Neurology April 2023 PMID 36657992

Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease.

Christopher Gibbons, Ningshan Wang, Sharika Rajan, Drew Kern, Jose-Alberto Palma, Horacio Kaufmann, Roy Freeman

Mentions

50
Peak: 3 in Jan 2023
across 4 sources since Jan 2023

Extended reach

18,469
potential audience

Total likes

25

Video views

1,061

Mentions per month

Jan 2023 – Mar 2024

Where it's discussed

  • News39 articles
  • X / Twitter7 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The group shows strong interest and moderate agreement with the study's potential, exemplified in posts that highlight the importance of skin biopsies for differential diagnosis and in comments about training in neurology, which reflect deeper engagement. The tone suggests anticipation of clinical impact, such as the connection to early Parkinson’s symptoms and neurodegenerative disease management.

AgreementModerate agreement

Most discussions show support or recognition of the article’s findings and potential, especially acknowledging the significance of skin-based biomarkers.

InterestHigh interest

Participants display high interest, referencing biomarker detection, clinical applications, and related neurological conditions, indicating engagement with the research.

EngagementModerate engagement

Posts involve some degree of reflection, such as training in neurology or drawing parallels to COVID-19, suggesting moderate but meaningful engagement.

ImpactModerate impact

The discussions hint at the research's potential to influence diagnostic approaches and clinical practice, though mostly in an exploratory or optimistic context.

Abstract in brief

  • The study focused on identifying a unique skin-based biomarker involving phosphorylated synuclein to accurately differentiate between patients with Multiple System Atrophy (MSA) and Parkinson Disease (PD), as current diagnostic tools are limited.
  • Researchers found that phosphorylated synuclein deposits were more widespread and abundant in skin biopsies from MSA patients compared to those with PD and healthy controls, providing a method with 90% accuracy.
  • The findings suggest that detecting phosphorylated synuclein in peripheral nerves through skin biopsies could serve as a reliable, minimally invasive way to distinguish MSA from PD in clinical settings.]

Top posts

Most liked on X and Bluesky
Martha-JD, MBA, PCC-
@mryoung151 · X

Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms reported by long COVID patients are undeniable.” Skin biopsy biomarker Parkinson’s https://t.co/UFW8clPRUy https://t.co/Jql89VId9i

Aug 13, 2023 · 6 likes · 2 shares · 8,883 followers View post →
Paul Beach D.O., Ph.D. (he/him)
@PaulBeachDOPhD · X

Feeling incredibly lucky to be training in #autonomic neurology with this group @BIDMChealth. "Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease." https://t.co/rLRTkrpbzI

Jan 24, 2023 · 6 likes · 1 share · 616 followers View post →
American Autonomic Society
@AASAutonomic · X

RT @PaulBeachDOPhD: Feeling incredibly lucky to be training in #autonomic neurology with this group @BIDMChealth. "Cutaneous α-Synuclein Si…

Jan 25, 2023 · 1 share · 2,188 followers View post →
mark warling
@markwarling3 · X

RT @mryoung151: Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms…

Aug 13, 2023 · 2 shares · 1,825 followers View post →
Jan - TTI, wear respirator, demand more ACH. HEPA
@quarecuttie · X

RT @mryoung151: Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms…

Aug 13, 2023 · 2 shares · 1,626 followers View post →
My Neuropath News
@NeuropathClinic · X

Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease #neuropath https://t.co/xDHzoMzyud

Feb 8, 2023 · 1,580 followers View post →

All mentions

Jan - TTI, wear respirator, demand more ACH. HEPA
@quarecuttie · X

RT @mryoung151: Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms…

Aug 13, 2023 · 2 shares · 1,626 followers View post →
mark warling
@markwarling3 · X

RT @mryoung151: Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms…

Aug 13, 2023 · 2 shares · 1,825 followers View post →
Martha-JD, MBA, PCC-
@mryoung151 · X

Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms reported by long COVID patients are undeniable.” Skin biopsy biomarker Parkinson’s https://t.co/UFW8clPRUy https://t.co/Jql89VId9i

Aug 13, 2023 · 6 likes · 2 shares · 8,883 followers View post →
My Neuropath News
@NeuropathClinic · X

Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease #neuropath https://t.co/xDHzoMzyud

Feb 8, 2023 · 1,580 followers View post →
American Autonomic Society
@AASAutonomic · X

RT @PaulBeachDOPhD: Feeling incredibly lucky to be training in #autonomic neurology with this group @BIDMChealth. "Cutaneous α-Synuclein Si…

Jan 25, 2023 · 1 share · 2,188 followers View post →
Paul Beach D.O., Ph.D. (he/him)
@PaulBeachDOPhD · X

Feeling incredibly lucky to be training in #autonomic neurology with this group @BIDMChealth. "Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease." https://t.co/rLRTkrpbzI

Jan 24, 2023 · 6 likes · 1 share · 616 followers View post →
Valtteri Kaasinen
@ValKaasinen · X

Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease https://t.co/0g7allo5LG

Jan 20, 2023 · 675 followers View post →