The discussions demonstrate a positive attitude toward the study, with comments highlighting its scientific contribution, such as references to the role of lactate dehydrogenase in aging and memory, and sharing resources like summaries and preprints. Words like 'excited,' 'interesting,' and 'looking forward' convey both approval and curiosity, underpinning modest yet meaningful engagement and perceived impact.
AgreementModerate agreement
Most discussions recognize the significance of the research, with some expressing enthusiasm and support for the findings.
InterestModerate interest
Posts show moderate curiosity, with many sharing summaries or promoting the study, indicating a decent level of engagement.
EngagementModerate engagement
Several comments delve into the implications of manipulating lactate metabolism for aging and memory, reflecting active interest.
ImpactModerate impact
The discussions suggest recognition of the study's potential to influence future aging or neuroscience research, though mostly from a scientific perspective.
Abstract in brief
Scientists studied how a substance called lactate helps brain cells work together for memory and survival as animals get older.
They changed a specific gene (dLdh) in brain cells of tiny creatures to see how it affected their memory and lifespan.
The results showed that changing how lactate is processed makes a difference in memory and survival, especially depending on the age of the animals.
To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #aging. A recent study found that shifting lactate metabolism of flies in neurons caused decreased survival with age: https://t.co/BVrHSGt9i1
#biotech #longevity
Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In glia memory impacts are age-dependent ⬇️ldh -> ⬇️memory and ⬆️ldh -> ⬇️survival in old (21 day) flies only.
Goldilocks.
https://t.co/IugNqKmjx9 https://t.co/7IfhOw3IXB
Mar 1, 2023 · 15 likes · 6 shares · 1,255 followersView post →
A
Agingdoc
@agingdoc1 · X
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
https://t.co/hZeyY51mc5
Mar 18, 2023 · 11 likes · 3 shares · 43,746 followersView post →
AF
Ariel K. Frame
@arielframe · X
I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6vLQ0qPpY3 Looking forward to following up this #Drosophila study on #lactate #brainmetabolism, #Aging and #Memory with a similar study in mice. https://t.co/bVTJ8S8WaT
Mar 3, 2023 · 9 likes · 4 shares · 205 followersView post →
LV
Luis J. Castro-Vega
@LuisJaimeCastr3 · X
https://t.co/OmJelnlBgA
Mar 4, 2023 · 4 likes · 1 share · 657 followersView post →
TB
Thomas Brody
@interactivefly · X
Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies. Aging (Albany NY) 15(4): 947-981. https://t.co/IAWGz6MUOS
Aug 4, 2023 · 3 likes · 2 shares · 2,023 followersView post →
Researchers explored how altering lactate dehydrogenase genes in fly brain cells affects aging and memory. The study highlights the role of lactate in supporting neural function and longevity, emphasizing its importance…
Scientists studied how lactate influences brain cell collaboration for memory and aging by genetically modifying the dLdh gene in fly brains, revealing changes in memory and lifespan, especially with age.
Go #BehindtheStudy with Dr. Ariel K. Frame from Western University as he discusses a research paper he co-authored and published in Aging: “Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.”
https://t.co/nGkko3uHC1
Dec 27, 2023 · 2 likes · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
Go #BehindtheStudy with Dr. Ariel K. Frame from @WesternU as he discusses a research paper he co-authored and published in Aging, entitled, “Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.”
https://t.co/nGkko3uHC1
Aug 28, 2023 · 2 likes · 1 share · 4,400 followersView post →
D
Drosophilosopher
@HammedBadmos · X
RT @interactivefly: Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and me…
Aug 5, 2023 · 2 shares · 1,357 followersView post →
DC
Drosophila Genomics Resource Center
@DrosDGRC · X
RT @interactivefly: Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and me…
Aug 4, 2023 · 2 shares · 2,046 followersView post →
TB
Thomas Brody
@interactivefly · X
Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies. Aging (Albany NY) 15(4): 947-981. https://t.co/IAWGz6MUOS
Aug 4, 2023 · 3 likes · 2 shares · 2,023 followersView post →
M
Miha
@Miha15895372 · X
RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…
To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #aging. A recent study found that shifting lactate metabolism of flies in neurons caused decreased survival with age: https://t.co/BVrHSGt9i1
#biotech #longevity
RT @arielframe: With help from @westernuBio I made a short summary video about my recent paper in @AgingJrnl. (<5min) Check it out →→→ http…
Mar 29, 2023 · 2 shares · 1,098 followersView post →
AF
Ariel K. Frame
@arielframe · X
With help from @westernuBio I made a short summary video about my recent paper in @AgingJrnl. (<5min) Check it out →→→ https://t.co/m0V6NiEaw9 https://t.co/B6e3v9tIjj
Mar 29, 2023 · 1 like · 2 shares · 205 followersView post →
CH
Charlotte H
@C_A_Lott · X
RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…
Mar 21, 2023 · 6 shares · 918 followersView post →
FL
Filosofía -Ciencia - Liberación
@Practicala · X
RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
https://t.co…
Mar 21, 2023 · 3 shares · 4,774 followersView post →
DP
Dr L Boominathan PhD
@DrLBoominathan · X
RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
https://t.co…
Mar 18, 2023 · 3 shares · 905 followersView post →
JC
jebus christoff
@codo_nabu · X
RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
https://t.co…
Mar 18, 2023 · 3 shares · 129 followersView post →
A
Agingdoc
@agingdoc1 · X
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
https://t.co/hZeyY51mc5
Mar 18, 2023 · 11 likes · 3 shares · 43,746 followersView post →
RR
RRID Robot
@RobotRrid · X
The authors of "Aging and memory are altered by genetically manipu…" (https://t.co/Gc173yM0OB) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #STMpublishing #OpenScience
RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…
Mar 3, 2023 · 4 shares · 81,089 followersView post →
AF
Ariel K. Frame
@arielframe · X
I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6vLQ0qPpY3 Looking forward to following up this #Drosophila study on #lactate #brainmetabolism, #Aging and #Memory with a similar study in mice. https://t.co/bVTJ8S8WaT
Mar 3, 2023 · 9 likes · 4 shares · 205 followersView post →
LF
Luciano S. de Fraga
@lsdefraga · X
RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…
Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In glia memory impacts are age-dependent ⬇️ldh -> ⬇️memory and ⬆️ldh -> ⬇️survival in old (21 day) flies only.
Goldilocks.
https://t.co/IugNqKmjx9 https://t.co/7IfhOw3IXB
Mar 1, 2023 · 15 likes · 6 shares · 1,255 followersView post →
AE
Ariakas Enoreth
@Aenoreth · X
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
https://t.co/x6KqLocCah
Feb 28, 2023 · 2 likes · 1,009 followersView post →
GK
George Kolostoumpis
@gkolost · X
RT @biorxivpreprint: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https:…
Oct 22, 2022 · 1 share · 2,083 followersView post →
BN
bioRxiv Neuroscience
@biorxiv_neursci · X
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/JYiLb7OuII #biorxiv_neursci
Oct 21, 2022 · 1 like · 60,581 followersView post →
B
bioRxiv
@biorxivpreprint · X
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/df14Ade4Gl #bioRxiv
Oct 21, 2022 · 2 likes · 1 share · 138,282 followersView post →
N
Pyruvate Inhibition of Lactate Dehydrogenase Activity in Human ...
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