Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypothesis that human aging is: “driven by age-imposed systemic molecular excess, the attenuation of which reverses biological age.” https://t.co/MOtexkzAC2 https://t.co/eKDvDJxEDn
Old plasma dilution reduces human biological age: a clinical study.
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Aug 2022 – Sep 2025Where it's discussed
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AI synopsis
What people are saying
Many discussions reflect on the implications of plasma exchange for longevity, with users pointing out its potential to reduce biological age. Phrases like 'game changer' and 'lifespan extension' convey excitement, while critiques about the study's sample size emphasize skepticism. Comments such as 'I love the stick figure that they used' illustrate a mix of serious inquiry and lightheartedness, contributing to an overall engaged yet diverse conversation.
Many discussions express a consensus that the findings are noteworthy and agree with the potential benefits of plasma exchange.
The topic has clearly drawn significant curiosity, with multiple users commenting on its implications and suggesting further exploration.
While some discussions dive deep into the methodologies and underlying mechanisms, others exhibit a lighter touch, indicating varied levels of engagement.
A number of users believe that the study could reshape perspectives on aging and health, highlighting its possible transformative effects.
Abstract in brief
- The study suggests that therapeutic plasma exchange (TPE) can reduce biological age in humans by improving molecular balance in the bloodstream, similar to how it has been observed in mice.
- TPE leads to the restoration of youthful proteins and markers associated with regeneration and cancer resistance, while also reducing signs of cellular aging and DNA damage.
- The research highlights the importance of specific signaling pathways in promoting this rejuvenation, supported by extensive gene expression data.
Top posts
Most liked on X and BlueskyOld plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, implicate bacteria and gut health as drivers of aging. https://t.co/UnpvKHf13p
Old plasma dilution reduces human biological age: a clinical study Therapeutic plasma exchange, an intervention already in use, promotes "a younger systemic proteome" https://t.co/UnpvKHf13p
Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
The vampire approach to age reversal seems to work. But not an RCT. Each line is a person, so there's literally 8 people here. https://t.co/v8FoToijGj https://t.co/9UUMjLyy6g
Plasmapheresis for longevity: (therapeutic plasma exchange (TPE)) replaces blood plasma with saline & purified albumin, extends rodents’ lifespan. Also shown to have lasting age-reversal effects in humans. https://t.co/OXFdkRaUAv https://t.co/ba1ZQUMUm0
All mentions
Anti-Aging Breakthrough? THIS Therapy Reversed Aging, Improved Strength & Cognitive In Human Trial
Understanding Harold Katcher's Plasma Fraction Rejuvenation Findings
In this video, Nina Torres Zanvettor explains Harold Katcher's plasma fraction used to achieve significant advances in mammalian rejuvenation science. This research, examining the effects of young pig plasma on aging…
RT @robertlufkinmd: Plasmapheresis for longevity: (therapeutic plasma exchange (TPE)) replaces blood plasma with saline & purified albumi…
RT @robertlufkinmd: Plasmapheresis for longevity: (therapeutic plasma exchange (TPE)) replaces blood plasma with saline & purified albumi…
RT @robertlufkinmd: Plasmapheresis for longevity: (therapeutic plasma exchange (TPE)) replaces blood plasma with saline & purified albumi…
RT @robertlufkinmd: Plasmapheresis for longevity: (therapeutic plasma exchange (TPE)) replaces blood plasma with saline & purified albumi…
Plasmapheresis for longevity: (therapeutic plasma exchange (TPE)) replaces blood plasma with saline & purified albumin, extends rodents’ lifespan. Also shown to have lasting age-reversal effects in humans. https://t.co/OXFdkRaUAv https://t.co/ba1ZQUMUm0
@loopyrapper @bryan_johnson Thanks. I could not get the openlink thing to work. This works: https://t.co/FQ7eBsx89c
@GaryMarcus @bryan_johnson One of the studies this experiment is based on had 15 samples. Haven’t checked the other one, but it seems that there is much more research required… https://t.co/QvSbnxVoM9
1/ Therapeutic Plasma Exchange is an interesting therapy for health and longevity. https://t.co/4DiBTSSZQO https://t.co/uAS84WvGmI
@GrayM0untain @realericmoutsos You can do the basics like ESR or CRP. But in your case I would ask for something more comprehensive like in the study I just posted. See the following link to the full study and all the inflammation markers that were tested https://t.co/IsqBirVBVH
@RyanMarino https://t.co/FXsqoaaoaS This is one of the studies this is based on
RT @Mangan150: @eric_novack @ThommyTox Not about removing toxins, it's about removing blood borne age-promoting factors. Good read here: ht…
@eric_novack @ThommyTox Not about removing toxins, it's about removing blood borne age-promoting factors. Good read here: https://t.co/UnpvKHetdR
@Bier_Automata @bryan_johnson @Andercot @talmagejohnson_ It's spelled plasmapheresis, btw, and here is a research study that supports some of his claims: https://t.co/UhrgBYBeCL
RT @martykendall2: @bryan_johnson @talmagejohnson_ I'm eager to see the before and after results on this one. Us normies can donate their…
https://t.co/nEV7huFQxO
@SBakerMD Eat steak + donate plasma = win/win https://t.co/nEV7huFQxO
@AntiFragileJTS @bryan_johnson @talmagejohnson_ https://t.co/nEV7huFQxO
@bryan_johnson @talmagejohnson_ I'm eager to see the before and after results on this one. Us normies can donate their plasma fortnightly. No 'blood boy' required. In the US, they'll even pay you for it! https://t.co/nEV7huFQxO
@realJohnCox @DefiantLs a) That's bullshit, you can just buy plasma from normal donors b) this is even wrong because what works is old plasma dilution. You don't actually need the young plasma. https://t.co/j6qimybAlF
@RealDiegoVera @davidasinclair There's been some worthwhile result in old people by removing their old plasma. https://t.co/j6qimybAlF Of course, given that most medical papers are fake.. who knows ?
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Therapeutic plasma exchange, an intervention already in…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Therapeutic plasma exchange, an intervention already in…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Therapeutic plasma exchange, an intervention already in…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Therapeutic plasma exchange, an intervention already in…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Therapeutic plasma exchange, an intervention already in…
Old plasma dilution reduces human biological age: a clinical study Therapeutic plasma exchange, an intervention already in use, promotes "a younger systemic proteome" https://t.co/UnpvKHf13p
RT @hernangraffe: https://t.co/g4Y04xIt9a
Anti-Aging Breakthrough? THIS Therapy Reversed Aging, Improved Strength ... https://t.co/sRPnROng1T via @YouTube
https://t.co/g4Y04xIt9a
@stanete https://t.co/nHZC8L8pph
RT @JuliaB_fitness: @exosome «Through String analysis, we found that only one protein (#TLR4) was linked to all the age-specific TPE-rejuve…
@krishnanrohit https://t.co/kuT7IUcM4n
@bryan_johnson likely primarily due to dilution https://t.co/kuT7IUcM4n
Old plasma dilution reduces human biological age: a clinical study https://t.co/yGSrtIIMB2 Kim, D, Kiprov, D.D, Luellen, C et al. Old plasma dilution reduces human biological age: a clinical study. GeroScience 44, 2701–2720 (2022) https://t.co/VHemOMgVl2 #vampire #antiaging https://t.co/2fy6Xx4jpU
@dmarusic though there are also studies claiming this effect is mostly about diluting harmful things in old blood rather than getting beneficial things in young blood https://t.co/57rWV1lGwt
A clinical study has shown that plasma dilution can reduce human biological age by up to three years. The technique involves exchanging blood plasma from elderly participants with blood plasma from younger participants https://t.co/PrY4rgxUP8
RT @JuliaB_fitness: @exosome «Through String analysis, we found that only one protein (#TLR4) was linked to all the age-specific TPE-rejuve…
RT @JuliaB_fitness: @exosome «Through String analysis, we found that only one protein (#TLR4) was linked to all the age-specific TPE-rejuve…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
@SheekeyScience Here is a UC Berkeley article from 2022 that seems a lot more credible. Let me know what you think of it! : https://t.co/4C5bLA3CeM
@ruthhook_ Apparently the rat plasma dilution works in humans too https://t.co/z9cMIHapk6
@BWalkerTTAGGG I think I found it, application of rounds of TPE. https://t.co/UL3d0LXIiV
@haidut Do you see this study? Old plasma dilution reduces human biological age: a clinical study - Mechanistically,through normalization of TLR4 https://t.co/Z3setVWLry
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
RT @Mangan150: Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, i…
Old plasma dilution reduces human biological age: a clinical study Oddly enough, these results, through normalizing TLR4, implicate bacteria and gut health as drivers of aging. https://t.co/UnpvKHf13p
https://t.co/ttJ05KiDWg
1/3 It remains elusive why blood donation, plasma exchange & plasma dilution all lead to systemic rejuvenation. New study found that TLR4 normalization is a nodal point in molecular rejuvenation via plasma exchange in humans ⬇️ https://t.co/MOljyVljSp
Plasmapheresis for longevity: (therapeutic plasma exchange (TPE)) replaces blood plasma with saline & purified albumin, extends rodents’ lifespan. Also shown to have lasting age-reversal effects in humans. https://t.co/OXFdkRaUAv https://t.co/oPyynkEobX
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @KirkegaardEmil: The vampire approach to age reversal seems to work. But not an RCT. Each line is a person, so there's literally 8 peopl…
RT @KirkegaardEmil: The vampire approach to age reversal seems to work. But not an RCT. Each line is a person, so there's literally 8 peopl…
'''La dilución del plasma antiguo reduce la edad biológica humana: estudio clínico''' https://t.co/9TxQ7YPj9Q
The vampire approach to age reversal seems to work. But not an RCT. Each line is a person, so there's literally 8 people here. https://t.co/v8FoToijGj https://t.co/9UUMjLyy6g
@DrDorotaSK @exosome Yeah but this TLR4/plasma exchange paper from the Conboys et al is about ~systemic aging (that seems to be effectuated by immune cells in humans). «Fig. 1. The remodeling effect of TPE (therapeutic plasma exchange) treatment on aged blood.» https://t.co/AQHreg0a8u https://t.co/cj1vRcULUS
@LifespanIO @JuliaB_fitness we like the human results https://t.co/r4BmvoG7TC
Check out this clinical study involving aging and therapeutic plasma exchange in humans. Researchers found that, much like mice, human aging is driven by age-imposed systemic molecular excess. Link below. https://t.co/uO2d7INdHw
What’s more, the changes "are not limited to a reduction of inflammaging but encompass diminished circulatory protein markers of neurodegeneration and cancer, as well as reduced senescence, lower DNA damage, and improved myeloid/lymphoid homeostasis." 5/ https://t.co/C9nz59Tnxa
"Old plasma dilution reduces human biological age: a clinical study" — Read it on @ResearchGate: https://t.co/eUcIgogpmK
Old plasma dilution reduces human biological age: a clinical study https://t.co/97ryOv2Obv To gain mechanistic insights into ageing and longevity: https://t.co/ev3fKAQQ7D https://t.co/Sw8Uba3Nwd https://t.co/ujJwFcHcnv https://t.co/gdNuBXR0Ow https://t.co/FA8rkBNPVZ https://t.co/H05UcntCL0
Old plasma dilution reduces human biological age: a clinical study https://t.co/XTNkdD2U1Y
Should be of interest: "Old plasma dilution reduces human biological age: a clinical study" "plasma dilution... replaces a patient’s plasma with saline and purified albumin" h/t @KentKemmish from @demonpore https://t.co/EMz7jjhkoA
If you haven't been following this, quite interesting. Replacing/diluting your blood plasma seems to make mice (and in this paper 3 people) younger. Obviously caution is warranted. But a line of research to worth paying attention to. https://t.co/lTtVuPLNaX https://t.co/j91Z3TDkEr
RT @JuliaB_fitness: @exosome «Through String analysis, we found that only one protein (#TLR4) was linked to all the age-specific TPE-rejuve…
RT @JuliaB_fitness: @exosome «Through String analysis, we found that only one protein (#TLR4) was linked to all the age-specific TPE-rejuve…
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
@exosome «Through String analysis, we found that only one protein (#TLR4) was linked to all the age-specific TPE-rejuvenated networks. The levels of TLR4 protein were significantly decreased after TPE, as compared to before this procedure.» https://t.co/AQHreg0a8u https://t.co/fIxPKhhDke https://t.co/Oj1zq4dmtN
RT @Orlando_uy: Old plasma dilution reduces human biological age: a clinical study. Therapeutic plasma exchange promote a global shift to…
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @mike_lustgarten: Old plasma dilution reduces human biological age: a clinical study https://t.co/5DLHerejBK
RT @mike_lustgarten: Old plasma dilution reduces human biological age: a clinical study https://t.co/5DLHerejBK
Old plasma dilution reduces human biological age: a clinical study https://t.co/5DLHerejBK
RT @kelvinY: Not sure if I believe all the claims in this paper, but I love the stick figure that they used to represent an older person tr…
Not sure if I believe all the claims in this paper, but I love the stick figure that they used to represent an older person treated with their plasma exchange protocol: https://t.co/wOIQqunpms https://t.co/Mu6tiOgY6G
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @davidasinclair: Plasmapheresis or therapeutic plasma exchange (TPE), replaces blood plasma with saline & purified albumin, extends rode…
RT @Orlando_uy: Old plasma dilution reduces human biological age: a clinical study. Therapeutic plasma exchange promote a global shift to…
Old plasma dilution reduces human biological age: a clinical study. Therapeutic plasma exchange promote a global shift to a younger systemic proteome, including youthfully restored pro-regenerative, anticancer, and apoptotic regulators. https://t.co/TCvh5fbK6w https://t.co/gZQmUX4Nqr
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @davidasinclair: Plasmapheresis or therapeutic plasma exchange (TPE), replaces blood plasma with saline & purified albumin, extends rode…
RT @davidasinclair: Plasmapheresis or therapeutic plasma exchange (TPE), replaces blood plasma with saline & purified albumin, extends rode…
RT @davidasinclair: Plasmapheresis or therapeutic plasma exchange (TPE), replaces blood plasma with saline & purified albumin, extends rode…
RT @davidasinclair: Plasmapheresis or therapeutic plasma exchange (TPE), replaces blood plasma with saline & purified albumin, extends rode…
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @elidourado: New Conboy lab paper confirms that repeated plasma dilution has lasting age-reversal effects in humans. (It’s happening!)…
RT @davidasinclair: Plasmapheresis or therapeutic plasma exchange (TPE), replaces blood plasma with saline & purified albumin, extends rode…
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
RT @AgingBiology: Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
Old plasma dilution reduces human biological age: a clinical study https://t.co/Lfdtx78AGt
Old plasma dilution reduces human biological age: a clinical study | SpringerLink https://t.co/urwQviGiwo
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
8 months ago, I began my second rotation at the Conboy Lab working on two great projects. Today, one of these projects has been published in Geroscience as“Old plasma dilution reduces human biological age: a clinical study" https://t.co/RmUvm0fAcm
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
RT @agingdoc1: Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypo…
Old plasma dilution reduces human biological age: a clinical study Daehwan Kim, Michael & Irina Conboy et al Supports hypothesis that human aging is: “driven by age-imposed systemic molecular excess, the attenuation of which reverses biological age.” https://t.co/MOtexkzAC2 https://t.co/eKDvDJxEDn
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