Signal Transduct Target Ther September 2022 PMID 36050306

Lactate metabolism in human health and disease.

Xiaolu Li, Yanyan Yang, Bei Zhang, Xiaotong Lin, Xiuxiu Fu, Yi An, Yulin Zou, Jian-Xun Wang, Zhibin Wang, Tao Yu

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Peak: 38 in Sep 2022

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Sep 2022 – Sep 2025

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The overall tone of the discussions reveals a recognition of the article’s illustrative figures and the importance of lactate in regulating cellular processes, with comments like 'excelentes figuras' emphasizing visual or conceptual clarity. The use of words like 'implicado' (implying involvement) and references to specific pathways shows an analytical tone, reflecting a moderate level of deep engagement and interest in the subject's scientific implications.

AgreementModerate agreement

Most discussions acknowledge the importance of the article, with some posts highlighting its relevance in understanding physiological and pathological processes.

InterestHigh interest

Discussions show a high level of curiosity, especially with posts referencing figures, figure descriptions, and mention of the implications in health and disease contexts.

EngagementModerate engagement

The comments range from brief mentions of figures and highlights to more substantive references linking lactate metabolism to broader physiological functions, indicating moderate but meaningful engagement.

ImpactModerate impact

While some posts suggest the article may influence ongoing research and understanding, most express appreciation or highlight its significance rather than direct calls for immediate clinical application.

Abstract in brief

Lactate, once seen mainly as a waste product of glycolysis, is now understood to play a crucial role in cell signaling, energy metabolism, and tumor growth, especially through the Warburg effect.
The concept of the lactate shuttle highlights its importance in connecting different cells, organs, and tissues through signaling functions, with recent discoveries like lactylation revealing its involvement in processes such as tumor proliferation, neural activity, and inflammation.
This review emphasizes the significance of lactate in maintaining physiological balance and its impact on diseases, particularly cancer and inflammation, while also exploring how lactylation modifies proteins and influences biological functions, guiding future research directions.

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Lactate Metabolism's Role in Human Health and Disease Progression

Lactate, once considered merely a waste product, is now recognized for its vital roles in cell signaling, energy metabolism, and tumor growth. The review discusses lactate's involvement in physiological processes…

Medicine RTCL TV · Aug 5, 2023 24 views

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Lactate metabolism in human health and disease.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

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All mentions

Lactate Metabolism's Role in Human Health and Disease Progression