Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation.

Aurélien Trompette, Julie Pernot, Olaf Perdijk, Rayed Ali A Alqahtani, Jaime Santo Domingo, Dolores Camacho-Muñoz, Nicholas C Wong, Alexandra C Kendall, Andreas Wiederkehr, Laurent P Nicod, Anna Nicolaou, Christophe von Garnier, Niki D J Ubags, Benjamin J Marsland

May 2022

Synopsis of Social media discussions

The digital discussions show strong interest and partial agreement, with comments highlighting the rapid transport of microbial metabolites from gut to skin and emphasizing the potential for dietary interventions to improve skin health. The tone is curious and optimistic, reflecting an appreciation for the significance of the gut-skin axis in maintaining health.

A
Agreement
 Moderate agreement

Most discussions agree that the research presents promising evidence of a gut-skin connection, with some praise for its potential impact.

I
Interest
 High level of interest

The posts demonstrate high curiosity about the biological mechanisms and implications for health.

E
Engagement
 Moderate level of engagement

The comments reflect moderate engagement, with some users discussing how microbial metabolites influence skin health and encouraging further exploration.

I
Impact
 Moderate level of impact

The discussions suggest the findings could influence future research and treatment approaches, indicating a moderate to high potential impact.

Social Mentions

YouTube

3 Videos

Facebook

4 Posts

Twitter

18 Posts

Instagram

10 Posts

TikTok

40 Posts

News

3 Articles

Metrics

Video Views

1,946

Total Likes

76

Extended Reach

167,109

Social Features

78

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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Gut-derived short-chain fatty acids, especially butyrate, improve skin barrier function by promoting keratinocyte metabolism and differentiation, potentially preventing skin conditions like atopic dermatitis. A diet rich in fermentable fiber enhances this gut-skin connection, strengthening skin health.

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168 views

  • Ben Marsland
    @BenJMarsland (Twitter)

    Agreed, good call @ArrietaLab. In fact, there is gut microbiome data for the #PreventADALL cohort––we should dig into the crosstalk between the compartments. Still blows my mind how fast microbial metabolites get from the gut to the skin! #GutSkinAxis https://t.co/Cqc7u8bD2D https://t.co/inT8spMUe9
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    RT @DptMedecineCHUV: L'étude démontrant un lien
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    RT @DptMedecineCHUV: L'étude démontrant un lien
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    RT @DptMedecineCHUV: L'étude démontrant un lien
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    @finance_free39 (Twitter)

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  • ニッチトピア
    @nichetopia (Twitter)

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    @ustky (Twitter)

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  • YES
    @ejoooj12 (Twitter)

    RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…
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  • Atanas G. Atanasov
    @_atanas_ (Twitter)

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  • Toshiyuki Horie｜堀江 俊之
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    『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation" https://t.co/84XR3sGIDU
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  • Dr Anthony Martin
    @AMAinsight (Twitter)

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    @Aenoreth (Twitter)

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Abstract Synopsis

  • Gut-derived shortchain fatty acids (SCFA), especially butyrate, enhance skin barrier function by improving keratinocyte metabolism and differentiation, which helps prevent conditions like atopic dermatitis (AD) and related allergies.
  • A diet rich in fermentable fiber boosts SCFA production in the gut, which in turn strengthens the skin barrier and reduces systemic allergen sensitization and disease severity.
  • The study highlights a gut-skin connection, where dietary fiber influences skin health by modulating mitochondrial activity in skin cells, ultimately offering a potential strategy to prevent allergic diseases.]