Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease.

Christopher Gibbons, Ningshan Wang, Sharika Rajan, Drew Kern, Jose-Alberto Palma, Horacio Kaufmann, Roy Freeman

April 2023 Neurology

Synopsis of Social media discussions

The group shows strong interest and moderate agreement with the study's potential, exemplified in posts that highlight the importance of skin biopsies for differential diagnosis and in comments about training in neurology, which reflect deeper engagement. The tone suggests anticipation of clinical impact, such as the connection to early Parkinson’s symptoms and neurodegenerative disease management.

A
Agreement
 Moderate agreement

Most discussions show support or recognition of the article’s findings and potential, especially acknowledging the significance of skin-based biomarkers.

I
Interest
 High level of interest

Participants display high interest, referencing biomarker detection, clinical applications, and related neurological conditions, indicating engagement with the research.

E
Engagement
 Moderate level of engagement

Posts involve some degree of reflection, such as training in neurology or drawing parallels to COVID-19, suggesting moderate but meaningful engagement.

I
Impact
 Moderate level of impact

The discussions hint at the research's potential to influence diagnostic approaches and clinical practice, though mostly in an exploratory or optimistic context.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

7 Posts

News

39 Articles

Metrics

Video Views

1,061

Total Likes

25

Extended Reach

18,469

Social Features

50

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Skin Biomarkers for Differentiating Parkinson's Disease and MSA

Skin Biomarkers for Differentiating Parkinson's Disease and MSA

This episode discusses a study on identifying skin-based biomarkers, involving phosphorylated synuclein, to accurately differentiate between Multiple System Atrophy and Parkinson's Disease with 90% accuracy. Skin biopsies could offer a minimally invasive diagnostic tool.

Neurology Journal

May 29, 2023

752 views

Skin Biomarkers for Accurate Differentiation of Multiple System Atrophy and Parkinson Disease

Skin Biomarkers for Accurate Differentiation of Multiple System Atrophy and Parkinson Disease

The study focused on identifying a unique skin-based biomarker involving phosphorylated synuclein to differentiate MSA and Parkinson Disease. Detection of phosphorylated synuclein deposits in skin biopsies shows promise with 90% accuracy.

Научный центр неврологии

March 28, 2024

309 views

  • Jan - TTI, wear respirator, demand more ACH. HEPA
    @quarecuttie (Twitter)

    RT @mryoung151: Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms…
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    August 13, 2023

    2

  • mark warling
    @markwarling3 (Twitter)

    RT @mryoung151: Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms…
    view full post

    August 13, 2023

    2

  • Martha-JD, MBA, PCC-
    @mryoung151 (Twitter)

    Covid➡️ #Longcovid ➡️Parkinson’s disease❓”Parallels between the early Parkinson's symptoms outlined above and the symptoms reported by long COVID patients are undeniable.” Skin biopsy biomarker Parkinson’s https://t.co/UFW8clPRUy https://t.co/Jql89VId9i
    view full post

    August 13, 2023

    6

    2

  • My Neuropath News
    @NeuropathClinic (Twitter)

    Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease #neuropath https://t.co/xDHzoMzyud
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    February 8, 2023

  • American Autonomic Society
    @AASAutonomic (Twitter)

    RT @PaulBeachDOPhD: Feeling incredibly lucky to be training in #autonomic neurology with this group @BIDMChealth. "Cutaneous α-Synuclein Si…
    view full post

    January 25, 2023

    1

  • Paul Beach D.O., Ph.D. (he/him)
    @PaulBeachDOPhD (Twitter)

    Feeling incredibly lucky to be training in #autonomic neurology with this group @BIDMChealth. "Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease." https://t.co/rLRTkrpbzI
    view full post

    January 24, 2023

    6

    1

  • Valtteri Kaasinen
    @ValKaasinen (Twitter)

    Cutaneous α-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease https://t.co/0g7allo5LG
    view full post

    January 20, 2023

Abstract Synopsis

  • The study focused on identifying a unique skin-based biomarker involving phosphorylated synuclein to accurately differentiate between patients with Multiple System Atrophy (MSA) and Parkinson Disease (PD), as current diagnostic tools are limited.
  • Researchers found that phosphorylated synuclein deposits were more widespread and abundant in skin biopsies from MSA patients compared to those with PD and healthy controls, providing a method with 90% accuracy.
  • The findings suggest that detecting phosphorylated synuclein in peripheral nerves through skin biopsies could serve as a reliable, minimally invasive way to distinguish MSA from PD in clinical settings.]