Cancer Med March 2023 PMID 36479637

Biomarkers predictive of response to pembrolizumab in head and neck cancer.

David G Pfister, Robert I Haddad, Francis P Worden, Jared Weiss, Ranee Mehra, Laura Q M Chow, Stephen V Liu, Hyunseok Kang, Nabil F Saba, Lori J Wirth, Ammar Sukari, Erminia Massarelli, Mark Ayers, Andrew Albright, Andrea L Webber

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Mentions

9
Peak: 4 in Dec 2022
across 3 sources since Dec 2022

Extended reach

8,287
potential audience

Total likes

29

Video views

20

Mentions per month

Dec 2022 – Oct 2025

Where it's discussed

  • X / Twitter6 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a shared interest in biomarker analysis, with mentions of specific studies and collaborations that underscore its importance. Words like 'assess,' 'another one here,' and references to combined analyses suggest a focus on advancing personalized approaches, emphasizing both interest and perceived impact within the clinical community.

AgreementModerate agreement

Most discussions acknowledge the importance of identifying biomarkers for predicting treatment response, showing overall agreement with the publication's focus.

InterestModerate interest

Participants demonstrate moderate interest by referencing multiple discussions and emphasizing the relevance of combined biomarker analysis.

EngagementModerate engagement

Engagement is moderate, as posts mention specific aspects such as the analysis methods and collaborations, indicating thoughtful participation.

ImpactModerate impact

The posting of discussions by multiple professionals and references to clinical trials suggest recognition of significant potential impact on treatment strategies.

Abstract in brief

  • This study analyzed various biomarkers such as PDL1, TMB, Tcell GEP, and HPV status to predict how patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) respond to pembrolizumab treatment, showing that higher levels of these biomarkers are associated with better response rates.
  • The research found that PDL1 and Tcell GEP are independently predictive of better outcomes, with higher biomarker levels leading to increased objective response rates (ORR), and these biomarkers generally correlated well regardless of HPV status.
  • Overall, TMB, PDL1, and Tcell GEP, whether assessed alone or together, could be useful tools for identifying patients more likely to benefit from pembrolizumab therapy in recurrent/metastatic HNSCC.]

Top posts

Most liked on X and Bluesky
Robert Haddad
@DrHaddadRobert · X

Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess combined biomarker analysis from K012 and 055 @DrUppaluri @DrNabilSaba @KaramLab @DrEzraCohen

Dec 8, 2022 · 29 likes · 4 shares · 1,412 followers View post →
Timothy Chan
@GeneCollector · X

@marklewismd @NEJM @MSKCancerCenter Another one here. https://t.co/ITJn69HFFp

Jun 4, 2023 · 5,035 followers View post →
Ravi Uppaluri, MDPhD
@DrUppaluri · X

RT @DrHaddadRobert: Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess…

Dec 8, 2022 · 4 shares · 1,191 followers View post →
Alice Weaver, MD, PhD
@AWeaverMDPhD · X

RT @DrHaddadRobert: Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess…

Dec 9, 2022 · 4 shares · 332 followers View post →
@EORTC_HNCG_YI
@EortcY · X

RT @DrHaddadRobert: Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess…

Dec 9, 2022 · 4 shares · 196 followers View post →
Lin Wanqing
@wanqing168168 · X

RT @DrHaddadRobert: Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess…

Oct 7, 2025 · 4 shares · 42 followers View post →

All mentions

Lin Wanqing
@wanqing168168 · X

RT @DrHaddadRobert: Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess…

Oct 7, 2025 · 4 shares · 42 followers View post →
Timothy Chan
@GeneCollector · X

@marklewismd @NEJM @MSKCancerCenter Another one here. https://t.co/ITJn69HFFp

Jun 4, 2023 · 5,035 followers View post →
Alice Weaver, MD, PhD
@AWeaverMDPhD · X

RT @DrHaddadRobert: Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess…

Dec 9, 2022 · 4 shares · 332 followers View post →
@EORTC_HNCG_YI
@EortcY · X

RT @DrHaddadRobert: Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess…

Dec 9, 2022 · 4 shares · 196 followers View post →
Ravi Uppaluri, MDPhD
@DrUppaluri · X

RT @DrHaddadRobert: Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess…

Dec 8, 2022 · 4 shares · 1,191 followers View post →
Robert Haddad
@DrHaddadRobert · X

Out today Biomarkers predictive of response to pembrolizumab in head and neck cancer https://t.co/jLn9M3Gg6z we assess combined biomarker analysis from K012 and 055 @DrUppaluri @DrNabilSaba @KaramLab @DrEzraCohen

Dec 8, 2022 · 29 likes · 4 shares · 1,412 followers View post →
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