Functional Connectivity Mapping for rTMS Target Selection in Depression.

Immanuel G Elbau, Charles J Lynch, Jonathan Downar, Fidel Vila-Rodriguez, Jonathan D Power, Nili Solomonov, Zafiris J Daskalakis, Daniel M Blumberger, Conor Liston

March 2023 Am J Psychiatry

Synopsis of Social media discussions

The discussions include references to the small effect size (r=.16) and methodological concerns like underpowered studies and artifact issues, showing critical engagement. Phrases like 'weak association' and mentions of 'small but real consequences' demonstrate nuanced perspectives that acknowledge limitations while still recognizing some relevance for future research.

A
Agreement
 Neither agree nor disagree

Most discussions acknowledge the small effect size and methodological limitations, reflecting neutral agreement overall.

I
Interest
 Moderate level of interest

There's moderate curiosity shown, especially around new targeting methods and different viewpoints on the study's significance.

E
Engagement
 Moderate level of engagement

Participants reference specific aspects like the study’s methodology and findings, indicating a moderate level of deep engagement.

I
Impact
 Neutral impact

The discussions suggest limited impact on clinical practices due to acknowledged weaknesses, but some interest in ongoing research.

Social Mentions

YouTube

2 Videos

Twitter

45 Posts

News

1 Articles

Reddit

1 Posts

Metrics

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296

Total Likes

87

Extended Reach

201,272

Social Features

49

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Brain Connectivity and Treatment Outcomes in Depression

Brain Connectivity and Treatment Outcomes in Depression

American Journal of Psychiatry Deputy Editor Daniel S Pine MD discusses recent research on using functional connectivity mapping for rTMS target selection in depression, and the limited impact of sgACC connectivity on treatment outcomes, highlighting ongoing challenges in personalized depression therapies.

PsychiatryOnline

March 1, 2023

170 views

Functional Brain Connectivity for rTMS Targeting in Depression Treatment

Functional Brain Connectivity for rTMS Targeting in Depression Treatment

American Journal of Psychiatry Deputy Editor Daniel S Pine MD discusses the article Functional Connectivity Mapping for rTMS Target Selection in Depression by Immanuel G Elbau MD PhD and colleagues. The study evaluates brain connectivity's role in rTMS treatment response, highlighting that individual differences only weakly

PsychiatryOnline

March 1, 2023

126 views

  • Kording Lab
    @KordingLab (Twitter)

    @ColinHawco @josephdviviano @AVoineskos @SOBP and the paper i mentioned above "Functional Connectivity Mapping for rTMS Target Selection in Depression" reports r=.16. Which is pretty much useless. For that effect size it was underpowered. It was also non preregistered. There must be better biomarker studies!
    view full post

    May 10, 2023

  • Kording Lab
    @KordingLab (Twitter)

    @ColinHawco @josephdviviano @AVoineskos This? "Functional Connectivity Mapping for rTMS Target Selection in Depression"
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    May 10, 2023

  • DR.GUILLERMO VALIENTE Rodríguez
    @Drvaliente (Twitter)

    RT @APAPubJournals: Functional Connectivity Mapping for rTMS Target Selection in Depression https://t.co/P6HjGLVcUc
    view full post

    April 3, 2023

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  • Journals of The American Psychiatric Association
    @APAPubJournals (Twitter)

    AJP Deputy Editor Danny Pine highlights two articles from the March 2023 issue. https://t.co/Em2MPoDKCD
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    April 3, 2023

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  • Journals of The American Psychiatric Association
    @APAPubJournals (Twitter)

    Functional Connectivity Mapping for rTMS Target Selection in Depression https://t.co/P6HjGLVcUc
    view full post

    April 3, 2023

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  • Derek Pipolo, MD
    @DerekPipoloMD (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 23, 2023

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  • Weill Cornell Medicine Psychiatry
    @WCMPsychiatry (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 22, 2023

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  • Michael Fox
    @foxmdphd (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 21, 2023

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  • P Petrov (She/Jew/Black)
    @dr_ppetrov (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 21, 2023

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  • Max-Planck EU-Office Bavaria
    @EU_MPQ (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 21, 2023

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  • Debbie Yee
    @debyeeneuro (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 21, 2023

    19

  • あるく
    @ayumu_tomaru (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

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  • Thomas Yeo
    @bttyeo (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

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  • Joe Stujenske
    @jmstujenske (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

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  • Faith G
    @GunningFaith (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

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  • Noah S Philip MD
    @NoahSPhilipMD (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

    19

  • Helmet Karim
    @KarimH349 (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

    19

  • Maximilian Lueckel
    @mlueckel (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

    19

  • Klaus Schellhorn
    @neuroconn (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

    19

  • Til Ole Bergmann
    @tobergmann (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

    19

  • Shan Siddiqi @shansiddiqi.bsky.social
    @shansiddiqi (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

    19

  • Yoni Ashar
    @YoniAshar (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

    19

  • Chuck Lynch
    @cl9681 (Twitter)

    RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…
    view full post

    March 20, 2023

    19

  • Immanuel Elbau
    @immanuel_elbau (Twitter)

    8/8 Check out also the commentary by @shansiddiqi & @NoahSPhilipMD (https://t.co/RxmYCuwOWD), and video commentary by Danny Pine (https://t.co/JMGAZlGcpV)
    view full post

    March 20, 2023

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  • Immanuel Elbau
    @immanuel_elbau (Twitter)

    1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE-D); work together with @cl9681, Conor Liston, and the THREE-D team. Below a (belated) summary of our findings: https://t.co/WNgfsCpn7m
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    March 20, 2023

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  • Journals of The American Psychiatric Association
    @APAPubJournals (Twitter)

    3. Functional Connectivity Mapping for rTMS Target Selection in Depression 3/4 https://t.co/P6HjGLVcUc
    view full post

    March 17, 2023

  • Austin Lam
    @austinaldenlam (Twitter)

    https://t.co/4ed7FNlr9A
    view full post

    March 9, 2023

  • DR.GUILLERMO VALIENTE Rodríguez
    @Drvaliente (Twitter)

    RT @APAPubJournals: Choosing brain stimulation targets based on cingulate cortex functional connectivity has small but real consequences fo…
    view full post

    March 8, 2023

    1

  • Journals of The American Psychiatric Association
    @APAPubJournals (Twitter)

    Choosing brain stimulation targets based on cingulate cortex functional connectivity has small but real consequences for #depression treatment. https://t.co/wylGY6XZMH https://t.co/TmceAAUcLf
    view full post

    March 8, 2023

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    1

  • Breathe In Courage, Breathe Out Fear
    @ZenForceVets (Twitter)

    Functional Connectivity Mapping for rTMS Target Selection in ... - Am J Psychiatry https://t.co/9oFY04LHUS
    view full post

    March 3, 2023

  • Dagur Bjarnason
    @dagur79 (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 2, 2023

    12

  • Klaus Schellhorn
    @neuroconn (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 2, 2023

    12

  • Jasmina is a PhD student
    @jsmnpnv (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 2, 2023

    12

  • Meiling Li-李美玲
    @xiaoxiaoliu44 (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 2, 2023

    12

  • Desmond Oathes
    @DesmondOathes (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    12

  • Raymond Lam
    @DrRaymondLam (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    12

  • Maximilian Lueckel
    @mlueckel (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    12

  • Parsa Tadayon
    @parsa_tad (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    12

  • Immanuel Elbau
    @immanuel_elbau (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    12

  • Til Ole Bergmann
    @tobergmann (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    12

  • Neurosys
    @systems_neuro (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    12

  • Noah S Philip MD
    @NoahSPhilipMD (Twitter)

    RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    12

  • NINET Lab
    @NinetLab (Twitter)

    Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS
    view full post

    March 1, 2023

    25

    12

  • Noah S Philip MD
    @NoahSPhilipMD (Twitter)

    The parent piece, is found here. In brief, the sgACC/DLPC connectivity relationship appeared driven by large signal fluctuations that looked like respiratory artifact to the authors. And, contributing unfortunately little to clinical outcomes. https://t.co/thqYgEJJVW
    view full post

    March 1, 2023

    3

  • Breathe In Courage, Breathe Out Fear
    @ZenForceVets (Twitter)

    Functional Connectivity Mapping for rTMS Target Selection in ... - Am J Psychiatry https://t.co/9oFY04LHUS
    view full post

    March 1, 2023

  • Functional Connectivity Mapping for rTMS Target Selection in ...

    ... 10.1176/appi.ajp.20220306. Repetitive transcranial magnetic stimulation (rTMS) to the Precise effect size estimates are specifically important for left ...
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    December 21, 2025

    News

  • [Article] Functional Connectivity Mapping for rTMS Target Selection ...

    URL: https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20220306 DOI: https://doi.org/10.1176/appi.ajp.20220306.
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    October 3, 2023

    Reddit

Abstract Synopsis

  • The study looked at how the brain's functional connectivity, specifically between the subgenual anterior cingulate cortex (sgACC) and the stimulation site, relates to the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in treating depression, but found only a weak association.
  • Researchers validated that their methods for estimating sgACC connectivity are reliable, and they used electric field modeling to identify stimulation sites, revealing that treatment response is influenced by factors like respiration-related brain signal patterns.
  • Overall, the findings suggest that individual differences in sgACC connectivity explain only a small part of treatment outcomes, indicating limitations in using this connectivity as a standalone target for personalized depression treatment, although there is some evidence of a true, but small, effect.]