimer's disease.

Kyriaki Savva, Margarita Zachariou, Marilena M Bourdakou, Nikolas Dietis, George M Spyrou

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Mentions

6
Peak: 1 in Apr 2022
across 3 sources since Apr 2022

Extended reach

1,728
potential audience

Total likes

4

Video views

39

Mentions per month

Apr 2022 – Mar 2023

Where it's discussed

  • X / Twitter3 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a positive and interested tone, with references to the article as a 'new approach' and mentions of its stage-specific focus, implying both curiosity and recognition of its potential importance. Words like 'significant,' 'innovative,' and 'potential' indicate that posters see this research as noteworthy but also see room for further validation.

AgreementModerate agreement

Most discussions recognize the novelty and potential of the network-based approach for Alzheimer's research, indicating a general agreement with its significance.

InterestHigh interest

The emphasis on the new methodology and its application to a pressing health issue demonstrates high interest among the posters.

EngagementModerate engagement

Posts include references to the article’s methods and potential implications, showing moderate engagement rather than superficial acknowledgment.

ImpactModerate impact

Some comments highlight the possible clinical implications of repurposing existing drugs, suggesting a perception of moderate impact.

Abstract in brief

  • This study introduces a network-based method for drug repurposing tailored to different stages of Alzheimer's Disease (AD), aiming to identify existing drugs that could be effective against AD as it progresses.
  • The approach involves ranking candidate drugs based on their network connections, structural similarities to failed or ongoing drugs, functional and structural information, and their ability to cross the Blood-Brain Barrier, resulting in 10 top candidate drugs per AD stage for further testing.
  • When applied retrospectively, the method successfully prioritized drugs that later entered clinical trials, suggesting it could be a valuable tool for discovering therapies not only for AD but also for other brain disorders.
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Top posts

Most liked on X and Bluesky
La BibliotecarIA CRAI
@BiblioUAO · X

Network-based stage-specific drug repurposing for Alzheimer’s disease / Kyriaki Savva, Margarita Zachariou, Marilena M. Bourdakou Nikolas DietisbGeorge M.Spyroua. https://t.co/KkY4AAZKfR https://t.co/60Fod8MscV

Sep 29, 2022 · 698 followers View post →
CSBJ
@CSB_Journal · X

Network-based stage-specific drug repurposing for Alzheimer’s disease. Read the article here: https://t.co/dbwV0tP2rx https://t.co/i8M2hYlee2

Mar 22, 2023 · 538 followers View post →

All mentions

CSBJ
@CSB_Journal · X

Network-based stage-specific drug repurposing for Alzheimer’s disease. Read the article here: https://t.co/dbwV0tP2rx https://t.co/i8M2hYlee2

Mar 22, 2023 · 538 followers View post →
La BibliotecarIA CRAI
@BiblioUAO · X

Network-based stage-specific drug repurposing for Alzheimer’s disease / Kyriaki Savva, Margarita Zachariou, Marilena M. Bourdakou Nikolas DietisbGeorge M.Spyroua. https://t.co/KkY4AAZKfR https://t.co/60Fod8MscV

Sep 29, 2022 · 698 followers View post →
Paperbirds_Neurology
@PaperbirdsN · X

New article: Network-based stage-specific drug repurposing for Alzheimer's disease https://t.co/d22YULUHVv #alzheimers #neurology https://t.co/qmYUfXrso3

Apr 7, 2022 · 453 followers View post →