Nat Commun August 2022 PMID 35974106

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.

Dominik Saul, Robyn Laura Kosinsky, Elizabeth J Atkinson, Madison L Doolittle, Xu Zhang, Nathan K LeBrasseur, Robert J Pignolo, Paul D Robbins, Laura J Niedernhofer, Yuji Ikeno, Diana Jurk, João F Passos, LaTonya J Hickson, Ailing Xue, David G Monroe

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Several discussions highlight the significance of the new gene set in identifying senescent cells and its potential applications in various health issues, such as 'age-related diseases' and 'inflammation.' The repeated emphasis on terms like 'senescence' and 'pathways' reveals an underlying excitement about advancements in the field, contributing to a tone of optimism and importance throughout the discussions.

AgreementModerate agreement

Most discussions reflect a general support for the findings, with numerous references to the publication's importance.

InterestHigh interest

There is a strong interest shown in the subject matter, as participants frequently mention the implications of the research.

EngagementModerate engagement

While some comments simply reiterate the title, others show a moderate level of reflection on the research methods and potential uses.

ImpactHigh impact

The consensus is that the research could have substantial implications for understanding senescence and its related pathways.

Abstract in brief

A new gene set called SenMayo has been developed to identify senescent cells and predict related pathways across different tissues, showing effectiveness in human bone biopsies.
SenMayo levels were found to decrease in bone and adipose tissue following the genetic or pharmacological clearance of senescent cells, demonstrating its reliability in tracking these cells.
This gene set allows for detailed characterization of senescent cells at the single-cell level, which could be useful in monitoring aging, related health issues, and testing senolytic drugs.

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SenMayo Gene Set Identifies Senescent Cells Across Tissues

A new gene set called SenMayo has been developed to identify senescent cells and predict pathways across different tissues. Its effectiveness was confirmed in human bone biopsies, allowing for detailed characterization…

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"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues | Nature Communications" https://t.co/Kin2Dojp8S

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Kelvin Yin

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A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues | bioRxiv https://t.co/Q6R42fOmmg

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For your weekend reading: "A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues." Nat Commun 13, 4827 (2022). https://t.co/QE3fTSSsnj @brunovellas @isaperarnau @RestoreInstitut @InfinityTLS @I2mcT

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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues by Dominik Saul https://t.co/MT2F2XASNk

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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues https://t.co/QvfEPyWYZw https://t.co/oTCy7drx7n

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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.

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SenMayo Gene Set Identifies Senescent Cells Across Tissues