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Sci Transl Med August 2022 PMID 35947675

Adenoviral-based vaccine promotes neoantigen-specific CD8 T cell stemness and tumor rejection.

Anna Morena D'Alise, Nadia Brasu, Carlo De Intinis, Guido Leoni, Valentina Russo, Francesca Langone, Denis Baev, Elisa Micarelli, Luca Petiti, Simone Picelli, Marwan Fakih, Dung T Le, Michael J Overman, Anthony F Shields, Katrina S Pedersen

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Mentions

45
Peak: 16 in Aug 2022
across 4 sources since Aug 2022

Extended reach

128,672
potential audience

Total likes

75

Video views

237

Mentions per month

Aug 2022

All 16 dated mentions so far are from Aug 2022.

Where it's discussed

  • News27 articles
  • X / Twitter15 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect strong support and excitement for the research, such as mentions of increased T cell stemness and tumor rejection, with phrases like 'promising effects' and 'game changer,' indicating high relevance and potential impact. The tone includes both scientific detail and optimistic language, emphasizing the significance of the findings.

AgreementModerate agreement

Most posts express positive views and support for the findings, highlighting the vaccine's potential and promising results.

InterestHigh interest

Discussions are highly engaging, with enthusiasm for the innovative approach and its implications for cancer therapy.

EngagementModerate engagement

Posts reference scientific details like neoantigen-specific T cells and tumor rejection, indicating thoughtful participation.

ImpactModerate impact

The majority see this research as a significant advancement, potentially transforming immunotherapy strategies.

Abstract in brief

  • The adenoviral-based vaccine targeting tumor neoantigens boosts the immune response by increasing the number of effective CD8 T cells, especially those with stem-like properties, leading to better tumor control when combined with PD1 therapy.
  • Single-cell RNA sequencing and TCR analysis show that this vaccine enhances the diversity and functionality of neoantigen-specific T cells, both in mice and in patients, contributing to improved tumor infiltration and responses.
  • These findings suggest that such vaccines can potentially overcome resistance to PD1 therapies by making the immune response more robust and widespread against tumor-specific neoantigens.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Federico Pio Fabrizio
@FPFabrizioPhD · X

Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 19, 2022 · 66 likes · 8 shares · 7,539 followers View post →
Science Translational Medicine
@ScienceTM · X

A series of #cancer vaccines based on a great ape viral vector revives exhausted T cells and potentiates the efficacy of anti-PD-L1 #immunotherapy in mice, and shows promising effects in a first-in-human trial with 12 patients. @NouscomS @ArmeniseHarvard https://t.co/scACZy82v9 https://t.co/ghCSx0gqll

Aug 11, 2022 · 3 likes · 1 share · 33,742 followers View post →
Johan Van Weyenbergh
@johanvawe · X

Adenoviral-based #vaccine promotes neoantigen-specific CD8+ T cell stemness and #tumor rejection https://t.co/ilck2t6dzK

Aug 13, 2022 · 3 likes · 4,741 followers View post →
NatureRevClinOncol
@NatRevClinOncol · X

Study shows that the gorilla adenovirus-based vaccine targeting tumour neoepitopes Nous-209, combined with anti-PD-1 mAbs, expands neoantigen-specific CD8 T cells in mouse cancer models, with evidence of similar effects in 12 pts with dMMR solid tumours: https://t.co/oyEm1I81bw

Aug 19, 2022 · 1 like · 41,577 followers View post →
Human Immunology News
@humanimmunenews · X

#Immunotherapy that is not monkeying around

Aug 13, 2022 · 1 like · 14,430 followers View post →
Waggoner Lab
@LabWaggoner · X

Adenoviral-based vaccine enhances αPD-1 antitumor immunity by promoting expansion and diversification of neoepitope-specific stem-like memory CD8+ T cells. https://t.co/OCCUm0NCfh

Aug 11, 2022 · 1 like · 11,371 followers View post →

All mentions

Andrea Faticoni
@AndreaFaticoni · X

RT @FPFabrizioPhD: Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 20, 2022 · 8 shares · 185 followers View post →
Clara Porta
@ClaraPorta4 · X

RT @FPFabrizioPhD: Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 19, 2022 · 8 shares · 694 followers View post →
Maurizio Piani
@PianiMaurizio · X

RT @FPFabrizioPhD: Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 19, 2022 · 8 shares · 114 followers View post →
Cristel 70
@cinziasams · X

RT @FPFabrizioPhD: Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 19, 2022 · 8 shares · 2,255 followers View post →
Paolo
@PaoloSartori4 · X

RT @FPFabrizioPhD: Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 19, 2022 · 8 shares · 2,593 followers View post →
DiavolettoDiMaxwell
@MaxweIISDemon · X

RT @FPFabrizioPhD: Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 19, 2022 · 8 shares · 359 followers View post →
NatureRevClinOncol
@NatRevClinOncol · X

Study shows that the gorilla adenovirus-based vaccine targeting tumour neoepitopes Nous-209, combined with anti-PD-1 mAbs, expands neoantigen-specific CD8 T cells in mouse cancer models, with evidence of similar effects in 12 pts with dMMR solid tumours: https://t.co/oyEm1I81bw

Aug 19, 2022 · 1 like · 41,577 followers View post →
MICHELE
@MikeZapMG · X

RT @FPFabrizioPhD: Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 19, 2022 · 8 shares · 3,030 followers View post →
Federico Pio Fabrizio
@FPFabrizioPhD · X

Fonte: https://t.co/XQWILXMa8Q https://t.co/K0xRnvp6v3 https://t.co/SQcKiXxKP5 17/17 FINE

Aug 19, 2022 · 66 likes · 8 shares · 7,539 followers View post →
Fabio Grizzi
@FabioGrizzi · X

Adenoviral-based vaccine promotes neoantigen-specific CD8+ T cell stemness and tumor rejection https://t.co/GSsA2coT5D #immunotherapy #vaccine #Cancer

Aug 15, 2022 · 811 followers View post →
Human Immunology News
@humanimmunenews · X

#Immunotherapy that is not monkeying around

Aug 13, 2022 · 1 like · 14,430 followers View post →
Johan Van Weyenbergh
@johanvawe · X

Adenoviral-based #vaccine promotes neoantigen-specific CD8+ T cell stemness and #tumor rejection https://t.co/ilck2t6dzK

Aug 13, 2022 · 3 likes · 4,741 followers View post →
Science Translational Medicine
@ScienceTM · X

A series of #cancer vaccines based on a great ape viral vector revives exhausted T cells and potentiates the efficacy of anti-PD-L1 #immunotherapy in mice, and shows promising effects in a first-in-human trial with 12 patients. @NouscomS @ArmeniseHarvard https://t.co/scACZy82v9 https://t.co/ghCSx0gqll

Aug 11, 2022 · 3 likes · 1 share · 33,742 followers View post →
Science Press Package
@scipak · X

"@NouscomS ... announces in [@ScienceTM] preclinical and clinical research describing a novel mechanism of action driven by its viral vector-based vaccine platform encoding tumor neoantigens." Paper

Aug 11, 2022 · 4,864 followers View post →
Waggoner Lab
@LabWaggoner · X

Adenoviral-based vaccine enhances αPD-1 antitumor immunity by promoting expansion and diversification of neoepitope-specific stem-like memory CD8+ T cells. https://t.co/OCCUm0NCfh

Aug 11, 2022 · 1 like · 11,371 followers View post →