Alzheimers Dement January 2023 PMID 35522844

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis.

Theophania Ashleigh, Russell H Swerdlow, M Flint Beal

Mentions

47
Peak: 13 in Apr 2023
across 4 sources since May 2022

Extended reach

177,210
potential audience

Total likes

2,207

Video views

55,581

Mentions per month

May 2022 – Jun 2025

Where it's discussed

  • X / Twitter28 posts
  • News12 articles
  • Blogs5 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions exhibit enthusiasm and support for shifting the understanding of Alzheimer's toward mitochondrial dysfunction, with phrases like 'promising target' and 'drives the pathogenesis' reflecting strong agreement and perceived importance. The tone is scientific yet optimistic, emphasizing the article’s potential to influence future therapeutic directions and challenge traditional hypotheses.

AgreementStrong agreement

Most discussions strongly support the idea that mitochondrial dysfunction plays a central role in Alzheimer's disease, with multiple posts emphasizing it as a promising target for new therapies.

InterestHigh interest

Posts demonstrate high interest through mentions of new models, potential treatments, and references to prominent researchers, indicating relevance and curiosity.

EngagementModerate engagement

Many posts reference key concepts like the 'Mitochondrial Cascade Hypothesis' and critique of traditional models, reflecting engagement with the scientific content, although some remain surface-level.

ImpactHigh impact

The discussions highlight the perceived transformative potential of viewing mitochondrial dysfunction as primary in AD, suggesting high impact on future research and treatment strategies.

Abstract in brief

  • The text discusses the importance of mitochondrial dysfunction in the development of Alzheimer's disease (AD), suggesting it may be a primary cause of the disease rather than just a consequence of amyloid beta accumulation.
  • The traditional Amyloid Cascade Hypothesis, which focuses on amyloid beta as the main driver of AD, is seen as insufficient, and a new unified model emphasizing mitochondrial dysfunction is proposed to better explain disease progression.
  • Targeting mitochondrial dysfunction could lead to new, effective therapies for AD, as mitochondria are crucial for maintaining neuronal and synaptic health, and their impairment appears central to the disease's pathology.]

Top posts

Most liked on X and Bluesky
Madam Mitochondria
@Madam_Mito · X

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis. The Amyloid Cascade Model does not readily account for various parameters associated with Alzheimer's disease https://t.co/khoSAmMyS6

Apr 14, 2023 · 22 likes · 3 shares · 10,653 followers View post →
MitoSense
@MitoSenseInc · X

Apr 14, 2023 · 14 likes · 9 shares · 1,456 followers View post →
Dr. Matthew CL Phillips
@drmclphillips · X

Nice paper on mitochondria dysfunction as the etiology of Alzheimer's by Dr Swerdlow and the team out of Kansas: https://t.co/lrpCt7yZEc

May 6, 2022 · 12 likes · 3,567 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

Mitochondrial dysfunction may be the primary cause of AD, and is a promising target for new therapeutic strategies. https://t.co/F4KOtH0kK1

Jul 18, 2024 · 6 likes · 2 shares · 390 followers View post →
Vee
@ramanveena · X

$CYCN Interesting! mitochondrial dysfunction drives the pathogenesis of AD, as baseline mitochondrial function and mitochondrial change rates influence the progression of cognitive decline. https://t.co/cEqvoX43Io

Jun 15, 2022 · 2 likes · 334 followers View post →
Centre de Neurologie Cognitive
@CNC_Alzheimer · X

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis - Ashleigh - - Alzheimer's & Dementia - Wiley Online Library https://t.co/m78gBxQJkU

May 7, 2022 · 1 like · 1 share · 1,120 followers View post →

All mentions

Targeting Mitochondrial Metabolism in Cancer Therapy

Mitochondrial metabolism plays a crucial role in tumor growth by supplying essential metabolites and helping maintain the cancer phenotype. This video explores the effectiveness of targeting mitochondrial metabolism in…

Physionic · Nov 6, 2023 29,804 views
Alzheimer's Prevention
@AlzheimersPrev2 · X

@slavov_n @GaryMarcus Now search “Mitochondrial Cascade Hypothesis” https://t.co/Fg0Niuq2Av

Apr 5, 2025 · 390 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

@DaniBeckman @vbwyll The Amyloid Cascade Model does not readily account for various parameters associated with Alzheimer's disease. https://t.co/Fg0Niuq2Av Targeting mitochondrial function is a promising strategy for developing new treatments for Alzheimer's. https://t.co/rxoRxqweT6

Jan 30, 2025 · 390 followers View post →
Billy Hanlon
@bhanlon15 · X

RT @AlzheimersPrev2: Mitochondrial dysfunction may be the primary cause of AD, and is a promising target for new therapeutic strategies. h…

Jul 18, 2024 · 2 shares · 13,676 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

Mitochondrial dysfunction may be the primary cause of AD, and is a promising target for new therapeutic strategies. https://t.co/F4KOtH0kK1

Jul 18, 2024 · 6 likes · 2 shares · 390 followers View post →
Birgitta
@NeherBirgitta · X

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis https://t.co/MCYqRrxffr

Jul 10, 2024 · 1,159 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @Madam_Mito: The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis. The Amyloid Cascade Model does not readily acco…

Feb 23, 2024 · 3 shares · 10,653 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

Mitochondrial dysfunction may be the primary cause of AD, and is a promising target for new therapeutic strategies. https://t.co/F4KOtGZMUt

Jul 25, 2023 · 390 followers View post →
Van Hipp
@VanHipp · X

RT @MitoSenseInc:

Apr 17, 2023 · 9 shares · 25,462 followers View post →
Andrew Morris
@andrewmorrisuk · X

RT @MitoSenseInc:

Apr 15, 2023 · 9 shares · 15,368 followers View post →
CLA
@c8kin4 · X

RT @MitoSenseInc:

Apr 15, 2023 · 9 shares · 1,444 followers View post →
Lori Clydesdale
@lori_clydesdale · X

RT @MitoSenseInc:

Apr 14, 2023 · 9 shares · 6,757 followers View post →
Grace Vasquez
@itsYourGrace · X

RT @MitoSenseInc:

Apr 14, 2023 · 9 shares · 9,357 followers View post →
Daniel Sandoval
@danielsts23 · X

RT @philosophising4: The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis. The Amyloid Cascade Model does not readily…

Apr 14, 2023 · 3 shares · 284 followers View post →
Stephanie Williams
@jetmeix · X

RT @MitoSenseInc:

Apr 14, 2023 · 9 shares · 217 followers View post →
津田克彦
@KatsuhikoTsuda · X

RT @MitoSenseInc:

Apr 14, 2023 · 9 shares · 4,211 followers View post →
Brent Segal
@bsegal73 · X

RT @MitoSenseInc:

Apr 14, 2023 · 9 shares · 830 followers View post →
BeeNotWeary
@LuvOregonMtns · X

RT @MitoSenseInc:

Apr 14, 2023 · 9 shares · 3,644 followers View post →
Madam Mitochondria
@Madam_Mito · X

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis. The Amyloid Cascade Model does not readily account for various parameters associated with Alzheimer's disease https://t.co/khoSAmMyS6

Apr 14, 2023 · 22 likes · 3 shares · 10,653 followers View post →
재명이 빵에가는날...
@son5667 · X

RT @MitoSenseInc:

Apr 14, 2023 · 9 shares · 453 followers View post →
MitoSense
@MitoSenseInc · X

Apr 14, 2023 · 14 likes · 9 shares · 1,456 followers View post →
Vee
@ramanveena · X

$CYCN Interesting! mitochondrial dysfunction drives the pathogenesis of AD, as baseline mitochondrial function and mitochondrial change rates influence the progression of cognitive decline. https://t.co/cEqvoX43Io

Jun 15, 2022 · 2 likes · 334 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/ro8VWo66R4

May 17, 2022 · 1 share · 3,156 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/ro8VWo66R4

May 16, 2022 · 1 share · 3,156 followers View post →
Laure Rouch
@RouchLaure · X

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis https://t.co/goD2AEsg4N

May 10, 2022 · 1 like · 716 followers View post →
iBraiN Inserm Lab
@iBrain_Inserm · X

RT @CNC_Alzheimer: The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis - Ashleigh - - Alzheimer's & Dementia - Wi…

May 7, 2022 · 1 share · 1,712 followers View post →
Centre de Neurologie Cognitive
@CNC_Alzheimer · X

The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis - Ashleigh - - Alzheimer's & Dementia - Wiley Online Library https://t.co/m78gBxQJkU

May 7, 2022 · 1 like · 1 share · 1,120 followers View post →
Dr. Matthew CL Phillips
@drmclphillips · X

Nice paper on mitochondria dysfunction as the etiology of Alzheimer's by Dr Swerdlow and the team out of Kansas: https://t.co/lrpCt7yZEc

May 6, 2022 · 12 likes · 3,567 followers View post →
Paperbirds_Neurology
@PaperbirdsN · X

New article: The role of mitochondrial dysfunction in Alzheimer's disease pathogenesis https://t.co/sEpTkGHCvx #alzheimers #neurology https://t.co/PI3g0CapMo

May 6, 2022 · 453 followers View post →