Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G9fzw Great to see this now officially in print @ScienceMagazine @AnastasiaShind @gladyshev_lab & colleagues including @jpoganik @JPCastro_Aging @akaya_lab https://t.co/hDlY6c49Nj
Rapamycin treatment during development extends life span and health span of male mice and .
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Sep 2022 – Mar 2025Where it's discussed
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AI synopsis
What people are saying
Several discussions highlight the remarkable findings of the research, emphasizing how rapamycin can extend lifespan and healthspan and referencing its effects seen not only in mice but also in Daphnia magna. Expressions like 'interesting' and 'game-changing' indicate an enthusiastic tone, while mentions of specific results suggest a well-informed audience that is actively contemplating the importance of these findings in the context of longevity research.
The majority of discussions express strong support for the study's findings, with many users explicitly praising the research.
Posts consistently reflect a high level of curiosity about the implications of the study and its results.
While many posts acknowledge the research, few display deep engagement or discussion of its methodologies or broader implications.
There is a widely held belief that this research could significantly influence the field of aging and longevity.
Abstract in brief
- Rapamycin treatment during the first 45 days of life in genetically diverse UMHET3 male mice significantly extended their median lifespan by 10%, demonstrating a strong effect on males.
- The treatment also delayed reproductive age and resulted in smaller body size without affecting the number of offspring produced.
- Additionally, treated mice showed improved health markers and a younger liver transcriptome and epigenome, indicating that targeting development pharmacologically could be a new approach to longevity.
Top posts
Most liked on X and BlueskyOur new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulations to @AnastasiaShind and everyone involved. https://t.co/xVdJK0Bhf0
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP0cGLeE
This is secretly the first paper showing that rapamycin decreases mouse frailty index, no? So far the FI had very little pharmacologic validation so it is great to see the data. https://t.co/6eoKQGqUmE
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/sQupYmQ0m4
All mentions
Bryan Johnson's Decision to Stop Using Rapamycin for Longevity
Impact of Methionine Restriction on Longevity and Metabolic Health
Methionine restriction from middle age has been shown to extend lifespan, reduce tumor growth, and promote weight loss in animals, mimicking rapamycin effects. This video explores how dietary methionine influences…
@cutleraging @ydeigin @prof_horvath I believe this is closely linked to why rapamycin given only during development still extends lifespan https://t.co/3wiVEE5iNZ
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @Aging_Scientist: This is secretly the first paper showing that rapamycin decreases mouse frailty index, no? So far the FI had very litt…
This is secretly the first paper showing that rapamycin decreases mouse frailty index, no? So far the FI had very little pharmacologic validation so it is great to see the data. https://t.co/6eoKQGqUmE
@philosophising4 @MedEckardt @yeeseak this? https://t.co/c152WibXrY just one wild guess
@drmichaellevin Here's one very cool example studying the same aging intervention in both mice and daphnia https://t.co/OXUJIWU2Xc (also there's lots of c elegans work out there)
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @hernangraffe: https://t.co/iW6AAwtNmd
https://t.co/iW6AAwtNmd
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/4Dy26EHMaZ
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
The same effect was seen in a similar study of the planktonic crustacean Daphnia magna. 4/ @VadimGladyshev @AnastasiaShind @gladyshev_lab @jpoganik @harvardmed @akaya_lab @VCU https://t.co/Ng3ZSgh1bq
Do NOT give a mouse a cookie. Give him rapamycin instead: https://t.co/yrxoqJa8UU
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
1/ Mice who are given Rapamycin, an immunosuppressant drug, for the first 45 days of life end up living 10% longer and show signs https://t.co/FUP5c263ya
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @hernangraffe: https://t.co/tNCdF4DqTz
https://t.co/tNCdF4DqTz
https://t.co/eAHuwB8ZOA
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @AgingBiology: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
https://t.co/5v0aoIKz89
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
we obtained a hint of pheno-transitivity between mice and Daphnia, combining advantages of pharmaco-biology across two species is very promising for Longevity field. https://t.co/Wz9s2RaHBx
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna 美国哈佛医学院的Anastasia V. Shindyapina与Vadim N. Gladyshev发现雷帕霉素治疗可延长发育期中雄性小鼠和大型溞的寿命和健康期,其中小鼠中位寿命延长10%。 https://t.co/H4Kr1DKBK4
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna | Science Advances. Interesting! https://t.co/zXUUf446yo
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
Study demonstrated that short-term rapamycin treatment during development is a novel longevity intervention that acts by slowing down development and aging, suggesting that aging may be targeted already early in life. https://t.co/IgHZ0z9fho
RT @_atanas_:
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @_atanas_:
RT @AgingBiology: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @AgingBiology: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/Z4usIFBXUm
RT @AgingBiology: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP…
RT @AgingBiology: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP…
RT @AgingBiology: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP…
RT @AgingBiology: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP…
RT @AgingBiology: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP…
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ojcP0cGLeE
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @jfcryan: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/sQupYmQ0m4
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
RT @gladyshev_lab: Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulatio…
#WeekendRead! #LiveForever! Rapamycin delays growth & reproductive age but extends the lifespan & preserve health in adulthood when given during development by affecting liver transcription & DNA methylation! @ScienceAdvances @gladyshev_lab https://t.co/dAm0lPwymq
Our new paper shows that rapamycin given during development extends lifespan and healthspan later in life. Congratulations to @AnastasiaShind and everyone involved. https://t.co/xVdJK0Bhf0
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna | Science Advances https://t.co/HhEAlJ4cGe
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/sQupYmQ0m4
RT @_atanas_:
RT @_atanas_:
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @_atanas_:
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @_atanas_:
RT @_atanas_:
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/ct3rPEj9yG
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
RT @agingdoc1: Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G…
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna https://t.co/O7k20G9fzw Great to see this now officially in print @ScienceMagazine @AnastasiaShind @gladyshev_lab & colleagues including @jpoganik @JPCastro_Aging @akaya_lab https://t.co/hDlY6c49Nj