A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study).

Feng Wang, Ming-Ming He, Jian Xiao, Yan-Qiao Zhang, Xiang-Lin Yuan, Wei-Jia Fang, Yan Zhang, Wei Wang, Xiao-Hua Hu, Zhi-Gang Ma, Yi-Chen Yao, Zhi-Xiang Zhuang, Fu-Xiang Zhou, Jie-Er Ying, Ying Yuan

October 2022 Clin Cancer Res

Synopsis of Social media discussions

The groups of discussions reveal widespread skepticism about the effectiveness of high-dose vitamin C in improving outcomes for colorectal cancer, with phrases like 'failed to improve metrics' and 'no effect' reflecting a dismissive tone. However, some comments highlight potential benefits in specific genetic contexts, such as RAS mutations, indicating ongoing interest and nuanced engagement with the scientific evidence.

A
Agreement
 Low agreement

Most discussions recognize that high-dose vitamin C does not provide clear benefits for metastatic colorectal cancer, with some acknowledging the lack of significant effects observed in the study.

I
Interest
 High level of interest

There is high interest in the topic, especially regarding its potential effects on specific mutations like RAS, and in the debate around vitamin C's role in cancer treatment.

E
Engagement
 Moderate level of engagement

The discussions show moderate engagement, with some users referencing preclinical evidence, clinical trial outcomes, and genetic factors, but many comments are brief or dismissive.

I
Impact
 Neutral impact

The overall influence appears modest; while the topic sparks curiosity, few comments suggest the findings will drastically change clinical practices or perceptions about vitamin C’s efficacy in cancer treatment.

Social Mentions

YouTube

2 Videos

Bluesky

1 Posts

Facebook

7 Posts

Twitter

42 Posts

Instagram

3 Posts

Metrics

Video Views

130,457

Total Likes

7,049

Extended Reach

267,044

Social Features

55

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Enhancing Cancer Treatment with Fasting-Mimicking Diet and Vitamin C

Enhancing Cancer Treatment with Fasting-Mimicking Diet and Vitamin C

Severe calorie restriction through cyclic fasting or fasting-mimicking diets enhances chemotherapy effectiveness in triple-negative breast cancer, lowering glucose levels and boosting immune response. Clinical data shows improved survival outcomes when combined with vitamin C.

Physionic

August 28, 2025

88,598 views

Evaluating High-Dose Vitamin C in Metastatic Colorectal Cancer Treatment

Evaluating High-Dose Vitamin C in Metastatic Colorectal Cancer Treatment

This video discusses a clinical study assessing the addition of high-dose vitamin C to standard chemotherapy in metastatic colorectal cancer patients, highlighting the outcomes and potential benefits for specific genetic mutations.

Physionic

December 1, 2025

41,859 views

  • John Murphy
    @JohnMur75812933 (Twitter)

    The Resurgence of Vitamin C against Cancer https://t.co/QyOjMgotx9 via @YouTube
    view full post

    December 2, 2025

    1

  • Dotcomnieuws
    @dotcomnieuws (Twitter)

    The Resurgence of Vitamin C against Cancer - YouTube https://t.co/fWWlZwMjMg
    view full post

    December 1, 2025

    1

  • Commissar of tomfoolery
    @Kakabhushundi (Twitter)

    https://t.co/4sLVYr2MTC Lmao another Ray Peat W Such a great man
    view full post

    December 1, 2025

    9

  • Natalia
    @Natalia58027012 (Twitter)

    @BSCrusher1 @lantwehr63 @BogRymanowski nie no, powstało dziesiątki innych prac np. https://t.co/KpiFH8jzD1
    view full post

    November 28, 2025

  • Coach Milly
    @Coach_Milly_ (Twitter)

    RT @ZKForTre: In the few examples in which it’s actually been tested (see one such case below), it has failed to improve metrics. https:/…
    view full post

    September 28, 2025

    1


  • @ZKForTre (Twitter)

    In the few examples in which it’s actually been tested (see one such case below), it has failed to improve metrics. https://t.co/r7AioGRCV7 https://t.co/Rl16iqNvdH
    view full post

    September 27, 2025

    7

    1

  • gerfaud
    @Gerfaud07 (Twitter)

    @LeMediaEn442 Le taux de réponse objective (ORR) et la survie globale (OS) des groupes expérimental et témoin étaient similaires (ORR, 44,3 % contre 42,1 % ; P = 0,9 ; OS médiane, 20,7 contre 19,7 mois ; P = 0,7). https://t.co/2wY5KnuPdO colon https://t.co/b8be5z4cyb prostate https://t.co/MjTxwyyfKD
    view full post

    April 22, 2025

  • Onco404
    @onco404.bsky.social (Bluesky)

    Thank you for correcting us. Based on some preclinical evidence (10.1126/science.aaa5004), vitC could selectively target RAS and BRAF-mutant CRC models. However, a clinical study reported a significant PFS difference only in RAS-mutant CRC (chemo+vitC, 10.1158/1078-0432.CCR-22-0655). Thanks again!
    view full post

    March 25, 2025

  • Teoman Yanmaz
    @mtymtyyanmaz (Twitter)

    @ilyassahinMD Ras mut+ met crc’de etkili olabilir https://t.co/B3iDBKQ4hS
    view full post

    January 30, 2025

  • Pashtoon Kasi MD, MS
    @pashtoonkasi (Twitter)

    @Aiims1742 @OncoAlert @PanCAN This is the first randomized trial I believe showing a tangible benefit in #KRAS-mutant cancers as a primary endpoint.
    view full post

    December 5, 2024

    2

  • Engelbert Valstar
    @euler55 (Twitter)

    A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX… https://t.co/tU6lGiMWUd Ingeval van een RAS-mutatie significant langer leven (6 weken); bij geen RAS-mutatie niet. Er zijn relevantere voedingsfactoren en kruiden
    view full post

    January 16, 2023

  • Daniel Izzo
    @DanielIzzo1 (Twitter)

    @CharlieEch07 @ChefGruel Hi: re Processed Meat and Cancer. I edited out the part about Vitamin C's alleged cancer treatment properties but after further research it doesn't work as thought https://t.co/8odFvjAi16
    view full post

    November 22, 2022

  • Dr Carol Granger
    @CarolGranger2 (Twitter)

    A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study) https://t.co/Ejnq2jVO1h
    view full post

    November 2, 2022

  • Tina Kaczor, ND, FABNO
    @naturopathiconc (Twitter)

    Null. “A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study)”| Clinical Cancer Research | ⁦@AACR⁩ https://t.co/3nI9i4aeT5
    view full post

    October 15, 2022

  • Karol Polom
    @polom_karol (Twitter)

    RT @WimCeelen: Intriguing: high dose vit C seems to augment effect of FOLFOX-bev in KRASmut CRC in preplanned subgroup analysis https://t.…
    view full post

    October 15, 2022

    1

  • Niraj Neupane
    @Nirajneu (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 15, 2022

    12

  • Tomas Pokrivcak, M.D.
    @pokrivcak (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 15, 2022

    12

  • Sergio
    @sergiomejiaonco (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 15, 2022

    12

  • Charon
    @CharonCalypso (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 15, 2022

    12

  • ŞAHSIMANAZARDEĞİYO
    @noopetrolyesbor (Twitter)

    RT @ukefeli: Metastatik kolorektal kanserlerde yüksek doz C vitamininin faydası olmadığı gösterildi. https://t.co/DHb3sSz3Mt
    view full post

    October 15, 2022

    1

  • aref Zribi
    @zribi_aref (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 15, 2022

    12

  • Pablo Alonso
    @PabloAlonso73 (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 15, 2022

    12

  • Umut Kefeli
    @ukefeli (Twitter)

    Metastatik kolorektal kanserlerde yüksek doz C vitamininin faydası olmadığı gösterildi. https://t.co/DHb3sSz3Mt
    view full post

    October 15, 2022

    6

    1

  • Wim Ceelen
    @WimCeelen (Twitter)

    Intriguing: high dose vit C seems to augment effect of FOLFOX-bev in KRASmut CRC in preplanned subgroup analysis https://t.co/gvRGvBZhjU
    view full post

    October 15, 2022

    5

    1

  • Loxandra Skarlatou
    @Dr_Metanastria (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 15, 2022

    12

  • Sehbanul Islam
    @sehbanamu (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 15, 2022

    12

  • Ricardo Carvalho
    @rcarvalhoonco (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 14, 2022

    12

  • Oncologia Campinas
    @OncologiaCampi1 (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 14, 2022

    12

  • OncoAlert
    @OncoAlert (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 14, 2022

    12

  • Marc Vincent Barcelona, MD, FPCR, DPBR-RO
    @MarcBarcieMD (Twitter)

    RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 14, 2022

    12

  • Clinical Cancer Research
    @CCR_AACR (Twitter)

    Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW
    view full post

    October 14, 2022

    67

    12

  • Prof.Dr.Mutlu Demiray
    @eceyrem (Twitter)

    @ilyassahinMD Faz 3 çalışma yayınlandı sayın hocam. https://t.co/eu31LOZmrT
    view full post

    October 12, 2022

  • Clinical Cancer Research
    @CCR_AACR (Twitter)

    Wang et al administered high-dose #VitaminC plus FOLFOX +/- bevacizumab to patients with unresectable untreated metastatic #ColorectalCancer. While vitamin C failed to prolong PFS, it showed benefit in patients with RAS mutation. https://t.co/vI40SiU8HB @FengWan25720657 https://t.co/ijSN0ZrxbK
    view full post

    September 29, 2022

    1

    2

  • Martin Smollich
    @ErnMedBlog (Twitter)

    RT @FrankBettina: #Kolorektalkarzinom: Hochdosiertes Vitamin C ohne Effekt auf Erstlinien-Chemotherapie.“ #VitaminC #Krebs #NEM https://…
    view full post

    August 31, 2022

    1

  • Bettina Frank
    @FrankBettina (Twitter)

    #Kolorektalkarzinom: Hochdosiertes Vitamin C ohne Effekt auf Erstlinien-Chemotherapie.“ #VitaminC #Krebs #NEM https://t.co/hmrIcuBNve
    view full post

    August 31, 2022

    5

    1

  • Delia Cortés Guiral
    @DeliaCortesGuir (Twitter)

    RT @WimCeelen: No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On
    view full post

    August 7, 2022

    3

  • Dr Celestino Gutiérrez González MD
    @CelestinoGutirr (Twitter)

    RT @WimCeelen: No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On
    view full post

    August 7, 2022

    3

  • JHHerreraK
    @JHHerreraK (Twitter)

    RT @WimCeelen: No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On
    view full post

    August 7, 2022

    3

  • Manju George MVSc PhD Rectal Cancer Survivor
    @manjuggm (Twitter)

    RT @angelopirozzi3: https://t.co/4apqsTKeCf
    view full post

    August 6, 2022

    1

  • Alfonso De Stefano
    @alfdestefano (Twitter)

    “Vitamin C plus chemotherapy failed to show superior PFS compared with chemotherapy in mCRC patients as first-line treatment…” https://t.co/2C8tijLGWB
    view full post

    August 6, 2022

  • Wim Ceelen
    @WimCeelen (Twitter)

    No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On
    view full post

    August 6, 2022

    5

    3

  • Angelo Pirozzi
    @angelopirozzi3 (Twitter)

    https://t.co/4apqsTKeCf
    view full post

    August 5, 2022

    3

    1

  • Paperbirds_Oncology
    @PaperbirdsO (Twitter)

    New article: A randomized, open-label, multicenter, phase 3 study of high-dose vitamin C plus FOLFOX +/- bevacizumab versus FOLFOX +/- bevacizumab in unresectable untreated metastatic colorectal cancer https://t.co/GhcEOY6wbF #colorectalcancer #oncology https://t.co/6oqBQxZdrw
    view full post

    August 5, 2022

  • HOMOTOXICOLOGY AND AUTOSANGUIS THERAPY ... - Facebook

    ... 10.1158/1078-0432.CCR-22-0655 #biomedclinicpagadiancity #integrativemedicine #alternativemedicine #homotoxicology #complementarymedicine #HDIVC. May be an ...
    view full post

    December 15, 2025

    Facebook

  • HUMAN PLACENTA EXTRACT INJECTION AND SHOULDER ...

    ... 10.1158/1078-0432.CCR-22-0655 #biomedclinicpagadiancity #integrativemedicine #alternativemedicine #homotoxicology #complementarymedicine #HDIVC · May be an ...
    view full post

    December 15, 2025

    Facebook

  • Behauptung: Vitamin C zerstört Krebs, was steckt ... - Facebook

    ... 10.1158/1078-0432.CCR-22-0655 National Institutes of Health (NIH): National Cancer Institute. "Vitamin C and Cancer Treatment: What You Need to Know ...
    view full post

    December 15, 2025

    Facebook

  • Bio Med Pagadian | Our 5 Years Breast Cancer Patient Mrs ...

    ... :4232-9 doi: 10.1158/1078-0432.CCR-22-0655 #biomedclinicpagadiancity · #integrativemedicine · #alternativemedicine · #homotoxicology
    view full post

    June 3, 2025

    Instagram

  • Bio Med Pagadian | MAJOR OZONE AUTOHEMOTHERAPY ...

    ... :4232-9 doi: 10.1158/1078-0432.CCR-22-0655 #biomedclinicpagadiancity · #integrativemedicine · #alternativemedicine · #homotoxicology
    view full post

    May 18, 2025

    Instagram

  • High-dose intravenous vitamin C plus chemotherapy may be ...

    ... 10.1158/1078-0432.CCR-22-0655 #biomedclinicpagadiancity #integrativemedicine #alternativemedicine #homotoxicology #complementarymedicine #HDIVC.
    view full post

    April 29, 2025

    Facebook

  • Bio - High-dose intravenous vitamin C plus chemotherapy may be ...

    ... 10.1158/1078-0432.CCR-22-0655 #biomedclinicpagadiancity #integrativemedicine #alternativemedicine #homotoxicology #complementarymedicine ...
    view full post

    April 29, 2025

    Facebook

  • Bio Oncology CDO added a new photo. - Bio Oncology ... - Facebook

    ... 10.1158/1078-0432.CCR-22-0655 #biomedclinicpagadiancity #integrativemedicine #alternativemedicine #homotoxicology #complementarymedicine #HDIVC.
    view full post

    April 29, 2025

    Facebook

  • Dr. Michael Ian... - Dr. Michael Ian Redelosa Uriarte - Facebook

    ... 10.1158/1078-0432.CCR-22-0655 #biomedclinicpagadiancity #integrativemedicine #alternativemedicine #homotoxicology #complementarymedicine #HDIVC.
    view full post

    February 14, 2025

    Facebook

  • #高濃度ビタミンc ＃がん治療 ＃がん ＃ビタミンc ヒト ... - Instagram

    ... untreated metastatic colorectal cancer PMID: 35929990 DOI: 10.1158/1078-0432.CCR-22-0655. Instagram. Log in · Open app · aoyama_medicalclinic.
    view full post

    September 23, 2022

    Instagram

Abstract Synopsis

  • - The study aimed to assess whether adding high-dose vitamin C to the standard chemotherapy (FOLFOX ± bevacizumab) would improve outcomes for patients with metastatic colorectal cancer (mCRC).
  • - Results showed that there was no significant difference in progression-free survival (PFS), overall survival (OS), or response rates between the vitamin C group and the control group, although patients with RAS mutations did experience longer PFS with vitamin C.
  • - Overall, high-dose vitamin C did not provide a clear benefit over standard chemotherapy for mCRC, except potentially for patients with specific genetic mutations (RAS mutation).