Circ Heart Fail January 2023 PMID 36524472

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure.

Kymberleigh A Romano, Ina Nemet, Prasenjit Prasad Saha, Arash Haghikia, Xinmin S Li, Maradumane L Mohan, Beth Lovano, Laurie Castel, Marco Witkowski, Jennifer A Buffa, Yu Sun, Lin Li, Christopher M Menge, Ilja Demuth, Maximilian König

Mentions

91
Peak: 38 in Dec 2022
across 6 sources since Dec 2022

Extended reach

420,500
potential audience

Total likes

76

Video views

117

Mentions per month

Dec 2022 – Sep 2025

Where it's discussed

  • X / Twitter60 posts
  • News17 articles
  • Reddit6 posts
  • Facebook3 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The group overwhelmingly agrees that PAGln is associated with heart failure, supported by technical terms such as 'dose-dependently associated' and mechanistic implications like 'modulation of adrenergic receptor signaling,' which demonstrate active engagement and recognition of both the scientific significance and potential for significant health impact.

AgreementModerate agreement

Most discussions support the connection between PAGln levels and heart failure, with terminology like 'linked to' and 'associated with' indicating consensus.

InterestHigh interest

Many posts highlight the relevance of the findings to health risks and potential treatments, reflecting high interest, especially with phrases like 'clinical and mechanistic link' and 'predictive value.'

EngagementModerate engagement

Posts reference detailed mechanistic insights and call for monitoring or further research, showing moderate to deep engagement.

ImpactHigh impact

There is a strong belief that these findings could influence future clinical practices or dietary guidelines, as evidenced by comments on potential treatment approaches and disease prevention.

Abstract in brief

  • The study found that higher levels of a gut microbiota-produced compound called PAGln are associated with the presence and severity of heart failure, regardless of other risk factors.
  • Mechanistic experiments showed that PAGln can negatively affect heart cells by reducing their contraction and increasing markers linked to heart failure, suggesting it may directly contribute to heart dysfunction.
  • These findings suggest that targeting the gut bacteria responsible for producing PAGln could be a new approach to treating or preventing heart failure.

Top posts

Most liked on X and Bluesky
John Damianos, M.D.
@john_damianosMD · X

⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein rich in phenylalanine (e.g., red meat) are associated with the presence and severity of heart failure independent of other risk factors.

Dec 26, 2022 · 28 likes · 15 shares · 24,006 followers View post →
Medical Xpress
@medical_xpress · X

Study finds higher levels of common diet-associated microbe elevates #heartfailure risk @CellCellPress https://t.co/UHIIGlPsw7 https://t.co/3hXDHjS5Su

Dec 16, 2022 · 15 likes · 5 shares · 173,245 followers View post →
Circ: Heart Failure
@CircHF · X

Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2Tsv1Ga https://t.co/ery9lDcwYa

Dec 16, 2022 · 10 likes · 8 shares · 7,860 followers View post →
Ina Nemet
@NemetGroup · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/eQ6a9wtEDv

Dec 16, 2022 · 9 likes · 56 followers View post →
British Society for Heart Failure #theFword
@BSHeartFailure · X

Possible relationship between gut microbiome and heart failure (in shape of metabolite - phenylacetylgutamine). In animal studies PAG mechanistically linked to HF. Circulation: Heart Failure 2022 https://t.co/oFuAdaVPhr

Dec 21, 2022 · 4 likes · 11,483 followers View post →
Sergey Minaev
@sminaev2015 · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure | Circulation: Heart Failure https://t.co/cbGhe1lnk3

Mar 6, 2023 · 3 likes · 1 share · 31,508 followers View post →

All mentions

For health-promoting environments
@SilkeLeFay · X

@JACCJournals @GuelGueder . Levels of the gut-liver metabolite PAGln are dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1m6hj

Sep 6, 2025 · 4,589 followers View post →
For health-promoting environments
@SilkeLeFay · X

#AI #healthcare #agedcare #datascience #microbiome #NCDs #ehealth #healthspan #hepatology #gerontology #geriatrics Circulating prothrombotic gut-liver metabolites, such as indoxyl sulfate and phenylacetylglutamine (PAGln) must be monitored and reduced. . https://t.co/kncAh909oO

Jan 3, 2025 · 4,589 followers View post →
For health-promoting environments
@SilkeLeFay · X

#ehealth #NCDs Circulating PAGln levels were dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1mE6R

Oct 28, 2024 · 4,589 followers View post →
For health-promoting environments
@SilkeLeFay · X

#hepatology NT-proBNP Circulating PAGln levels were dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1mE6R

Oct 19, 2024 · 4,589 followers View post →
For health-promoting environments
@SilkeLeFay · X

#gastroenterology #geriatrics #gerontology #microbiome #hepatology #cardiology #heartfailure #HF #aging The prothrombotic gut-liver metabolite phenylacetylglutamine (PAGln) is clinically and mechanistically linked to heart failure presence and severity. . https://t.co/kncAh8ZBzg

Sep 21, 2024 · 4,589 followers View post →
For health-promoting environments
@SilkeLeFay · X

#ehealth #NCDs Circulating PAGln levels were dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1mE6R

Aug 31, 2024 · 4,589 followers View post →
For health-promoting environments
@SilkeLeFay · X

#ehealth #geriatrics Circulating PAGln levels were dose-dependently associated with heart failure and indices of severity (reduced ventricular ejection fraction, elevated N-terminal pro-B-type natriuretic peptide) independent of traditional risk factors https://t.co/6zDCB1mE6R

Aug 15, 2024 · 4,589 followers View post →
Chidambara .ML.
@chidambara09 · X

RT @SilkeLeFay: #geriatrics #primaryhealthcare #gastroenterology #cardiology #metabolomics #microbiome #CVD Circulating levels of the tox…

May 6, 2024 · 1 share · 11,694 followers View post →
For health-promoting environments
@SilkeLeFay · X

#geriatrics #primaryhealthcare #gastroenterology #cardiology #metabolomics #microbiome #CVD Circulating levels of the toxic gut microbiota metabolite phenylacetylglutamine (PAGln) are dose-dependently associated with heart failure and severity. . https://t.co/6zDCB1mE6R

May 6, 2024 · 1 share · 4,589 followers View post →
Rene Sugar
@renesugar · X

@Alina_MSN_RN Can be low in Long COVID: https://t.co/ZLOlDJRks5 Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/p35OmJ6eNk Phenylalanine https://t.co/rgiXmqMSC1 https://t.co/osbCsbBr0f https://t.co/R6fAvioRtq Amino acid profile: https://t.co/eSqXaNev89

Feb 4, 2024 · 3,975 followers View post →
For health-promoting environments
@SilkeLeFay · X

#cardiology #HF #heartfailure #ESCCongress #ESC2023 #microbiome Circulating levels of the toxic gut microbiota metabolite PAGln are dose-dependently associated with heart failure and severity . https://t.co/6zDCB1mE6R https://t.co/Ut7i3VbqZ9

Aug 26, 2023 · 4,589 followers View post →
Linus LAW
@law_linus · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/tSXyXSiRk6

Jul 24, 2023 · 951 followers View post →
Linus LAW
@law_linus · X

RT @didius_marcus: @NatureCustom phenylacetylglutamine.. But this study https://t.co/CHogiKT1iZ associated it with heart failure.

Jul 24, 2023 · 1 share · 951 followers View post →
Marcus Didius
@didius_marcus · X

@NatureCustom phenylacetylglutamine.. But this study https://t.co/CHogiKT1iZ associated it with heart failure.

Jul 19, 2023 · 1 like · 1 share · 129 followers View post →
For health-promoting environments
@SilkeLeFay · X

#thrombosis coronary artery disease #atherosclerosis #microbiome #aging #geriatrics MONITOR-HF #heartdisease #bloodclots Circulating levels of the toxic gut microbiota metabolite PAGln are dose-dependently associated with heart failure and severity . https://t.co/IMlNqDLyA6 https://t.co/WyqEtTKfDD

May 20, 2023 · 4,589 followers View post →
For health-promoting environments
@SilkeLeFay · X

#ehealth MONITOR-HF #microbiome #generalpractice Circulating levels of the toxic gut microbiota metabolite phenylacetylglutamine (PAGln) were dose-dependently associated with heart failure and indices of severity independent of traditional risk factors . https://t.co/IMlNqDLyA6

May 20, 2023 · 4,589 followers View post →
For health-promoting environments
@SilkeLeFay · X

#microbiome #primaryhealthcare #geriatrics Circulating levels of the toxic gut microbiota metabolite phenylacetylglutamine (PAGln) were dose-dependently associated with heart failure and indices of severity independent of traditional risk factors. . https://t.co/IMlNqDLyA6

Mar 31, 2023 · 4,589 followers View post →
Reddit Journal of Science
@rsciencejournal · X

Product of Gut Microbiome Linked with Heart Failure Risk https://t.co/6PKtyOVku2 #science #health #product #gut #microbiome #linked

Mar 7, 2023 · 336 followers View post →
Sergey Minaev
@sminaev2015 · X

RT @sminaev2015: Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure | Circulation: Heart Failure https://t.co/cbGhe1lnk3

Mar 7, 2023 · 1 share · 31,508 followers View post →
Sergey Minaev
@sminaev2015 · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure | Circulation: Heart Failure https://t.co/cbGhe1lnk3

Mar 6, 2023 · 3 likes · 1 share · 31,508 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Study finds higher levels of common diet-associated microbe elevates heart failure risk https://t.co/Pb4fga1tOa https://t.co/foYHwaaykz https://t.co/alCRabZgsk https://t.co/PjBarRFlwl

Feb 25, 2023 · 94 followers View post →
Reddit Journal of Science
@rsciencejournal · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/O6PkOj9uMI #science #health #gut #microbiotagenerated #phenylacetylglutamine #heart

Jan 10, 2023 · 336 followers View post →
Xinyu Wang
@marlyn_aj09 · X

RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…

Dec 31, 2022 · 8 shares · 105 followers View post →
For health-promoting environments
@SilkeLeFay · X

#publichealth #COVID19 #LongCovid #microbiome Circulating levels of the toxic gut microbiota metabolite phenylacetylgutamine (PAGln) were dose-dependently associated with heart failure and indices of severity independent of traditional risk factors. . https://t.co/IMlNqDLyA6

Dec 30, 2022 · 4,589 followers View post →
Daniel S.
@asecretcrow · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 543 followers View post →
Tomasz Grzywa, MD, PhD
@drtomaszgrzywa · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 381 followers View post →
Urban
@qfb_urban · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 209 followers View post →
Mª Eugenia Ruiz-Diaz N.
@maugeruizdiaz · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 330 followers View post →
Laboratorio Cobas
@Cobassalud · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 1,182 followers View post →
Dr Yane Valdez Tejeira
@YaneValdezT · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 2,686 followers View post →
Viviana
@VivianAya93 · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 134 followers View post →
Warwick Dunn
@rickdunnblade · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 2,507 followers View post →
AB Johnson
@Hijo_de_Juan · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 152 followers View post →
Mémé
@Meme_nutrition · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 126 followers View post →
Katie Guzzetta
@ktguzz · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 27, 2022 · 15 shares · 4,772 followers View post →
Munawar Abbas
@munawarabbas93 · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 26, 2022 · 15 shares · 95 followers View post →
Santosh Thapa
@SantoshThapa11 · X

RT @john_damianosMD: ⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein ric…

Dec 26, 2022 · 15 shares · 180 followers View post →
John Damianos, M.D.
@john_damianosMD · X

⬆️ levels of phenylacetylgutamine, a metabolite produced by the gut microbiota in the breakdown of dietary protein rich in phenylalanine (e.g., red meat) are associated with the presence and severity of heart failure independent of other risk factors.

Dec 26, 2022 · 28 likes · 15 shares · 24,006 followers View post →
Tatyana Shamliyan
@ShamliyanTA · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/rteufqWjsH

Dec 26, 2022 · 280 followers View post →
Maria Queralt Gorgas
@qgorgas · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/t86R7i2eKH

Dec 26, 2022 · 1,470 followers View post →
@investigando
@rocatanho · X

Fenilacetilglutamina, metabolito de la microbiota, está relacionada clínica y mecanísticamente con la presencia y gravedad de a insuficiencia cardíaca #HF #PAGln #microbiota https://t.co/gB5WgBr8Z2

Dec 23, 2022 · 395 followers View post →
Efstratios A. Apostolou
@EApostolouMD · X

RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…

Dec 21, 2022 · 8 shares · 408 followers View post →
W. H. Wilson Tang, MD
@WilsonTangMD · X

RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…

Dec 21, 2022 · 8 shares · 1,503 followers View post →
LibKey
@libkey_io · X

@BSHeartFailure Access the paywalled article from your library: https://t.co/QxpSXNjhNV Promote scholarly access to content by simply adding https://t.co/SXSePSX5De to the DOI URL

Dec 21, 2022 · 555 followers View post →
British Society for Heart Failure #theFword
@BSHeartFailure · X

Possible relationship between gut microbiome and heart failure (in shape of metabolite - phenylacetylgutamine). In animal studies PAG mechanistically linked to HF. Circulation: Heart Failure 2022 https://t.co/oFuAdaVPhr

Dec 21, 2022 · 4 likes · 11,483 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Gut #Microbiota-Generated Phenylacetylglutamine and #HeartFailure @CircAHA https://t.co/nFT7OqDIBB

Dec 20, 2022 · 1 like · 6,463 followers View post →
Italo Kumamoto
@fikkumamoto · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/tjaiz97Me8

Dec 18, 2022 · 1 like · 8,796 followers View post →
Kanokwan (Mandy) Bunsawat, PhD
@K_Bunsawat · X

RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…

Dec 17, 2022 · 8 shares · 572 followers View post →
James Fang
@JamesCFangMD · X

RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…

Dec 17, 2022 · 8 shares · 2,291 followers View post →
Raul Osorio
@remyosorio · X

RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…

Dec 16, 2022 · 8 shares · 1 followers View post →
Lanzule, Inc.
@lanzule · X

RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…

Dec 16, 2022 · 8 shares · 1,053 followers View post →
Thanat Chaikijurajai, MD
@TChaikijurajai · X

RT @CircHF: Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2…

Dec 16, 2022 · 8 shares · 461 followers View post →
Circ: Heart Failure
@CircHF · X

Gut microbiota-generated phenylacetylglutamine and heart failure @CCLRI @WilsonTangMD @vanwagd #AHAJournals https://t.co/A5X2Tsv1Ga https://t.co/ery9lDcwYa

Dec 16, 2022 · 10 likes · 8 shares · 7,860 followers View post →
Rene Sugar
@renesugar · X

https://t.co/p35OmJ6eNk "and mechanistically linked to cardiovascular disease pathogenesis in animal models via modulation of adrenergic receptor signaling."

Dec 16, 2022 · 1 like · 3,975 followers View post →
Rene Sugar
@renesugar · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/p35OmJ6eNk "The gut microbiota-dependent metabolite phenylacetylgutamine (PAGln) is both associated with atherothrombotic heart disease in humans,"

Dec 16, 2022 · 3,975 followers View post →
$PIN_BOUT_U...47
@STEPHANZAIL · X

RT @medical_xpress: Study finds higher levels of common diet-associated microbe elevates #heartfailure risk @CellCellPress https://t.co/UHI…

Dec 16, 2022 · 5 shares · 2,155 followers View post →
Medical Xpress
@physorg_health · X

RT @medical_xpress: Study finds higher levels of common diet-associated microbe elevates #heartfailure risk @CellCellPress https://t.co/UHI…

Dec 16, 2022 · 5 shares · 7,078 followers View post →
Medical Xpress
@medical_xpress · X

Study finds higher levels of common diet-associated microbe elevates #heartfailure risk @CellCellPress https://t.co/UHIIGlPsw7 https://t.co/3hXDHjS5Su

Dec 16, 2022 · 15 likes · 5 shares · 173,245 followers View post →
Ina Nemet
@NemetGroup · X

Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure https://t.co/eQ6a9wtEDv

Dec 16, 2022 · 9 likes · 56 followers View post →
Microbiome Articles
@microbe_article · X

Gut microbiota-generated phenylacetylglutamine and heart failure. - Romano KA et al. - https://t.co/u1IFD4qVZJ #microbiome

Dec 16, 2022 · 7,155 followers View post →