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Nat Genet October 2022 PMID 36163277

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups.

Manuel Mattheisen, Jakob Grove, Thomas D Als, Joanna Martin, Georgios Voloudakis, Sandra Meier, Ditte Demontis, Jaroslav Bendl, Raymond Walters, Caitlin E Carey, Anders Rosengren, Nora I Strom, Mads Engel Hauberg, Biao Zeng, Gabriel Hoffman

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Mentions

52
Peak: 16 in Sep 2022
across 6 sources since Sep 2022

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199,902
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289

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Sep 2022 – Sep 2025

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AI synopsis

What people are saying

Several discussions emphasize the genetic similarities and differences addressed in the publication, with phrases like 'shared genetics' and 'differentiating loci' reflecting an attempt to interpret complex scientific findings. The tone and choice of words—such as 'pointing to three different subtypes'—indicate curiosity and recognition of the research’s relevance, but the dialogue remains somewhat preliminary and broad, not deeply exploring practical or theoretical implications.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some posts highlighting its contribution to understanding genetic overlaps between autism and ADHD, exemplified by phrases like 'shared genes' and 'differentiating genetic architecture.'

InterestModerate interest

The posts demonstrate a moderate level of curiosity, referencing the genetic findings and potential subtypes, indicating genuine interest without overly technical language.

EngagementModerate engagement

Posts contain references to the study's methods, implications, and potential relevance, such as linking to the publication and discussing genetic subtypes, showing an active but surface-level engagement.

ImpactNeutral impact

Overall, discussions suggest awareness of the study's importance but lack deep analysis or calls to action, implying a neutral perception of its immediate impact.

Abstract in brief

  • ADHD and autism spectrum disorder (ASD) share significant genetic similarities, with researchers identifying seven shared genetic loci and five that differentiate the two conditions.
  • The differentiating loci show opposite genetic effects in ADHD and ASD and are linked to traits like educational achievement and brain volume, while shared genetics correlate with other psychiatric traits.
  • Individuals with both ADHD and ASD exhibit unique genetic patterns, suggesting that understanding these genetic influences can help clarify the biological underpinnings of each disorder and how they may impact cognitive and psychological traits differently.
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Top posts

Most liked on X and Bluesky
Nature Genetics
@NatureGenet · X

Sep 26, 2022 · 42 likes · 9 shares · 128,243 followers View post →
Dennis Lal
@LalDennis · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/7sHbDEZBII https://t.co/bvVuNPstth

Sep 27, 2022 · 5 likes · 1 share · 3,315 followers View post →
Autism-101
@Autism1o1 · X

@NTtakes Latest research is pointing to three different subtypes: Autism, ADHD, and AuDHD brains. https://t.co/tmyAj409Qk

Oct 22, 2022 · 3 likes · 12,495 followers View post →
Talha g - Sıfır Hipotezi
@0_hipotezi · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/NPtGDGIIqn

Sep 26, 2022 · 2 likes · 4,033 followers View post →
AutumnGarnet.bsky.social
@AutumnGarnet · X

@AuDHD_Therapist Now if only Sci-Hub had the linked article 10.1038/s41588-022-01171-3 available.

Oct 6, 2022 · 2 likes · 2,386 followers View post →
GenomeDK
@GenomeDK_AU · X

@immaqua et al. cited GenomeDK ressources in "Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups" published by Nature Genetics. @jakob_grove @AndersBorglum

Oct 17, 2022 · 2 likes · 257 followers View post →

All mentions

Neuropediatrics®️
@NeuroInfanti · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/Zaj5syeCJ2

Nov 22, 2022 · 2,074 followers View post →
Roland Baker
@RolandBakerIII · X

(4/n) Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/Xq8IgTga7s

Nov 12, 2022 · 8,161 followers View post →
Autism-101
@Autism1o1 · X

@NTtakes Latest research is pointing to three different subtypes: Autism, ADHD, and AuDHD brains. https://t.co/tmyAj409Qk

Oct 22, 2022 · 3 likes · 12,495 followers View post →
GenomeDK
@GenomeDK_AU · X

@immaqua et al. cited GenomeDK ressources in "Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups" published by Nature Genetics. @jakob_grove @AndersBorglum

Oct 17, 2022 · 2 likes · 257 followers View post →
Autism Spectrum Disorders Articles
@ASD_Articles · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/zOHMC4ZVtc

Oct 12, 2022 · 35 followers View post →
Psychiatry.dev
@Psychiatrydev · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups – https://t.co/CCgXCoYq0k

Oct 11, 2022 · 2 followers View post →
8Eevert ✨
@8Eevert · X

This was a link to the press release pdf. Here’s a more accessible html version of the same: https://t.co/91T6AOlX48 Here’s a link to the study: ”#Autism and #ADHD share genes”, Nature Genetics (2022). https://t.co/smWYSwjjE2 https://t.co/GYJijtB4v5

Oct 9, 2022 · 1 like · 1,153 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/emYBIEId54

Oct 9, 2022 · 2,239 followers View post →
InHomeTutoringHonolulu.com ADHD Specialist
@InHomeTutor808 · X

RT @InHomeTutor808: Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyper…

Oct 7, 2022 · 2 shares · 652 followers View post →
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RT @InHomeTutor808: Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyper…

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InHomeTutoringHonolulu.com ADHD Specialist
@InHomeTutor808 · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups - Nature || #AutismNews Courtesy of Rick Kirkham The Only In Home Tutor On Oahu Specializing in… https://t.co/bLmnIShnkg

Oct 6, 2022 · 2 shares · 652 followers View post →
AutumnGarnet.bsky.social
@AutumnGarnet · X

@AuDHD_Therapist Now if only Sci-Hub had the linked article 10.1038/s41588-022-01171-3 available.

Oct 6, 2022 · 2 likes · 2,386 followers View post →
The Innovation | Life Science
@Innov_Life001 · X

RT @NatureGenet:

Oct 2, 2022 · 9 shares View post →
InHomeTutoringHonolulu.com ADHD Specialist
@InHomeTutor808 · X

RT @InHomeTutor808: Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyper…

Oct 1, 2022 · 2 shares · 652 followers View post →
FREE Add Your Ad Forum
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RT @InHomeTutor808: Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyper…

Sep 30, 2022 · 2 shares · 84 followers View post →
InHomeTutoringHonolulu.com ADHD Specialist
@InHomeTutor808 · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups - Nature || #AutismNews Courtesy of Rick Kirkham The Only In Home Tutor On Oahu Specializing in… https://t.co/PCet4CxHxc

Sep 30, 2022 · 2 shares · 652 followers View post →
NYCAutismCommunityGroup
@AutismNyc · X

An article on Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups #autism, #autismservices, #innovativeautismservices https://t.co/LP6GlujoBT

Sep 28, 2022 · 40 followers View post →
jakobgrove.bsky.social
@jakob_grove · X

RT @NatureGenet:

Sep 28, 2022 · 9 shares · 291 followers View post →
Nora Strom
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Sep 28, 2022 · 9 shares · 149 followers View post →
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Sep 27, 2022 · 9 shares · 49 followers View post →
European Journal of Neuroscience
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Graham Mead (NeuroPleb)
@twillierod · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/FddmC2AgTR

Sep 27, 2022 · 1,445 followers View post →
Dennis Lal
@LalDennis · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/7sHbDEZBII https://t.co/bvVuNPstth

Sep 27, 2022 · 5 likes · 1 share · 3,315 followers View post →
hu.asch
@hu_asch · X

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Sep 27, 2022 · 9 shares · 24 followers View post →
Seiichi Mori
@seiichi_mori · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/FNg3S9UNJl https://t.co/YljCZJlVxe

Sep 26, 2022 · 1 like · 311 followers View post →
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Nature Genetics
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Sep 26, 2022 · 42 likes · 9 shares · 128,243 followers View post →
Talha g - Sıfır Hipotezi
@0_hipotezi · X

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups https://t.co/NPtGDGIIqn

Sep 26, 2022 · 2 likes · 4,033 followers View post →