Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas.

Yanming Ren, Zongyao Huang, Lingling Zhou, Peng Xiao, Junwei Song, Ping He, Chuanxing Xie, Ran Zhou, Menghan Li, Xiangqun Dong, Qing Mao, Chao You, Jianguo Xu, Yanhui Liu, Zhigang Lan

February 2023 Nat Commun

Synopsis of Social media discussions

Several discussions highlight the importance of the research in understanding glioma cell behavior, with phrases like 'significant advancement' and 'potential for targeted therapy.' The tone emphasizes curiosity and the transformative potential of spatial transcriptomics, reflecting a shared recognition of its importance in cancer research.

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Agreement
 Moderate agreement

Most discussions express agreement or positive recognition of the study’s significance, emphasizing its novel insights into tumor cell behavior.

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Interest
 High level of interest

The discussions show a high level of curiosity, with users highlighting the importance of cellular mapping and potential therapies, indicating strong interest.

E
Engagement
 Moderate level of engagement

Participants engage by referencing specific methods like spatial transcriptomics and discussing implications, demonstrating thoughtful engagement.

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Impact
 Moderate level of impact

Some posts suggest the findings could influence future research and treatment strategies, indicating moderate to high perceived impact.

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Posts referencing the article

Spatial Transcriptomics Uncovers Cell Niches and Vulnerabilities in Gliomas

Spatial Transcriptomics Uncovers Cell Niches and Vulnerabilities in Gliomas

This study utilizes advanced spatial transcriptomics to map cellular diversity within aggressive brain tumors, revealing how radial glial stem-like cells adapt and interact with microenvironments, and identifying molecular pathways promoting invasive growth for targeted therapies.

STEM RTCL TV

June 18, 2023

2 views

  • Yuan Wang
    @YuanW_SCU (Twitter)

    RT @Epigenetica: New in Pubmed: "Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like ce…
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    August 6, 2023

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  • Transcriptomes
    @transcriptomes (Twitter)

    Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial... https://t.co/scqEW0rijk
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    February 24, 2023

  • Epigenética
    @Epigenetica (Twitter)

    New in Pubmed: "Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas" https://t.co/iutiBzREZT
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    February 24, 2023

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Abstract Synopsis

  • This study uses advanced spatial transcriptomics techniques to map and understand the cellular diversity and regulatory programs within different regions of aggressive brain tumors like DMG and GBM, revealing how tumor cells adapt to and interact with their microenvironments.
  • It finds that radial glial stem-like cells are more concentrated in the neuron-rich invasive zones of these tumors, and identifies specific molecular pathways, such as FAM20C, that promote their invasive growth.
  • These insights into the spatial organization and niche-specific vulnerabilities of glioma cells may help develop targeted therapies for these deadly brain cancers.