急性非代償性心不全患者に対して、ループ利尿薬に加えてアセタゾラミドを投与することでうっ血解除の成功率が上昇した報告 まだ利尿剤の手札が少ないので、アセタゾラミドをうまく使いこなせるようになりたい
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload.
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Aug 2022 – Oct 2025Where it's discussed
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AI synopsis
What people are saying
Several discussions refer to the ADVOR trial, emphasizing results like 'the addition of acetazolamide to loop diuretics improved decongestion rates.' The choice of words such as 'game changer' and expressions of excitement contribute to an overall enthusiastic tone, suggesting the potential for changes in standard treatment protocols.
Most discussions reflect strong support for the findings, highlighting the effectiveness of acetazolamide in conjunction with loop diuretics.
Participants show high levels of curiosity about the implications of acetazolamide's use in treatment protocols.
While many are quite engaged, discussions mainly focus on results rather than in-depth analysis or personal experiences.
The findings are perceived to significantly influence clinical practices regarding heart failure management.
Abstract in brief
- Acetazolamide, a drug that inhibits carbonic anhydrase, was tested to see if it could enhance the effectiveness of loop diuretics for treating acute decompensated heart failure with fluid overload.
- In a randomized, double-blind trial involving 519 patients, those receiving acetazolamide showed a higher rate of successful decongestion (42.2%) compared to the placebo group (30.5%) within 3 days.
- While acetazolamide improved urinary output, it did not significantly reduce the risk of death or rehospitalization for heart failure compared to the placebo, indicating it may help with fluid removal but not overall survival outcomes.
Top posts
Most liked on X and Bluesky数年前にNEJMに出たアセタゾラミドの論文 「世はまさに、SGLT2i時代(ドン!)」 という風潮の中、敢えてのアセタゾラミドって事で話題になったが、、、 確かにADHFでの上乗せ利尿効果はありそうだけど、解釈に注意が必要。何点か思ったことを書いてみる
Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardiorenal #AKIinICU #VisualAbstract by @Api_chew
Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of loop diuretic in all EF ranges. 'Door to combo-diuretic' time but based upon scientific data available probably Acetazolamide first. https://t.co/9uDtNS1WOt https://t.co/p9InzbRf7q https://t.co/QTw94pcOud
#ADVOR clearly demonstrated that the addition of acetazolamide to loop diuretic therapy in patients with ADHF resulted in a greater incidence of successful decongestion. (7/9) https://t.co/vahcXcCxji https://t.co/C1Ptj0TwIK
All mentions
Role of Diuretics in Managing Heart Failure with Congestion
Professor Wilfried Mullens discusses the vital role of diuretics in treating heart failure patients experiencing congestion. The ADVOR study compares acetazolamide to placebo, highlighting the challenges and…
Enhancing Diuretic Therapy in Heart Failure Management
This week, John Mandrola MD discusses diuretic therapy in HFrEF, and the role of acetazolamide in enhancing loop diuretics. In a trial, acetazolamide improved successful decongestion rates. Explore insights on heart…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
RT @edgarvlermamd: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardio…
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @nejm.org #NephJC #Nephpearls #Cardiorenal #AKIinICU #NephSky
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload ca. 2023 from @NEJM #NephJC #Nephpearls #Cardiorenal #AKIinICU #VisualAbstract by @Api_chew
RT @JeroenDauw: Very proud of the results of our #ADVOR trial!
RT @sumikko_dr: 急性非代償性心不全患者に対して、ループ利尿薬に加えてアセタゾラミドを投与することでうっ血解除の成功率が上昇した報告 まだ利尿剤の手札が少ないので、アセタゾラミドをうまく使いこなせるようになりたい
RT @sumikko_dr: 急性非代償性心不全患者に対して、ループ利尿薬に加えてアセタゾラミドを投与することでうっ血解除の成功率が上昇した報告 まだ利尿剤の手札が少ないので、アセタゾラミドをうまく使いこなせるようになりたい
急性非代償性心不全患者に対して、ループ利尿薬に加えてアセタゾラミドを投与することでうっ血解除の成功率が上昇した報告 まだ利尿剤の手札が少ないので、アセタゾラミドをうまく使いこなせるようになりたい
ADVOR https://t.co/vfI20yuEWU
RT @TT58852391: 数年前にNEJMに出たアセタゾラミドの論文 「世はまさに、SGLT2i時代(ドン!)」 という風潮の中、敢えてのアセタゾラミドって事で話題になったが、、、 確かにADHFでの上乗せ利尿効果はありそうだけど、解釈に注意が必要。何点か思ったこと…
RT @TT58852391: 数年前にNEJMに出たアセタゾラミドの論文 「世はまさに、SGLT2i時代(ドン!)」 という風潮の中、敢えてのアセタゾラミドって事で話題になったが、、、 確かにADHFでの上乗せ利尿効果はありそうだけど、解釈に注意が必要。何点か思ったこと…
RT @TT58852391: 数年前にNEJMに出たアセタゾラミドの論文 「世はまさに、SGLT2i時代(ドン!)」 という風潮の中、敢えてのアセタゾラミドって事で話題になったが、、、 確かにADHFでの上乗せ利尿効果はありそうだけど、解釈に注意が必要。何点か思ったこと…
RT @TT58852391: 数年前にNEJMに出たアセタゾラミドの論文 「世はまさに、SGLT2i時代(ドン!)」 という風潮の中、敢えてのアセタゾラミドって事で話題になったが、、、 確かにADHFでの上乗せ利尿効果はありそうだけど、解釈に注意が必要。何点か思ったこと…
RT @TT58852391: 数年前にNEJMに出たアセタゾラミドの論文 「世はまさに、SGLT2i時代(ドン!)」 という風潮の中、敢えてのアセタゾラミドって事で話題になったが、、、 確かにADHFでの上乗せ利尿効果はありそうだけど、解釈に注意が必要。何点か思ったこと…
RT @TT58852391: 数年前にNEJMに出たアセタゾラミドの論文 「世はまさに、SGLT2i時代(ドン!)」 という風潮の中、敢えてのアセタゾラミドって事で話題になったが、、、 確かにADHFでの上乗せ利尿効果はありそうだけど、解釈に注意が必要。何点か思ったこと…
数年前にNEJMに出たアセタゾラミドの論文 「世はまさに、SGLT2i時代(ドン!)」 という風潮の中、敢えてのアセタゾラミドって事で話題になったが、、、 確かにADHFでの上乗せ利尿効果はありそうだけど、解釈に注意が必要。何点か思ったことを書いてみる
RT @FH_Verbrugge: Early combination #diuretics may improve successful decongestion: #ADVOR: https://t.co/Ib9hvdUkDE #CLOROTIC: https://t.…
Early combination #diuretics may improve successful decongestion: #ADVOR: https://t.co/Ib9hvdUkDE #CLOROTIC: https://t.co/kWLQCvGwkL
Lasix dose: all of it No. Take a look at the ADVOR trial: pubmed.ncbi.nlm.nih.gov/36027559/ NephJC: www.nephjc.com/news/advor Freely Filtered: www.nephjc.com/freelyfilter...
@DrNiere https://t.co/wtqaIgHgkG 劇的に効く症例いますよね!
ダイアモックス https://t.co/Wr77rlDQzH マクラデンサって輸液のcl濃度はsensingしないだろ…… https://t.co/y83Ljgl9Eg
@RachelDNurse @Toaster_Pastry Yeah, we all do that. I do that occasionally b/c of: https://t.co/xjfISmG3yd
https://t.co/kkuGJKemiY https://t.co/SwFxOvEV3R
@kidney_boy We have rather started with Acetazolamide as an add on based on the ADVOR trial, which really works quite nicely (especially in patients with a high bicarbonate - they published the subgroup later Martens et al. Eur Heart J 2023) https://t.co/HRKClSBtK1
RT @DoctorBhavsar: These are the one’s I found interesting to discuss, sharing with #MedTwitter 1.ADVOR trial (Acetazolamide in Acute Dec…
These are the one’s I found interesting to discuss, sharing with #MedTwitter 1.ADVOR trial (Acetazolamide in Acute Decompensated Heart Failure with Volume Overload) - DOI: 10.1056/NEJMoa2203094 2.PARADIGM HF trial - Angiotensin–Neprilysin Inhibition versus Enalapril in Heart
RT @LeslieMegom:
急性非代償性心不全および容量負荷の患者を対象に、 アセタゾラミドの上乗せ(1 日 1 回 500 mg×3日)で うっ血解除は得られるが3 か月の追跡期間中の全死亡+心不全入院は差がつかない(ADVOR試験https://t.co/VaMmuVNT8B)
RT @javier20ch: Acetazolamida en ICAd (ADVOR trial). Artículo original @NEJM
@cimutHandayani This is the dose studied in the #ADVOR trial: https://t.co/Ib9hvdUkDE
RT @Neal94G: Does anyone routinely give acetazolamide with loop diuretics in acute decomp heart failure? Have you found it reduced LoS/ t…
Does anyone routinely give acetazolamide with loop diuretics in acute decomp heart failure? Have you found it reduced LoS/ time to decongestion? Based on: https://t.co/9VmDAVSSiF
RT @AmbrizMau: En este estudio multicéntrico aleatorizado, la adición de ACETAZOLAMIDA a la terapia con diuréticos de asa en pacientes con…
• September 29, 2022 • N Engl J Med 2022 • 387:1185-1195 DOI: 10.1056/NEJMoa2203094
RT @JonathanNefro: En hospitalizados por falla cardíaca congestiva, agregar a diuréticos acetazolamida 500mg IV por 3 días, comparado a pla…
RT @theindianheart: Full article open access #FOAMed #nejm: https://t.co/dE7rRuK36e
Full article open access #FOAMed #nejm: https://t.co/dE7rRuK36e
RT @JonathanNefro: En hospitalizados por falla cardíaca congestiva, agregar a diuréticos acetazolamida 500mg IV por 3 días, comparado a pla…
RT @medical_910: 急性代償性心不全患者において,ループ利尿薬治療にアセタゾラミドを追加すると,うっ血の改善率が高くなった。 #NEJM この論文あったね…当時話題になってたけど、結局ダイアモックス使ったこと無いな https://t.co/VlHrOaxF…
RT @medical_910: 急性代償性心不全患者において,ループ利尿薬治療にアセタゾラミドを追加すると,うっ血の改善率が高くなった。 #NEJM この論文あったね…当時話題になってたけど、結局ダイアモックス使ったこと無いな https://t.co/VlHrOaxF…
急性代償性心不全患者において,ループ利尿薬治療にアセタゾラミドを追加すると,うっ血の改善率が高くなった。 #NEJM この論文あったね…当時話題になってたけど、結局ダイアモックス使ったこと無いな https://t.co/VlHrOaxF7K
ADVOR trial https://t.co/PQMxr4oDJK
It has been a year since the ADVOR trial was published in @NEJM, and I'm wondering whether it has impacted practice. https://t.co/lZsfLmJPNu #MedTwitter, how often are you using acetazolamide to augment diuresis in patients hospitalized with ADHF? Comment & say why or why not.
RT @drhungo: @AlexMedBytes https://t.co/pXbO8NfCZl https://t.co/qqQG5CscwC
@AlexMedBytes https://t.co/pXbO8NfCZl https://t.co/qqQG5CscwC
@Allison_Dupont @jl35wilsonMD @Procyrion @PuzzleMedical Bumex/lasix bolus, then drip, no good response at 2-4 hours, diamox 500 mg. I would then try metolazone and increasing drip. If no response cvvh. No role for novel MCS devices outside of studies yet, drain-HF (NCT05677100) starting this yr. https://t.co/tKBxRE4our
The #ADVOR trial randomized 519 patients with acute decompensated heart failure to 500 mg IV #acetazolamide OD + standardized IV loop diuretics vs. standardized IV loop diuretics alone. https://t.co/GGzs6N4NqJ
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @javier20ch: Acetazolamida en ICAd (ADVOR trial). Artículo original @NEJM
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @RealTNagasawa: #利尿薬 #アセタゾラミド によるうっ血解除はいこちら、4.6±1.7 vs. 4.1±1.8L(2nd Morning、30-48h後)で尿量増。腎機能増悪、低カリウム、低血圧差無し。 Acetazolamide in Acute Dec…
#利尿薬 #アセタゾラミド によるうっ血解除はいこちら、4.6±1.7 vs. 4.1±1.8L(2nd Morning、30-48h後)で尿量増。腎機能増悪、低カリウム、低血圧差無し。 Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/5VaIsb4N9C
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @javier20ch: Acetazolamida en ICAd (ADVOR trial). Artículo original @NEJM
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @gcfmd: Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
Loop diuretic + acetazolamide vs loop alone PRO ⬇️ congestion score ⬇️
RT @javier20ch: Acetazolamida en ICAd (ADVOR trial). Artículo original @NEJM
RT @WICSBottomLine: #TBL Mini: ADVOR: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/UFoTk8bhNI Artic…
RT @WICSBottomLine: #TBL Mini: ADVOR: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/UFoTk8bhNI Artic…
RT @WICSBottomLine: #TBL Mini: ADVOR: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/UFoTk8bhNI Artic…
RT @WICSBottomLine: #TBL Mini: ADVOR: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/UFoTk8bhNI Artic…
#TBL Mini: ADVOR: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/UFoTk8bhNI Article by @WilfriedMullens Review by @hgmwalker89 #FOAMed https://t.co/mRmBujD8j8
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
Resultados del ADVOR Trial:Agregar acetazolamida IV al tratamiento estándar con diurético de asa al manejo de pacientes con #ICC descompensada mejoró la cogestión más rápidamente:
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
RT @edgarvlermamd: ADVOR: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulte…
体液過剰を伴う急性非代償心不全におけるアセタゾラミド Acetazolamide in Acute Decompensated Heart Failure with Volume Overload - PubMed https://t.co/0l6T3E2TUn
@SSCG2023 普通に使いますし安価で安全ですね。切れ味的にも不要なものを入れたくないときにきっちり管理できていいと思います。https://t.co/L7pKG4zSed
Anyone started using Acetazolamide in Acute heart failure after the NEJM paper ? Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/NZdqihxExm
RT @_anmco:
RT @_anmco:
RT @_anmco:
Dr. Catherine Lindsay reviewed Acetazolamide in Acute Decompensated Heart Failure with Volume Overload in #JournalClub. Exceptional work! https://t.co/RNJObkIP45
RT @mandres80: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/aqe4U5lJi0
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/aqe4U5lJi0
RT @InternaHCSC:
(5/5) ‼️ Trullas JC et al. Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. Eur Heart J 2022, 00, 1–11; ‼️ Mullens W et al. Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. N Engl J Med. 2022
The ADVOR trial (N Engl J Med 2022; 387: 1185-1195 DOI: 10.1056/NEJMoa2203094) has showed that the addition of acetazolamide to a loop diuretic in pts with acute decompensated heart failure results in a greater incidence of successful decongestion. Would you give it here?
RT @SBNephrology: This week’s journal club with Rushang Parikh MD @NorthportVAMC @StonyBrookMed: “Acetazolamide in Acute Decompensated Hear…
This week’s journal club with Rushang Parikh MD @NorthportVAMC @StonyBrookMed: “Acetazolamide in Acute Decompensated Heart Failure with Volume Overload” #NephTwitter #MedTwitter #HF https://t.co/dyGLwjepD3
RT @emergmedottawa: EMOttawa JC: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload via @NEJM https://t.co/3wrC60YGPl…
RT @emergmedottawa: EMOttawa JC: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload via @NEJM https://t.co/3wrC60YGPl…
EMOttawa JC: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload via @NEJM https://t.co/3wrC60YGPl Interpretation: Acetazolamide added to loop diuretics may increase rate of decongestion for patients admitted with acute decompensated heart failure. https://t.co/7F4BFAIGth
6. ADVOR Q. ループ利尿薬に加えてアセタゾラミドが近位尿細管でのNa再吸収を抑制するか? 体液過剰、NT-proBNP≥1000pg/ml以上のAHF患者519例 ✅プラセボと比較して有意にうっ血が解除 ✅死亡や再入院に有意な差は見られず ✅累積の尿量、Na利尿が増加し、利尿効果が向上 https://t.co/AEWRqRSgIw
What a great way to kick off 2023! An excellent Resident Grand Rounds presented by Dr. Alain Kameni, PGY2, and moderated by Dr. Anand Shukla @mshshospitalist. Dr. Kameni discussed the ADVOR trial titled "Acetazolamide in Acute Decompensated Heart Failure with Volume Overload"! https://t.co/uwBMPas3kM
昨日の抄読会① "Acetazolamide in acute decompensated heart failure with volume overload" (https://t.co/wlqudxZurx)
利尿薬 フロセミド+ダイアモックスが良いかも、て話 フロセミドのみだと尿へH+排泄促進→代謝性アルカローシス→CO2貯留 これを防ぐためにダイアモックス、 て使い方はしていたが、、 Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/YBCAMA7THM
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload - PubMed https://t.co/RAbyKtXdeY
RT @tkisogib4: https://t.co/uq6AwfsgRB ラシックス投与中の心不全患者にダイアモックス500㎎1日1回を併用VSプラセボ群 うっ血改善率42.2%VS30.5%RR1.46 95%CI1.17-1.82 合併症は有意なものはなし 臨床的には…
Hannah Hixenbaugh (@hannah_hix) will present: Acetazolamide in acute decompensated heart failure with volume overload. https://t.co/gUbYXQD9eX
Another great addition to the @uvaimr journal club family - Cardiology! Thanks to @shivanihanchate for getting things flowing by reviewing “Acetazolamide in Acute decompensated Heart Failure with Volume Overload”. https://t.co/qjiltpkjjL
#SCCMJC #PharmICU Presenter 3: Hannah Hixenbaugh, PharmD @Hannah__Hix PGY2 Critical Care Pharmacy Resident Cleveland Clinic Hillcrest Hospital Acetazolamide in acute decompensated heart failure with volume overload. @NEJM https://t.co/x1ddY78YlA
Tonight we resume the ACCP Critical Care PRN Journal Club. @cecilia_schowe will lead a discussion of Acetazolamide in Acute Decompensated Heart Failure with Volume Overload recently published in @NEJM by Mullins, et al. Discussion starts tonight at 8p EST! #TwitteRX #PharmCrit
RT @WilfriedMullens: #ADVOR clearly demonstrated that the addition of acetazolamide to loop diuretic therapy in patients with ADHF resulted…
@costiganishero I love that man. Here’s another one for your arsenal, came out a few months ago. ADVOR trial: https://t.co/DD5Sl3k3Tz I’m stoked to try this and see how it works
RT @WilfriedMullens: #ADVOR clearly demonstrated that the addition of acetazolamide to loop diuretic therapy in patients with ADHF resulted…
RT @WilfriedMullens: #ADVOR clearly demonstrated that the addition of acetazolamide to loop diuretic therapy in patients with ADHF resulted…
RT @WilfriedMullens: #ADVOR clearly demonstrated that the addition of acetazolamide to loop diuretic therapy in patients with ADHF resulted…
#ADVOR clearly demonstrated that the addition of acetazolamide to loop diuretic therapy in patients with ADHF resulted in a greater incidence of successful decongestion. (7/9) https://t.co/vahcXcCxji https://t.co/C1Ptj0TwIK
#Acetazolamide in Acute Decompensated Heart Failure with Volume Overload For more: https://t.co/uDOkYaf9RA
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/9gyF5XnBdx
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/DQfU8ElJZR
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/Eref98gwud via @YouTube
Moderate sized RCT: addition of acetazolamide to standard decongestion in heart failure. worked: better decongestion & even a slightly shorter stay. Can't imagine it would impact bigger outcomes. Take home: more diuresis produces... more diuresis https://t.co/ANGg9YqkKP
https://t.co/Sg0r3SjTnc - @gbosslet doesn’t know but his son won the spelling bee….
RT @YaleCardiology: Excited to welcome @WilfriedMullens for the @YaleHF Weekly Academic Conference "Acetazolamide in Acute Decompensated H…
RT @YaleCardiology: Excited to welcome @WilfriedMullens for the @YaleHF Weekly Academic Conference "Acetazolamide in Acute Decompensated H…
Excited to welcome @WilfriedMullens for the @YaleHF Weekly Academic Conference "Acetazolamide in Acute Decompensated Heart Failure with Volume Overload."
Étude multicentrique, contrôlée avec placebo, sur l’acétazolamide dans l’insuffisance cardiaque aiguë décompensée. https://t.co/L4T5pzUeaM #cardiologie https://t.co/SkMr51vEEM
本日の抄読会の論文。 ADHF患者に対するAcetazolamideのうっ血解除の効果をみたRCT。 結果は、治療開始から3日目までのcongestion scoreが有意に低かったものの、再入院や死亡は両群で有意差なし。 心リハとの関連は不明ですが、医者の考えを知る機会としては貴重です。 https://t.co/vhKg3zWLZO
RT @SFMU_MS: https://t.co/LLQGnrOm5V Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. NEJM aout 2022
https://t.co/LLQGnrOm5V Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. NEJM aout 2022
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM これは、primary outcomeだけでなく、再入院率を評価しなければいけないような気がします。 https://t.co/Zc4nBAXWjb
RT @mnaesens: Acetazolamide in acute decompensated heart failure with volume overload - ⬆️incidence of successful decongestion Congrats @W…
RT @com_SFNDT:
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/Nd1QGPDcWT
NEJM: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/DErit3nWWk まさかのダイアモックス…!
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/wyuIS3NgoQ @CardiologiaSVC @secardiologia @SIAC_cardio @3Ccardio @SVMI_Nacional
RT @mnaesens: Acetazolamide in acute decompensated heart failure with volume overload - ⬆️incidence of successful decongestion Congrats @W…
Acetazolamide in acute decompensated heart failure with volume overload - ⬆️incidence of successful decongestion Congrats @WilfriedMullens @JeroenDauw @PieterMartensMD @FH_Verbrugge et al @futurehealthzol Important work with impact
Add a little Diamox to your (patient’s) day. Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/fzj6M51XNd
RT @com_SFNDT:
RT @com_SFNDT:
RT @NephJC: Hello everyone and welcome to NephJC! The discussion tonight is about the ADVOR Trial published in NEJM: Acetazolamide in Acute…
Hello everyone and welcome to NephJC! The discussion tonight is about the ADVOR Trial published in NEJM: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. doi: 10.1056/NEJMoa2203094 https://t.co/pjwKxvk3A0 #NephJC
RT @NephJC: Happening in just one hour from now! NephJC Chat on Acetazolamide in Acute Decompensated Heart Failure with Volume Overload @NS…
Happening in just one hour from now! NephJC Chat on Acetazolamide in Acute Decompensated Heart Failure with Volume Overload @NSMCInternship #nephjc #POD1 #Awesomolars
アセタゾラミドの心不全急性期治療の効果を今更斜め読み。eGFR<20は除外されてる。アシドーシスは問題にならなかった。入院期間短縮はNNT 9程度。だが1-2日程度の短縮。3ヶ月後死亡や再入院は減らさない。層別解析で元の利尿薬が少なく、eGFR<40、HFpEFの方が良い結果。 https://t.co/kHKweUeJ1r
RT @NephJC: Hello everyone and welcome to NephJC! The discussion tonight is about ADVOR Trial published in NEJM Acetazolamide in Acute Dec…
RT @NephJC: Hello everyone and welcome to NephJC! The discussion tonight is about ADVOR Trial published in NEJM Acetazolamide in Acute Dec…
Hello everyone and welcome to NephJC! The discussion tonight is about ADVOR Trial published in NEJM Acetazolamide in Acute Decompensated Heart Failure with Volume Overload N Engl J Med 2022 Aug 27. doi: 10.1056/NEJMoa2203094 #NephJC
Happening in one hour from now! NephJC Chat on Acetazolamide in Acute Decompensated Heart Failure with Volume overload @NSMC internship #nephjc #POD1 # Awesomolars
2 min Cardiology(臨床論文、担当:山田祐資) Acetazolamide in Acute Decompensated Heart Failure with Volume Overload N Engl J Med. 2022 Aug 27. doi: 10.1056/NEJMoa2203094. #Cardiology
ADVOR試験の結果により、うっ血は早期から積極的に治療する重要性が強調され、利尿反応の指標としてナトリウム利尿を使用することが支持された Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/ZwTV9AjlrA
若干アセタゾラミドで腎臓のイベントが多い気するなぁ。 Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/xKybJ7GM5P
【RCT】体液量過剰の臨床兆候、NT-proBNP>1000pg/mLまたはBNP>250pg/mLを伴う急性非代償性心不全患者に対するループ利尿薬の静注へのアセタゾラミドの追加は、プラセボの追加と比較して、うっ血解除を増加させた。 #ペ読 https://t.co/C77smLcDkM
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
RT @bryanacotton1: Better volume offload/diuretic efficiency with addition of acetazolamide to loop diuretics Acetazolamide in Acute Dec…
RT @bryanacotton1: Better volume offload/diuretic efficiency with addition of acetazolamide to loop diuretics Acetazolamide in Acute Dec…
RT @ALEX_MISCHIE: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/iB2E0LHvWf
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/iB2E0LHvWf
RT @bryanacotton1: Better volume offload/diuretic efficiency with addition of acetazolamide to loop diuretics Acetazolamide in Acute Dec…
Better volume offload/diuretic efficiency with addition of acetazolamide to loop diuretics Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/owmb1hBRoa
Bugün #NEJM Akut dekompanse #kalpyetersizliği olgularında #Furosemide'e karbonik anhidraz inhibitörü #Acetazolamide eklenmesinin sonuçları. Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/YA4c10On3x
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/vw1wbxWf96
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/4SZPikm3lk
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
RT @WilfriedMullens: Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of…
Both diuretic #heartfailure trials are of additive value but #advor strongly supports use of #acetazolamide on top of loop diuretic in all EF ranges. 'Door to combo-diuretic' time but based upon scientific data available probably Acetazolamide first. https://t.co/9uDtNS1WOt https://t.co/p9InzbRf7q https://t.co/QTw94pcOud
Provocative new trial in @nejm on acetazolamide in acute decompensated heart failure... something to add to the toolbox @QuanBuiMD @EricAdler17? Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/5F7vVRmgXF
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/TUSPFEcq6s #revistas #feedly
RT @drpaari: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/9A1bVhg53s
当科スタッフが最近読んだ論文紹介(不定期) 非代償性急性心不全に対するアセタゾラミド "Acetazolamide in Acute Decompensated Heart Failure with Volume Overload" (https://t.co/wlqudxZurx)
RT @drpaari: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/9A1bVhg53s
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/9A1bVhg53s
Trend up+16: Mullens W, ..., Advor Study Group (N Engl J Med) __Acetazolamide in Acute Decompensated Heart Failure with Volume Overload__ https://t.co/dKMd43hfdv
#Acetazolamide helps treat volume overload in #heartfailure @nejm https://t.co/GgFI0ujjRR https://t.co/DyhU4WmIdP
RT @kdjhaveri: Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/7UMkGKBY7I
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload | NEJM https://t.co/Du6FfUYyYn
https://t.co/uq6AwfsgRB ラシックス投与中の心不全患者にダイアモックス500㎎1日1回を併用VSプラセボ群 うっ血改善率42.2%VS30.5%RR1.46 95%CI1.17-1.82 合併症は有意なものはなし 臨床的にはダイアモックス投与で低Cl性アルカローシスによる代償性CO2貯留を防げている効果も感じるため有用な薬
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/jXCI9S83vb
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload. https://t.co/c8dv1FBEKu
RT @rudolf_deboer: Congratulations to @WilfriedMullens and team for executing the seminal ADVOR trial. Audience in room Barcelona exstatic!…
RT @rudolf_deboer: Congratulations to @WilfriedMullens and team for executing the seminal ADVOR trial. Audience in room Barcelona exstatic!…
#flozins https://www.nejm.org/doi/full/10.1056/NEJMoa2203094?query=featured_home
Congratulations to @WilfriedMullens and team for executing the seminal ADVOR trial. Audience in room Barcelona exstatic! @kevin_damman @jozinetm @ESCardioNews #esc2022 https://t.co/TfjPIld6uc https://t.co/u7bVVLrKTm
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload https://t.co/KRFXlDLqtJ https://t.co/EVWyzuAEYp