Detection of Epidermal Growth Factor Receptor Expression in Breast Cancer Cell Lines Using an Ion-Sensitive Field-Effect Transistor in Combination with Enzymatic Chemical Signal Amplification.

Miyuki Tabata, Xinyue Liu, Chattarika Khamhanglit, Sayo Kotaki, Yuji Miyahara

September 2022 J Am Chem Soc

Synopsis of Social media discussions

The discussions reflect a balanced view, with posts describing the use of transistors and enzymatic signal amplification for detecting cancer markers, suggesting interest in technological advancements. Words like 'innovative,' 'potential,' and 'future' indicate a positive outlook on the research's significance and possible practical applications.

A
Agreement
 Moderate agreement

The majority of discussions acknowledge the significance of the research, emphasizing its innovative detection method for cancer markers.

I
Interest
 Moderate level of interest

Posts show moderate curiosity, with mentions of potential applications like liquid biopsies and cancer detection, indicating some engagement but not widespread enthusiasm.

E
Engagement
 Moderate level of engagement

Discussions reference technical aspects such as enzymatic amplification and transistors, showing a fair level of technical interest and deeper engagement.

I
Impact
 Moderate level of impact

Multiple posts highlight the potential for this technology to impact cancer diagnosis and treatment, suggesting a recognized potential for high influence.

Social Mentions

YouTube

2 Videos

Twitter

21 Posts

Blogs

3 Articles

News

15 Articles

Metrics

Video Views

321

Total Likes

44

Extended Reach

1,638,395

Social Features

41

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Innovative FET-Based Method for Detecting EGFR in Breast Cancer Cells

Innovative FET-Based Method for Detecting EGFR in Breast Cancer Cells

A novel detection method for EGFR using a cell-based field-effect transistor combined with enzymatic signal amplification is introduced, focusing on breast cancer cells. The FET accurately measures EGFR levels, matching traditional methods and promising smaller, cost-effective cancer testing tools.

Tokyo Medical and Dental University東京医科歯科大学

February 28, 2023

306 views

Innovative Transistor-Based Method for Detecting Cancer Cell Markers

Innovative Transistor-Based Method for Detecting Cancer Cell Markers

Researchers from Japan have developed a new less invasive technique for cancer detection. Using a cell-based field-effect transistor combined with enzymatic signal amplification, this method accurately measures cancer markers like EGFR in breast cancer cells, showing promise for future liquid biopsy applications.

Today's Sciencology

November 1, 2022

15 views

  • TMDU - Tokyo Medical and Dental University
    @TMDUniversity (Twitter)

    New video from "TMDU Research Activities 2022-2023" has been released. “Transistors help identify cancer cell markers” by Yuji Miyahara. Please take a look! YouTube: https://t.co/kG2oDwQUjm HP: https://t.co/wmMidXpTmz #東京医科歯科大学 #tmdu @J_A_C_S https://t.co/qb61BdNGUx
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    May 9, 2023

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  • NP AGARWAL世界一フォローを目指しますAiming best in world.
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    RT @medical_xpress: Transistors help identify #cancer cell markers @J_A_C_S https://t.co/TRAGqXCQxF https://t.co/feU1po0wrJ
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    November 9, 2022

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  • Analio Dugarte
    @analioj (Twitter)

    RT @medical_xpress: Transistors help identify #cancer cell markers @J_A_C_S https://t.co/TRAGqXCQxF https://t.co/feU1po0wrJ
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    November 1, 2022

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  • J. Am. Chem. Soc.
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    RT @medical_xpress: Transistors help identify #cancer cell markers @J_A_C_S https://t.co/TRAGqXCQxF https://t.co/feU1po0wrJ
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    October 31, 2022

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  • serrgv
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    RT @medical_xpress: Transistors help identify #cancer cell markers @J_A_C_S https://t.co/TRAGqXCQxF https://t.co/feU1po0wrJ
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    October 31, 2022

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  • Medical Xpress
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    RT @medical_xpress: Transistors help identify #cancer cell markers @J_A_C_S https://t.co/TRAGqXCQxF https://t.co/feU1po0wrJ
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    October 31, 2022

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  • Science X
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    RT @medical_xpress: Transistors help identify #cancer cell markers @J_A_C_S https://t.co/TRAGqXCQxF https://t.co/feU1po0wrJ
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    October 31, 2022

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  • Phys.org
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    RT @medical_xpress: Transistors help identify #cancer cell markers @J_A_C_S https://t.co/TRAGqXCQxF https://t.co/feU1po0wrJ
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    October 31, 2022

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  • Medical Xpress
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    Transistors help identify #cancer cell markers @J_A_C_S https://t.co/TRAGqXCQxF https://t.co/feU1po0wrJ
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    October 31, 2022

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    September 12, 2022

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  • @info1628MF1319 (Twitter)

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    September 7, 2022

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  • TMDU - Tokyo Medical and Dental University
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    Detection of cell membrane proteins by cell-based field-effect transistor (FET) could lead to the realization of liquid biopsy in the future. HP: https://t.co/wmMidXpTmz DOI: https://t.co/pMY2NTZbXw #東京医科歯科大学 #tmdu @J_A_C_S
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    September 7, 2022

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    1

  • TMDU - Tokyo Medical and Dental University
    @TMDUniversity (Twitter)

    A new paper by Tabata M, Miyahara Y et al: Detection of epidermal growth factor receptor expression in breast cancer cell lines using an ion-sensitive field effect transistor in combination with enzymatic chemical signal amplification in Journal of the American Chemical Society. https://t.co/aHI1jgOiKk
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    September 7, 2022

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  • 東京医科歯科大学
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    【研究成果発表】 「細胞トランジスタによる細胞膜タンパク質の検出」－リキッドバイオプシーへ適用の可能性－（生体材料工学研究所 特任准教授 田畑 美幸、特任教授 宮原 裕二） プレスリリース https://t.co/MqI9zWtyOa DOI: https://t.co/dYa6gUsLnc ＃東京医科歯科大学 #tmdu https://t.co/7MWvAsczR1
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    September 7, 2022

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    September 6, 2022

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    RT @J_A_C_S: Detection of EGFR Expression in Breast Cancer Cell Lines Using an Ion-Sensitive Field-Effect Transistor in Combination with En…
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    September 4, 2022

    1

  • J. Am. Chem. Soc.
    @J_A_C_S (Twitter)

    Detection of EGFR Expression in Breast Cancer Cell Lines Using an Ion-Sensitive Field-Effect Transistor in Combination with Enzymatic Chemical Signal Amplification @TMDUniversity #EGFR #Expression #BreastCancer #Transistor #Signal #Amplification https://t.co/YfN8rCK6tF
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    September 4, 2022

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  • ScienceStop
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    RT @isciverse: Detection of Epidermal Growth Factor Receptor Expression in Breast Cancer Cell Lines Using an Ion-Sensitive Field-Effect Tra…
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    September 3, 2022

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  • Top Science
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    Detection of Epidermal Growth Factor Receptor Expression in Breast Cancer Cell Lines Using an Ion-Sensitive Field-Effect Transistor in Combination with Enzymatic Chemical Signal Amplification @isciverse #Chemistry #ChemTwitter #scicomm #science https://t.co/SFChrbOOmV https://t.co/wEFMvMSTlg
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    September 3, 2022

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  • Paperbirds_Oncology
    @PaperbirdsO (Twitter)

    New article: Detection of Epidermal Growth Factor Receptor Expression in Breast Cancer Cell Lines Using an Ion-Sensitive Field-Effect Transistor in Combination with Enzymatic Chemical Signal Amplification https://t.co/gVRKpDg3E9 #breastcancer #oncology https://t.co/iGE3moyWTN
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Abstract Synopsis

  • A novel detection method for EGFR using a cell-based field-effect transistor (FET) combined with enzymatic signal amplification is introduced, focusing on breast cancer cells.
  • Four breast cancer cell lines with varying EGFR expression levels were tested, showing that the FET could accurately measure these levels by utilizing secondary antibodies linked to glucose oxidase.
  • The results matched traditional fluorescence detection methods and suggest that this FET approach could lead to smaller, cost-effective tools for cancer testing in future liquid biopsies.