August 2022 PMID 36034582

Targeting : Crossroads of Signaling and Immune Inhibition.

Shumei Kato, Yu Fujiwara, David S Hong

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Mentions

42
Peak: 11 in Aug 2022
across 2 sources since Aug 2022

Extended reach

56,867
potential audience

Total likes

93

Video views

738

Mentions per month

Aug 2022 – Feb 2023

Where it's discussed

  • X / Twitter40 posts
  • YouTube2 videos

AI synopsis

What people are saying

Participants widely praise the article's significance, referencing its status as the most downloaded in 2022 and noting the detailed review on targeting KRAS and immune inhibition, fostering interest and recognition of its impact. The tone is generally positive and engaged, with mentions of related interviews and developments, although some comments are more about learning from the content rather than critical analysis.

AgreementModerate agreement

Most discussions express favorable views, highlighting the significance of the research and its potential impact, indicating general agreement with the publication's importance.

InterestHigh interest

The strong focus on KRAS, immunotherapy, and biomarkers shows high interest among participants, with multiple mentions of ongoing developments and clinical relevance.

EngagementModerate engagement

Comments reflect some in-depth engagement, such as discussions about KRAS inhibitors and the potential for future strategies, but lack extensive critique or detailed analysis.

ImpactModerate impact

The discussions suggest the article is considered influential, especially as it being the top downloaded publication of 2022 and sparking multiple interviews and online discussions.

Abstract in brief

  • The text explains that mutations in the RAS gene are common in cancers like lung, colorectal, and pancreatic cancer, but targeting these mutations has been difficult due to the instability of the RAS protein, except for the recent success with the G12C inhibitor.
  • The development of immune checkpoint inhibitors has transformed cancer treatment by improving our understanding of the tumor immune environment and enhancing the immune system's ability to fight cancer.
  • The review discusses the clinical features of cancers with RAS mutations, the impact of G12C inhibitors on the tumor environment, and future strategies combining these inhibitors with immune therapies to overcome resistance and improve outcomes for patients.]

Top posts

Most liked on X and Bluesky
Razelle Kurzrock, MD
@Dr_R_Kurzrock · X

Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice review by Kato, Fujiwara, and Hong! https://t.co/1NzXUnnFuu

Sep 2, 2022 · 19 likes · 8 shares · 8,278 followers View post →
JIPO Editors
@JIPOEditors · X

New #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35mF5cYMAB Read: https://t.co/coCAlZqOww #Biomarker @R_Okamura_MD @jacobadashek @Dr_R_Kurzrock @mirella_nardo @OncologyNetwork

Oct 5, 2022 · 11 likes · 5 shares · 816 followers View post →
Yu Fujiwara, MD
@waraonc23 · X

Now available online! It was really fun to learn how KRAS inhibitors have been developed and work with Dr. Kato and Dr. Hong (@DavidHongMD). Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology https://t.co/We7ll1i6Bn

Aug 18, 2022 · 11 likes · 3 shares · 752 followers View post →
Mirella Nardo, MD
@mirella_nardo · X

What a pleasure to conduct this @JIPOEditors Interview: Dr Razelle Kurzrock on PD-1 for predicting response to anti-PF1/PD-L1. https://t.co/7uxyLsNhKV via @YouTube

Oct 3, 2022 · 11 likes · 1 share · 686 followers View post →
JIPO Editors
@JIPOEditors · X

#JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35mF5cYMAB Read: https://t.co/coCAlZqOww #Biomarker @R_Okamura_MD @jacobadashek @Dr_R_Kurzrock @mirella_nardo @OncologyNetwork

Dec 21, 2022 · 9 likes · 3 shares · 816 followers View post →
JIPO Editors
@JIPOEditors · X

#1 most downloaded #JIPO article of 2022: "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Kato et al. https://t.co/qDi8i1ufHm #KRAS #immunotherapy #ICIs #review https://t.co/tkFueBhYvz

Feb 15, 2023 · 7 likes · 2 shares · 816 followers View post →

All mentions

Christophe Massard
@drcmassard · X

RT @JIPOEditors: #1 most downloaded #JIPO article of 2022: "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Kato et al.…

Feb 15, 2023 · 2 shares · 2,116 followers View post →
CancerLinks 
@CancerLinks · X

RT @JIPOEditors: #1 most downloaded #JIPO article of 2022: "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Kato et al.…

Feb 15, 2023 · 2 shares · 97 followers View post →
JIPO Editors
@JIPOEditors · X

#1 most downloaded #JIPO article of 2022: "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Kato et al. https://t.co/qDi8i1ufHm #KRAS #immunotherapy #ICIs #review https://t.co/tkFueBhYvz

Feb 15, 2023 · 7 likes · 2 shares · 816 followers View post →
Sewanti Limaye
@SewantiLimaye · X

RT @JIPOEditors: #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35m…

Dec 21, 2022 · 3 shares · 3,119 followers View post →
Razelle Kurzrock, MD
@Dr_R_Kurzrock · X

RT @JIPOEditors: #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35m…

Dec 21, 2022 · 3 shares · 8,278 followers View post →
CancerLinks 
@CancerLinks · X

RT @JIPOEditors: #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35m…

Dec 21, 2022 · 3 shares · 97 followers View post →
JIPO Editors
@JIPOEditors · X

#JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35mF5cYMAB Read: https://t.co/coCAlZqOww #Biomarker @R_Okamura_MD @jacobadashek @Dr_R_Kurzrock @mirella_nardo @OncologyNetwork

Dec 21, 2022 · 9 likes · 3 shares · 816 followers View post →
Aysun Ş. Yıkılmaz
@aysunsenturk · X

RT @JIPOEditors: #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35m…

Nov 20, 2022 · 5 shares · 280 followers View post →
Iylon
@IylonOncology · X

RT @JIPOEditors: #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35m…

Nov 20, 2022 · 5 shares · 266 followers View post →
Sewanti Limaye
@SewantiLimaye · X

RT @JIPOEditors: #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35m…

Nov 19, 2022 · 5 shares · 3,119 followers View post →
CancerLinks 
@CancerLinks · X

RT @JIPOEditors: #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35m…

Nov 19, 2022 · 5 shares · 97 followers View post →
JIPO Editors
@JIPOEditors · X

#JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35mF5cZkq9 Read: https://t.co/coCAlZrmm4 #Biomarker @R_Okamura_MD @jacobadashek @Dr_R_Kurzrock @mirella_nardo @OncologyNetwork

Nov 19, 2022 · 6 likes · 5 shares · 816 followers View post →
Innovative Oncology Network
@OncologyNetwork · X

RT @JIPOEditors: New #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co…

Oct 7, 2022 · 5 shares · 140 followers View post →
Innovations Journals
@InnoJournals · X

RT @JIPOEditors: New #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co…

Oct 5, 2022 · 5 shares · 149 followers View post →
Sewanti Limaye
@SewantiLimaye · X

RT @JIPOEditors: New #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co…

Oct 5, 2022 · 5 shares · 3,119 followers View post →
Deniz Can Guven
@DenizCanGuven1 · X

RT @JIPOEditors: New #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co…

Oct 5, 2022 · 5 shares · 2,475 followers View post →
CancerLinks 
@CancerLinks · X

RT @JIPOEditors: New #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co…

Oct 5, 2022 · 5 shares · 97 followers View post →
JIPO Editors
@JIPOEditors · X

New #JIPO interview: Dr. Razelle Kurzrock discusses using PD-1 to predict response to #immunotherapy Listen: https://t.co/35mF5cYMAB Read: https://t.co/coCAlZqOww #Biomarker @R_Okamura_MD @jacobadashek @Dr_R_Kurzrock @mirella_nardo @OncologyNetwork

Oct 5, 2022 · 11 likes · 5 shares · 816 followers View post →
Aysun Ş. Yıkılmaz
@aysunsenturk · X

RT @mirella_nardo: What a pleasure to conduct this @JIPOEditors Interview: Dr Razelle Kurzrock on PD-1 for predicting response to anti-PF1/…

Oct 4, 2022 · 1 share · 280 followers View post →
Mirella Nardo, MD
@mirella_nardo · X

What a pleasure to conduct this @JIPOEditors Interview: Dr Razelle Kurzrock on PD-1 for predicting response to anti-PF1/PD-L1. https://t.co/7uxyLsNhKV via @YouTube

Oct 3, 2022 · 11 likes · 1 share · 686 followers View post →
Gregory Botta
@gregorybotta · X

RT @Dr_R_Kurzrock: Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice…

Sep 4, 2022 · 8 shares · 102 followers View post →
Hasan Tahir
@hasantahir1990 · X

RT @Dr_R_Kurzrock: Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice…

Sep 3, 2022 · 8 shares · 1,395 followers View post →
Gillian Smith
@gillianthurso · X

RT @Dr_R_Kurzrock: Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice…

Sep 3, 2022 · 8 shares · 50 followers View post →
Kevin Spring
@KevinSpring20 · X

RT @Dr_R_Kurzrock: Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice…

Sep 3, 2022 · 8 shares · 485 followers View post →
Jayprakash Mandal, PhD
@CancerSleuth · X

RT @Dr_R_Kurzrock: Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice…

Sep 3, 2022 · 8 shares · 255 followers View post →
tappo
@tappo70933491 · X

RT @Dr_R_Kurzrock: Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice…

Sep 2, 2022 · 8 shares · 36 followers View post →
Iylon
@IylonOncology · X

RT @Dr_R_Kurzrock: Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice…

Sep 2, 2022 · 8 shares · 266 followers View post →
David S. Hong MD
@DavidHongMD · X

RT @Dr_R_Kurzrock: Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice…

Sep 2, 2022 · 8 shares · 3,665 followers View post →
Razelle Kurzrock, MD
@Dr_R_Kurzrock · X

Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology. Nice review by Kato, Fujiwara, and Hong! https://t.co/1NzXUnnFuu

Sep 2, 2022 · 19 likes · 8 shares · 8,278 followers View post →
Aysun Ş. Yıkılmaz
@aysunsenturk · X

New interview about targeting KRAS from JIPO! ⁦@JIPOEditors⁩ ⁦@jibranahmed1⁩ https://t.co/nUP8H3kaNx

Sep 1, 2022 · 3 likes · 280 followers View post →
Yu Fujiwara, MD
@waraonc23 · X

RT @JIPOEditors: Watch and read "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Shumei Kato, Yu Fujiwara, and David S. H…

Aug 31, 2022 · 4 shares · 752 followers View post →
Mohamed Derbala, MD
@MDerbalaMD · X

RT @JIPOEditors: Watch and read "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Shumei Kato, Yu Fujiwara, and David S. H…

Aug 31, 2022 · 4 shares · 403 followers View post →
Aysun Ş. Yıkılmaz
@aysunsenturk · X

RT @JIPOEditors: Watch and read "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Shumei Kato, Yu Fujiwara, and David S. H…

Aug 31, 2022 · 4 shares · 280 followers View post →
David S. Hong MD
@DavidHongMD · X

RT @JIPOEditors: Watch and read "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Shumei Kato, Yu Fujiwara, and David S. H…

Aug 31, 2022 · 4 shares · 3,665 followers View post →
JIPO Editors
@JIPOEditors · X

Watch and read "Targeting KRAS: Crossroads of Signaling and Immune Inhibition" by Shumei Kato, Yu Fujiwara, and David S. Hong. Read: https://t.co/qDi8i1ufHm Watch: https://t.co/LntuYyzdPR #KRASmutation #immunecheckpointinhibitor @waraonc23 @DavidHongMD @ANaingMD

Aug 31, 2022 · 6 likes · 4 shares · 816 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Targeting KRAS: Crossroads of Signaling and Immune Inhibition https://t.co/gLzoxLedYv #pancreaticcancer #oncology https://t.co/AyeMNvXsXl

Aug 29, 2022 · 891 followers View post →
Carmine Fedele
@CarminuzzoF · X

RT @waraonc23: Now available online! It was really fun to learn how KRAS inhibitors have been developed and work with Dr. Kato and Dr. Hong…

Aug 20, 2022 · 3 shares · 412 followers View post →
Ashraf Saad, bridging Glycobiology and Oncology!
@AsAshraf123321 · X

RT @waraonc23: Now available online! It was really fun to learn how KRAS inhibitors have been developed and work with Dr. Kato and Dr. Hong…

Aug 19, 2022 · 3 shares · 1,644 followers View post →
David S. Hong MD
@DavidHongMD · X

RT @waraonc23: Now available online! It was really fun to learn how KRAS inhibitors have been developed and work with Dr. Kato and Dr. Hong…

Aug 18, 2022 · 3 shares · 3,665 followers View post →
Yu Fujiwara, MD
@waraonc23 · X

Now available online! It was really fun to learn how KRAS inhibitors have been developed and work with Dr. Kato and Dr. Hong (@DavidHongMD). Targeting KRAS: Crossroads of Signaling and Immune Inhibition | Journal of Immunotherapy and Precision Oncology https://t.co/We7ll1i6Bn

Aug 18, 2022 · 11 likes · 3 shares · 752 followers View post →