PubHawk
Clin Cancer Res October 2022 PMID 35929990

A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study).

Feng Wang, Ming-Ming He, Jian Xiao, Yan-Qiao Zhang, Xiang-Lin Yuan, Wei-Jia Fang, Yan Zhang, Wei Wang, Xiao-Hua Hu, Zhi-Gang Ma, Yi-Chen Yao, Zhi-Xiang Zhuang, Fu-Xiang Zhou, Jie-Er Ying, Ying Yuan

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Mentions

55
Peak: 19 in Oct 2022
across 5 sources since Aug 2022

Extended reach

267,044
potential audience

Total likes

7,049

Video views

130,457

Mentions per month

Aug 2022 – Dec 2025

Where it's discussed

  • X / Twitter42 posts
  • Facebook7 posts
  • Instagram3 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The groups of discussions reveal widespread skepticism about the effectiveness of high-dose vitamin C in improving outcomes for colorectal cancer, with phrases like 'failed to improve metrics' and 'no effect' reflecting a dismissive tone. However, some comments highlight potential benefits in specific genetic contexts, such as RAS mutations, indicating ongoing interest and nuanced engagement with the scientific evidence.

AgreementLow agreement

Most discussions recognize that high-dose vitamin C does not provide clear benefits for metastatic colorectal cancer, with some acknowledging the lack of significant effects observed in the study.

InterestHigh interest

There is high interest in the topic, especially regarding its potential effects on specific mutations like RAS, and in the debate around vitamin C's role in cancer treatment.

EngagementModerate engagement

The discussions show moderate engagement, with some users referencing preclinical evidence, clinical trial outcomes, and genetic factors, but many comments are brief or dismissive.

ImpactNeutral impact

The overall influence appears modest; while the topic sparks curiosity, few comments suggest the findings will drastically change clinical practices or perceptions about vitamin C’s efficacy in cancer treatment.

Abstract in brief

  • The study aimed to assess whether adding high-dose vitamin C to the standard chemotherapy (FOLFOX ± bevacizumab) would improve outcomes for patients with metastatic colorectal cancer (mCRC).
  • Results showed that there was no significant difference in progression-free survival (PFS), overall survival (OS), or response rates between the vitamin C group and the control group, although patients with RAS mutations did experience longer PFS with vitamin C.
  • Overall, high-dose vitamin C did not provide a clear benefit over standard chemotherapy for mCRC, except potentially for patients with specific genetic mutations (RAS mutation).
Read the full abstract

Top posts

Most liked on X and Bluesky
Clinical Cancer Research
@CCR_AACR · X

Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 14, 2022 · 67 likes · 12 shares · 7,960 followers View post →
Commissar of tomfoolery
@Kakabhushundi · X

https://t.co/4sLVYr2MTC Lmao another Ray Peat W Such a great man

Dec 1, 2025 · 9 likes · 3,254 followers View post →
ZKForTre
@ZKForTre · X

In the few examples in which it’s actually been tested (see one such case below), it has failed to improve metrics. https://t.co/r7AioGRCV7 https://t.co/Rl16iqNvdH

Sep 27, 2025 · 7 likes · 1 share · 2,866 followers View post →
Umut Kefeli
@ukefeli · X

Metastatik kolorektal kanserlerde yüksek doz C vitamininin faydası olmadığı gösterildi. https://t.co/DHb3sSz3Mt

Oct 15, 2022 · 6 likes · 1 share · 1,268 followers View post →
Bettina Frank
@FrankBettina · X

#Kolorektalkarzinom: Hochdosiertes Vitamin C ohne Effekt auf Erstlinien-Chemotherapie.“ #VitaminC #Krebs #NEM https://t.co/hmrIcuBNve

Aug 31, 2022 · 5 likes · 1 share · 5,974 followers View post →
Wim Ceelen
@WimCeelen · X

No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On

Aug 6, 2022 · 5 likes · 3 shares · 1,093 followers View post →

All mentions

John Murphy
@JohnMur75812933 · X

The Resurgence of Vitamin C against Cancer https://t.co/QyOjMgotx9 via @YouTube

Dec 2, 2025 · 1 like · 5,796 followers View post →
Dotcomnieuws
@dotcomnieuws · X

The Resurgence of Vitamin C against Cancer - YouTube https://t.co/fWWlZwMjMg

Dec 1, 2025 · 1 like · 2,043 followers View post →
Commissar of tomfoolery
@Kakabhushundi · X

https://t.co/4sLVYr2MTC Lmao another Ray Peat W Such a great man

Dec 1, 2025 · 9 likes · 3,254 followers View post →
Natalia
@Natalia58027012 · X

@BSCrusher1 @lantwehr63 @BogRymanowski nie no, powstało dziesiątki innych prac np. https://t.co/KpiFH8jzD1

Nov 28, 2025 · 4 followers View post →
Coach Milly
@Coach_Milly_ · X

RT @ZKForTre: In the few examples in which it’s actually been tested (see one such case below), it has failed to improve metrics. https:/…

Sep 28, 2025 · 1 share · 48 followers View post →
ZKForTre
@ZKForTre · X

In the few examples in which it’s actually been tested (see one such case below), it has failed to improve metrics. https://t.co/r7AioGRCV7 https://t.co/Rl16iqNvdH

Sep 27, 2025 · 7 likes · 1 share · 2,866 followers View post →
gerfaud
@Gerfaud07 · X

@LeMediaEn442 Le taux de réponse objective (ORR) et la survie globale (OS) des groupes expérimental et témoin étaient similaires (ORR, 44,3 % contre 42,1 % ; P = 0,9 ; OS médiane, 20,7 contre 19,7 mois ; P = 0,7). https://t.co/2wY5KnuPdO colon https://t.co/b8be5z4cyb prostate https://t.co/MjTxwyyfKD

Apr 22, 2025 · 103 followers View post →
Onco404
@onco404.bsky.social · Bluesky

Thank you for correcting us. Based on some preclinical evidence (10.1126/science.aaa5004), vitC could selectively target RAS and BRAF-mutant CRC models. However, a clinical study reported a significant PFS difference only in RAS-mutant CRC (chemo+vitC, 10.1158/1078-0432.CCR-22-0655). Thanks again!

Mar 25, 2025 View post →
Teoman Yanmaz
@mtymtyyanmaz · X

@ilyassahinMD Ras mut+ met crc’de etkili olabilir https://t.co/B3iDBKQ4hS

Jan 30, 2025 · 1,001 followers View post →
Pashtoon Kasi MD, MS
@pashtoonkasi · X

@Aiims1742 @OncoAlert @PanCAN This is the first randomized trial I believe showing a tangible benefit in #KRAS-mutant cancers as a primary endpoint.

Dec 5, 2024 · 2 likes · 19,857 followers View post →
Engelbert Valstar
@euler55 · X

A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX… https://t.co/tU6lGiMWUd Ingeval van een RAS-mutatie significant langer leven (6 weken); bij geen RAS-mutatie niet. Er zijn relevantere voedingsfactoren en kruiden

Jan 16, 2023 · 84 followers View post →
Daniel Izzo
@DanielIzzo1 · X

@CharlieEch07 @ChefGruel Hi: re Processed Meat and Cancer. I edited out the part about Vitamin C's alleged cancer treatment properties but after further research it doesn't work as thought https://t.co/8odFvjAi16

Nov 22, 2022 · 534 followers View post →
Dr Carol Granger
@CarolGranger2 · X

A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study) https://t.co/Ejnq2jVO1h

Nov 2, 2022 · 356 followers View post →
Tina Kaczor, ND, FABNO
@naturopathiconc · X

Null. “A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study)”| Clinical Cancer Research | ⁦@AACR⁩ https://t.co/3nI9i4aeT5

Oct 15, 2022 · 481 followers View post →
Karol Polom
@polom_karol · X

RT @WimCeelen: Intriguing: high dose vit C seems to augment effect of FOLFOX-bev in KRASmut CRC in preplanned subgroup analysis https://t.…

Oct 15, 2022 · 1 share · 1,214 followers View post →
Niraj Neupane
@Nirajneu · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 15, 2022 · 12 shares · 167 followers View post →
Tomas Pokrivcak, M.D.
@pokrivcak · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 15, 2022 · 12 shares · 25 followers View post →
Sergio
@sergiomejiaonco · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 15, 2022 · 12 shares · 82 followers View post →
Charon
@CharonCalypso · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 15, 2022 · 12 shares · 29 followers View post →
ŞAHSIMANAZARDEĞİYO
@noopetrolyesbor · X

RT @ukefeli: Metastatik kolorektal kanserlerde yüksek doz C vitamininin faydası olmadığı gösterildi. https://t.co/DHb3sSz3Mt

Oct 15, 2022 · 1 share · 169 followers View post →
aref Zribi
@zribi_aref · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 15, 2022 · 12 shares · 196 followers View post →
Pablo Alonso
@PabloAlonso73 · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 15, 2022 · 12 shares · 124 followers View post →
Umut Kefeli
@ukefeli · X

Metastatik kolorektal kanserlerde yüksek doz C vitamininin faydası olmadığı gösterildi. https://t.co/DHb3sSz3Mt

Oct 15, 2022 · 6 likes · 1 share · 1,268 followers View post →
Wim Ceelen
@WimCeelen · X

Intriguing: high dose vit C seems to augment effect of FOLFOX-bev in KRASmut CRC in preplanned subgroup analysis https://t.co/gvRGvBZhjU

Oct 15, 2022 · 5 likes · 1 share · 1,093 followers View post →
Loxandra Skarlatou
@Dr_Metanastria · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 15, 2022 · 12 shares · 328 followers View post →
Sehbanul Islam
@sehbanamu · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 15, 2022 · 12 shares · 641 followers View post →
Ricardo Carvalho
@rcarvalhoonco · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 14, 2022 · 12 shares · 2,272 followers View post →
Oncologia Campinas
@OncologiaCampi1 · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 14, 2022 · 12 shares · 38 followers View post →
OncoAlert
@OncoAlert · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 14, 2022 · 12 shares · 40,463 followers View post →
Marc Vincent Barcelona, MD, FPCR, DPBR-RO
@MarcBarcieMD · X

RT @CCR_AACR: Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 14, 2022 · 12 shares · 310 followers View post →
Clinical Cancer Research
@CCR_AACR · X

Phase 3 Study: Chemotherapy plus high-dose vitamin C in CRC. https://t.co/rMzzBip7u8 https://t.co/XoPGaPekCW

Oct 14, 2022 · 67 likes · 12 shares · 7,960 followers View post →
Prof.Dr.Mutlu Demiray
@eceyrem · X

@ilyassahinMD Faz 3 çalışma yayınlandı sayın hocam. https://t.co/eu31LOZmrT

Oct 12, 2022 · 1,015 followers View post →
Clinical Cancer Research
@CCR_AACR · X

Wang et al administered high-dose #VitaminC plus FOLFOX +/- bevacizumab to patients with unresectable untreated metastatic #ColorectalCancer. While vitamin C failed to prolong PFS, it showed benefit in patients with RAS mutation. https://t.co/vI40SiU8HB @FengWan25720657 https://t.co/ijSN0ZrxbK

Sep 29, 2022 · 1 like · 2 shares · 7,960 followers View post →
Martin Smollich
@ErnMedBlog · X

RT @FrankBettina: #Kolorektalkarzinom: Hochdosiertes Vitamin C ohne Effekt auf Erstlinien-Chemotherapie.“ #VitaminC #Krebs #NEM https://…

Aug 31, 2022 · 1 share · 6,065 followers View post →
Bettina Frank
@FrankBettina · X

#Kolorektalkarzinom: Hochdosiertes Vitamin C ohne Effekt auf Erstlinien-Chemotherapie.“ #VitaminC #Krebs #NEM https://t.co/hmrIcuBNve

Aug 31, 2022 · 5 likes · 1 share · 5,974 followers View post →
Delia Cortés Guiral
@DeliaCortesGuir · X

RT @WimCeelen: No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On

Aug 7, 2022 · 3 shares · 4,710 followers View post →
Dr Celestino Gutiérrez González MD
@CelestinoGutirr · X

RT @WimCeelen: No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On

Aug 7, 2022 · 3 shares · 11,323 followers View post →
JHHerreraK
@JHHerreraK · X

RT @WimCeelen: No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On

Aug 7, 2022 · 3 shares · 246 followers View post →
Manju George MVSc PhD Rectal Cancer Survivor
@manjuggm · X

RT @angelopirozzi3: https://t.co/4apqsTKeCf

Aug 6, 2022 · 1 share · 2,537 followers View post →
Alfonso De Stefano
@alfdestefano · X

“Vitamin C plus chemotherapy failed to show superior PFS compared with chemotherapy in mCRC patients as first-line treatment…” https://t.co/2C8tijLGWB

Aug 6, 2022 · 267 followers View post →
Wim Ceelen
@WimCeelen · X

No effect of adding high dose IV vitamin C to FOLFOX in mCRC https://t.co/hXpulyu0On

Aug 6, 2022 · 5 likes · 3 shares · 1,093 followers View post →
Angelo Pirozzi
@angelopirozzi3 · X

https://t.co/4apqsTKeCf

Aug 5, 2022 · 3 likes · 1 share · 1,244 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: A randomized, open-label, multicenter, phase 3 study of high-dose vitamin C plus FOLFOX +/- bevacizumab versus FOLFOX +/- bevacizumab in unresectable untreated metastatic colorectal cancer https://t.co/GhcEOY6wbF #colorectalcancer #oncology https://t.co/6oqBQxZdrw

Aug 5, 2022 · 888 followers View post →
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