Recreating the heart's helical structure-function relationship with focused rotary jet spinning.

Huibin Chang, Qihan Liu, John F Zimmerman, Keel Yong Lee, Qianru Jin, Michael M Peters, Michael Rosnach, Suji Choi, Sean L Kim, Herdeline Ann M Ardoña, Luke A MacQueen, Christophe O Chantre, Sarah E Motta, Elizabeth M Cordoves, Kevin Kit Parker

July 2022 Science

Synopsis of Social media discussions

The overall tone is highly positive, with comments like 'fascinating work,' 'a step forward,' and references to the groundbreaking nature of creating biohybrid models with helical fiber arrangements. The choice of words such as 'game-changer' and 'proof-of-concept' reflects excitement and recognition of significant progress, while mentions of foundational studies give context to the current innovations.

A
Agreement
 Moderate agreement

Most discussions praise the significance of the research, highlighting its advancements and potential breakthroughs, indicating general agreement with its importance.

I
Interest
 High level of interest

The enthusiasm and curiosity are high, with many mentions of innovative methods, implications for organ fabrication, and citations of foundational work, demonstrating strong interest.

E
Engagement
 High engagement

Several discussions delve into methods like additive manufacturing, helical fiber alignments, and the potential impact on cardiac tissue engineering, showing deep engagement.

I
Impact
 Moderate level of impact

While some discussions emphasize the promising advances, others call for recognition of past foundational work, suggesting moderate but meaningful impact on the field.

Social Mentions

YouTube

2 Videos

Facebook

3 Posts

Twitter

108 Posts

Blogs

8 Articles

News

59 Articles

Reddit

2 Posts

Metrics

Video Views

1,083

Total Likes

585

Extended Reach

13,878,115

Social Features

182

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

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  • Shaoting Lin
    @lin_shaoting (Twitter)

    @QihanLiu1 at the University of Pittsburgh presents his recent fascinating work on a new manufacturing method: Aerodynamic Fiber Deposition. Here is the paper link https://t.co/SRiyBNexun https://t.co/bja0iNDLjn
    view full post

    October 18, 2022

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  • Rodrigo Nunes Cal
    @CalZole (Twitter)

    RT @NatureBiotech: To better mimic the structure of the heart, a new tissue-engineering method builds ventricles with helical fiber alignme…
    view full post

    September 15, 2022

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  • Muthalath Platform
    @muthalath180 (Twitter)

    The first biohybrid model of human ventricles – a step forward for organ bio-fabrication. Bioengineers have developed the first biohybrid model of human ventricles with helically aligned beating cardiac cells Full story
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    August 29, 2022

  • Rodrigo Nunes Cal
    @CalZole (Twitter)

    RT @NatureBiotech: To better mimic the structure of the heart, a new tissue-engineering method builds ventricles with helical fiber alignme…
    view full post

    August 18, 2022

    7

  • Faby G.
    @Fabiolaghh (Twitter)

    RT @Shamsan_ha: Recreating the heart’s helical structure-function relationship with focused rotary jet spinning https://t.co/15vH0r7AcN
    view full post

    August 16, 2022

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  • Jason Mullikin
    @jason_mullikin (Twitter)

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    August 14, 2022

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    @FjvJjo (Twitter)

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    @jonagarciar (Twitter)

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  • deadfishbones
    @treysmither (Twitter)

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    @bonillacuevas (Twitter)

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    @clustersen (Twitter)

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    @localmexican98 (Twitter)

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    @devitt_james (Twitter)

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    @taqh1 (Twitter)

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    @j_P_Jo (Twitter)

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  • Science Magazine
    @ScienceMagazine (Twitter)

    Researchers have created 3D helically aligned biohybrid models of human heart tissue using a new type of additive manufacturing. The results provide proof-of-concept for a streamlined approach to fabricating tissues and organs with complex 3D geometries. https://t.co/d6OBtmjiEb https://t.co/5HhoseOHZT
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  • rafavidalperez
    @rafavidalperez (Twitter)

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    view full post

    August 10, 2022

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  • Cardiodiagnosis
    @CardioBCN (Twitter)

    Recreating the heart’s helical structure-function relationship with focused rotary jet spinning https://t.co/8g9uVT9Rln - Congratulations, but do not forget Torrent-Guasp F seminal work on the helical heart anatomy!!! https://t.co/B6rBObLhCt - https://t.co/3yyssNo7Oc #Science
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    August 10, 2022

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  • 公募戦士KI
    @_kiitani (Twitter)

    Recreating the heart’s helical structure-function relationship with focused rotary jet spinning https://t.co/9vq9lBlP16
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    August 8, 2022

  • ADInstruments
    @ADInstruments (Twitter)

    Congratulations to Chang et al. for their publication in Science! Using #LabChart and #Millar PV Catheters, Chang et al. performed pressure-volume loops to determine the cardiac output of bio-fabricated model hearts.
    view full post

    August 1, 2022

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  • Abbas Shah
    @Abbas_Shah_07 (Twitter)

    Recreating the heart’s helical structure-function relationship with Focused Rotary Jet Spinning https://t.co/CtkxDMb7e8
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    July 31, 2022

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  • Aparna Pandey
    @OMG_itsaparna (Twitter)

    RT @MDforLives: Bioengineers created the first biohybrid model of #humanventricles with helically aligned beating #heartcells, demonstratin…
    view full post

    July 20, 2022

    1

  • MDForLives
    @MDforLives (Twitter)

    Bioengineers created the first biohybrid model of #humanventricles with helically aligned beating #heartcells, demonstrating that muscle alignment significantly enhances the amount of blood the ventricle can pump with each contraction. Read more- https://t.co/7narWKAFfM https://t.co/D5cNCeJtfB
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    July 20, 2022

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    July 18, 2022

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    @AkazawaHiroshi (Twitter)

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    @CBolognato (Twitter)

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    @elcaborotativo (Twitter)

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    @StavrosGiaglis (Twitter)

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    @sawsanvalorIris (Twitter)

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  • Science Magazine
    @ScienceMagazine (Twitter)

    Researchers have created 3D helically aligned biohybrid models of human heart tissue using a new type of additive manufacturing. The results provide proof-of-concept for a streamlined approach to fabricating tissues and organs with complex 3D geometries. https://t.co/d6OBtm1HfB https://t.co/yoTUAFmjRr
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    Bioeng pick of the week! Helically-aligned heart scaffold fabricated with focused rotary jet spinning closely improves cardiac pumping function @hseas @ScienceMagazine Kit Parker lab, Huibin Chang, @QihanLiu1, John Zimmerman et al. https://t.co/JHZUfMiBPe https://t.co/fISoWtZcmp
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  • Science Magazine
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    Researchers have created 3D helically aligned biohybrid models of human heart tissue using a new type of additive manufacturing. The results provide proof-of-concept for a streamlined approach to fabricating tissues and organs with complex 3D geometries. https://t.co/d6OBtmjiEb https://t.co/mD9jqjOi19
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  • Journal of Clinical and Experimental Cardiology
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    Recreating the #heart’s helical structure-function relationship with focused rotary jet spinning https://t.co/xU9jLWhtm9
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  • Genç İVEK
    @gencivek (Twitter)

    3. İnsana uygun yapay bir kalp üretmede büyük adım: https://t.co/uZdQZuesfn 4. Asteroit Bennu'nun yüzeyi ve yapısı hakkında yeni bilgiler: https://t.co/GivfCJYmAh
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    July 10, 2022

  • Haleem Shamsan
    @Shamsan_ha (Twitter)

    Recreating the heart’s helical structure-function relationship with focused rotary jet spinning https://t.co/15vH0r7AcN
    view full post

    July 9, 2022

    1

    1

  • Francis Villatoro
    @emulenews (Twitter)

    #ScienceMag Recreating the heart’s helical structure-function relationship with focused rotary jet spinning https://t.co/lqfvI6A5Tm models displaying more uniform deformations, greater apical shortening, and increased ejection fractions compared with circumferential alignments. https://t.co/BoARuIEy4S
    view full post

    July 9, 2022

  • Partho P Sengupta
    @ppsengupta1 (Twitter)

    RT @RRBaligaMD: The Concertina Pump! https://t.co/U1lLykurX8 Recreating the heart’s helical structure-function relationship with focused r…
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    July 9, 2022

    3

  • CardioEd Bot
    @CardioBot (Twitter)

    RT @RRBaligaMD: The Concertina Pump! https://t.co/U1lLykurX8 Recreating the heart’s helical structure-function relationship with focused r…
    view full post

    July 8, 2022

    3

  • RR BaligaMD, Professor & Cardiologist
    @RRBaligaMD (Twitter)

    The Concertina Pump! https://t.co/UlghtnVJdf Recreating the heart’s helical structure-function relationship with focused rotary jet spinning https://t.co/6lkZ7mrXtZ https://t.co/oan7hqjgkO
    view full post

    July 8, 2022

  • RR BaligaMD, Professor & Cardiologist
    @RRBaligaMD (Twitter)

    The Concertina Pump! https://t.co/U1lLykurX8 Recreating the heart’s helical structure-function relationship with focused rotary jet spinning https://t.co/icy3W9DYjy #MedEd #Cardiotwitter #CardioEd @ACCinTouch @American_Heart @HFSA @CNCFCardio @ESCardioNews @wyssinstitute https://t.co/YhV0KBXt45
    view full post

    July 8, 2022

    10

    3

  • Hao Yin
    @HaoYin20 (Twitter)

    RT @YYZscientist: Kit Parker’s group out today: Recreating the heart’s helical structure-function relationship with focused rotary jet spin…
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    July 7, 2022

    1

  • Dr. Sara Nunes Vasconcelos (she/her)
    @YYZscientist (Twitter)

    Kit Parker’s group out today: Recreating the heart’s helical structure-function relationship with focused rotary jet spinning. Interesting. One more to the reading list. https://t.co/WVhWidvRRv
    view full post

    July 7, 2022

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Abstract Synopsis

  • Researchers speculate that the helical arrangement of heart muscle fibers is crucial for effective pumping but face challenges in recreating this structure for testing.
  • Focused rotary jet spinning (FRJS) is introduced as a new manufacturing method that allows for the rapid creation of micro/nanofiber scaffolds with specifically programmed alignments in three dimensions.
  • Tissue-engineered ventricles created with helical alignments showed improved performance, such as more uniform movement and higher efficiency, demonstrating the significance of fiber orientation in cardiac function.