J Transl Med February 2023 PMID 36841805

Global landscape of SARS-CoV-2 mutations and conserved regions.

Mohammad Hadi Abbasian, Mohammadamin Mahmanzar, Karim Rahimian, Bahar Mahdavi, Samaneh Tokhanbigli, Bahman Moradi, Mahsa Mollapour Sisakht, Youping Deng

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Mentions

11
Peak: 7 in Jun 2023
across 2 sources since Feb 2023

Extended reach

365,150
potential audience

Total likes

36

Video views

12

Mentions per month

Feb 2023 – Dec 2024

Where it's discussed

  • X / Twitter10 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall discussion demonstrates moderate engagement with technical details, such as the use of BWA mem for sequencing and references to sequencing artifacts, reflecting a nuanced interest in the scientific and technical implications of the publication; the tone remains largely informational and skeptical, emphasizing the importance of robust analysis and caution in drawing conclusions.

AgreementNeither agree nor disagree

The discussions reflect a mix of neutral or factual comments, with some skepticism or critique, indicating neither strong support nor opposition.

InterestModerate interest

Most posts show moderate curiosity, mainly discussing technical aspects like sequencing methods and mutation rates.

EngagementModerate engagement

Posts provide detailed comments or questions, indicating some depth of discussion about the genetic analysis and methodological details.

ImpactModerate impact

The posts highlight ongoing conversations about mutation monitoring and sequencing challenges, suggesting a meaningful but not transformative influence.

Abstract in brief

  • The study analyzes the mutations in the SARS-CoV-2 virus by examining over 102,872 genome sequences from early 2020 to April 2022, highlighting key mutations such as P323L and D614G that are highly prevalent globally.
  • Certain regions of the virus, like nsp11, nsp7, nsp10, nsp9, nsp8, and nsp16, showed no mutations in over 90% of cases, indicating they are highly conserved, while others like N, nsp3, S, nsp4, nsp12, and M had higher mutation rates.
  • Monitoring these mutations, especially in the spike protein and other key regions, is crucial for improving diagnostics and vaccine design by targeting conserved regions and understanding mutation hot spots.]

Top posts

Most liked on X and Bluesky
Kevin McKernan
@Kevin_McKernan · X

He demands someone else find his bug. Done! BWA mem solves it. Even if one couldn't cover 4 bases on the end of the reference, No one uses the ends of the genome as they are error prone due to the 5'cap and the PolyA tail creating sequencing artifacts https://t.co/3kOX3c5gVa https://t.co/Rp5WCV41Dw

Jun 29, 2023 · 23 likes · 3 shares · 118,598 followers View post →
Kevin McKernan
@Kevin_McKernan · X

@USMortality @PaulineC73 @NotJasonReal @jjcouey @denisrancourt @Jikkyleaks Read what others have done here. They do not include the regions you are obsessed with as they have known sequencing artifacts. 10.2M sample study. You’re looking at 2 and drawing conclusions with a single mapper. https://t.co/3kOX3c5gVa https://t.co/Z93fyomQKD

Jun 29, 2023 · 7 likes · 1 share · 118,598 followers View post →
Jerry Tessap
@JerryTess · X

Le SARS-CoV-2 29 protéines et des mutations... Publi à lire absolument ! "la fréquence de ces mutations supérieures était plus élevée en Amérique du Nord et en Europe qu'en Afrique du Sud et en Océanie" Les affreux non-vaccinés mutagènes...

Feb 26, 2023 · 3 likes · 238 followers View post →
Rob C
@Rob66733000 · X

@Texas4Progress @vipintukur RNA viruses vary in mutation rates, 1.35 × 10–5 in Influenza H3N2 and −1 4 × 10−5 mutations in HIV. Covid mutation rate is lower 9.0 × 10−7 mutations per nucleotide per replication cycle (m/n/rc). RNA proofreading preserves its genome. https://t.co/LG23kDr5CX

Mar 26, 2023 · 2 likes · 1,057 followers View post →
Sir Autumn Mandrake
@AutumnMandrake · X

@AltenbergLee @LongDesertTrain @Mike_Honey_ @SolidEvidence Conservation of SARS-CoV-2 sequences: https://t.co/W8vhpWuvAP https://t.co/P8XFfeO748

Dec 13, 2024 · 1 like · 1,571 followers View post →
Stealth Medical
@StealthMedical1 · X

RT @Kevin_McKernan: He demands someone else find his bug. Done! BWA mem solves it. Even if one couldn't cover 4 bases on the end of the ref…

Jun 30, 2023 · 3 shares · 81,630 followers View post →

All mentions

Sir Autumn Mandrake
@AutumnMandrake · X

@AltenbergLee @LongDesertTrain @Mike_Honey_ @SolidEvidence Conservation of SARS-CoV-2 sequences: https://t.co/W8vhpWuvAP https://t.co/P8XFfeO748

Dec 13, 2024 · 1 like · 1,571 followers View post →
Ryan sikorski
@Ryansikorski10 · X

Introduction to the SARS-COV-2 Genome Browser https://t.co/8Q9VD1geyk How to extract the spike sequence of the omicron variant from uploaded samples at GISAID? https://t.co/9Pue3tmJi9 Global landscape of SARS-CoV-2 mutations and conserved regions https://t.co/mcYr7RgQ7D https://t.co/JZpDN0SAEd

Sep 16, 2024 · 35,806 followers View post →
Stealth Medical
@StealthMedical1 · X

RT @Kevin_McKernan: He demands someone else find his bug. Done! BWA mem solves it. Even if one couldn't cover 4 bases on the end of the ref…

Jun 30, 2023 · 3 shares · 81,630 followers View post →
G.Wenger
@bricolix · X

RT @Kevin_McKernan: He demands someone else find his bug. Done! BWA mem solves it. Even if one couldn't cover 4 bases on the end of the ref…

Jun 30, 2023 · 3 shares · 1,533 followers View post →
dopaminergic13
@dopaminergic13 · X

RT @Kevin_McKernan: He demands someone else find his bug. Done! BWA mem solves it. Even if one couldn't cover 4 bases on the end of the ref…

Jun 29, 2023 · 3 shares · 5,299 followers View post →
Kevin McKernan
@Kevin_McKernan · X

He demands someone else find his bug. Done! BWA mem solves it. Even if one couldn't cover 4 bases on the end of the reference, No one uses the ends of the genome as they are error prone due to the 5'cap and the PolyA tail creating sequencing artifacts https://t.co/3kOX3c5gVa https://t.co/Rp5WCV41Dw

Jun 29, 2023 · 23 likes · 3 shares · 118,598 followers View post →
Elizabeth Brown
@ElizabethB60282 · X

RT @Kevin_McKernan: @USMortality @PaulineC73 @NotJasonReal @jjcouey @denisrancourt @Jikkyleaks Read what others have done here. They do no…

Jun 29, 2023 · 1 share · 780 followers View post →
Kevin McKernan
@Kevin_McKernan · X

@USMortality @PaulineC73 @NotJasonReal @jjcouey @denisrancourt @Jikkyleaks Read what others have done here. They do not include the regions you are obsessed with as they have known sequencing artifacts. 10.2M sample study. You’re looking at 2 and drawing conclusions with a single mapper. https://t.co/3kOX3c5gVa https://t.co/Z93fyomQKD

Jun 29, 2023 · 7 likes · 1 share · 118,598 followers View post →
Rob C
@Rob66733000 · X

@Texas4Progress @vipintukur RNA viruses vary in mutation rates, 1.35 × 10–5 in Influenza H3N2 and −1 4 × 10−5 mutations in HIV. Covid mutation rate is lower 9.0 × 10−7 mutations per nucleotide per replication cycle (m/n/rc). RNA proofreading preserves its genome. https://t.co/LG23kDr5CX

Mar 26, 2023 · 2 likes · 1,057 followers View post →
Jerry Tessap
@JerryTess · X

Le SARS-CoV-2 29 protéines et des mutations... Publi à lire absolument ! "la fréquence de ces mutations supérieures était plus élevée en Amérique du Nord et en Europe qu'en Afrique du Sud et en Océanie" Les affreux non-vaccinés mutagènes...

Feb 26, 2023 · 3 likes · 238 followers View post →