Annu Rev Nutr August 2022 PMID 35588443

The Origins, Evolution, and Future of Dietary Methionine Restriction.

Han Fang, Kirsten P Stone, Desiree Wanders, Laura A Forney, Thomas W Gettys

Full text PDF Download social card

Mentions

Peak: 3 in May 2022

across 3 sources since May 2022

Extended reach

470,613

potential audience

Total likes

6,721

Video views

321,003

Mentions per month

May 2022 – Mar 2025

Where it's discussed

X / Twitter8 posts
YouTube2 videos
Blogs2 articles

AI synopsis

What people are saying

The overall tone indicates strong interest and support, with posts stating the review is a 'timely publication' and encouraging others to explore its insights, emphasizing the article’s relevance to current debates and development in dietary methionine restriction. The words used, such as 'good summary' and 'please check out,' reflect appreciation and engagement, supporting a positive view of its potential influence.

AgreementModerate agreement

Most discussions express support and recognition of the importance of the research, especially with positive remarks like 'very good summary' and the call to check out the review.

InterestHigh interest

The discussions demonstrate high interest, particularly with comments highlighting the review's relevance and timeliness, such as referencing the ongoing AGE2022 conference.

EngagementModerate engagement

There is moderate engagement, with posts prompting others to read the review or highlighting its significance, but few delve into detailed critique or analysis.

ImpactModerate impact

The publication is viewed as impactful, especially given references to its relevance in current research and conference themes, implying it may influence ongoing studies.

Abstract in brief

The text discusses the history and effects of dietary methionine restriction (MR), which was initially shown to increase longevity and improve metabolic health in rats by limiting methionine intake to 20% of normal levels.
Recent research has focused on understanding how reduced methionine intake influences nutrient sensing, signaling systems, and gene expression, especially highlighting the role of hepatic fibroblast growth factor 21 (FGF21) as a key mediator of the beneficial metabolic effects.
These insights suggest the potential for developing therapeutic diets based on MR that could mimic the health benefits of increased FGF21 levels, offering promising strategies for metabolic health improvements.]

Read the full abstract

All mentions

Dietary Methionine Restriction and Its Impact on Longevity and Metabolism

The video discusses the effects of dietary methionine restriction, initially shown to increase longevity and metabolic health in rats by limiting methionine intake. It explores how reduced methionine influences nutrient…

Ázsiába Szakadtam · Dec 9, 2023 320,073 views

Impact of Methionine Restriction on Longevity and Metabolic Health

Methionine restriction from middle age has been shown to extend lifespan, reduce tumor growth, and promote weight loss in animals, mimicking rapamycin effects. This video explores how dietary methionine influences…

NeuroEverything · Mar 11, 2025 930 views

Nutrition Science

@NutrioSci · X

https://t.co/O6QRjX4Lbu

Aug 30, 2022 · 2 likes · 63,963 followers View post →

Alan2102z

@alan2102z · X

@NiacinCreatine @MuscleMiike @Ironysquared1 @MichaelEid18 https://t.co/jHpJIBBdI3

Jul 2, 2022 · 830 followers View post →

Philip M.M. Ruppert

@pmmruppert · X

A very good summary of the current state of #methionine restriction research. #MR #MetR https://t.co/qdrmSK7cYO

Jun 8, 2022 · 1 like · 489 followers View post →

ted griggs

@tedgriggsbr · X

RT @HanFang_Hannah: Please check out our latest review on Methionine Restriction - past, present, and future! https://t.co/m0T42zgyNO

Jun 1, 2022 · 1 share · 549 followers View post →

Hannah Fang PhD

@HanFang_Hannah · X

Please check out our latest review on Methionine Restriction - past, present, and future! https://t.co/m0T42zgyNO

Jun 1, 2022 · 1 like · 1 share · 78 followers View post →

Agingdoc

@agingdoc1 · X

RT @agingdoc1: The Origins, Evolution, and Future of Dietary Methionine Restriction https://t.co/K8zcxuk4Zi Timely publication with the o…

May 28, 2022 · 2 shares · 41,804 followers View post →

Carlos Colmenero

@colme99 · X