July 2022 PMID 35865092

Why 90% of clinical drug development fails and how to improve it?

Duxin Sun, Wei Gao, Hongxiang Hu, Simon Zhou

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Mentions

305

Peak: 21 in Oct 2022

across 6 sources since Feb 2022

Extended reach

142,693

potential audience

Total likes

164

Video views

2,532

Mentions per month

Feb 2022 – May 2025

Where it's discussed

News238 articles
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Blogs18 articles
Bluesky2 posts
YouTube2 videos
Reddit2 posts

AI synopsis

What people are saying

Several discussions highlight the significance of the STAR system and its potential to reduce failure rates by improving drug selectivity and tissue exposure, with phrases like 'could be a game changer' and 'aims to refine clinical success.' The tone varies from cautiously optimistic to inquisitive, reflecting an interest in the practical applications of the proposed model and its ability to address long-standing challenges in drug development.

AgreementModerate agreement

Most discussions seem aligned with the article's emphasis on the importance of tissue exposure and the STAR model, with several posts supporting its potential to improve success rates.

InterestHigh interest

Posts display curiosity about innovative approaches like the STAR system, suggesting users find the topic relevant and worth exploring further.

EngagementModerate engagement

Comments mention specifics such as the need for better dose optimization and clinical trial design, indicating a moderate level of detailed engagement.

ImpactModerate impact

There is a general perception that adopting the STAR model could positively influence drug development outcomes, though some posts are more cautious or exploratory in tone.

Abstract in brief

Ninety percent of clinical drug development fails due to an overemphasis on potency and specificity in drug optimization, overlooking important factors like tissue exposure and selectivity.
The proposed structure‒tissue exposure/selectivity-activity relationship (STAR) model classifies drug candidates into four classes based on their potency, selectivity, and tissue exposure, which can help guide clinical efficacy and safety evaluations.
Implementing STAR could enhance drug optimization and increase the success rate of clinical drug development by ensuring a better balance between clinical doses, efficacy, and toxicity.

Read the full abstract

All mentions

The Factors Behind High Cost of New Drugs and Development Challenges

This video explains why new medicines are so expensive. It also explores the high failure rate in clinical drug development and suggests strategies like the STAR model to improve success rates and optimize drug safety…

Mirko von Hein · Nov 17, 2024 1,773 views

Drug Development Process from Lab to Patient: Key Steps Explained

Learn about the 7 essential steps in the drug development process from initial lab research to delivering lifesaving medications to patients in this comprehensive guide.

Mirko von Hein · Aug 11, 2024 759 views

Matthis @ Real Scientists DE

@realscientists.de · Bluesky

Mehr dazu: "Why 90% of clinical drug development fails and how to improve it?" (www.sciencedirect.com/science/arti...)

May 12, 2025 · 2 likes · 1 share View post →

Sean Manion

@TheUnjournaling · X

May 8, 2025 · 3 likes · 576 followers View post →

The Henrique ⌬

@scihenrique.bsky.social · Bluesky

Why 90% of clinical drug development fails and how to improve it? doi.org/10.1016/j.ap...

Apr 24, 2025 View post →

love being humans

@sh97742284 · X

@Sujata1978 Why 90% of clinical drug development fails and how to improve it? https://t.co/OSQ4PacaYi

Mar 26, 2024 · 15 followers View post →

Stetson

@stetson_thacker · X

Sources: 1) https://t.co/jTZAM45IKK 2) https://t.co/6aJDBKLjb1 3) https://t.co/SChsF8rd9Q 4) https://t.co/6aJDBKLjb1

Nov 15, 2023 · 875 followers View post →

Crying Wolf

@OncologyCompany · X

Why 90% of clinical drug development fails and how to improve it. @sciencedirect https://t.co/ZnToGzens4

Aug 21, 2023 · 1 like · 1 share · 1,319 followers View post →

biotech archives

@bot_biotech · X

Why 90% of clinical drug development fails and how to improve it? https://t.co/AYzssIEO5f

Mar 25, 2023 · 162 followers View post →

cinnamon roll

@xyifa · X

Why 90% of clinical drug development fails and how to improve it? https://t.co/KLX3bUP14J

Mar 5, 2023 · 2,848 followers View post →

Ranjeet Kumar

@kumar_ranjeet · X

RT @DrYukselUrun: Why we need Phase III trial?

Nov 3, 2022 · 25 shares · 1,078 followers View post →

Brenda González

@BrendaGzzMD · X

RT @DrYukselUrun: Why we need Phase III trial?

Nov 1, 2022 · 25 shares · 136 followers View post →

Andrea Apolo, M.D.

@apolo_andrea · X

RT @DrYukselUrun: Why we need Phase III trial?

Nov 1, 2022 · 25 shares · 8,891 followers View post →

Rafael Fonseca MD

@Rfonsi1 · X

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Nov 1, 2022 · 25 shares · 15,546 followers View post →

A. Brock

@ABrock91938744 · X

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Abhijit Pal

@DrAbhiPal · X

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@RenoHemonc · X

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luis basbus

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Oct 31, 2022 · 25 shares · 224 followers View post →

CParkMD

@CParkMD · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 21,505 followers View post →

Peter van der Wal (he/him)

@pavdwal · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 64 followers View post →

Cristina Ibáñez

@cribanec · X

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Oct 31, 2022 · 25 shares · 397 followers View post →

Daniela Shveid Gerson

@DSG_MD · X

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Oct 31, 2022 · 25 shares · 358 followers View post →

Neeraj Agarwal, MD, FASCO

@neerajaiims · X

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Oct 31, 2022 · 25 shares · 16,427 followers View post →

G Curigliano MD PhD

@curijoey · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 7,615 followers View post →

Antonio Torres

@viniciu_antonio · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 340 followers View post →

Cristiane D Bergerot

@crisbergerot · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 8,161 followers View post →

Petros Grivas

@PGrivasMDPhD · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 18,381 followers View post →

Ceprec

@CeprecOaxaca · X

Why 90% of clinical drug development fails and how to improve it? - ScienceDirect https://t.co/gJJZumSR0q

Oct 31, 2022 · 498 followers View post →

biodomtomi

@biodomtomi · X

Why 90% of clinical drug development fails and how to improve it? - ScienceDirect #clinical #drugdevelopment https://t.co/EN3lgaVwxM

Oct 31, 2022 · 171 followers View post →

Ricardo Carvalho

@rcarvalhoonco · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 2,268 followers View post →

Yuly A. Remolina

@Yuly_Remo · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 209 followers View post →

Stetson

@stetson_thacker · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 875 followers View post →

Pablo Nieto Guindo

@Pablonietog82 · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 228 followers View post →

Daniel Castellano

@cdanicas · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 3,684 followers View post →

Garbiñe Lizeaga

@GarbineLizeaga · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 1,214 followers View post →

nel cuevas muñoz

@MunozNel · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 147 followers View post →

ONCOVID

@ONCOVID_19 · X

RT @DrYukselUrun: Why we need Phase III trial?

Oct 31, 2022 · 25 shares · 374 followers View post →

Yüksel Ürün

@DrYukselUrun · X

Why we need Phase III trial?

Oct 31, 2022 · 71 likes · 25 shares · 9,797 followers View post →

biotech archives

@bot_biotech · X

Why 90% of clinical drug development fails and how to improve it? https://t.co/AYzssIEO5f

Aug 21, 2022 · 162 followers View post →

Duxin Sun

@DuxinSun · X

Jul 11, 2022 · 2 likes · 194 followers View post →

Mirage News

@MirageNewsCom · X

Why 90% of clinical drug development fails and how to improve it? https://t.co/QfQaRoHiBC

Apr 11, 2022 · 1,252 followers View post →

Duxin Sun

@DuxinSun · X

Why 90% of Clinical Drug Development Fails and How to Improve it? https://t.co/zaC5o1r4Db. https://t.co/FdjlDqUCob https://t.co/QaARkEXybk

Mar 12, 2022 · 194 followers View post →

PharmaExcipients

@PharmaExcipient · X

RT @PharmaExcipient: Why 90% of clinical drug development fails and how to improve it? https://t.co/QDTDhsld02 #excipients #pharmaceutical…

Mar 9, 2022 · 1 share · 2,368 followers View post →

PharmaExcipients

@PharmaExcipient · X

Why 90% of clinical drug development fails and how to improve it? https://t.co/QDTDhsld02 #excipients #pharmaceutical #formulation https://t.co/tsbGJMUmG6

Mar 9, 2022 · 3 likes · 1 share · 2,368 followers View post →

Duxin Sun

@DuxinSun · X

Why 90% of Clinical Drug Development Fails and How to Improve It? STAR System for general public: https://t.co/FdjlDqUCob Perspective of STAR system: https://t.co/zaC5o1r4Db Research paper of STAR system: https://t.co/7aEgzLvFOd Prof. Sun Lab webpage: https://t.co/9i7yiOLu92 https://t.co/SQryhbk6bp

Feb 23, 2022 · 1 like · 194 followers View post →

Miguel Pereira-Silva, PharmD | PhD, PG

@miguel_persilva · X

Why 90% of clinical drug development fails and how to improve it? https://t.co/r6qklTndz1

Feb 17, 2022 · 1,446 followers View post →

Why 90% of clinical drug development fails and how to improve it?

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

The Factors Behind High Cost of New Drugs and Development Challenges

Drug Development Process from Lab to Patient: Key Steps Explained