Nat Commun February 2023 PMID 36854724

Chemogenetic attenuation of cortical seizures in nonhuman primates.

Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, Asumi Orihara, Kei Oyama, Takeshi Matsuo, Ken-Ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto

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Peak: 7 in Mar 2023

across 5 sources since Feb 2023

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Feb 2023 – Jun 2023

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What people are saying

The overall tone reflects a moderate appreciation for the research, with many posts acknowledging the importance of chemogenetics in neuroscience; for example, mentions of 'attenuation of seizures' and the relevance to 'epilepsy' indicate recognition of potential clinical impact. Words like 'significant,' 'innovative,' and references to the publication's source suggest respectful engagement, but the limited depth of discussion points to a general curiosity rather than deep analytical engagement.

AgreementModerate agreement

Most discussions recognize the significance of the study, and some explicitly praise its innovative approach to seizure treatment.

InterestModerate interest

Participants show moderate interest, with many posts simply referencing the publication without deep analysis, but some express curiosity about the methodology.

EngagementModerate engagement

Posts include retweets and brief mentions, indicating surface engagement, though a few comment on the potential implications of the research.

ImpactModerate impact

The collective tone suggests that the study could influence future research and treatment options, though its immediate impact remains speculative.

Abstract in brief

This study explores a new way to treat seizures in monkeys using chemogenetics, specifically DREADDs, which are engineered receptors that can be controlled with specific drugs.
The researchers induced seizures in monkeys by injecting a substance that causes overexcitation in the brain, then used DREADDs to selectively turn off the affected neurons, which successfully reduced seizure activity.
These findings suggest that DREADDs could be an effective, targeted approach for controlling seizures without disrupting normal brain functions, potentially offering a more precise treatment option for epilepsy.]

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Targeted Chemogenetic Approach Reduces Cortical Seizures in Primates

This study explores a new way to treat seizures in monkeys using chemogenetics, specifically DREADDs, which are engineered receptors that can be controlled with specific drugs. The researchers induced seizures by…

STEM RTCL TV · Jun 15, 2023 17 views

NikkeNyfiken

@CuriouzMonkey · X

Chemogenetic attenuation of cortical seizures in nonhuman primates #neuroscience #brain #neurology #science #chmeogenetics #seizure #epilepsy https://t.co/azdPSygREG

Apr 9, 2023 · 43 followers View post →

WILLIAM DARAN(daranwilliam.bsky.social)

@DaranWilliam · X

RT @leafs_s: Nature Communications Chemogenetic attenuation of cortical seizures in nonhuman primates https://t.co/h1MMrWw9Uu

Mar 6, 2023 · 3 shares · 112 followers View post →

BryanRoth

@zenbrainest · X

RT @leafs_s: Nature Communications Chemogenetic attenuation of cortical seizures in nonhuman primates https://t.co/h1MMrWw9Uu

Mar 6, 2023 · 3 shares · 17,016 followers View post →

Jibran Khokhar

@DrJKhokhar · X

RT @leafs_s: Nature Communications Chemogenetic attenuation of cortical seizures in nonhuman primates https://t.co/h1MMrWw9Uu

Mar 6, 2023 · 3 shares · 10,770 followers View post →

CLaE

@leafs_s · X

Nature Communications Chemogenetic attenuation of cortical seizures in nonhuman primates https://t.co/h1MMrWw9Uu

Mar 6, 2023 · 13 likes · 3 shares · 28,091 followers View post →

/r/Neuroscience

@neuroreddit · X

Chemogenetic attenuation of cortical seizures in nonhuman primates https://t.co/yGHNA8lccV

Mar 4, 2023 · 6 followers View post →

Empyrean Protocol

@empyreanprotoc1 · X

Chemogenetic attenuation of cortical seizures in nonhuman primates:https://t.co/u6ofF7Glrt #arms_control

Mar 1, 2023 · 58 followers View post →

Kyohei Ueda

@DHXisr · X

RT @NeuroPaperBot: Chemogenetic attenuation of cortical seizures in nonhuman primates https://t.co/8kjm9Um0YW

Mar 1, 2023 · 2 shares · 377 followers View post →

New neuroscience papers in Nature Communications

@NeuroPaperBot · X

Chemogenetic attenuation of cortical seizures in nonhuman primates https://t.co/8kjm9Um0YW

Feb 28, 2023 · 9 likes · 2 shares · 1,956 followers View post →

Chemogenetic attenuation of cortical seizures in nonhuman primates.

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Targeted Chemogenetic Approach Reduces Cortical Seizures in Primates