Acta Mater Med May 2022 PMID 35734447

PROTAC Degraders with Ligands Recruiting MDM2 E3 Ubiquitin Ligase: An Updated Perspective.

Xin Han, Wenyi Wei, Yi Sun

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Peak: 10 in Jun 2022

across 3 sources since May 2022

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73,931

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May 2022 – Jan 2024

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What people are saying

The overall discussions reflect a positive outlook on the potential of MDM2-targeting PROTACs, with posters noting the article's relevance to advances in cancer treatment, reinforced by enthusiastic tone and keywords like 'updated perspective' and hashtags related to drug discovery. While some posts mainly share links and titles, others express genuine interest, indicating a broad but not deeply analytical engagement.

AgreementModerate agreement

Most discussions recognize the significance of the research, with many sharing positive sentiments or supportive comments about the advances presented.

InterestHigh interest

The comments demonstrate high interest, especially with the frequent use of hashtags like #ScienceOpen and #drugdiscovery, indicating engagement with the topic.

EngagementModerate engagement

Many posts simply share links or references without deep analysis, but some include brief remarks, showing moderate engagement.

ImpactModerate impact

The repeated sharing and acknowledgment of the article suggest that the discussions acknowledge a noteworthy contribution to the field of cancer therapeutics.

Abstract in brief

The text explains that MDM2 is an enzyme that degrades the tumor suppressor p53, and many inhibitors have been developed to block this process, but they often have limited success because of the complex feedback loop between MDM2 and p53.
PROTACs (proteolysis targeting chimeras) are a new therapeutic approach that can overcome these limitations by promoting the degradation of MDM2 itself or other cancer-related proteins, using MDM2 as a target or as part of the degradation process.
The review discusses recent advances in designing MDM2-based PROTAC drugs, highlighting their potential for effective cancer treatment and addressing future challenges in this emerging field.]

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Updated Perspective on MDM2 E3 Ubiquitin Ligase PROTAC Degraders

This video discusses an updated perspective on PROTAC degraders that target MDM2 E3 ubiquitin ligase, highlighting key advancements in drug discovery for human cancer. We explore the implications and potential…

Medicine RTCL TV · Dec 29, 2023 83 views

Acta Materia Medica

@AMM_journal · X

PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jan 10, 2024 · 2 likes · 602 followers View post →

Acta Materia Medica

@AMM_journal · X

PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jan 10, 2024 · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https…

Nov 22, 2023 · 2 shares · 1,238 followers View post →

YMED-X

@YmedX269 · X

RT @AMM_journal: PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https…

Nov 21, 2023 · 2 shares · 230 followers View post →

Acta Materia Medica

@AMM_journal · X

PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJK3W

Nov 21, 2023 · 1 like · 2 shares · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https…

Oct 9, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Oct 9, 2023 · 2 likes · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Aug 28, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJK3W

Aug 28, 2023 · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Jul 31, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jul 31, 2023 · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Jun 27, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jun 25, 2023 · 1 like · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

May 25, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJK3W

May 24, 2023 · 1 like · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Apr 20, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Apr 20, 2023 · 2 likes · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Mar 17, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Mar 17, 2023 · 2 likes · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Feb 20, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Feb 19, 2023 · 1 like · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Jan 24, 2023 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jan 23, 2023 · 1 like · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Dec 16, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Dec 16, 2022 · 2 likes · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Nov 14, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Nov 13, 2022 · 1 like · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Nov 1, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJK3W

Nov 1, 2022 · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Oct 10, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJK3W

Oct 9, 2022 · 3 likes · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Sep 8, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Sep 8, 2022 · 1 like · 1 share · 602 followers View post →

ScienceOpen Research

@SO_Research · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Sep 1, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAi0N5W

Aug 27, 2022 · 1 share · 602 followers View post →

ScienceOpen

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RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Aug 24, 2022 · 1 share · 17,022 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAi0N5W

Aug 24, 2022 · 1 like · 1 share · 602 followers View post →

ScienceOpen Research

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RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Aug 8, 2022 · 3 shares · 1,238 followers View post →

Narkhyun Bae

@ghostbnh · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Aug 7, 2022 · 3 shares · 526 followers View post →

michele pagano

@paganolab · X

RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Aug 7, 2022 · 3 shares · 2,263 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Aug 7, 2022 · 5 likes · 3 shares · 602 followers View post →

ScienceOpen Research

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RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Jul 26, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jul 25, 2022 · 1 share · 602 followers View post →

ScienceOpen Research

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RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Jul 7, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jul 7, 2022 · 1 like · 1 share · 602 followers View post →

Guillaume Laconde

@Glaconde34 · X

'PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective' https://t.co/rnlzLSAzHV

Jun 23, 2022 · 6 likes · 4,863 followers View post →

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RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Jun 23, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jun 23, 2022 · 1 share · 602 followers View post →

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RT @XueHaibao: 'PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective' an article on #ScienceOpen: http…

Jun 14, 2022 · 1 share · 1,238 followers View post →

haibao.xue

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'PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective' an article on #ScienceOpen: https://t.co/CBGOqFaMGq

Jun 14, 2022 · 1 like · 1 share · 49 followers View post →

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RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Jun 13, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jun 11, 2022 · 1 like · 1 share · 602 followers View post →

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RT @AMM_journal: #PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen htt…

Jun 2, 2022 · 1 share · 1,238 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective an article on #ScienceOpen https://t.co/SbwhAhJceo

Jun 2, 2022 · 3 likes · 1 share · 602 followers View post →

Acta Materia Medica

@AMM_journal · X

#PROTAC degraders with #ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective https://t.co/LmpciKrgsE

Jun 1, 2022 · 602 followers View post →

CompChemBio Bot

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RT @AMM_journal: PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective https://t.co/oOaWIzWZfJ #drugdis…

May 31, 2022 · 1 share · 2,749 followers View post →

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PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective https://t.co/oOaWIzWZfJ #drugdiscovery #humancancer https://t.co/Foit7gBXeU

May 31, 2022 · 1 like · 1 share · 602 followers View post →

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RT @XueHaibao: 'PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective' an article on #ScienceOpen: http…

May 31, 2022 · 1 share · 1,238 followers View post →

haibao.xue

@XueHaibao · X

'PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective' an article on #ScienceOpen: https://t.co/CBGOqFrPIq

May 30, 2022 · 1 like · 1 share · 49 followers View post →

PROTAC Degraders with Ligands Recruiting MDM2 E3 Ubiquitin Ligase: An Updated Perspective.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Updated Perspective on MDM2 E3 Ubiquitin Ligase PROTAC Degraders