Precise transcript targeting by CRISPR-Csm complexes.

David Colognori, Marena Trinidad, Jennifer A Doudna

September 2023 Nat Biotechnol

Synopsis of Social media discussions

Many discussions emphasize the high efficiency of RNA knockdown achieved by the CRISPR-Csm complex, with users noting its superiority over existing methods. Phrases like 'really cool work' and 'looks very promising' reflect excitement and positivity, contributing to a tone of enthusiasm around the article. Additionally, references to developers of CRISPR technology highlight respect and recognition for past advancements in the field.

A
Agreement
 Moderate agreement

Most discussions indicate a supportive view of the publication's findings, highlighting the innovative aspects of the CRISPR-Csm complex.

I
Interest
 High level of interest

The high level of curiosity about RNA targeting technologies is evident, signaling a strong interest in the advancements presented.

E
Engagement
 Moderate level of engagement

While discussions reference specific elements of the research, the comments tend to remain on the surface without deep analysis or critique.

I
Impact
 High level of impact

The consensus is that this research represents a significant advancement with real potential applications in gene editing and live-cell imaging.

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296

Extended Reach

1,976,997

Social Features

111

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Top Social Media Posts

Posts referencing the article

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59 views

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February 24, 2023

29 views

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    RT @biorxivpreprint: Precise Transcript Targeting by CRISPR-Csm Complexes https://t.co/IWPteBS0jh #bioRxiv
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    June 21, 2022

    6

  • Ben Adler
    @ben_a_adler (Twitter)

    RT @biorxivpreprint: Precise Transcript Targeting by CRISPR-Csm Complexes https://t.co/IWPteBS0jh #bioRxiv
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    June 21, 2022

    6

  • bioRxiv Bioengineering
    @bioRxiv_bioE (Twitter)

    Precise Transcript Targeting by CRISPR-Csm Complexes https://t.co/riogSthXWJ #biorxiv_bioE
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    June 21, 2022

  • bioRxiv
    @biorxivpreprint (Twitter)

    Precise Transcript Targeting by CRISPR-Csm Complexes https://t.co/IWPteBS0jh #bioRxiv
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    June 21, 2022

    19

    6

Abstract Synopsis

  • Researchers demonstrate that the CRISPR-Csm complex effectively targets and degrades RNA in mammalian cells, overcoming inefficiencies of current methods.
  • This system allows for high-efficiency RNA knockdown (90-99%) while minimizing off-target effects, outperforming existing techniques like Cas13.
  • The study also reveals that a catalytically inactive version of Csm can bind RNA specifically, enabling new possibilities for live-cell RNA imaging.