Nat Commun August 2022 PMID 35948557

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection.

Khadija Khan, Farina Karim, Yashica Ganga, Mallory Bernstein, Zesuliwe Jule, Kajal Reedoy, Sandile Cele, Gila Lustig, Daniel Amoako, Nicole Wolter, Natasha Samsunder, Aida Sivro, James Emmanuel San, Jennifer Giandhari, Houriiyah Tegally

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Peak: 13 in Aug 2022

across 5 sources since Aug 2022

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Aug 2022 – Aug 2023

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What people are saying

Most discussions emphasize the significance of the mutations in BA.4 and BA.5 and their ability to evade immunity, illustrated by posts highlighting the need for booster shots and referencing the study’s data on reduced neutralization. The tone varies from supportive to skeptical, but overall, the conversations reflect a focus on understanding the public health impact of these viral changes, with terms like 'escape mutations' and calls for 'more data' shaping the dialogue.

AgreementModerate agreement

Most discussions recognize and support the findings about immune escape, reflecting broad agreement on the study's implications.

InterestHigh interest

The social discussions display high curiosity about vaccine efficacy and the threat posed by new variants, indicating substantial interest.

EngagementModerate engagement

Postings include references to the study details and opinions about vaccination strategies, showing active engagement.

ImpactModerate impact

Many comments concern public health decisions and vaccine updates, suggesting these discussions could influence individual and policy actions.

Abstract in brief

SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5 have mutations in their spike protein that enable them to partially evade immunity developed from earlier strains, specifically BA.1.
In individuals previously infected with BA.1 but unvaccinated, their ability to neutralize the new variants drops significantly, with a 7.5 to 7.6-fold reduction in effectiveness against BA.4 and BA.5 compared to BA.1.
Vaccination helps improve immune response, reducing the neutralization drop to about 3.2-fold for BA.4 and 2.6-fold for BA.5, but these new variants still show a higher degree of escape from immunity compared to the earlier strains, especially

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Omicron BA.4 and BA.5 Spike Mutations Reduce Immunity from BA.1 Infection

Omicron sublineages BA.4 and BA.5 carry spike mutations that partially evade immunity from BA.1 infection. Vaccination improves immune response, but these variants still significantly escape past immunity, highlighting…

STEM RTCL TV · Aug 1, 2023 8 views

末永けい

@suenaga_kei · X

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection | Nature Communications https://t.co/j59352z9gT

Oct 3, 2022 · 5 likes · 14,088 followers View post →

Prof. Dr. Sanjeev Bagai

@BagaiDr · X

Oct 3, 2022 · 34,743 followers View post →

Carlos Guzman Quilo

@GuzmanQCarlos · X

An important reason to receive booster dhots: “Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection” | Nature Communications https://t.co/qHlPvAcDeo

Oct 3, 2022 · 646 followers View post →

andyrififi

@andyrififi · X

@Karl_Lauterbach Wieviel Menschen wollen Sie noch schädigen bzw. töten? Es ist vorbei! https://t.co/4idsuffzkV

Sep 1, 2022 · 307 followers View post →

andyrififi

@andyrififi · X

@stohr_klaus @welt https://t.co/4idsuffzkV

Sep 1, 2022 · 307 followers View post →

andyrififi

@andyrififi · X

@MiddiMath @stohr_klaus @welt nämlich keine, denn BA.4/BA.5 ist eine "Escape"-Mutation. Dass heißt, mit dem "angepassten" Impfstoff (ein Mix aus dem Wildtyp und der BA.1-Variante), wird es keine Immunantwort geben bzw. nur gering https://t.co/4idsuffzkV

Sep 1, 2022 · 307 followers View post →

andyrififi

@andyrififi · X

@MTubeman @stohr_klaus @welt Haben Sie eben sich selbst gemeint? Informieren Sie sich bitte https://t.co/4idsuffzkV https://t.co/35L62aEea8

Sep 1, 2022 · 307 followers View post →

andyrififi

@andyrififi · X

@wi_anette @stohr_klaus @welt Wer keine Ahnung hat, sollte entweder sich informieren oder einfach mal still sein https://t.co/4idsuffzkV

Sep 1, 2022 · 307 followers View post →

andyrififi

@andyrififi · X

@mbuzz_ @stohr_klaus @welt BA.4/BA.5 ist eine "Escape"-Mutation, falls Sie wissen, was das bedeutet. Wenn nicht lesen Sie diese Studie https://t.co/4idsuffzkV

Sep 1, 2022 · 307 followers View post →

andyrififi

@andyrififi · X

@StellaFassmich1 @stohr_klaus @Ladia80 @welt Das ist völliger Quark, was Lauterbach von sich gibt. Er sollte endlich zugeben, dass er nur ein Scharlatan ist. https://t.co/4idsuffzkV

Sep 1, 2022 · 2 likes · 307 followers View post →

andyrififi

@andyrififi · X

@stohr_klaus @welt https://t.co/4idsuffzkV

Sep 1, 2022 · 307 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection https://t.co/xUzxJxjzYm https://t.co/gRMOg70L75

Aug 12, 2022 · 878 followers View post →

Lisa Sullivan

@LisaSul30155840 · X

⁦@drbeen_medical ⁦@PierreKory⁩ ⁩ Your thoughts, good doctors? Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection | Nature Communications https://t.co/KHcBOz60yM

Aug 11, 2022 · 125 followers View post →

Carlos Guzman Quilo

@GuzmanQCarlos · X

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection | Nature Communications https://t.co/qHlPvAcDeo

Aug 11, 2022 · 646 followers View post →

matiere*

@matiere · X

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection | Nature Communications https://t.co/QNZrFV8eIb

Aug 11, 2022 · 2,839 followers View post →

สังคมจิ้งจอก Sozial Fox

@nineyoii · X

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection #BA4 #BA5 #COVID19 https://t.co/oHUUIvcd59

Aug 11, 2022 · 1,115 followers View post →

hashem

@hashemkoohy · X

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection | Nature Communications https://t.co/QCUh4z3O0K

Aug 11, 2022 · 766 followers View post →

Phage Papers

@Phage_Papers · X

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection https://t.co/DgXYkb6b4V

Aug 11, 2022 · 646 followers View post →

Laboratorio de Genética Molecular. FO. UNAM

@LGM_FO_UNAM · X

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection | Nature Communications https://t.co/Q4nH1vjfB0

Aug 10, 2022 · 1 like · 2,695 followers View post →

Prof. Dr. Sanjeev Bagai

@BagaiDr · X

Aug 10, 2022 · 4 likes · 34,743 followers View post →

Patrick Rankine

@coachRankine · X

RT @ejustin46: @MeetJess @C_A_Gustave @xabitron1 NEW STUDY Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection https:…

Aug 10, 2022 · 3 shares · 4,077 followers View post →

Jacques Pyrat

@jpyrat · X

RT @ejustin46: @MeetJess @C_A_Gustave @xabitron1 NEW STUDY Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection https:…

Aug 10, 2022 · 3 shares · 875 followers View post →

C-A-G

@C_A_G0101 · X

RT @ejustin46: @MeetJess @C_A_Gustave @xabitron1 NEW STUDY Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection https:…

Aug 10, 2022 · 3 shares · 17,042 followers View post →

Emmanuel

@ejustin46 · X

@MeetJess @C_A_Gustave @xabitron1 NEW STUDY Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection https://t.co/csPp7sRWGh

Aug 10, 2022 · 6 likes · 3 shares · 17,288 followers View post →

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection.

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Omicron BA.4 and BA.5 Spike Mutations Reduce Immunity from BA.1 Infection