Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Nature Chemistry https://t.co/jkUyjUfBlo just a reminder that, possibly, enzymes haven't "invented" chemistry
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways.
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Oct 2021 – Nov 2022Where it's discussed
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What people are saying
The discussions reflect strong agreement and high interest, with posts describing the research as a 'major step towards understanding life's origins,' and emphasizing its potential to reshape biochemistry. The tone is enthusiastic and forward-looking, with some participating in detailed scientific exchanges while others highlight its significance broadly.
Most discussions endorse the significance of the research, with some calling it a 'discovery' or 'breakthrough,' demonstrating strong consensus on its importance.
Postings express high curiosity and enthusiasm, frequently highlighting potential implications for understanding life's origins and using keywords like 'exciting' and 'game-changing.'
Participants refer to specific chemical pathways and scientific terms, showing active engagement; however, some simply share links or headlines without deep commentary.
Many believe this research could revolutionize the understanding of early Earth chemistry and origins of life, suggesting it has high scientific impact.
Abstract in brief
- The study explores how prebiotic chemical reactions, specifically involving ketoacids, cyanide, and ammonia, can produce amino acids and nucleobase precursors like orotate, potentially bridging the gap between simple chemical processes and the complex metabolic pathways seen in living organisms.
- It highlights that reactions like the Bucherer-Bergs pathway enable the conversion of ketoacids such as oxaloacetate into amino acids like aspartate and to compounds like dihydroorotate, which are critical for pyrimidine synthesis, suggesting a natural progression toward modern biochemistry.
- The findings imply that early Earth chemistry could have naturally evolved into the intricate metabolic pathways found in today's life forms, offering insights into how primitive chemical reactions could transition into the biological systems we observe now.]
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Most liked on X and BlueskyNat. Chem. #Prebiotic synthesis of α-amino acids and orotate from α-ketoacids #potentiates transition to extant metabolic pathways @NatureChemistry @GeorgiaTech #science #Chemistry https://t.co/LgLiDgt7Et
“Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways” by Ramanarayanan Krishnamurthy et al. Nature Chemistry https://t.co/0Al8Uuq1NX
Here is our #preprint on @researchsquare: Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways https://t.co/us9OZ1EZQw
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/WYPMgzWVnA https://t.co/uXLSufaNiE
An investigation of amino acid synthesis from α-ketoacid analogues of TCA and glyoxylate pathway intermediates. https://t.co/Shw2zilGBX
All mentions
Chemical Processes Potentially Responsible for the Origin of Life on Earth
Scientists at Scripps Research have discovered chemical reactions involving cyanide, ammonia, and carbon dioxide, likely present on early Earth, that produce amino acids and nucleic acid precursors. These findings…
Origins of Life: Transition from Prebiotic Chemistry to Modern Metabolism
Explore how prebiotic reactions involving ketoacids, cyanide, and ammonia could have led to amino acids and nucleobases, facilitating the evolution of biochemical pathways crucial for the emergence of life, as explained…
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways with Ram Krishnamurthy, Victoria Wills, and Frank Wang https://t.co/eK3iqWtxdU
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways with Ram Krishnamurthy, Victoria Wills, and Frank Wang https://t.co/bmNfD9sckz
An investigation of amino acid synthesis from α-ketoacid analogues of TCA and glyoxylate pathway intermediates. https://t.co/Shw2zilGBX
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/WYPMgzWVnA https://t.co/uXLSufaNiE
The chemical Origin of Life may have been found https://t.co/LJDsltnPoD
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/DajySJXuey
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
Prebiotic #synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant #metabolic #pathways | Nature Chemistry https://t.co/1iRLMoQDU5… just a reminder that, possibly, enzymes haven't "invented" chemistry https://t.co/C7qx5snyDY
RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Nature Chemistry https://t.co/jkUyjUfBlo just a reminder that, possibly, enzymes haven't "invented" chemistry
RT @DNA_Nanotech: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways htt…
Nat. Chem. #Prebiotic synthesis of α-amino acids and orotate from α-ketoacids #potentiates transition to extant metabolic pathways @NatureChemistry @GeorgiaTech #science #Chemistry https://t.co/LgLiDgt7Et
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/WYPMgzWVnA https://t.co/5jltuwKiKI
“Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways” by Ramanarayanan Krishnamurthy et al. Nature Chemistry https://t.co/uA3QmSCHg1 https://t.co/HC7Q9ze7M1
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/qmZXt6mQkg #prebiotics #alphaaminoacids #orotate #alphaketoacids #metabolic #pathways
RT @NeuroscienceNew: “Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways…
“Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways” by Ramanarayanan Krishnamurthy et al. Nature Chemistry https://t.co/0Al8Uuq1NX
RT @I_Sunil_IITB: Here is our #preprint on @researchsquare: Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates T…
Here is our #preprint on @researchsquare: Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways https://t.co/us9OZ1EZQw