PubHawk
September 2022 PMID 35878791

Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review.

Michiel van Elk, David Bryce Yaden

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Mentions

52
Peak: 9 in Jul 2022
across 6 sources since Jul 2022

Extended reach

256,717
potential audience

Total likes

96

Video views

411

Mentions per month

Jul 2022 – Jan 2024

Where it's discussed

  • X / Twitter35 posts
  • News9 articles
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts
  • Bluesky1 posts

AI synopsis

What people are saying

The overall discussions convey strong support and enthusiasm for the review, with posts describing it as a 'fantastic paper' and highlighting its role in advancing understanding of psychedelics' mechanisms. The tone and emphasis on detailed mechanisms like neuroplasticity and therapeutic potential indicate a high level of engagement and recognition of its importance for scientific progress.

AgreementModerate agreement

Most discussions reflect support for the review, emphasizing its thoroughness and importance in understanding psychedelics.

InterestHigh interest

Posts show high interest, with many referencing the publication as a valuable, critical overview and highlighting its relevance for ongoing research and therapy development.

EngagementHigh engagement

Posts demonstrate deep engagement by citing specific figures, the significance of mechanisms, and calling attention to research weaknesses and future directions.

ImpactModerate impact

While influential within the research community, the discussions suggest the publication could shape future studies, though its immediate societal impact remains moderate.

Abstract in brief

  • The paper reviews how psychedelics work on different levels, including biochemistry (mainly affecting 5HT receptors and promoting neuroplasticity), brain activity (such as loosening of thalamocortical filtering and increased sensitivity to prediction errors), and psychological effects (altered states, belief changes, social impacts, and lasting behavioral changes).
  • It explores the possibility of a unified explanation for how psychedelics influence various mechanisms versus a pluralistic approach that considers multiple causes, emphasizing the importance of understanding these processes to develop targeted therapies.
  • The authors discuss current challenges in psychedelic research and propose a research agenda aimed at uncovering the specific causal pathways behind their therapeutic effects, which could improve treatment effectiveness and safety.
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Top posts

Most liked on X and Bluesky
Johns Hopkins Psychedelic Research Center
@JHPsychedelics · X

A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review," which summarizes and points to weaknesses in psychedelic research. https://t.co/mi900R2EPo https://t.co/LGjGy0rvIG

Oct 19, 2023 · 34 likes · 7 shares · 45,475 followers View post →
Johns Hopkins Psychedelic Research Center
@JHPsychedelics · X

Check out this new paper by Dr. David Yaden (@ExistWell), 'Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review' https://t.co/kDM1lzq9Pz

Aug 1, 2022 · 9 likes · 2 shares · 45,475 followers View post →
Yasser Ad-Dab'bagh
@yasseraddabbagh · X

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/6eOyQ6Z7T2

Jul 25, 2022 · 7 likes · 72,235 followers View post →
PSYCSpotlight
@PSYC_Spot · X

#ScientificStudy: Pharmacological, neural, and psychological mechanisms underlying #psychedelics: A critical review This paper reviews the possible types of brain mechanisms that are involved after the ingestion of a psychedelic drug. https://t.co/FRIAN3Ty1t

Oct 4, 2022 · 5 likes · 3,033 followers View post →
PRISM News
@PRISMNews · X

Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review https://t.co/ZnFYpPDxl0 @PRISMNews supports research into #psychedelics Help us by: Donating - https://t.co/xlrjyGWhZR Learning More - https://t.co/7rTh5aQ90W https://t.co/DxBvubANG6

Dec 28, 2022 · 4 likes · 5,368 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/tFVs01LLhM

Jul 26, 2022 · 4 likes · 1 share · 4,007 followers View post →

All mentions

Chris Alfaro
@LucidPneuma · X

RT @JHPsychedelics: A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychol…

Oct 20, 2023 · 7 shares · 18 followers View post →
Kan Dita
@MariaCa56837741 · X

RT @JHPsychedelics: A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychol…

Oct 19, 2023 · 7 shares · 44 followers View post →
World Well-Being Prj
@WWBProject · X

RT @JHPsychedelics: A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychol…

Oct 19, 2023 · 7 shares · 1,572 followers View post →
Burritos Nostradamus
@BurritosNostra · X

RT @JHPsychedelics: A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychol…

Oct 19, 2023 · 7 shares · 499 followers View post →
Matheus H S Mello❤️‍
@mhsmellopsi · X

RT @JHPsychedelics: A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychol…

Oct 19, 2023 · 7 shares · 1,751 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @JHPsychedelics: A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychol…

Oct 19, 2023 · 7 shares · 4,070 followers View post →
Lorenzo Gutiérrez
@Lojoga · X

RT @JHPsychedelics: A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychol…

Oct 19, 2023 · 7 shares · 591 followers View post →
Johns Hopkins Psychedelic Research Center
@JHPsychedelics · X

A year ago, Drs. David Yaden @ExistWell and Michiel van Elk @MichielElk published “Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review," which summarizes and points to weaknesses in psychedelic research. https://t.co/mi900R2EPo https://t.co/LGjGy0rvIG

Oct 19, 2023 · 34 likes · 7 shares · 45,475 followers View post →
HOPE
@psychedelethics · X

RT @drjedsiev: Interested in an overview and critical review of explanatory mechanisms of psychedelics' therapeutic effects? Check out thi…

Sep 8, 2023 · 3 shares · 279 followers View post →
David B. Yaden
@ExistWell · X

RT @drjedsiev: Interested in an overview and critical review of explanatory mechanisms of psychedelics' therapeutic effects? Check out thi…

Sep 8, 2023 · 3 shares · 7,180 followers View post →
Jake Eaton
@jkeatn · X

@zackamenetz https://t.co/9MyCE7OXCI

Sep 7, 2023 · 1 like · 1,591 followers View post →
Burritos Nostradamus
@BurritosNostra · X

RT @drjedsiev: Interested in an overview and critical review of explanatory mechanisms of psychedelics' therapeutic effects? Check out thi…

Sep 5, 2023 · 3 shares · 499 followers View post →
Jed Siev
@drjedsiev · X

Interested in an overview and critical review of explanatory mechanisms of psychedelics' therapeutic effects? Check out this fantastic paper by @MichielElk and @ExistWell: https://t.co/eQjXMLGTsG

Sep 5, 2023 · 2 likes · 3 shares · 2,246 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@YourBrainOnSci @DEOlsonLab @JasterAlaina @zarmeen_z Figure 2 | #Pharmacological, #neural, and #psychological mechanisms underlying #psychedelics: A critical review | #Neuroscience & Biobehavioral Reviews [Sep 2022]: https://t.co/lYYhmR86fg https://t.co/8vUBaFWT9i

Feb 23, 2023 · 740 followers View post →
Thomas Pfeiffer
@th_pfeiffer · X

RT @Neurons2Nirvana: @zenbrainest Figure 2 | #Pharmacological, #neural, and #psychological mechanisms underlying #psychedelics: A critical…

Feb 22, 2023 · 1 share · 529 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

@zenbrainest Figure 2 | #Pharmacological, #neural, and #psychological mechanisms underlying #psychedelics: A critical review | #Neuroscience & Biobehavioral Reviews [Sep 2022]: https://t.co/lYYhmR86fg https://t.co/3PwllYoWAG

Feb 22, 2023 · 2 likes · 1 share · 740 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

I just posted "Figures 1-2 | #Pharmacological, #neural, and #psychological mechanisms underlying #psychedelics: A critical review | #Neuroscience & Biobehavioral Reviews [Sep 2022]" on Reddit https://t.co/YekJqYWp3h

Jan 17, 2023 · 740 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

#Pharmacological, #neural, and #psychological mechanisms underlying #psychedelics: A critical review - https://t.co/tkkQD9slhX https://t.co/CPiXQA35DX https://t.co/cLtlbPVCqD

Dec 28, 2022 · 740 followers View post →
PRISM News
@PRISMNews · X

Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review https://t.co/ZnFYpPDxl0 @PRISMNews supports research into #psychedelics Help us by: Donating - https://t.co/xlrjyGWhZR Learning More - https://t.co/7rTh5aQ90W https://t.co/DxBvubANG6

Dec 28, 2022 · 4 likes · 5,368 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

RT @ViewsOnDrugsBot: Pharmacological, neural, and psychological mechanisms underlying #psychedelics: A critical review 1/5 https://t.co/d6…

Dec 17, 2022 · 1 share · 2,060 followers View post →
PSYCSpotlight
@PSYC_Spot · X

#ScientificStudy: Pharmacological, neural, and psychological mechanisms underlying #psychedelics: A critical review This paper reviews the possible types of brain mechanisms that are involved after the ingestion of a psychedelic drug. https://t.co/FRIAN3Ty1t

Oct 4, 2022 · 5 likes · 3,033 followers View post →
Views on Drugs
@ViewsOnDrugsBot · X

Pharmacological, neural, and psychological mechanisms underlying #psychedelics: A critical review 1/5 https://t.co/d6GWyFbU7q

Sep 30, 2022 · 3 likes · 1 share · 2,060 followers View post →
David B. Yaden
@ExistWell · X

RT @Alta_Flora: Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review https://t.co/gSF9tkGttU

Sep 12, 2022 · 1 share · 7,180 followers View post →
Research Smart
@ResearchSmartAI · X

Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review https://t.co/gSF9tkGttU

Sep 7, 2022 · 2 likes · 1 share · 413 followers View post →
Psychedelic Health Professionals Network
@PsychedelicHea6 · X

The authors of this excellent, free full-text paper write: "This paper provides a critical review of several possible mechanisms at different levels of analysis underlying the effects and therapeutic potential of psychedelics. At the (1) https://t.co/MbjAQLV4GE https://t.co/zqw1VmFFzZ

Aug 4, 2022 · 70 followers View post →
David B. Yaden
@ExistWell · X

RT @JHPsychedelics: Check out this new paper by Dr. David Yaden (@ExistWell), 'Pharmacological, neural, and psychological mechanisms underl…

Aug 2, 2022 · 2 shares · 7,180 followers View post →
Johns Hopkins Psychedelic Research Center
@JHPsychedelics · X

Check out this new paper by Dr. David Yaden (@ExistWell), 'Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review' https://t.co/kDM1lzq9Pz

Aug 1, 2022 · 9 likes · 2 shares · 45,475 followers View post →
THERADELICS
@theradelics · X

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/cfdkt9LQlx https://t.co/bq1pOvje4m

Jul 26, 2022 · 3,381 followers View post →
THERADELICS
@theradelics · X

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/58SD196DOQ https://t.co/cRV9dIO0Zy

Jul 26, 2022 · 1 like · 3,381 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @APRA_bot: Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/tFVs01LLhM

Jul 26, 2022 · 1 share · 4,070 followers View post →
Cyril Costines
@costines · X

RT @aliusresearch: Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/bqQcVg9wbX

Jul 26, 2022 · 1 share · 96 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/tFVs01LLhM

Jul 26, 2022 · 4 likes · 1 share · 4,007 followers View post →
ALIUS - @aliusresearch.bsky.social
@aliusresearch · X

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/bqQcVg9wbX

Jul 26, 2022 · 1 like · 1 share · 730 followers View post →
Yasser Ad-Dab'bagh
@yasseraddabbagh · X

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://t.co/6eOyQ6Z7T2

Jul 25, 2022 · 7 likes · 72,235 followers View post →
Yasser Ad-Dab'bagh ياسر الدباغ
@yasseraddabbagh.bsky.social · Bluesky

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review https://www.sciencedirect.com/science/article/pii/S0149763422002822

Jul 25, 2022 View post →
Brian D. Earp, Ph.D.
@briandavidearp · X

Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review - ScienceDirect https://t.co/oSo3aiZEqM

Jul 24, 2022 · 3 likes · 1 share · 26,098 followers View post →