⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein rich in phenylalanine (e.g., red meat) are associated with the presence and severity of heart failure independent of other risk factors.
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure.
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Dec 2022 – Sep 2025Where it's discussed
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Reddit6 posts
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What people are saying
The group overwhelmingly agrees that PAGln is associated with heart failure, supported by technical terms such as 'dose-dependently associated' and mechanistic implications like 'modulation of adrenergic receptor signaling,' which demonstrate active engagement and recognition of both the scientific significance and potential for significant health impact.
Most discussions support the connection between PAGln levels and heart failure, with terminology like 'linked to' and 'associated with' indicating consensus.
Many posts highlight the relevance of the findings to health risks and potential treatments, reflecting high interest, especially with phrases like 'clinical and mechanistic link' and 'predictive value.'
Posts reference detailed mechanistic insights and call for monitoring or further research, showing moderate to deep engagement.
There is a strong belief that these findings could influence future clinical practices or dietary guidelines, as evidenced by comments on potential treatment approaches and disease prevention.
Abstract in brief
- The study found that higher levels of a gut microbiota-produced compound called PAGln are associated with the presence and severity of heart failure, regardless of other risk factors.
- Mechanistic experiments showed that PAGln can negatively affect heart cells by reducing their contraction and increasing markers linked to heart failure, suggesting it may directly contribute to heart dysfunction.
- These findings suggest that targeting the gut bacteria responsible for producing PAGln could be a new approach to treating or preventing heart failure.
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Most liked on X and BlueskyStudy finds higher levels of common diet-associated microbe elevates #heartfailure risk @CellCellPress https://t.co/UHIIGlPsw7 https://t.co/3hXDHjS5Su
Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2Tsv1Ga https://t.co/ery9lDcwYa
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/eQ6a9wtEDv
Possible relationship between gut microbiome and heart failure (in shape of metabolite - phenylacetylgutamine). In animal studies PAG mechanistically linked to HF. Circulation: Heart Failure 2022 https://t.co/oFuAdaVPhr
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure | Circulation: Heart Failure https://t.co/cbGhe1lnk3
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@JACCJournals @GuelGueder . Levels of the gut-liver metabolite PAGln are dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1m6hj
#AI #healthcare #agedcare #datascience #microbiome #NCDs #ehealth #healthspan #hepatology #gerontology #geriatrics Circulating prothrombotic gut-liver metabolites, such as indoxyl sulfate and phenylacetylglutamine (PAGln) must be monitored and reduced. . https://t.co/kncAh909oO
#ehealth #NCDs Circulating PAGln levels were dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1mE6R
#hepatology NT-proBNP Circulating PAGln levels were dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1mE6R
#gastroenterology #geriatrics #gerontology #microbiome #hepatology #cardiology #heartfailure #HF #aging The prothrombotic gut-liver metabolite phenylacetylglutamine (PAGln) is clinically and mechanistically linked to heart failure presence and severity. . https://t.co/kncAh8ZBzg
#ehealth #NCDs Circulating PAGln levels were dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1mE6R
#ehealth #geriatrics Circulating PAGln levels were dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1mE6R
RT @SilkeLeFay: #geriatrics #primaryhealthcare #gastroenterology #cardiology #metabolomics #microbiome #CVD Circulating levels of the tox…
#geriatrics #primaryhealthcare #gastroenterology #cardiology #metabolomics #microbiome #CVD Circulating levels of the toxic gut microbiota metabolite phenylacetylglutamine (PAGln) are dose-dependently associated with heart failure and severity. . https://t.co/6zDCB1mE6R
@Alina_MSN_RN Can be low in Long COVID: https://t.co/ZLOlDJRks5 Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/p35OmJ6eNk Phenylalanine https://t.co/rgiXmqMSC1 https://t.co/osbCsbBr0f https://t.co/R6fAvioRtq Amino acid profile: https://t.co/eSqXaNev89
#cardiology #HF #heartfailure #ESCCongress #ESC2023 #microbiome Circulating levels of the toxic gut microbiota metabolite PAGln are dose-dependently associated with heart failure and severity . https://t.co/6zDCB1mE6R https://t.co/Ut7i3VbqZ9
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/tSXyXSiRk6
RT @didius_marcus: @NatureCustom phenylacetylglutamine.. But this study https://t.co/CHogiKT1iZ associated it with heart failure.
@NatureCustom phenylacetylglutamine.. But this study https://t.co/CHogiKT1iZ associated it with heart failure.
#thrombosis coronary artery disease #atherosclerosis #microbiome #aging #geriatrics MONITOR-HF #heartdisease #bloodclots Circulating levels of the toxic gut microbiota metabolite PAGln are dose-dependently associated with heart failure and severity . https://t.co/IMlNqDLyA6 https://t.co/WyqEtTKfDD
#ehealth MONITOR-HF #microbiome #generalpractice Circulating levels of the toxic gut microbiota metabolite phenylacetylglutamine (PAGln) were dose-dependently associated with heart failure and indices of severity independent of traditional risk factors . https://t.co/IMlNqDLyA6
#microbiome #primaryhealthcare #geriatrics Circulating levels of the toxic gut microbiota metabolite phenylacetylglutamine (PAGln) were dose-dependently associated with heart failure and indices of severity independent of traditional risk factors. . https://t.co/IMlNqDLyA6
Product of Gut Microbiome Linked with Heart Failure Risk https://t.co/6PKtyOVku2 #science #health #product #gut #microbiome #linked
RT @sminaev2015: Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure | Circulation: Heart Failure https://t.co/cbGhe1lnk3
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure | Circulation: Heart Failure https://t.co/cbGhe1lnk3
Study finds higher levels of common diet-associated microbe elevates heart failure risk https://t.co/Pb4fga1tOa https://t.co/foYHwaaykz https://t.co/alCRabZgsk https://t.co/PjBarRFlwl
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/O6PkOj9uMI #science #health #gut #microbiotagenerated #phenylacetylglutamine #heart
RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…
#publichealth #COVID19 #LongCovid #microbiome Circulating levels of the toxic gut microbiota metabolite phenylacetylgutamine (PAGln) were dose-dependently associated with heart failure and indices of severity independent of traditional risk factors. . https://t.co/IMlNqDLyA6
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…
⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein rich in phenylalanine (e.g., red meat) are associated with the presence and severity of heart failure independent of other risk factors.
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/rteufqWjsH
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/t86R7i2eKH
Fenilacetilglutamina, metabolito de la microbiota, está relacionada clínica y mecanísticamente con la presencia y gravedad de a insuficiencia cardíaca #HF #PAGln #microbiota https://t.co/gB5WgBr8Z2
RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…
RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…
@BSHeartFailure Access the paywalled article from your library: https://t.co/QxpSXNjhNV Promote scholarly access to content by simply adding https://t.co/SXSePSX5De to the DOI URL
Possible relationship between gut microbiome and heart failure (in shape of metabolite - phenylacetylgutamine). In animal studies PAG mechanistically linked to HF. Circulation: Heart Failure 2022 https://t.co/oFuAdaVPhr
Gut #Microbiota-Generated Phenylacetylglutamine and #HeartFailure @CircAHA https://t.co/nFT7OqDIBB
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/tjaiz97Me8
RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…
RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…
RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…
RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…
RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…
Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2Tsv1Ga https://t.co/ery9lDcwYa
https://t.co/p35OmJ6eNk "and mechanistically linked to cardiovascular disease pathogenesis in animal models via modulation of adrenergic receptor signaling."
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/p35OmJ6eNk "The gut microbiota-dependent metabolite phenylacetylgutamine (PAGln) is both associated with atherothrombotic heart disease in humans,"
RT @medical_xpress: Study finds higher levels of common diet-associated microbe elevates #heartfailure risk @CellCellPress https://t.co/UHI…
RT @medical_xpress: Study finds higher levels of common diet-associated microbe elevates #heartfailure risk @CellCellPress https://t.co/UHI…
Study finds higher levels of common diet-associated microbe elevates #heartfailure risk @CellCellPress https://t.co/UHIIGlPsw7 https://t.co/3hXDHjS5Su
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/eQ6a9wtEDv
Gut microbiota-generated phenylacetylglutamine and heart failure. - Romano KA et al. - https://t.co/u1IFD4qVZJ #microbiome
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