Mod Pathol January 2023 PMID 36788065

Psammomatoid Ossifying Fibroma Is Defined by SATB2 Rearrangement.

Arjen H G Cleven, Karoly Szuhai, David G P van IJzendoorn, Eline Groen, Hans Baelde, Willem H Schreuder, Inge H Briaire-de Bruijn, Stijn W van der Meeren, Maarten C Kleijwegt, Wouter R Furth, Herman M Kroon, Albert J H Suurmeijer, Dilara C Savci-Heijink, Daniel Baumhoer, Judith V M G Bovée

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Mentions

Peak: 2 in Feb 2023

across 2 sources since Feb 2023

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2,058

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209

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Feb 2023 – Jan 2024

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AI synopsis

What people are saying

Several posts praise the discovery of SATB2 rearrangement as a key marker for distinguishing Psammomatoid Ossifying Fibroma, with phrases like 'important breakthrough' and 'could change diagnostics.' Some discuss the potential for targeted treatments, showing curiosity and engagement, while the tone remains positive and forward-looking, highlighting both scientific interest and perceived impact.

AgreementModerate agreement

Most discussions highlight agreement with the article's findings, emphasizing the significance of the SATB2 gene fusion in diagnosing Psammomatoid Ossifying Fibroma.

InterestModerate interest

Participants show moderate interest, often referencing the genetic aspects and diagnostic implications but not delving into extensive details.

EngagementModerate engagement

Posts reflect active engagement through sharing insights and raising questions about the molecular mechanisms involved.

ImpactModerate impact

The overall tone suggests recognition of the research's importance for future diagnosis and treatment, signaling moderate impact on the field.

Abstract in brief

Psammomatoid ossifying fibroma (PsOF) is a benign bone tumor mainly affecting the frontal and ethmoid bones in young people, and its diagnosis can be challenging because it shares features with other similar tumors.
Researchers identified a specific gene fusion involving SATB2 and AL5134871 in PsOF cases, which was confirmed through sequencing and FISH tests, indicating a genetic basis for the tumor.
The study found that over half of PsOF cases have rearrangements in the SATB2 gene, whereas these genetic changes were not seen in other similar tumors, and the presence of SATB2 protein varied among tumor cells, suggesting complex molecular mechanisms behind PsOF.]

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All mentions

Genetic Basis of Psammomatoid Ossifying Fibroma Identified by SATB2 Rearrangement

Psammomatoid ossifying fibroma is a benign bone tumor mainly affecting the frontal and ethmoid bones in young people. Researchers identified a specific gene fusion involving SATB2, which may aid in diagnosis and…

USCAP Your Academy · Jan 10, 2024 194 views

Genetic Marker SATB2 Rearrangement in Psammomatoid Ossifying Fibroma

Psammomatoid ossifying fibroma is a benign bone tumor affecting young adults, mainly in the frontal and ethmoid bones. Researchers identified SATB2 gene rearrangements in over half of the cases, providing a molecular…

USCAP YouTube · Jan 8, 2024 15 views

Fish Chromosomes

@FishChromosomes · X

Psammomatoid Ossifying Fibroma Is Defined by SATB2 Rearrangement https://t.co/LZfKvQomBs https://t.co/6ilLQSo7LH

Feb 18, 2023 · 46 followers View post →

Transcriptomes

@transcriptomes · X

Psammomatoid Ossifying Fibroma Is Defined by SATB2 Rearrangement. https://t.co/3jbufx5gH4

Feb 15, 2023 · 1,804 followers View post →