Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Mentions
Extended reach
Total likes
Video views
Mentions per month
Nov 2022 – Jul 2025Where it's discussed
-
X / Twitter186 posts
-
News76 articles
-
Blogs9 articles
-
Facebook5 posts
-
YouTube4 videos
-
Reddit3 posts
AI synopsis
What people are saying
Discussions reveal a range of reactions focusing on the study's implications, with many users pointing out that while triglycerides were lowered, this did not translate to a decrease in cardiovascular events. Posts like 'lowering triglycerides doesn't do anything for CVD' and comments on the 'disappointment' over the results reflect a critical tone. The language used, such as 'no benefit' and 'failed to meet primary endpoints,' highlights the authors' concerns and frustration with the findings, contributing to an overall skeptical sentiment.
Many posts express skepticism about the effectiveness of pemafibrate in reducing cardiovascular events, indicating a notable level of disagreement with its anticipated benefits.
There is a high level of curiosity regarding the findings of the publication, as users actively discuss its implications and question its outcomes.
While several users express interest and pose questions about the study, the depth of engagement remains moderate with less extensive analysis of the research content.
Contributors perceive the overall impact of the study as limited since it did not yield the expected benefits in cardiovascular risk reduction.
Abstract in brief
- High triglyceride levels increase cardiovascular risk, and pemafibrate is a drug that reduces these levels and improves other lipids.
- In a trial involving nearly 10,500 patients with type 2 diabetes and high triglycerides, participants were randomly assigned to either receive pemafibrate or a placebo.
- After 3.4 years, while pemafibrate significantly lowered triglycerides and other lipid measures, it didn’t show a meaningful difference in reducing serious cardiovascular events compared to placebo, suggesting more research is needed.
Top posts
Most liked on X and BlueskyThis week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX0 #cardiology https://t.co/v6nY0m7dPm
Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! https://t.co/Zm3nslZPoM https://t.co/jy9kHSUv3z
5. The incidence of cardiovascular events-heart attack, stroke or death due to these diseases- was similar in patients who took pemafibrate or placebo. Moreover, pemafibrate caused more renal adverse effects and venous thromboembolism. Ref: https://t.co/nb5Coo6Vq1
Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the incidence of cardiovascular events was not lower among those who received pemafibrate than among those who received placebo. https://t.co/MOSTmXeOCk https://t.co/JK8TMAlzuj
In @nejm study of > 10K pts with diabetes and mean TG level of 271, no benefit seen with pemafibrate vs placebo. Despite 26% reduction in TG and VLDL. 12% increase in LDL observed. Disappointing but icosapent ethyl remains evidence-based option @DLBHATTMD https://t.co/0ZvjRy5Pbw
All mentions
Optimizing Low Carb Diets for Heart Health with Dr. Weiss
Low carb doesn't have to increase heart disease risk. Dr. Ethan Weiss, a cardiologist and Prof of Medicine at UCSF, shares expert insights on how to maintain heart health on a low carb diet by focusing on the importance…
Evaluating Cholesterol Ratios and Lipids in Heart Disease Risk Assessment
Are ratios like triglyceridesHDLC or total cholesterolHDLC reliable measures of heart disease risk? This video discusses the strengths and limitations of cholesterol ratios and explores recent genetic research on…
Pemafibrate's Impact on Cardiovascular Risk in Diabetes Patients
This video discusses pemafibrate, a drug that lowers high triglyceride levels and improves lipids. A trial with nearly 10,500 patients showed that while it significantly reduced triglycerides, it did not lead to fewer…
Triglyceride Lowering Strategies in Cardiovascular Health
High triglyceride levels increase cardiovascular risk. This podcast discusses findings from AHA 2022, focusing on pemafibrate's role in lowering triglycerides and improving lipid profiles, as well as comparing…
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/aqh01npRQ2
RT @37phoenix: 高中性脂肪血症、低HDLの糖尿病患者へのペマフィブラート(パルモディア)は複合心血管イベントを減少させなった。Pradhan, Aruna Das. N Engl J Med. https://t.co/TAmdXJCUFE
https://t.co/SlptJYsW9p
RT @DrDerekConnolly: does lowering triglycerides reduce cardiovascular risk as per the new IAS guidance? the elephant in the room is this…
does lowering triglycerides reduce cardiovascular risk as per the new IAS guidance? the elephant in the room is this study https://t.co/QHKpck05cw Lets see what result the ANGPTL3 studies produce https://t.co/3WLtngRMY5
@penguin_pharm TGは下げるが 心血管イベント減らさない薬って飲む意義あるんだろうか? https://t.co/fQCddtezyU https://t.co/ctd6XjQsO9
@Dr_moto_clinic @tbHbXZE9flNNe1W NEJM:DMで低HDL、高TG例には パルモディア効果なしかも!? https://t.co/nPBxAoHd5k
RT @Cardio_Pharm_JP: PROMINENT試験 ※96%でスタチン服用にてLDL-C<100 ※ペマフィブラート投与でLDL-C79から91へ上昇したことでTG低下の利益が相殺されているかも…? https://t.co/IBt10pASlo
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | New England Journal of Medicine https://t.co/5CdhKyzLbR
@BrezanSimonMD @Drlipid @drpablocorral @MohammedAlo @Lipoprotein Based on this observational study, you'd think a big reduction in VLDL-C accompanied by an increase in LDL-C would be beneficial. In the PROMINENT study, pemafibrate did just that and the MACE hazard ratio was 1.03. https://t.co/EVFF7exwsC
Pemifibrate fails even though TG, remnant and VLDL decrease! "−26.2% triglycerides, −25.8% very-low-density lipoprotein, −25.6% remnant cholesterol, −27.6% apolipoprotein C-III, and 4.8% for apolipoprotein B" https://t.co/DiuusgHWTO @lipo_fan @Drlipid @JohnKastelein
this is propensity matched registry study not a randomised controlled trial suggesting benefit of fibrates in metabolic syndrome the problem is that in an proper RCT of fibrates v placebo in diabetics with raised triglycerides, there was NO BENEFIT. DOI: 10.1056/NEJMoa2210645 https://t.co/cuxkEUyzLy
PROMINENT試験 これ読んでなかったな。 Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/NptB9uranX
@doctorveera Recent cardiovascular example: pemafibrate (PROMINENT) 4/22 press release https://t.co/OvK6zDvGBA 11/22 trial publication https://t.co/ciSX2W6Uv9
PROMINENT試験 ※96%でスタチン服用にてLDL-C<100 ※ペマフィブラート投与でLDL-C79から91へ上昇したことでTG低下の利益が相殺されているかも…? https://t.co/IBt10pASlo
17/ #Fibrates reduce TG levels but their impact on #CV outcomes is less clear. The PROMINENT study of pemafibrate was stopped early due to failure to meet the primary endpoint.
RT @MR02160602: パルモディア、厳しいなぁ
あと、フィブラートは慎重に。フィブラートにはTG低下のエビデンスはあるが予後に影響しないか悪化の可能性もある。まずはnon-HDLを見て、それを下げる目的にスタチンを使う。>1000や脂質関連膵炎ならフィブラート使う。 上記ガイドラインおよび、 https://t.co/RSqftG0ihP
Check out this highly cited OA paper titled Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk in The New England Journal of Medicine: https://t.co/wPTy8J1RV0… https://t.co/kMlJvBWcfF… #OpenAccess @DEgyetem @deenklibrary
RT @ph_minimal: ペマフィブラートはどうなのか知りたい人はこちらの56ページをみてください https://t.co/K5fN2LyVQs
ペマフィブラートはどうなのか知りたい人はこちらの56ページをみてください https://t.co/K5fN2LyVQs https://t.co/KqGD3baXXh
@SteakAndWeights @cactusapinyona @SBakerMD Lowering LDL-c decreases CVD based on the trial I sent. Lowering triglycerides doesn’t do anything for CVD. https://t.co/kVhMWoSpAc https://t.co/IrbJ9sTNMF
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.co/bNtIAwWTX0 #cardiology View all trending articles: https://t.co/ORZDa6ntRn https://t.co/XfGM78RtZq
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
RT @mi_cardiologo: Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! http…
Nuevo palo a los Fibratos para reducir el riesgo cardiovascular reduciendo los triglicéridos. Por ahí vamos mal!!!! https://t.co/Zm3nslZPoM https://t.co/jy9kHSUv3z
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
RT @NEJM: This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX…
This week’s most cited articles: 1. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bNtIAwWTX0 #cardiology https://t.co/v6nY0m7dPm
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/gUepfhH0Ia
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @CMichaelGibson: Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @CMichaelGibson: Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the…
RT @CMichaelGibson: Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the…
RT @CMichaelGibson: Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @CMichaelGibson: Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @CMichaelGibson: Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
Among patients with type 2 diabetes, mild-to-moderate hypertriglyceridemia, and low HDL and LDL cholesterol levels, the incidence of cardiovascular events was not lower among those who received pemafibrate than among those who received placebo. https://t.co/MOSTmXeOCk https://t.co/JK8TMAlzuj
RT @NEJM: This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.…
This week’s most cited article: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (PROMINENT trial) https://t.co/bNtIAwWTX0 #cardiology View all trending articles: https://t.co/ORZDa6ntRn https://t.co/j1pQF0hkvg
Triglyceride Lowering with Pemafibrate to Reduce #Cardiovascular Risk For More: https://t.co/vqDE02SEeE
Fascinating: this drug lowered triglycerides but NOT CVS events (against expectations) The explanation may be that high triglycerides are a marker of other risk factors (e.g. metabolic syndrome) but not causal Association is not causation! https://t.co/Goii3JKiGq
RT @hyderabaddoctor: 5. The incidence of cardiovascular events-heart attack, stroke or death due to these diseases- was similar in patient…
RT @hyderabaddoctor: 5. The incidence of cardiovascular events-heart attack, stroke or death due to these diseases- was similar in patient…
RT @hyderabaddoctor: 5. The incidence of cardiovascular events-heart attack, stroke or death due to these diseases- was similar in patient…
RT @hyderabaddoctor: 5. The incidence of cardiovascular events-heart attack, stroke or death due to these diseases- was similar in patient…
5. The incidence of cardiovascular events-heart attack, stroke or death due to these diseases- was similar in patients who took pemafibrate or placebo. Moreover, pemafibrate caused more renal adverse effects and venous thromboembolism. Ref: https://t.co/nb5Coo6Vq1
RT @microagencia: En un RCT probaron 3 años una droga que baja los triglicéridos. La droga los baja, pero no mejora la incidencia de evento…
En un RCT probaron 3 años una droga que baja los triglicéridos. La droga los baja, pero no mejora la incidencia de eventos cardiovasculares. Sorpresa, un indicador aislado no predice demasiado. https://t.co/0vU3TcfmrG
Reference (https://t.co/L3hcCPHN0X)
@DaleWil39870290 @aricarbins @wcu98 @ifixhearts No benefit of lowering trigs (fibrate trial last year) https://t.co/nHh44HW86i No benefit of raising HDL (multiple trials on CETP inhibitors) https://t.co/bgPBd6OgpW Great benefit of lowering LDL (JUPITER trial) https://t.co/neildyItZ4
https://t.co/ogUOh5CpB2
@A9eelqh @iK2NAN @DrNouraM1 I think the association between triglycerides and CVS events stil a debate question! For example this study on Pemafibrate shown decreased in level of triglycerides but does not decrease CVD events https://t.co/4EjQVotNTD
@TriglycerideF @mmillermd1 @DLBHATTMD The Good
RT @hbadanig: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/ywRZ1HDqsy
@lucasllach @golmig - Los triglicéridos son un factor de riesgo secundario. Acaba de terminar un ensayo con un medicamento que los baja y no dio beneficio cardiovascular (1). - Más que el tamaño, lo importante es el número de partículas y la exposición acumulada. 1- https://t.co/EpPd1YnCsg
RT @ChaturvediNeuro: In @nejm study of > 10K pts with diabetes and mean TG level of 271, no benefit seen with pemafibrate vs placebo. Despi…
【備忘録】PROMINENT試験 高中性脂肪(TG200-499mg/dl)血症 かつHDL-C 40mg/dL未満など。 にペマフィブラート(add on)投与でも、 主要有害心血管イベント(MACE:心筋梗塞+虚血性脳卒中+冠動脈の血行再建術施行+心血管死亡)とプラセボで軍間差、『無し』。 https://t.co/ngnt9IbkGq
Los medicamentos para reducir los TRIGLICÉRIDOS, no disminuyen los eventos cardiacos en DIABÉTICOS Estudio PROMINENT https://t.co/sPa40Szc8d #diabetes #trigliceridos https://t.co/5eW2ALdO2l
RT @the_paper_link: Trend up+10: Das Pradhan A, ..., Prominent Investigators (N Engl J Med) __Triglyceride Lowering with Pemafibrate to Re…
Trend up+10: Das Pradhan A, ..., Prominent Investigators (N Engl J Med) __Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk__ https://t.co/t9sXAbHUzO
コロナになってからやっていなかった社内有志によるEBM形式の消毒会。3年ぶり〜 ↓読んだ論文 N Engl J Med. 2022 Nov 5. doi: 10.1056/NEJMoa2210645. https://t.co/eLlJHkBEpg https://t.co/VKbOfzLGvC
RT @sociedadSEEN:
This edition of #WhatsNewWednesday features the PROMINENT Trial!
Journal Club SID Un risultato deludente per uno studio “prominente” - A cura di Domenico Tricò https://t.co/IzPy4IW8wu
Entre los pacientes con DM tipo 2 e hipertrigliciremia, los fibratos no disminuyen los eventos cardiovasculares. https://t.co/0yB9k7JU5H
(180/347) #論文マラソン ペマフィブラートは心イベントを抑制するか 多国籍、二重盲検、無作為化、対照試験 2 型糖尿病 プラセボコントロール 10,497人を3.4年追跡 イベント発生に違いはなく。ぺマは有害な腎イベントおよびDVTの上昇、NAFLDの低下と関連。 https://t.co/KuWjaqScaY
Trend up+10: Das Pradhan A, ..., Prominent Investigators (N Engl J Med) __Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk__ https://t.co/t9sXAbHUzO
RT @toki_wo_koe: やっぱり、これね。イベントは減らさない。DVT増えんだ
In a randomized trial, the incidence of #cardiovascular events was not lower in patients with #diabetes, HTG, and low HDL cholesterol levels who received #pemafibrate (a selective PPARα), although TG, VLDL cholesterol, remnant cholesterol, and Apo C-III ⬇️ https://t.co/SfSgEY8tmi
RT @toki_wo_koe: やっぱり、これね。イベントは減らさない。DVT増えんだ
やっぱり、これね。イベントは減らさない。DVT増えんだ
RT @ChaturvediNeuro: In @nejm study of > 10K pts with diabetes and mean TG level of 271, no benefit seen with pemafibrate vs placebo. Despi…
Will this put the Fibrate story "to bed"... i will likely only use this class of medications if TGs > 500 despite EPA..lowering surrogate markers typically not enough! @DLBHATTMD @NEJM https://t.co/S1qm4CGatA
RT @RevistaMFSamfyc: Bajar los triglicéridos con pemafibrato para reducir el riesgo cardiovascular https://t.co/17c4FN42NR PMID 36342113
RT @ChaturvediNeuro: In @nejm study of > 10K pts with diabetes and mean TG level of 271, no benefit seen with pemafibrate vs placebo. Despi…
RT @ChaturvediNeuro: In @nejm study of > 10K pts with diabetes and mean TG level of 271, no benefit seen with pemafibrate vs placebo. Despi…
Bajar los triglicéridos con pemafibrato para reducir el riesgo cardiovascular https://t.co/17c4FN42NR PMID 36342113
In @nejm study of > 10K pts with diabetes and mean TG level of 271, no benefit seen with pemafibrate vs placebo. Despite 26% reduction in TG and VLDL. 12% increase in LDL observed. Disappointing but icosapent ethyl remains evidence-based option @DLBHATTMD https://t.co/0ZvjRy5Pbw
Eine Studie, die gegen Fibrate spricht. #medizin #kardiologie #triglyceride #stoffwechsel #cholesterin https://t.co/biZeVEnEKN
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/RfQUVDgZvf
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
2型DM+中性脂肪高値患者へのパルモディア投与(pemafibrate)で心血管イベントに差出ず、とのことです。中性脂肪の取り扱いは悩ましいですが、自分の現状の方針を変える必要はなさそう。 Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/yor0FuIGzt
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/A7rmP67tgL
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk - PubMed https://t.co/XDGe4okglL “incidence of cardiovascular events was not lower among those who received pemafibrate than among those who received placebo, although… https://t.co/OcP81d9PLV
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @DrDanMO: Pemafibrate: More potent than fenofibrate, and just as useless for reducing CV events. Triglyceride Lowering with Pemafibrate…
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @DrDanMO: Pemafibrate: More potent than fenofibrate, and just as useless for reducing CV events. Triglyceride Lowering with Pemafibrate…
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
Pemafibrate: More potent than fenofibrate, and just as useless for reducing CV events. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/dkKfbuM4DA
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/rptFgJreK9
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/pGXSUtHU21
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @vic_pallares: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
初日のFibrate系のTrialがNegative https://t.co/cZbF4md0O8 であったことから、RESPECT EPAやJELISを踏まえるとStatinを使用してのHTGはEPAがいいとは思います。しかしながらREDUCE ITのPlaceboのMineral oilがhsCRPを増やしてしまったため、懐疑的な部分もあります。 https://t.co/fhPmwQnYZ5
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
In patients with type 2 diabetes and mild-to-moderate hypertriglyceridemia, pemafibrate imporved lipid profile but failed at reducing cardiovascular events. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/UrhAg08gLJ
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @vic_pallares: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/p2mdhDg51k
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
RT @ValleAlfonso: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk #PROMINENT
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/bBBr7RRy1r
RT @vic_pallares: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM
結局中性脂肪は下げるが心筋梗塞などのイベントは減らさない。パルモディア、お前もか。 Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/e3ypsrTIpU
RT @pinacol: 【RCT】軽度から中等度の高トリグリセリド血症、HDL-コレステロール≤40mg/dLの2型糖尿病患者へのペマフィブラート投与は、プラセボ投与と比較して、非致死性心筋梗塞、虚血性脳卒中、冠血行再建術、心血管死亡の複合転帰を減少させなかった。 #ペ読 h…
JournalWise: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk. -> Sadly, no https://t.co/cn4LN6aKm6
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/hbTXxdHxrG
RT @pinacol: 【RCT】軽度から中等度の高トリグリセリド血症、HDL-コレステロール≤40mg/dLの2型糖尿病患者へのペマフィブラート投与は、プラセボ投与と比較して、非致死性心筋梗塞、虚血性脳卒中、冠血行再建術、心血管死亡の複合転帰を減少させなかった。 #ペ読 h…
RT @medical_xpress: Triglyceride-lowering trial neutral for cardiovascular event reduction @brighamwomens @nejm https://t.co/QMw5nLm2wP htt…
【RCT】軽度から中等度の高トリグリセリド血症、HDL-コレステロール≤40mg/dLの2型糖尿病患者へのペマフィブラート投与は、プラセボ投与と比較して、非致死性心筋梗塞、虚血性脳卒中、冠血行再建術、心血管死亡の複合転帰を減少させなかった。 #ペ読 https://t.co/6p1aRNQJLO
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/tShnDP3VkE
Wie viele klinische Studien mit Fibraten müssen eigentlich noch scheitern, bevor wirklich alle glauben, dass diese Dinger kardiovaskulär nix bringen
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/sjmzK9TYm0 https://t.co/yR6GuIytJe
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk | NEJM https://t.co/ACEMYW9IWh
RT @medical_xpress: Triglyceride-lowering trial neutral for cardiovascular event reduction @brighamwomens @nejm https://t.co/QMw5nLm2wP htt…
Triglyceride-lowering trial neutral for cardiovascular event reduction @brighamwomens @nejm https://t.co/QMw5nLm2wP https://t.co/KJsOfQHBZs
RT @nick_krontiris: Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/BwQN84HvLC #MetabolicSyndrome #Di…
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk https://t.co/BwQN84HvLC #MetabolicSyndrome #Diabetes #Cholesterol #Triglycerides #InsulinResistance