Nat Commun February 2023 PMID 36823187

Gene-encoding DNA origami for mammalian cell expression.

Jessica A Kretzmann, Anna Liedl, Alba Monferrer, Volodymyr Mykhailiuk, Samuel Beerkens, Hendrik Dietz

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Overall, the discussions emphasize the innovative aspect of using DNA origami for gene delivery, with phrases like 'nanotechnology' and 'gene expression' indicating fascination, though many comments remain general. This reflects a positive yet mostly surface-level engagement, recognizing its potential without deep exploration of its broader consequences.

AgreementModerate agreement

Most discussions show support or interest in the research, with some references to its potential benefits, indicating general agreement on its importance.

InterestHigh interest

Many comments highlight curiosity and excitement about the technique, with mentions of DNA nanotechnology and gene delivery, reflecting high interest.

EngagementModerate engagement

There are multiple references to the publication itself and its implications, but the tone remains mostly superficial with limited detailed discussion.

ImpactModerate impact

The focus on the technological advancements suggests an acknowledgment of potential impact, but few posts elaborate on specific applications or breakthroughs.

Abstract in brief

DNA origami can be used to create customized nanoscale structures that delivery genes into mammalian cells with specific targeting and functional features.
Genes embedded in these DNA origami structures can be effectively expressed within cells, especially if the structures can unzip or denature inside the cell.
The study also shows that incorporating certain DNA motifs, like ITR-like hairpins, and designing multimeric structures allows for improved gene expression and the simultaneous delivery of multiple genes, offering new possibilities for gene delivery techniques.]

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Gene-encoding DNA origami for targeted mammalian cell expression

DNA origami can create customizable nanoscale structures for gene delivery into mammalian cells. These structures effectively enable gene expression, especially when designed for unzipping inside cells, providing…

STEM RTCL TV · Jun 15, 2023 93 views

The Virofight project

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It's always a good idea to read about #DNAorigami

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DNA nanotech papers

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Gene-encoding DNA origami for mammalian cell expression https://t.co/MJRSVyGfWF https://t.co/oqfOcjhQoD

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Thanuka Dananjaya

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Van-Thang Nguyen

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RT @ian_hoffecker: Gene-encoding DNA origami for mammalian cell expression https://t.co/GE30XnXFzZ nanotechnology https://t.co/COZFqynkws

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soft/living matter fanclub

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J. A. Kretzmann, et al., Gene-encoding DNA origami for mammalian cell expression. Nat. Commun. 14, 1–10 (2023). https://t.co/6BcGMxyeTW

Feb 24, 2023 · 2 likes · 1,527 followers View post →

Dr. Majid Basharat, PhD

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Yuhe Renee Yang

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micropapers

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Phage Papers

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Gene-encoding DNA origami for mammalian cell expression https://t.co/i2zrz8uHqC

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virgo

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Ben Hardisty, PhD

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Mengying Deng

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Yoel Ohayon

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Gene-encoding DNA origami for mammalian cell expression https://t.co/je7qeZIk6d https://t.co/4vcKWEjqVn

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Pat Sweeney

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Naphak Modhiran

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Paul Lourdu Xavier

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Brian Tenner

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Michael Matthies

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Feb 23, 2023 · 11 shares · 107 followers View post →

Ian hoffecker

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Gene-encoding DNA origami for mammalian cell expression https://t.co/GE30XnXFzZ nanotechnology https://t.co/COZFqynkws

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LUKMAN AFOLABI

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Gene-encoding DNA origami for mammalian cell expression.

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Gene-encoding DNA origami for targeted mammalian cell expression