Aging (Albany NY) February 2023 PMID 36849157

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.

Ariel K Frame, J Wesley Robinson, Nader H Mahmoudzadeh, Jason M Tennessen, Anne F Simon, Robert C Cumming

Mentions

45
Peak: 24 in Mar 2023
across 3 sources since Oct 2022

Extended reach

367,558
potential audience

Total likes

85

Video views

302

Mentions per month

Oct 2022 – Dec 2023

Where it's discussed

  • X / Twitter41 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The discussions demonstrate a positive attitude toward the study, with comments highlighting its scientific contribution, such as references to the role of lactate dehydrogenase in aging and memory, and sharing resources like summaries and preprints. Words like 'excited,' 'interesting,' and 'looking forward' convey both approval and curiosity, underpinning modest yet meaningful engagement and perceived impact.

AgreementModerate agreement

Most discussions recognize the significance of the research, with some expressing enthusiasm and support for the findings.

InterestModerate interest

Posts show moderate curiosity, with many sharing summaries or promoting the study, indicating a decent level of engagement.

EngagementModerate engagement

Several comments delve into the implications of manipulating lactate metabolism for aging and memory, reflecting active interest.

ImpactModerate impact

The discussions suggest recognition of the study's potential to influence future aging or neuroscience research, though mostly from a scientific perspective.

Abstract in brief

  • Scientists studied how a substance called lactate helps brain cells work together for memory and survival as animals get older.
  • They changed a specific gene (dLdh) in brain cells of tiny creatures to see how it affected their memory and lifespan.
  • The results showed that changing how lactate is processed makes a difference in memory and survival, especially depending on the age of the animals.

Top posts

Most liked on X and Bluesky
Rejuve Biotech
@Rejuve_Bio · X

To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #aging. A recent study found that shifting lactate metabolism of flies in neurons caused decreased survival with age: https://t.co/BVrHSGt9i1 #biotech #longevity

Apr 14, 2023 · 32 likes · 8 shares · 2,248 followers View post →
BrainEnergyMetabolism
@BrainMetabolism · X

Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In glia memory impacts are age-dependent ⬇️ldh -> ⬇️memory and ⬆️ldh -> ⬇️survival in old (21 day) flies only. Goldilocks. https://t.co/IugNqKmjx9 https://t.co/7IfhOw3IXB

Mar 1, 2023 · 15 likes · 6 shares · 1,255 followers View post →
Agingdoc
@agingdoc1 · X

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/hZeyY51mc5

Mar 18, 2023 · 11 likes · 3 shares · 43,746 followers View post →
Ariel K. Frame
@arielframe · X

I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6vLQ0qPpY3 Looking forward to following up this #Drosophila study on #lactate #brainmetabolism, #Aging and #Memory with a similar study in mice. https://t.co/bVTJ8S8WaT

Mar 3, 2023 · 9 likes · 4 shares · 205 followers View post →
Luis J. Castro-Vega
@LuisJaimeCastr3 · X

https://t.co/OmJelnlBgA

Mar 4, 2023 · 4 likes · 1 share · 657 followers View post →
Thomas Brody
@interactivefly · X

Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies. Aging (Albany NY) 15(4): 947-981. https://t.co/IAWGz6MUOS

Aug 4, 2023 · 3 likes · 2 shares · 2,023 followers View post →

All mentions

Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Ariel K. Frame from Western University as he discusses a research paper he co-authored and published in Aging: “Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.” https://t.co/nGkko3uHC1

Dec 27, 2023 · 2 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

Go #BehindtheStudy with Dr. Ariel K. Frame from @WesternU as he discusses a research paper he co-authored and published in Aging, entitled, “Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies.” https://t.co/nGkko3uHC1

Aug 28, 2023 · 2 likes · 1 share · 4,400 followers View post →
Drosophilosopher
@HammedBadmos · X

RT @interactivefly: Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and me…

Aug 5, 2023 · 2 shares · 1,357 followers View post →
Drosophila Genomics Resource Center
@DrosDGRC · X

RT @interactivefly: Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and me…

Aug 4, 2023 · 2 shares · 2,046 followers View post →
Thomas Brody
@interactivefly · X

Frame, A. K., Robinson, J. W., Mahmoudzadeh, N. H., Tennessen, J., Simon, A. F. and Cumming, R. C. (2023). Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies. Aging (Albany NY) 15(4): 947-981. https://t.co/IAWGz6MUOS

Aug 4, 2023 · 3 likes · 2 shares · 2,023 followers View post →
Miha
@Miha15895372 · X

RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…

Apr 15, 2023 · 8 shares · 191 followers View post →
Nick Yen
@yqh1105 · X

RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…

Apr 14, 2023 · 8 shares · 280 followers View post →
Just Keep Going Inc.
@JustKeepGoingKF · X

RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…

Apr 14, 2023 · 8 shares · 396 followers View post →
Nais_ Turtle
@bedohoe86 · X

RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…

Apr 14, 2023 · 8 shares · 259 followers View post →
Bloody
@paulosnaja · X

RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…

Apr 14, 2023 · 8 shares · 1,423 followers View post →
⅂ᎧᎷ
@TomislavCrypto · X

RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…

Apr 14, 2023 · 8 shares · 889 followers View post →
Explorer_of_Imagination
@TheImaginator25 · X

RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…

Apr 14, 2023 · 8 shares · 1,195 followers View post →
Richie Carva
@RichieCripto · X

RT @Rejuve_Bio: To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #agi…

Apr 14, 2023 · 8 shares · 100 followers View post →
Rejuve Biotech
@Rejuve_Bio · X

To identify pathways that can be targeted to increase maximum lifespan we have to consider the process that limits it: #aging. A recent study found that shifting lactate metabolism of flies in neurons caused decreased survival with age: https://t.co/BVrHSGt9i1 #biotech #longevity

Apr 14, 2023 · 32 likes · 8 shares · 2,248 followers View post →
Aging-US
@AgingJrnl · X

RT @arielframe: With help from @westernuBio I made a short summary video about my recent paper in @AgingJrnl. (<5min) Check it out →→→ http…

Apr 1, 2023 · 2 shares · 4,400 followers View post →
Western Biology
@westernuBio · X

RT @arielframe: With help from @westernuBio I made a short summary video about my recent paper in @AgingJrnl. (<5min) Check it out →→→ http…

Mar 29, 2023 · 2 shares · 1,098 followers View post →
Ariel K. Frame
@arielframe · X

With help from @westernuBio I made a short summary video about my recent paper in @AgingJrnl. (<5min) Check it out →→→ https://t.co/m0V6NiEaw9 https://t.co/B6e3v9tIjj

Mar 29, 2023 · 1 like · 2 shares · 205 followers View post →
Charlotte H
@C_A_Lott · X

RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…

Mar 21, 2023 · 6 shares · 918 followers View post →
Filosofía -Ciencia - Liberación
@Practicala · X

RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co…

Mar 21, 2023 · 3 shares · 4,774 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co…

Mar 18, 2023 · 3 shares · 905 followers View post →
jebus christoff
@codo_nabu · X

RT @agingdoc1: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co…

Mar 18, 2023 · 3 shares · 129 followers View post →
Agingdoc
@agingdoc1 · X

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/hZeyY51mc5

Mar 18, 2023 · 11 likes · 3 shares · 43,746 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Aging and memory are altered by genetically manipu…" (https://t.co/Gc173yM0OB) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #STMpublishing #OpenScience

Mar 17, 2023 · 161 followers View post →
Ariel K. Frame
@arielframe · X

RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…

Mar 14, 2023 · 6 shares · 205 followers View post →
Nutriop Longevity
@nutriop · X

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies | Aging https://t.co/IosD8Z11J6

Mar 10, 2023 · 81 followers View post →
nfulcher, PhD
@nivful · X

RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…

Mar 9, 2023 · 4 shares · 282 followers View post →
Mile C.V.
@MilenaC27356365 · X

RT @LuisJaimeCastr3: https://t.co/OmJelnlBgA

Mar 4, 2023 · 1 share · 44 followers View post →
Luis J. Castro-Vega
@LuisJaimeCastr3 · X

https://t.co/OmJelnlBgA

Mar 4, 2023 · 4 likes · 1 share · 657 followers View post →
Angelo D'Alessandro
@dalessandrolab · X

RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…

Mar 4, 2023 · 4 shares · 803 followers View post →
Jason Tennessen
@TennessenLab · X

RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…

Mar 4, 2023 · 4 shares · 830 followers View post →
NSERC / CRSNG
@NSERC_CRSNG · X

RT @arielframe: I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6…

Mar 3, 2023 · 4 shares · 81,089 followers View post →
Ariel K. Frame
@arielframe · X

I am happy to announce that my #preprint baby has now matured into a fully formed publication in @AgingJrnl: https://t.co/6vLQ0qPpY3 Looking forward to following up this #Drosophila study on #lactate #brainmetabolism, #Aging and #Memory with a similar study in mice. https://t.co/bVTJ8S8WaT

Mar 3, 2023 · 9 likes · 4 shares · 205 followers View post →
Luciano S. de Fraga
@lsdefraga · X

RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…

Mar 2, 2023 · 6 shares · 262 followers View post →
Anne-Karine Bouzier-Sore
@ann_kar14 · X

RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…

Mar 2, 2023 · 6 shares · 103 followers View post →
Sarah Moyon
@NeuroSarah · X

RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…

Mar 1, 2023 · 6 shares · 686 followers View post →
Vanja Tepavcevic
@TepavcevicVanja · X

RT @BrainMetabolism: Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In gl…

Mar 1, 2023 · 6 shares · 911 followers View post →
BrainEnergyMetabolism
@BrainMetabolism · X

Increased or decreased expression of lactate dehydrogenase in fly neurons decreases survival and impacts memory. In glia memory impacts are age-dependent ⬇️ldh -> ⬇️memory and ⬆️ldh -> ⬇️survival in old (21 day) flies only. Goldilocks. https://t.co/IugNqKmjx9 https://t.co/7IfhOw3IXB

Mar 1, 2023 · 15 likes · 6 shares · 1,255 followers View post →
Ariakas Enoreth
@Aenoreth · X

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/x6KqLocCah

Feb 28, 2023 · 2 likes · 1,009 followers View post →
George Kolostoumpis
@gkolost · X

RT @biorxivpreprint: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https:…

Oct 22, 2022 · 1 share · 2,083 followers View post →
bioRxiv Neuroscience
@biorxiv_neursci · X

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/JYiLb7OuII #biorxiv_neursci

Oct 21, 2022 · 1 like · 60,581 followers View post →
bioRxiv
@biorxivpreprint · X

Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies https://t.co/df14Ade4Gl #bioRxiv

Oct 21, 2022 · 2 likes · 1 share · 138,282 followers View post →
Pyruvate Inhibition of Lactate Dehydrogenase Activity in Human ...
News

aging · Log In · Become A Member · Donate. Quick Search anywhere. Enter Search Term ... https://doi.org/10.18632/aging.204565 · Crossref. Cameron D. Haydinger ...

Dec 15, 2025 View →
Lactate Dehydrogenase Isozymes: Substrate Inhibition in Various ...
News

... Aging, (2023).https://doi.org/10.18632/aging.204565 · Crossref. Giuseppina Claps,; Sara Faouzi,; Virginie Quidville,; Feras Chehade,; Shensi Shen,; Stéphan ...

Dec 15, 2025 View →