Nat Chem October 2022 PMID 35902742

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways.

Sunil Pulletikurti, Mahipal Yadav, Greg Springsteen, Ramanarayanan Krishnamurthy

Mentions

102
Peak: 18 in Jul 2022
across 5 sources since Oct 2021

Extended reach

608,918
potential audience

Total likes

102

Video views

1,323

Mentions per month

Oct 2021 – Nov 2022

Where it's discussed

  • News54 articles
  • X / Twitter26 posts
  • Blogs16 articles
  • Facebook4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect strong agreement and high interest, with posts describing the research as a 'major step towards understanding life's origins,' and emphasizing its potential to reshape biochemistry. The tone is enthusiastic and forward-looking, with some participating in detailed scientific exchanges while others highlight its significance broadly.

AgreementStrong agreement

Most discussions endorse the significance of the research, with some calling it a 'discovery' or 'breakthrough,' demonstrating strong consensus on its importance.

InterestHigh interest

Postings express high curiosity and enthusiasm, frequently highlighting potential implications for understanding life's origins and using keywords like 'exciting' and 'game-changing.'

EngagementModerate engagement

Participants refer to specific chemical pathways and scientific terms, showing active engagement; however, some simply share links or headlines without deep commentary.

ImpactHigh impact

Many believe this research could revolutionize the understanding of early Earth chemistry and origins of life, suggesting it has high scientific impact.

Abstract in brief

  • The study explores how prebiotic chemical reactions, specifically involving ketoacids, cyanide, and ammonia, can produce amino acids and nucleobase precursors like orotate, potentially bridging the gap between simple chemical processes and the complex metabolic pathways seen in living organisms.
  • It highlights that reactions like the Bucherer-Bergs pathway enable the conversion of ketoacids such as oxaloacetate into amino acids like aspartate and to compounds like dihydroorotate, which are critical for pyrimidine synthesis, suggesting a natural progression toward modern biochemistry.
  • The findings imply that early Earth chemistry could have naturally evolved into the intricate metabolic pathways found in today's life forms, offering insights into how primitive chemical reactions could transition into the biological systems we observe now.]

Top posts

Most liked on X and Bluesky
FrezzaLab
@FrezzaLab · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Nature Chemistry https://t.co/jkUyjUfBlo just a reminder that, possibly, enzymes haven't "invented" chemistry

Jul 31, 2022 · 42 likes · 10 shares · 26,981 followers View post →
The Innovation Materials
@Innov_Materials · X

Nat. Chem. #Prebiotic synthesis of α-amino acids and orotate from α-ketoacids #potentiates transition to extant metabolic pathways @NatureChemistry @GeorgiaTech #science #Chemistry https://t.co/LgLiDgt7Et

Jul 30, 2022 · 13 likes · 5,382 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways” by Ramanarayanan Krishnamurthy et al. Nature Chemistry https://t.co/0Al8Uuq1NX

Jul 28, 2022 · 8 likes · 2 shares · 505,536 followers View post →
Sunil Pulletikurti
@I_Sunil_IITB · X

Here is our #preprint on @researchsquare: Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways https://t.co/us9OZ1EZQw

Oct 19, 2021 · 3 likes · 1 share · 24 followers View post →
Yoel Ohayon
@DNA_Nanotech · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/WYPMgzWVnA https://t.co/uXLSufaNiE

Aug 2, 2022 · 2 likes · 3,444 followers View post →
PCE3
@PCE3_Sci · X

An investigation of amino acid synthesis from α-ketoacid analogues of TCA and glyoxylate pathway intermediates. https://t.co/Shw2zilGBX

Sep 6, 2022 · 2 likes · 839 followers View post →

All mentions

Science Society
@ScienceSociety8 · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways with Ram Krishnamurthy, Victoria Wills, and Frank Wang https://t.co/eK3iqWtxdU

Oct 25, 2022 · 151 followers View post →
Catarina Cunha
@clemoscatarina · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways with Ram Krishnamurthy, Victoria Wills, and Frank Wang https://t.co/bmNfD9sckz

Oct 25, 2022 · 1,768 followers View post →
PCE3
@PCE3_Sci · X

An investigation of amino acid synthesis from α-ketoacid analogues of TCA and glyoxylate pathway intermediates. https://t.co/Shw2zilGBX

Sep 6, 2022 · 2 likes · 839 followers View post →
Yoel Ohayon
@DNA_Nanotech · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/WYPMgzWVnA https://t.co/uXLSufaNiE

Aug 2, 2022 · 2 likes · 3,444 followers View post →
The Neutronium Alchemist
@NeuAlchemy · X

The chemical Origin of Life may have been found https://t.co/LJDsltnPoD

Aug 2, 2022 · 9 followers View post →
Andras Toth
@tothur · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/DajySJXuey

Aug 1, 2022 · 1,823 followers View post →
King Lab
@DustinTKing · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 147 followers View post →
Karthik Raman
@karthikraman · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 1,465 followers View post →
Dr Dhandeep Singh
@DhandeepDr · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 529 followers View post →
Natalie Niemi
@nieminm · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 4,231 followers View post →
Federico Bernuzzi, PhD
@FedericoBernuzz · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 623 followers View post →
Vivia Sthel
@vivia_sthel · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 200 followers View post →
René Alfonso
@ReneAlfon_zoo · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 413 followers View post →
Gut-ness gracious me
@OnlyGutNews · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 15 followers View post →
Better tech
@digitalhealthxx · X

Prebiotic #synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant #metabolic #pathways | Nature Chemistry https://t.co/1iRLMoQDU5… just a reminder that, possibly, enzymes haven't "invented" chemistry https://t.co/C7qx5snyDY

Jul 31, 2022 · 8,497 followers View post →
ItoLab
@KUItoLab · X

RT @FrezzaLab: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Natu…

Jul 31, 2022 · 10 shares · 83 followers View post →
FrezzaLab
@FrezzaLab · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways | Nature Chemistry https://t.co/jkUyjUfBlo just a reminder that, possibly, enzymes haven't "invented" chemistry

Jul 31, 2022 · 42 likes · 10 shares · 26,981 followers View post →
Aderlieste
@Mynameistekkno · X

RT @DNA_Nanotech: Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways htt…

Jul 30, 2022 · 1 share · 740 followers View post →
The Innovation Materials
@Innov_Materials · X

Nat. Chem. #Prebiotic synthesis of α-amino acids and orotate from α-ketoacids #potentiates transition to extant metabolic pathways @NatureChemistry @GeorgiaTech #science #Chemistry https://t.co/LgLiDgt7Et

Jul 30, 2022 · 13 likes · 5,382 followers View post →
Yoel Ohayon
@DNA_Nanotech · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/WYPMgzWVnA https://t.co/5jltuwKiKI

Jul 30, 2022 · 1 like · 1 share · 3,444 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

“Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways” by Ramanarayanan Krishnamurthy et al. Nature Chemistry https://t.co/uA3QmSCHg1 https://t.co/HC7Q9ze7M1

Jul 29, 2022 · 24,172 followers View post →
Olubukola Benedicta Ojo, Ph.D
@Bukolabojo · X

Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways https://t.co/qmZXt6mQkg #prebiotics #alphaaminoacids #orotate #alphaketoacids #metabolic #pathways

Jul 29, 2022 · 33 followers View post →
Sébastien Chénier
@SebSciences · X

RT @NeuroscienceNew: “Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways…

Jul 28, 2022 · 2 shares · 246 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways” by Ramanarayanan Krishnamurthy et al. Nature Chemistry https://t.co/0Al8Uuq1NX

Jul 28, 2022 · 8 likes · 2 shares · 505,536 followers View post →
Research Square
@researchsquare · X

RT @I_Sunil_IITB: Here is our #preprint on @researchsquare: Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates T…

Oct 19, 2021 · 1 share · 16,584 followers View post →
Sunil Pulletikurti
@I_Sunil_IITB · X

Here is our #preprint on @researchsquare: Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways https://t.co/us9OZ1EZQw

Oct 19, 2021 · 3 likes · 1 share · 24 followers View post →