Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking (Huang et al.) https://t.co/8fWL8nxzuy https://t.co/F4fC77MMtA
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking.
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Apr 2022 – Apr 2024Where it's discussed
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News105 articles
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X / Twitter55 posts
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What people are saying
The discussions reflect strong interest with some posts emphasizing the novelty of single-cell sequencing in relation to aging and smoking, citing examples like why most smokers don't develop lung cancer. The tone varies from scientific inquiry to enthusiasm, highlighting the potential implications for health and genetics, which supports an overall moderate to high impact evaluation.
Most discussions acknowledge the significance of the research, with some even highlighting it as groundbreaking in understanding lung health related to smoking and aging.
Participants show high curiosity, frequently referencing the study's methods, implications, and broader relevance to lung cancer and genetics.
Many discussions include detailed responses, questions, and references to related concepts, indicating moderate to deep engagement.
The posts suggest the research could influence future studies and public understanding of lung health, though its immediate societal impact appears moderate.
Abstract in brief
- This study used single-cell whole-genome sequencing to analyze somatic mutations in bronchial epithelial cells from people aged 11 to 86, with varying smoking histories, to understand how aging and smoking influence mutation accumulation.
- Researchers found that both age and smoking increased the frequency of mutations, with a linear relationship up to about 23 pack-years of smoking, after which mutation frequency plateaued, suggesting possible individual selection against harmful mutations.
- Mutation signatures associated with lung cancer correlated with age and smoking exposure, but there was no significant increase in traditional lung cancer driver gene mutations, indicating complex factors in cancer development beyond just mutation accumulation.]
Top posts
Most liked on X and BlueskySingle-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/hz893gzf12
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/s7Hc0PxRbW #genomics
@Neo5512 @UQJXOh82l9gdBJk @20170211febhei これですかね。In Deepブログ様より [論文] 加齢と喫煙に関連したヒト気管支上皮細胞の体細胞変異の単一細胞分析 Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking
19人の喫煙者の、正常肺上皮細胞(最も癌化しやすい細胞)の変異を比較した結果、喫煙が突然変異の頻度を増加させる一方で、この増加は1日1箱23年間の喫煙量で止まることが判明。一部の喫煙者は突然変異を抑制することで肺がんから身を守るメカニズムを持っている可能性を示唆https://t.co/ECEbJM5qn1
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/Nawj0p5wkz #science #cancer #singlecell #analysis #mutations #cells
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Certain smokers may have resilient protective mechanisms that limit mutations and, thus, safeguard them against lung cancer. “Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking.” https://t.co/z4MZtVsNJu.+
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/aq4fVy6NBq
なぜ喫煙者で肺がんになる人と、ならない人がいるのか? ベビースモーカー
RT @renesugar: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co…
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/Ey3Wudq0Kx
Huang, Z., et. al. (2022). Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. Nature genetics, 54(4), 492–498. https://t.co/0MEyPhcoSf
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RT @rsciencejournal: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…
RT @rsciencejournal: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/Nawj0p5wkz #science #cancer #singlecell #analysis #mutations #cells
RT @NewScientistZon: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/wd7D8nzdrK
RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…
RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…
RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…
RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…
RT @TalatKl15: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/hz893gzf12
RT @rsciencejournal: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/Nawj0p5wkz #science #cancer #singlecell #analysis #mutations #cells
RT @BioDecoded: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gen…
RT @BioDecoded: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gen…
RT @BioDecoded: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gen…
RT @BioDecoded: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gen…
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/s7Hc0PxRbW #genomics
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
@Neo5512 @UQJXOh82l9gdBJk @20170211febhei これですかね。In Deepブログ様より [論文] 加齢と喫煙に関連したヒト気管支上皮細胞の体細胞変異の単一細胞分析 Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @the_paper_link: Trend new: Huang Z, ..., Vijg J (Nat Genet) __Single-cell analysis of somatic mutations in human bronchial epithelial…
Trend new: Huang Z, ..., Vijg J (Nat Genet) __Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking__ https://t.co/DUmlx6Gqs2
https://t.co/o3cNvmeZ3L Why most people who smoke don't get lung cancer? Researchers from the Einstein College of Medicine in the United States published a research paper entitled: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation....
RT @uchida_kawasaki: ヘビースモーカーなのに長生きする人がいるのはなぜなのか?肺がんに対する防御が備わっている : カラパイア https://t.co/QBkwLie5iV Single-cell analysis of somatic mutation…
ヘビースモーカーなのに長生きする人がいるのはなぜなのか?肺がんに対する防御が備わっている : カラパイア https://t.co/QBkwLie5iV Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics https://t.co/rvZooKLMqk
RT @Awesomics: Study: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to #aging & smoking https:/…
Study: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to #aging & smoking https://t.co/q038Cil2Op ($) Story: A breakthrough in DNA sequencing hints at why most smokers don't get lung cancer https://t.co/lHSk1WFVo4 #lungcancer #smoking
RT @genomeorganizer: Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https:/…
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking https://t.co/ZcJTdBCD7N #cell #science #genomics
RT @DOchayon: "Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Gene…
"Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking | Nature Genetics" https://t.co/lNOKEO57Se
RT @hypoxiabiology: Journal club 20220418 Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to agin…
Journal club 20220418 Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking Nat Genet https://t.co/YWyKibTEMT #hypoxia_journal
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
19人の喫煙者の、正常肺上皮細胞(最も癌化しやすい細胞)の変異を比較した結果、喫煙が突然変異の頻度を増加させる一方で、この増加は1日1箱23年間の喫煙量で止まることが判明。一部の喫煙者は突然変異を抑制することで肺がんから身を守るメカニズムを持っている可能性を示唆https://t.co/ECEbJM5qn1
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
RT @NatureGenet: Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking…
Online now! Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking (Huang et al.) https://t.co/8fWL8nxzuy https://t.co/F4fC77MMtA