Front Immunol October 2022 PMID 36248795

cGAS/STING and innate brain inflammation following acute high-fat feeding.

Sarah E Elzinga, Rosemary Henn, Benjamin J Murdock, Bhumsoo Kim, John M Hayes, Faye Mendelson, Ian Webber-Davis, Sam Teener, Crystal Pacut, Stephen I Lentz, Eva L Feldman

Mentions

21
Peak: 9 in Jan 2023
across 3 sources since Jan 2023

Extended reach

762,798
potential audience

Total likes

35

Video views

261

Mentions per month

Jan 2023 – Jun 2024

Where it's discussed

  • X / Twitter14 posts
  • News5 articles
  • YouTube2 videos

AI synopsis

What people are saying

Discussions reveal strong interest and moderate engagement, with users emphasizing the significance of the research by phrases like 'supports link to neurologic disease,' and referencing the immune pathways involved. The tone suggests curiosity about how high-fat diets influence brain inflammation and disease development, highlighting the potential clinical implications.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, with many emphasizing the connection between high-fat diets and brain inflammation, showing general support for the findings.

InterestHigh interest

The discussion highlights strong interest, as several posts use engaging language like 'supports link' and mention potential implications for neurologic diseases, indicating curiosity and concern.

EngagementModerate engagement

Users are engaging with the content by reflecting on research details, such as immune pathways and inflammatory responses, and sharing multiple reposts, demonstrating moderate depth.

ImpactModerate impact

The emphasis on the potential link to neurological and metabolic disorders suggests the community perceives the study as having a meaningful impact on understanding disease mechanisms.

Abstract in brief

  • The study explores how a high-fat diet can trigger rapid metabolic and inflammatory responses in obese mice, leading to insulin resistance and changes in immune cells both in the body and the brain.
  • It highlights the activation of the cGAS-STING pathway, a part of the innate immune system, as a key factor involved in brain inflammation and microglial activation, which are linked to neurodegenerative diseases like Alzheimer's.
  • Blocking communication between neurons and microglia reduces cGAS-STING activation, suggesting that early immune responses in both the body and brain may promote inflammation that contributes to cognitive impairment and metabolic disorders.]

Top posts

Most liked on X and Bluesky
Neuroscience News
@NeuroscienceNew · X

“cGAS/STING and innate brain inflammation following acute high-fat feeding” by Sarah E. Elzinga et al. Frontiers in Immunology https://t.co/mOHf2GoJSh

Jan 17, 2023 · 8 likes · 2 shares · 505,855 followers View post →
Medical Xpress
@medical_xpress · X

High fat diet activates early inflammation in mouse brains, supports link to neurologic disease @umich @frontiersin https://t.co/IcrYpI4T1W https://t.co/kphvjJiDhx

Jan 17, 2023 · 4 likes · 4 shares · 173,199 followers View post →
Agingdoc
@agingdoc1 · X

cGAS/STING and innate brain inflammation following acute high-fat feeding https://t.co/Iw9iDTjTz4

Jan 17, 2023 · 1 like · 41,793 followers View post →
CMIN
@IcahnCMIN · X

Researchers Sarah E. Elzinga, @EvaFeldmanMDPhD, et al. @MichMedicine have "discovered that a high-fat diet promotes an early inflammatory response in brains of mice thru an immune pathway linked to #Diabetes & #NeurologicDiseases...@Frontiers in Immunology https://t.co/95v1bGwVPJ

Feb 15, 2023 · 1 like · 3 shares · 853 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

cGAS/STING and innate brain inflammation following acute high-fat feeding https://t.co/sHWIqwv2Ik https://t.co/1HOSIM83qk

Jan 19, 2023 · 24,143 followers View post →
Medical Xpress
@physorg_health · X

RT @medical_xpress: High fat diet activates early inflammation in mouse brains, supports link to neurologic disease @umich @frontiersin htt…

Jan 17, 2023 · 4 shares · 7,101 followers View post →

All mentions

Altamiro Bottino
@BottinoAltamiro · X

High fat diet activates early inflammation in mouse brains, supports link to neurologic disease https://t.co/yiSIBPTyju https://t.co/ggsy3Q1T4q https://t.co/v26ohrULHH

Mar 5, 2023 · 93 followers View post →
Stéphanie Eid, PhD
@EidSteph · X

RT @IcahnCMIN: Researchers Sarah E. Elzinga, @EvaFeldmanMDPhD, et al. @MichMedicine have "discovered that a high-fat diet promotes an early…

Feb 16, 2023 · 3 shares · 764 followers View post →
Dr.KaczorowskiLab
@KaczorowskiLab · X

RT @IcahnCMIN: Researchers Sarah E. Elzinga, @EvaFeldmanMDPhD, et al. @MichMedicine have "discovered that a high-fat diet promotes an early…

Feb 16, 2023 · 3 shares · 4,107 followers View post →
Eva Feldman, MD, PhD
@EvaFeldmanMDPhD · X

RT @IcahnCMIN: Researchers Sarah E. Elzinga, @EvaFeldmanMDPhD, et al. @MichMedicine have "discovered that a high-fat diet promotes an early…

Feb 16, 2023 · 3 shares · 1,258 followers View post →
CMIN
@IcahnCMIN · X

Researchers Sarah E. Elzinga, @EvaFeldmanMDPhD, et al. @MichMedicine have "discovered that a high-fat diet promotes an early inflammatory response in brains of mice thru an immune pathway linked to #Diabetes & #NeurologicDiseases...@Frontiers in Immunology https://t.co/95v1bGwVPJ

Feb 15, 2023 · 1 like · 3 shares · 853 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

cGAS/STING and innate brain inflammation following acute high-fat feeding https://t.co/sHWIqwv2Ik https://t.co/1HOSIM83qk

Jan 19, 2023 · 24,143 followers View post →
Maurício Lima
@dj_surfista · X

@OZmandia @nicknorwitz https://t.co/8zN1bEEo3t

Jan 17, 2023 · 741 followers View post →
Agingdoc
@agingdoc1 · X

cGAS/STING and innate brain inflammation following acute high-fat feeding https://t.co/Iw9iDTjTz4

Jan 17, 2023 · 1 like · 41,793 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @medical_xpress: High fat diet activates early inflammation in mouse brains, supports link to neurologic disease @umich @frontiersin htt…

Jan 17, 2023 · 4 shares · 384 followers View post →
Javier Díaz-Nido
@Javier_DiazNido · X

RT @NeuroscienceNew: “cGAS/STING and innate brain inflammation following acute high-fat feeding” by Sarah E. Elzinga et al. Frontiers in Im…

Jan 17, 2023 · 2 shares · 1,834 followers View post →
Robert "Willie" Mays
@Sayhay66 · X

RT @NeuroscienceNew: “cGAS/STING and innate brain inflammation following acute high-fat feeding” by Sarah E. Elzinga et al. Frontiers in Im…

Jan 17, 2023 · 2 shares · 352 followers View post →
Neuroscience News
@NeuroscienceNew · X

“cGAS/STING and innate brain inflammation following acute high-fat feeding” by Sarah E. Elzinga et al. Frontiers in Immunology https://t.co/mOHf2GoJSh

Jan 17, 2023 · 8 likes · 2 shares · 505,855 followers View post →
Medical Xpress
@physorg_health · X

RT @medical_xpress: High fat diet activates early inflammation in mouse brains, supports link to neurologic disease @umich @frontiersin htt…

Jan 17, 2023 · 4 shares · 7,101 followers View post →
Medical Xpress
@medical_xpress · X

High fat diet activates early inflammation in mouse brains, supports link to neurologic disease @umich @frontiersin https://t.co/IcrYpI4T1W https://t.co/kphvjJiDhx

Jan 17, 2023 · 4 likes · 4 shares · 173,199 followers View post →