Nat Genet April 2022 PMID 35410377

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking.

Zhenqiu Huang, Shixiang Sun, Moonsook Lee, Alexander Y Maslov, Miao Shi, Spencer Waldman, Ava Marsh, Taha Siddiqui, Xiao Dong, Yakov Peter, Ali Sadoughi, Chirag Shah, Kenny Ye, Simon D Spivack, Jan Vijg

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Mentions

178
Peak: 38 in Apr 2022
across 6 sources since Apr 2022

Extended reach

303,419
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168

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Apr 2022 – Apr 2024

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AI synopsis

What people are saying

The discussions reflect strong interest with some posts emphasizing the novelty of single-cell sequencing in relation to aging and smoking, citing examples like why most smokers don't develop lung cancer. The tone varies from scientific inquiry to enthusiasm, highlighting the potential implications for health and genetics, which supports an overall moderate to high impact evaluation.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some even highlighting it as groundbreaking in understanding lung health related to smoking and aging.

InterestHigh interest

Participants show high curiosity, frequently referencing the study's methods, implications, and broader relevance to lung cancer and genetics.

EngagementModerate engagement

Many discussions include detailed responses, questions, and references to related concepts, indicating moderate to deep engagement.

ImpactModerate impact

The posts suggest the research could influence future studies and public understanding of lung health, though its immediate societal impact appears moderate.

Abstract in brief

  • This study used single-cell whole-genome sequencing to analyze somatic mutations in bronchial epithelial cells from people aged 11 to 86, with varying smoking histories, to understand how aging and smoking influence mutation accumulation.
  • Researchers found that both age and smoking increased the frequency of mutations, with a linear relationship up to about 23 pack-years of smoking, after which mutation frequency plateaued, suggesting possible individual selection against harmful mutations.
  • Mutation signatures associated with lung cancer correlated with age and smoking exposure, but there was no significant increase in traditional lung cancer driver gene mutations, indicating complex factors in cancer development beyond just mutation accumulation.]

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Nature Genetics
@NatureGenet · X

Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking (Huang et al.) https://t.co/8fWL8nxzuy https://t.co/F4fC77MMtA

Apr 11, 2022 · 69 likes · 13 shares · 128,329 followers View post →
Prof.Dr.Talat Kılıç
@TalatKl15 · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/hz893gzf12

May 21, 2022 · 8 likes · 7 shares · 156 followers View post →
BioDecoded
@BioDecoded · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/s7Hc0PxRbW #genomics

Apr 17, 2022 · 7 likes · 4 shares · 8,900 followers View post →
barabara
@babaaa8686 · X

@Neo5512 @UQJXOh82l9gdBJk @20170211febhei これですかね。In Deepブログ様より [論文] 加齢と喫煙に関連したヒト気管支上皮細胞の体細胞変異の単一細胞分析 Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

Apr 17, 2022 · 6 likes · 28 followers View post →
サイエンスあれこれ
@sarekore · X

19人の喫煙者の、正常肺上皮細胞(最も癌化しやすい細胞)の変異を比較した結果、喫煙が突然変異の頻度を増加させる一方で、この増加は1日1箱23年間の喫煙量で止まることが判明。一部の喫煙者は突然変異を抑制することで肺がんから身を守るメカニズムを持っている可能性を示唆https://t.co/ECEbJM5qn1

Apr 12, 2022 · 3 likes · 922 followers View post →
Reddit Journal of Science
@rsciencejournal · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/Nawj0p5wkz #science #cancer #singlecell #analysis #mutations #cells

May 26, 2022 · 3 likes · 2 shares · 335 followers View post →

All mentions

Dr. Christopher J Pino, Ph.D.
@ChrisJPino · X

Certain smokers may have resilient protective mechanisms that limit mutations and, thus, safeguard them against lung cancer. “Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking.” https://t.co/z4MZtVsNJu.+

Oct 5, 2023 · 420 followers View post →
BillOckham
@BillOccham0 · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/aq4fVy6NBq

Jun 18, 2023 · 585 followers View post →
WASH_st.zeno
@flomx1 · X

なぜ喫煙者で肺がんになる人と、ならない人がいるのか? ベビースモーカー

Jun 8, 2023 · 350 followers View post →
Devin Nunes' Cabrito Fella - NOT a nazi
@tallulahhulabel · X

RT @renesugar: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co…

Dec 23, 2022 · 1 share · 1,295 followers View post →
Rene Sugar
@renesugar · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/Ey3Wudq0Kx

Dec 23, 2022 · 1 share · 3,950 followers View post →
Wandi
@baobeitwit · X

Huang, Z., et. al. (2022). Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. Nature genetics, 54(4), 492–498. https://t.co/0MEyPhcoSf

Sep 6, 2022 · 92 followers View post →
Naukowo
@PodkastNaukowo · X

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Jun 1, 2022 · 1 like · 16 followers View post →
Ming "Tommy" Tang
@tangming2005 · X

RT @rsciencejournal: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…

May 26, 2022 · 2 shares · 40,899 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @rsciencejournal: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…

May 26, 2022 · 2 shares · 3,834 followers View post →
Reddit Journal of Science
@rsciencejournal · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/Nawj0p5wkz #science #cancer #singlecell #analysis #mutations #cells

May 26, 2022 · 3 likes · 2 shares · 335 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @NewScientistZon: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…

May 26, 2022 · 1 share · 3,834 followers View post →
New Scientist Zone
@NewScientistZon · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/wd7D8nzdrK

May 26, 2022 · 1 share · 178 followers View post →
aaaa
@ngsstudent · X

RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…

May 21, 2022 · 7 shares · 563 followers View post →
Zhen Qiao
@zhenqiao_zz · X

RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…

May 21, 2022 · 7 shares · 211 followers View post →
biotech archives
@bot_biotech · X

RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…

May 21, 2022 · 7 shares · 162 followers View post →
Ming "Tommy" Tang
@tangming2005 · X

RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…

May 21, 2022 · 7 shares · 40,899 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…

May 21, 2022 · 7 shares · 3,834 followers View post →
Prof.Dr.Talat Kılıç
@TalatKl15 · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/hz893gzf12

May 21, 2022 · 8 likes · 7 shares · 156 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @rsciencejournal: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…

Apr 19, 2022 · 1 share · 8,157 followers View post →
Reddit Journal of Science
@rsciencejournal · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/Nawj0p5wkz #science #cancer #singlecell #analysis #mutations #cells

Apr 19, 2022 · 1 like · 1 share · 335 followers View post →
Yang Fang
@xiaoxiaoyangs · X

RT @BioDecoded: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gen…

Apr 19, 2022 · 4 shares · 24 followers View post →
zhenzhen wang
@zhenzhen_wang · X

RT @BioDecoded: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gen…

Apr 18, 2022 · 4 shares · 16 followers View post →
رحابام
@Rehabiamu · X

RT @BioDecoded: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gen…

Apr 18, 2022 · 4 shares · 252 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @BioDecoded: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gen…

Apr 18, 2022 · 4 shares · 3,834 followers View post →
BioDecoded
@BioDecoded · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/s7Hc0PxRbW #genomics

Apr 17, 2022 · 7 likes · 4 shares · 8,900 followers View post →
Madhuri Koti
@CanImmun · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 17, 2022 · 13 shares · 455 followers View post →
barabara
@babaaa8686 · X

@Neo5512 @UQJXOh82l9gdBJk @20170211febhei これですかね。In Deepブログ様より [論文] 加齢と喫煙に関連したヒト気管支上皮細胞の体細胞変異の単一細胞分析 Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

Apr 17, 2022 · 6 likes · 28 followers View post →
Rodrigo Nunes Cal
@CalZole · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 15, 2022 · 13 shares · 2,924 followers View post →
hien
@AbleYansen · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 13, 2022 · 13 shares · 1 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @the_paper_link: Trend new: Huang Z, ..., Vijg J (Nat Genet) __Single-cell analysis of somatic mutations in human bronchial epithelial…

Apr 13, 2022 · 1 share · 3,834 followers View post →
the paper link
@the_paper_link · X

Trend new: Huang Z, ..., Vijg J (Nat Genet) __Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking__ https://t.co/DUmlx6Gqs2

Apr 13, 2022 · 1 share · 136 followers View post →
medicalnews
@medicalnews20 · X

https://t.co/o3cNvmeZ3L Why most people who smoke don't get lung cancer? Researchers from the Einstein College of Medicine in the United States published a research paper entitled: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation....

Apr 13, 2022 · 1 like · 1,168 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @uchida_kawasaki: ヘビースモーカーなのに長生きする人がいるのはなぜなのか?肺がんに対する防御が備わっている : カラパイア https://t.co/QBkwLie5iV Single-cell analysis of somatic mutation…

Apr 13, 2022 · 1 share · 3,834 followers View post →
内田
@uchida_kawasaki · X

ヘビースモーカーなのに長生きする人がいるのはなぜなのか?肺がんに対する防御が備わっている : カラパイア https://t.co/QBkwLie5iV Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/rvZooKLMqk

Apr 13, 2022 · 1 like · 1 share · 1,935 followers View post →
Dr. Neil Ashley
@NotWIMM · X

RT @Awesomics: Study: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to #aging & smoking https:/…

Apr 13, 2022 · 1 share · 1,048 followers View post →
Awesomics
@Awesomics · X

Study: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to #aging & smoking https://t.co/q038Cil2Op ($) Story: A breakthrough in DNA sequencing hints at why most smokers don't get lung cancer https://t.co/lHSk1WFVo4 #lungcancer #smoking

Apr 13, 2022 · 2 likes · 1 share · 6,732 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @genomeorganizer: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…

Apr 13, 2022 · 1 share · 3,834 followers View post →
Steve, PhD
@StevOmics · X

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/ZcJTdBCD7N #cell #science #genomics

Apr 12, 2022 · 1 like · 1 share · 271 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @DOchayon: "Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…

Apr 12, 2022 · 1 share · 3,834 followers View post →
David Ochayon
@DOchayon · X

"Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics" https://t.co/lNOKEO57Se

Apr 12, 2022 · 1 like · 1 share · 285 followers View post →
Single Cell Media
@SingleCellMedia · X

RT @hypoxiabiology: Journal club 20220418 Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to agin…

Apr 12, 2022 · 1 share · 3,834 followers View post →
ハイポキシア生物学
@hypoxiabiology · X

Journal club 20220418 Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking Nat Genet https://t.co/YWyKibTEMT #hypoxia_journal

Apr 12, 2022 · 1 like · 1 share · 46 followers View post →
Yasharz
@YasharZeighami · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 12, 2022 · 13 shares · 626 followers View post →
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@selense007 · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 12, 2022 · 13 shares · 1,830 followers View post →
abeldavidgp
@abel_gonzalezp · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 12, 2022 · 13 shares · 180 followers View post →
サイエンスあれこれ
@sarekore · X

19人の喫煙者の、正常肺上皮細胞(最も癌化しやすい細胞)の変異を比較した結果、喫煙が突然変異の頻度を増加させる一方で、この増加は1日1箱23年間の喫煙量で止まることが判明。一部の喫煙者は突然変異を抑制することで肺がんから身を守るメカニズムを持っている可能性を示唆https://t.co/ECEbJM5qn1

Apr 12, 2022 · 3 likes · 922 followers View post →
AgingResearch
@TheAgingField · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 11, 2022 · 13 shares · 5,269 followers View post →
Seyoon Lee
@Seyoon_L · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 11, 2022 · 13 shares · 213 followers View post →
Lavanya Muthukrishnan
@LavanyaMuthukr3 · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 11, 2022 · 13 shares · 72 followers View post →
Sheila Shin
@scshinyahoo · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 11, 2022 · 13 shares · 3,559 followers View post →
John Holloway
@ProfJWHolloway · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 11, 2022 · 13 shares · 1,155 followers View post →
Kasit Chatsirisupachai
@KasitC10 · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 11, 2022 · 13 shares · 338 followers View post →
biotech archives
@bot_biotech · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 11, 2022 · 13 shares · 162 followers View post →
lolly
@lollyHalla · X

RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…

Apr 11, 2022 · 13 shares · 455 followers View post →
Nature Genetics
@NatureGenet · X

Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking (Huang et al.) https://t.co/8fWL8nxzuy https://t.co/F4fC77MMtA

Apr 11, 2022 · 69 likes · 13 shares · 128,329 followers View post →