December 2022 PMID 36465175

cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque.

Xueqi Wan, Jinfan Tian, Peng Hao, Kuo Zhou, Jing Zhang, Yuquan Zhou, Changjiang Ge, Xiantao Song

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Mentions

3
Peak: 2 in Jun 2024
across 2 sources since May 2024

Extended reach

27,350
potential audience

Total likes

21

Video views

261

Mentions per month

May 2024 – Jun 2024

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

The overall analysis reflects a dismissive attitude, especially with phrases like 'no bueno', showing disagreement or skepticism but without deep elaboration. The tone and brevity indicate minimal engagement and an only moderate recognition of the biological significance of the pathway discussed.

AgreementLow agreement

The discussion shows skepticism about the mechanisms described, especially with phrases like 'no bueno', indicating disagreement or concern about the pathway's function.

InterestNeutral interest

The comments do not display high curiosity or detailed analysis; the focus is more on expressing a negative sentiment, implying neutral to low interest.

EngagementNeutral engagement

The posts seem to be brief reactions rather than in-depth discussions, suggesting a surface-level engagement.

ImpactModerate impact

Despite limited support or detailed analysis, the negative reaction hints at some recognition of the pathway's importance, making the potential impact moderate.

Abstract in brief

  • The cGASSTING pathway plays a significant role in atherosclerosis and plaque vulnerability by involving proteins like STIM1, which regulates calcium entry in cells and influences processes such as cell proliferation, apoptosis, and inflammation.
  • STIM1, when activated by calcium store depletion, interacts with proteins like Orai1 to boost calcium entry, leading to altered cell behavior that promotes formation of rupture-prone plaques.
  • The study suggests that targeting the STIM1-cGASSTING pathway could potentially help in preventing plaque progression and reducing the risk of plaque rupture in atherosclerosis.]

Top posts

Most liked on X and Bluesky
Christie Laura Grace
@_HeartofGrace_ · X

SMH https://t.co/rLnI0LLLpO In this mechanism, you are coming in at cGAS port of entry in this pathway, with pieces of DNA plasmid no bueno cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque https://t.co/B3ahwfkMht

Jun 21, 2024 · 27,089 followers View post →

All mentions

Christie Laura Grace
@_HeartofGrace_ · X

SMH https://t.co/rLnI0LLLpO In this mechanism, you are coming in at cGAS port of entry in this pathway, with pieces of DNA plasmid no bueno cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque https://t.co/B3ahwfkMht

Jun 21, 2024 · 27,089 followers View post →