May 2022 PMID 35672452

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation.

Aurélien Trompette, Julie Pernot, Olaf Perdijk, Rayed Ali A Alqahtani, Jaime Santo Domingo, Dolores Camacho-Muñoz, Nicholas C Wong, Alexandra C Kendall, Andreas Wiederkehr, Laurent P Nicod, Anna Nicolaou, Christophe von Garnier, Niki D J Ubags, Benjamin J Marsland

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Mentions

78
Peak: 13 in Jun 2022
across 6 sources since May 2022

Extended reach

167,109
potential audience

Total likes

76

Video views

1,946

Mentions per month

May 2022 – Dec 2025

Where it's discussed

  • TikTok40 posts
  • X / Twitter18 posts
  • Instagram10 posts
  • Facebook4 posts
  • YouTube3 videos
  • News3 articles

AI synopsis

What people are saying

The digital discussions show strong interest and partial agreement, with comments highlighting the rapid transport of microbial metabolites from gut to skin and emphasizing the potential for dietary interventions to improve skin health. The tone is curious and optimistic, reflecting an appreciation for the significance of the gut-skin axis in maintaining health.

AgreementModerate agreement

Most discussions agree that the research presents promising evidence of a gut-skin connection, with some praise for its potential impact.

InterestHigh interest

The posts demonstrate high curiosity about the biological mechanisms and implications for health.

EngagementModerate engagement

The comments reflect moderate engagement, with some users discussing how microbial metabolites influence skin health and encouraging further exploration.

ImpactModerate impact

The discussions suggest the findings could influence future research and treatment approaches, indicating a moderate to high potential impact.

Abstract in brief

  • Gut-derived shortchain fatty acids (SCFA), especially butyrate, enhance skin barrier function by improving keratinocyte metabolism and differentiation, which helps prevent conditions like atopic dermatitis (AD) and related allergies.
  • A diet rich in fermentable fiber boosts SCFA production in the gut, which in turn strengthens the skin barrier and reduces systemic allergen sensitization and disease severity.
  • The study highlights a gut-skin connection, where dietary fiber influences skin health by modulating mitochondrial activity in skin cells, ultimately offering a potential strategy to prevent allergic diseases.]

Top posts

Most liked on X and Bluesky
Toshiyuki Horie|堀江 俊之
@ToshiyukiHorie · X

『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation" https://t.co/84XR3sGIDU

Jun 15, 2022 · 28 likes · 9 shares · 25,088 followers View post →
Département de médecine / CHUV
@DptMedecineCHUV · X

L'étude démontrant un lien

Feb 16, 2023 · 10 likes · 4 shares · 138 followers View post →
Ben Marsland
@BenJMarsland · X

Agreed, good call @ArrietaLab. In fact, there is gut microbiome data for the #PreventADALL cohort––we should dig into the crosstalk between the compartments. Still blows my mind how fast microbial metabolites get from the gut to the skin! #GutSkinAxis https://t.co/Cqc7u8bD2D https://t.co/inT8spMUe9

Feb 27, 2023 · 2 likes · 1,122 followers View post →
Ariakas Enoreth
@Aenoreth · X

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation https://t.co/TiigqVokYl

Jun 7, 2022 · 1 like · 1,010 followers View post →
Marita Ostos
@MaritaOstos · X

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation | Mucosal Immunology https://t.co/uL58Bff9jP

Oct 17, 2022 · 1 like · 158 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 15, 2022 · 9 shares · 124,472 followers View post →

All mentions

Ben Marsland
@BenJMarsland · X

Agreed, good call @ArrietaLab. In fact, there is gut microbiome data for the #PreventADALL cohort––we should dig into the crosstalk between the compartments. Still blows my mind how fast microbial metabolites get from the gut to the skin! #GutSkinAxis https://t.co/Cqc7u8bD2D https://t.co/inT8spMUe9

Feb 27, 2023 · 2 likes · 1,122 followers View post →
Nathalie HUTTER
@NathalieHUTTER · X

RT @DptMedecineCHUV: L'étude démontrant un lien

Feb 22, 2023 · 4 shares · 2,479 followers View post →
Etoilemer ⭐•.¸¸.•´´¯
@Etoilemer1 · X

RT @DptMedecineCHUV: L'étude démontrant un lien

Feb 22, 2023 · 4 shares · 422 followers View post →
allergissima
@allergissima · X

RT @DptMedecineCHUV: L'étude démontrant un lien

Feb 21, 2023 · 4 shares · 109 followers View post →
Planète Santé (Compte inactif)
@PlaneteSante · X

RT @DptMedecineCHUV: L'étude démontrant un lien

Feb 21, 2023 · 4 shares · 1,973 followers View post →
Département de médecine / CHUV
@DptMedecineCHUV · X

L'étude démontrant un lien

Feb 16, 2023 · 10 likes · 4 shares · 138 followers View post →
Marita Ostos
@MaritaOstos · X

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation | Mucosal Immunology https://t.co/uL58Bff9jP

Oct 17, 2022 · 1 like · 158 followers View post →
LAN FITNESS
@LAN_FITNESS · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 16, 2022 · 9 shares · 58 followers View post →
David Manrique
@manriqueDVD · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 16, 2022 · 9 shares · 2,442 followers View post →
PICO
@msmiminta · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 15, 2022 · 9 shares · 853 followers View post →
Moneyfest
@finance_free39 · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 15, 2022 · 9 shares · 466 followers View post →
ニッチトピア
@nichetopia · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 15, 2022 · 9 shares · 817 followers View post →
まーち
@ustky · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 15, 2022 · 9 shares · 1,539 followers View post →
YES
@ejoooj12 · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 15, 2022 · 9 shares · 332 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @ToshiyukiHorie: 『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by pro…

Jun 15, 2022 · 9 shares · 124,472 followers View post →
Toshiyuki Horie|堀江 俊之
@ToshiyukiHorie · X

『腸由来の短鎖脂肪酸はケラチノサイトの代謝・分化を促進し、皮膚バリア機能を調節する』 "Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation" https://t.co/84XR3sGIDU

Jun 15, 2022 · 28 likes · 9 shares · 25,088 followers View post →
Dr Anthony Martin
@AMAinsight · X

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation | Mucosal Immunology https://t.co/WJYbjEu0a9

Jun 8, 2022 · 914 followers View post →
Ariakas Enoreth
@Aenoreth · X

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation https://t.co/TiigqVokYl

Jun 7, 2022 · 1 like · 1,010 followers View post →
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Reply to @acaig1rl More acne info: @dr.bryant.nd #acnefoods ...
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doi: 10.1038/s41385-022-00524-9. Epub 2022 Jun 7. PMID: 35672452; PMCID: PMC9385498. Xiao X, Hu X, Yao J, Cao W, Zou Z, Wang L, Qin H, Zhong ...

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doi: 10.1038/s41385-022-00524-9. Epub 2022 Jun 7. PMID: 35672452; PMCID: PMC9385498. Xiao X, Hu X, Yao J, Cao W, Zou Z, Wang L, Qin H, Zhong ...

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doi: 10.1038/s41385-022-00524-9. Epub 2022 Jun 7. PMID: 35672452; PMCID: PMC9385498. Xiao X, Hu X, Yao J, Cao W, Zou Z, Wang L, Qin H, Zhong ...

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doi: 10.1038/s41385-022-00524-9. Epub 2022 Jun 7. PMID: 35672452; PMCID: PMC9385498. Xiao X, Hu X, Yao J, Cao W, Zou Z, Wang L, Qin H, Zhong ...

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doi: 10.1038/s41385-022-00524-9. Epub 2022 Jun 7. PMID: 35672452; PMCID: PMC9385498. Xiao X, Hu X, Yao J, Cao W, Zou Z, Wang L, Qin H, Zhong ...

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doi: 10.1038/s41385-022-00524-9. Epub 2022 Jun 7. PMID: 35672452; PMCID: PMC9385498. #skinbarrier #skinbarrierrepair #skinbarrierhealth ...

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