Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.

Ariel K Frame, J Wesley Robinson, Nader H Mahmoudzadeh, Jason M Tennessen, Anne F Simon, Robert C Cumming

February 2023 Aging (Albany NY)

Synopsis of Social media discussions

The discussions demonstrate a positive attitude toward the study, with comments highlighting its scientific contribution, such as references to the role of lactate dehydrogenase in aging and memory, and sharing resources like summaries and preprints. Words like 'excited,' 'interesting,' and 'looking forward' convey both approval and curiosity, underpinning modest yet meaningful engagement and perceived impact.

A
Agreement
 Moderate agreement

Most discussions recognize the significance of the research, with some expressing enthusiasm and support for the findings.

I
Interest
 Moderate level of interest

Posts show moderate curiosity, with many sharing summaries or promoting the study, indicating a decent level of engagement.

E
Engagement
 Moderate level of engagement

Several comments delve into the implications of manipulating lactate metabolism for aging and memory, reflecting active interest.

I
Impact
 Moderate level of impact

The discussions suggest recognition of the study's potential to influence future aging or neuroscience research, though mostly from a scientific perspective.

Social Mentions

YouTube

2 Videos

Twitter

41 Posts

News

2 Articles

Metrics

Video Views

302

Total Likes

85

Extended Reach

367,558

Social Features

45

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Impact of Lactate Dehydrogenase Manipulation on Aging and Memory in Flies

Impact of Lactate Dehydrogenase Manipulation on Aging and Memory in Flies

Researchers explored how altering lactate dehydrogenase genes in fly brain cells affects aging and memory. The study highlights the role of lactate in supporting neural function and longevity, emphasizing its importance in cognitive health across the lifespan.

Aging-US

March 22, 2023

195 views

Impact of Lactate Dehydrogenase on Memory and Aging in Flies

Impact of Lactate Dehydrogenase on Memory and Aging in Flies

Scientists studied how lactate influences brain cell collaboration for memory and aging by genetically modifying the dLdh gene in fly brains, revealing changes in memory and lifespan, especially with age.

Aging-US

March 7, 2023

107 views

  • Aging-US
    @AgingJrnl (Twitter)

    Go #BehindtheStudy with Dr. Ariel K. Frame from Western University as he discusses a research paper he co-authored and published in Aging: “Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.” https://t.co/nGkko3uHC1
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    December 27, 2023

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  • Aging-US
    @AgingJrnl (Twitter)

    Go #BehindtheStudy with Dr. Ariel K. Frame from @WesternU as he discusses a research paper he co-authored and published in Aging, entitled, “Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.” https://t.co/nGkko3uHC1
    view full post

    August 28, 2023

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  • Drosophilosopher
    @HammedBadmos (Twitter)

    RT @interactivefly: Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and me…
    view full post

    August 5, 2023

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  • Drosophila Genomics Resource Center
    @DrosDGRC (Twitter)

    RT @interactivefly: Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and me…
    view full post

    August 4, 2023

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  • Thomas Brody
    @interactivefly (Twitter)

    Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies. Aging (Albany NY) 15(4): 947-981. https://t.co/IAWGz6MUOS
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    August 4, 2023

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  • Miha
    @Miha15895372 (Twitter)

    RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
    view full post

    April 15, 2023

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  • Nick Yen
    @yqh1105 (Twitter)

    RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
    view full post

    April 14, 2023

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  • Just Keep Going Inc.
    @JustKeepGoingKF (Twitter)

    RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
    view full post

    April 14, 2023

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  • Nais_ Turtle
    @bedohoe86 (Twitter)

    RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
    view full post

    April 14, 2023

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  • Bloody
    @paulosnaja (Twitter)

    RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
    view full post

    April 14, 2023

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  • ⅂ᎧᎷ
    @TomislavCrypto (Twitter)

    RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
    view full post

    April 14, 2023

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  • Explorer_of_Imagination
    @TheImaginator25 (Twitter)

    RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
    view full post

    April 14, 2023

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  • Richie Carva
    @RichieCripto (Twitter)

    RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
    view full post

    April 14, 2023

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  • Rejuve Biotech
    @Rejuve_Bio (Twitter)

    To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #aging. A recent study found that shifting lactate metabolism of flies in neurons caused decreased survival with age: https://t.co/BVrHSGt9i1 #biotech #longevity
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    April 14, 2023

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  • Aging-US
    @AgingJrnl (Twitter)

    RT @arielframe: With help from @westernuBio I made a short summary video about my recent paper in @AgingJrnl. (<5min) Check it out →→→ http…
    view full post

    April 1, 2023

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  • Western Biology
    @westernuBio (Twitter)

    RT @arielframe: With help from @westernuBio I made a short summary video about my recent paper in @AgingJrnl. (<5min) Check it out →→→ http…
    view full post

    March 29, 2023

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  • Ariel K. Frame
    @arielframe (Twitter)

    With help from @westernuBio I made a short summary video about my recent paper in @AgingJrnl. (<5min) Check it out →→→ https://t.co/m0V6NiEaw9 https://t.co/B6e3v9tIjj
    view full post

    March 29, 2023

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  • Charlotte H
    @C_A_Lott (Twitter)

    RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…
    view full post

    March 21, 2023

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  • Filosofía -Ciencia - Liberación
    @Practicala (Twitter)

    RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co…
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    March 21, 2023

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  • Dr L Boominathan PhD
    @DrLBoominathan (Twitter)

    RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co…
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    March 18, 2023

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  • jebus christoff
    @codo_nabu (Twitter)

    RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co…
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    March 18, 2023

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  • Agingdoc
    @agingdoc1 (Twitter)

    Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/hZeyY51mc5
    view full post

    March 18, 2023

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  • RRID Robot
    @RobotRrid (Twitter)

    The authors of "Aging and memory are altered by genetically manipu…" (https://t.co/Gc173yM0OB) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #STMpublishing #OpenScience
    view full post

    March 17, 2023

  • Ariel K. Frame
    @arielframe (Twitter)

    RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…
    view full post

    March 14, 2023

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  • Nutriop Longevity
    @nutriop (Twitter)

    Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies | Aging https://t.co/IosD8Z11J6
    view full post

    March 10, 2023

  • nfulcher, PhD
    @nivful (Twitter)

    RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…
    view full post

    March 9, 2023

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  • Mile C.V.
    @MilenaC27356365 (Twitter)

    RT @LuisJaimeCastr3: https://t.co/OmJelnlBgA
    view full post

    March 4, 2023

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  • Luis J. Castro-Vega
    @LuisJaimeCastr3 (Twitter)

    https://t.co/OmJelnlBgA
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    March 4, 2023

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  • Angelo D'Alessandro
    @dalessandrolab (Twitter)

    RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…
    view full post

    March 4, 2023

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  • Jason Tennessen
    @TennessenLab (Twitter)

    RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…
    view full post

    March 4, 2023

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  • NSERC / CRSNG
    @NSERC_CRSNG (Twitter)

    RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…
    view full post

    March 3, 2023

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  • Ariel K. Frame
    @arielframe (Twitter)

    I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6vLQ0qPpY3 Looking forward to following up this #Drosophila study on #lactate #brainmetabolism, #Aging and #Memory with a similar study in mice. https://t.co/bVTJ8S8WaT
    view full post

    March 3, 2023

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  • Luciano S. de Fraga
    @lsdefraga (Twitter)

    RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…
    view full post

    March 2, 2023

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  • Anne-Karine Bouzier-Sore
    @ann_kar14 (Twitter)

    RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…
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    March 2, 2023

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  • Sarah Moyon
    @NeuroSarah (Twitter)

    RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…
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    March 1, 2023

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  • Vanja Tepavcevic
    @TepavcevicVanja (Twitter)

    RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…
    view full post

    March 1, 2023

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  • BrainEnergyMetabolism
    @BrainMetabolism (Twitter)

    Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In glia memory impacts are age-dependent ⬇️ldh -> ⬇️memory and ⬆️ldh -> ⬇️survival in old (21 day) flies only. Goldilocks. https://t.co/IugNqKmjx9 https://t.co/7IfhOw3IXB
    view full post

    March 1, 2023

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  • Ariakas Enoreth
    @Aenoreth (Twitter)

    Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/x6KqLocCah
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    February 28, 2023

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  • George Kolostoumpis
    @gkolost (Twitter)

    RT @biorxivpreprint: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https:…
    view full post

    October 22, 2022

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  • bioRxiv Neuroscience
    @biorxiv_neursci (Twitter)

    Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/JYiLb7OuII #biorxiv_neursci
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    October 21, 2022

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  • bioRxiv
    @biorxivpreprint (Twitter)

    Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/df14Ade4Gl #bioRxiv
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    October 21, 2022

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Abstract Synopsis

  • Scientists studied how a substance called lactate helps brain cells work together for memory and survival as animals get older.
  • They changed a specific gene (dLdh) in brain cells of tiny creatures to see how it affected their memory and lifespan.
  • The results showed that changing how lactate is processed makes a difference in memory and survival, especially depending on the age of the animals.