August 2022 PMID 35640743

Metformin: Is it a drug for all reasons and diseases?

Chris R Triggle, Ibrahim Mohammed, Khalifa Bshesh, Isra Marei, Kevin Ye, Hong Ding, Ross MacDonald, Morley D Hollenberg, Michael A Hill

Download social card

Mentions

33
Peak: 7 in Jun 2022
across 3 sources since Jun 2022

Extended reach

343,883
potential audience

Total likes

10,288

Video views

160,292

Mentions per month

Jun 2022 – Sep 2025

Where it's discussed

  • X / Twitter21 posts
  • News9 articles
  • YouTube3 videos

AI synopsis

What people are saying

Many discussions highlight that metformin might extend lifespan and protect against various diseases, as shown by phrases like 'metformin meets the criteria of a geroprotective agent' and references to longevity research. The tone varies from scientific interest to enthusiasm, reflecting both curiosity and acknowledgment of possible transformative health effects.

AgreementModerate agreement

Most discussions support the idea that metformin could have broad health benefits beyond diabetes, indicating general agreement with the publication's hypothesis.

InterestHigh interest

Posts show high interest, with many discussing longevity, aging, and disease prevention, reflecting curiosity about potential wide-ranging effects.

EngagementModerate engagement

Participants reference specific mechanisms, studies, and pathways related to metformin, demonstrating active engagement and deeper analysis.

ImpactModerate impact

The discussions suggest recognition of the significant potential impact of this research on aging and healthspan, sharing optimism about its implications.

Abstract in brief

  • Metformin was first used to treat type 2 diabetes in the 1950s and remains a commonly prescribed medication, with ongoing research exploring its potential to treat various other diseases like COVID-19, polycystic ovary syndrome, certain cancers, and neurodegenerative conditions.
  • Studies, including clinical trials such as MILES and TAME, are investigating whether metformin can extend lifespan and combat aging, with some evidence suggesting protective effects on mitochondria, inflammation, and neuronal health.
  • There is debate about whether metformin's benefits for these diverse conditions are due to its primary role in blood sugar regulation or if other cellular mechanisms, such as mTOR inhibition or antiviral actions, play a part, alongside concerns about environmental impacts and effects on human reproduction.

Top posts

Most liked on X and Bluesky
Karsten Suhre
@ksuhre · X

Congrats to my @WCMQatar colleague Chris Triggle and colleagues for their excellent review of metformin and its benefits in diabetes: "#Metformin: Is it a drug for all reasons and diseases?" With very informative Figures summarizing different pathways

Aug 3, 2022 · 15 likes · 3 shares · 2,566 followers View post →
Giuseppe Maltese
@docmaltese · X

"Metformin may extend both healthspan and lifespan independent of its actions as an anti-diabetic drug thus suggesting metformin meets the criteria of a geroprotective agent" https://t.co/KDV5TuP1tT @NirBarzilaiMD @Rcmsiow @ARK_KCL @DrMichaelSagner https://t.co/71DrnS2kv3

Feb 1, 2025 · 12 likes · 2 shares · 1,769 followers View post →
Agingdoc
@agingdoc1 · X

Metformin: Is it a drug for all reasons and diseases? - Metabolism https://t.co/Zkk0i6LVHk

Jun 1, 2022 · 9 likes · 2 shares · 41,315 followers View post →
Simon Hill MSc, BSc
@theproof · X

New review on Metformin - is it a longevity compound? Is it protective against cancer? Cc @PeterAttiaMD @davidasinclair @mkaeberlein @hubermanlab https://t.co/vjp497WQog

Aug 27, 2022 · 8 likes · 1 share · 34,077 followers View post →
Simon Hill MSc, BSc
@theproof · X

@PeterAttiaMD you may be interested in this new review on Metformin https://t.co/vjp497WQog

Aug 27, 2022 · 3 likes · 34,077 followers View post →
Maryam Kazemi, RD, MSc, PhD, CPT
@MrmKzm · X

Metformin: Is it a drug for all reasons and diseases? https://t.co/oElsSHf82l

Jun 1, 2022 · 2 likes · 2,733 followers View post →

All mentions

Fran Pita
@doutorpita · X

RT @docmaltese: "Metformin may extend both healthspan and lifespan independent of its actions as an anti-diabetic drug thus suggesting metf…

Feb 2, 2025 · 2 shares · 1,675 followers View post →
Cristina Tejera
@cristinatejerap · X

RT @docmaltese: "Metformin may extend both healthspan and lifespan independent of its actions as an anti-diabetic drug thus suggesting metf…

Feb 2, 2025 · 2 shares · 11,448 followers View post →
Giuseppe Maltese
@docmaltese · X

"Metformin may extend both healthspan and lifespan independent of its actions as an anti-diabetic drug thus suggesting metformin meets the criteria of a geroprotective agent" https://t.co/KDV5TuP1tT @NirBarzilaiMD @Rcmsiow @ARK_KCL @DrMichaelSagner https://t.co/71DrnS2kv3

Feb 1, 2025 · 12 likes · 2 shares · 1,769 followers View post →
Dra. Maribel Lizarzábal | Health Coach
@soydramaribel · X

Fuente: Chris R Triggle (2022). Metformin: Is it a drug for all reasons and diseases? PubMed. https://t.co/60twXHrQ9W

Jul 2, 2024 · 16,509 followers View post →
Dra. Maribel Lizarzábal | Health Coach
@soydramaribel · X

Fuente: Chris R Triggle (2022). Metformin: Is it a drug for all reasons and diseases? - PubMed. https://t.co/60twXHsnZu #metformina #diabetes #higadograso #inflamacion #antiedad #rejuvenecer #habitosaludables

Aug 16, 2023 · 1 like · 16,509 followers View post →
Andrew Miller
@EndoMetabPub · X

Metabolism: Metformin, Is it a drug for all reasons and diseases? https://t.co/2nhYrNu34r

Feb 9, 2023 · 2,569 followers View post →
Woody Nist
@Woodynist · X

Metformin: Is it a drug for all reasons and diseases? https://t.co/zK8iq5H334

Sep 10, 2022 · 1,312 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @theproof: New review on Metformin - is it a longevity compound? Is it protective against cancer? Cc @PeterAttiaMD @davidasinclair @mka…

Aug 28, 2022 · 1 share · 1,369 followers View post →
Simon Hill MSc, BSc
@theproof · X

New review on Metformin - is it a longevity compound? Is it protective against cancer? Cc @PeterAttiaMD @davidasinclair @mkaeberlein @hubermanlab https://t.co/vjp497WQog

Aug 27, 2022 · 8 likes · 1 share · 34,077 followers View post →
Simon Hill MSc, BSc
@theproof · X

@PeterAttiaMD you may be interested in this new review on Metformin https://t.co/vjp497WQog

Aug 27, 2022 · 3 likes · 34,077 followers View post →
WCM Englander Institute for Precision Medicine
@WCMEnglanderIPM · X

RT @ksuhre: Congrats to my @WCMQatar colleague Chris Triggle and colleagues for their excellent review of metformin and its benefits in dia…

Aug 3, 2022 · 3 shares · 6,174 followers View post →
Alex Sigaras (he/him)
@AlexSigaras · X

RT @ksuhre: Congrats to my @WCMQatar colleague Chris Triggle and colleagues for their excellent review of metformin and its benefits in dia…

Aug 3, 2022 · 3 shares · 706 followers View post →
Olivier Elemento
@ElementoLab · X

RT @ksuhre: Congrats to my @WCMQatar colleague Chris Triggle and colleagues for their excellent review of metformin and its benefits in dia…

Aug 3, 2022 · 3 shares · 6,249 followers View post →
Karsten Suhre
@ksuhre · X

Congrats to my @WCMQatar colleague Chris Triggle and colleagues for their excellent review of metformin and its benefits in diabetes: "#Metformin: Is it a drug for all reasons and diseases?" With very informative Figures summarizing different pathways

Aug 3, 2022 · 15 likes · 3 shares · 2,566 followers View post →
Orlando_uy
@Orlando_uy · X

Metformin: Is it a drug for all reasons and diseases? Benefits of metformin result from its insulin-sensitizing and antihyperglycaemic effects that secondarily contribute to a reduced risk of a number of diseases and thereby enhancing healthspan. https://t.co/xRd38J4Fbv

Jun 26, 2022 · 690 followers View post →
the paper link
@the_paper_link · X

Trend new: Triggle CR, ..., Hill MA (Metabolism) __Metformin: Is it a drug for all reasons and diseases__ https://t.co/ZuiZfJeL6A

Jun 2, 2022 · 136 followers View post →
Alexander Dakhovnik
@ADakhovnik · X

RT @agingdoc1: Metformin: Is it a drug for all reasons and diseases? - Metabolism https://t.co/Zkk0i6LVHk

Jun 1, 2022 · 2 shares · 77 followers View post →
Maryam Kazemi, RD, MSc, PhD, CPT
@MrmKzm · X

Metformin: Is it a drug for all reasons and diseases? https://t.co/oElsSHf82l

Jun 1, 2022 · 2 likes · 2,733 followers View post →
Yurii
@Yurii08720681 · X

RT @agingdoc1: Metformin: Is it a drug for all reasons and diseases? - Metabolism https://t.co/Zkk0i6LVHk

Jun 1, 2022 · 2 shares · 34 followers View post →
Agingdoc
@agingdoc1 · X

Metformin: Is it a drug for all reasons and diseases? - Metabolism https://t.co/Zkk0i6LVHk

Jun 1, 2022 · 9 likes · 2 shares · 41,315 followers View post →
Malaria Papers
@MalariaPapers · X

Metformin: Is it a drug for all reasons and diseases? https://t.co/6uIiTdkEj5

Jun 1, 2022 · 1,546 followers View post →