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Am J Psychiatry March 2023 PMID 36855880

Functional Connectivity Mapping for rTMS Target Selection in Depression.

Immanuel G Elbau, Charles J Lynch, Jonathan Downar, Fidel Vila-Rodriguez, Jonathan D Power, Nili Solomonov, Zafiris J Daskalakis, Daniel M Blumberger, Conor Liston

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Mentions

49
Peak: 42 in Mar 2023
across 4 sources since Mar 2023

Extended reach

201,272
potential audience

Total likes

87

Video views

296

Mentions per month

Mar 2023 – Oct 2023

Where it's discussed

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  • YouTube2 videos
  • Reddit1 posts
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AI synopsis

What people are saying

The discussions include references to the small effect size (r=.16) and methodological concerns like underpowered studies and artifact issues, showing critical engagement. Phrases like 'weak association' and mentions of 'small but real consequences' demonstrate nuanced perspectives that acknowledge limitations while still recognizing some relevance for future research.

AgreementNeither agree nor disagree

Most discussions acknowledge the small effect size and methodological limitations, reflecting neutral agreement overall.

InterestModerate interest

There's moderate curiosity shown, especially around new targeting methods and different viewpoints on the study's significance.

EngagementModerate engagement

Participants reference specific aspects like the study’s methodology and findings, indicating a moderate level of deep engagement.

ImpactNeutral impact

The discussions suggest limited impact on clinical practices due to acknowledged weaknesses, but some interest in ongoing research.

Abstract in brief

  • The study looked at how the brain's functional connectivity, specifically between the subgenual anterior cingulate cortex (sgACC) and the stimulation site, relates to the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in treating depression, but found only a weak association.
  • Researchers validated that their methods for estimating sgACC connectivity are reliable, and they used electric field modeling to identify stimulation sites, revealing that treatment response is influenced by factors like respiration-related brain signal patterns.
  • Overall, the findings suggest that individual differences in sgACC connectivity explain only a small part of treatment outcomes, indicating limitations in using this connectivity as a standalone target for personalized depression treatment, although there is some evidence of a true, but small, effect.]
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Top posts

Most liked on X and Bluesky
Immanuel Elbau
@immanuel_elbau · X

1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE-D); work together with @cl9681, Conor Liston, and the THREE-D team. Below a (belated) summary of our findings: https://t.co/WNgfsCpn7m

Mar 20, 2023 · 47 likes · 19 shares · 217 followers View post →
NINET Lab
@NinetLab · X

Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 25 likes · 12 shares · 1,270 followers View post →
Immanuel Elbau
@immanuel_elbau · X

8/8 Check out also the commentary by @shansiddiqi & @NoahSPhilipMD (https://t.co/RxmYCuwOWD), and video commentary by Danny Pine (https://t.co/JMGAZlGcpV)

Mar 20, 2023 · 7 likes · 217 followers View post →
Noah S Philip MD
@NoahSPhilipMD · X

The parent piece, is found here. In brief, the sgACC/DLPC connectivity relationship appeared driven by large signal fluctuations that looked like respiratory artifact to the authors. And, contributing unfortunately little to clinical outcomes. https://t.co/thqYgEJJVW

Mar 1, 2023 · 3 likes · 1,979 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Functional Connectivity Mapping for rTMS Target Selection in Depression https://t.co/P6HjGLVcUc

Apr 3, 2023 · 2 likes · 1 share · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

AJP Deputy Editor Danny Pine highlights two articles from the March 2023 issue. https://t.co/Em2MPoDKCD

Apr 3, 2023 · 2 likes · 11,606 followers View post →

All mentions

Kording Lab
@KordingLab · X

@ColinHawco @josephdviviano @AVoineskos @SOBP and the paper i mentioned above "Functional Connectivity Mapping for rTMS Target Selection in Depression" reports r=.16. Which is pretty much useless. For that effect size it was underpowered. It was also non preregistered. There must be better biomarker studies!

May 10, 2023 · 47,109 followers View post →
Kording Lab
@KordingLab · X

@ColinHawco @josephdviviano @AVoineskos This? "Functional Connectivity Mapping for rTMS Target Selection in Depression"

May 10, 2023 · 47,109 followers View post →
DR.GUILLERMO VALIENTE Rodríguez
@Drvaliente · X

RT @APAPubJournals: Functional Connectivity Mapping for rTMS Target Selection in Depression https://t.co/P6HjGLVcUc

Apr 3, 2023 · 1 share · 1,465 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

AJP Deputy Editor Danny Pine highlights two articles from the March 2023 issue. https://t.co/Em2MPoDKCD

Apr 3, 2023 · 2 likes · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Functional Connectivity Mapping for rTMS Target Selection in Depression https://t.co/P6HjGLVcUc

Apr 3, 2023 · 2 likes · 1 share · 11,606 followers View post →
Derek Pipolo, MD
@DerekPipoloMD · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 23, 2023 · 19 shares · 174 followers View post →
Weill Cornell Medicine Psychiatry
@WCMPsychiatry · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 22, 2023 · 19 shares · 1,293 followers View post →
Michael Fox
@foxmdphd · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 21, 2023 · 19 shares · 6,685 followers View post →
P Petrov (She/Jew/Black)
@dr_ppetrov · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 21, 2023 · 19 shares · 421 followers View post →
Max-Planck EU-Office Bavaria
@EU_MPQ · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 21, 2023 · 19 shares · 596 followers View post →
Debbie Yee
@debyeeneuro · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 21, 2023 · 19 shares · 1,176 followers View post →
あるく
@ayumu_tomaru · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 297 followers View post →
Thomas Yeo
@bttyeo · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 11,814 followers View post →
Joe Stujenske
@jmstujenske · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 271 followers View post →
Faith G
@GunningFaith · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 407 followers View post →
Noah S Philip MD
@NoahSPhilipMD · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 1,979 followers View post →
Helmet Karim
@KarimH349 · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 414 followers View post →
Maximilian Lueckel
@mlueckel · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 398 followers View post →
Klaus Schellhorn
@neuroconn · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 1,216 followers View post →
Til Ole Bergmann
@tobergmann · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 3,674 followers View post →
Shan Siddiqi @shansiddiqi.bsky.social
@shansiddiqi · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 3,680 followers View post →
Yoni Ashar
@YoniAshar · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 1,660 followers View post →
Chuck Lynch
@cl9681 · X

RT @immanuel_elbau: 1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE…

Mar 20, 2023 · 19 shares · 713 followers View post →
Immanuel Elbau
@immanuel_elbau · X

8/8 Check out also the commentary by @shansiddiqi & @NoahSPhilipMD (https://t.co/RxmYCuwOWD), and video commentary by Danny Pine (https://t.co/JMGAZlGcpV)

Mar 20, 2023 · 7 likes · 217 followers View post →
Immanuel Elbau
@immanuel_elbau · X

1/8 Excited to share our new paper at AJP exploring sgACC-based targeting for TMS outcomes in a large MDD sample (THREE-D); work together with @cl9681, Conor Liston, and the THREE-D team. Below a (belated) summary of our findings: https://t.co/WNgfsCpn7m

Mar 20, 2023 · 47 likes · 19 shares · 217 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

3. Functional Connectivity Mapping for rTMS Target Selection in Depression 3/4 https://t.co/P6HjGLVcUc

Mar 17, 2023 · 11,606 followers View post →
Austin Lam
@austinaldenlam · X

https://t.co/4ed7FNlr9A

Mar 9, 2023 · 1,084 followers View post →
DR.GUILLERMO VALIENTE Rodríguez
@Drvaliente · X

RT @APAPubJournals: Choosing brain stimulation targets based on cingulate cortex functional connectivity has small but real consequences fo…

Mar 8, 2023 · 1 share · 1,465 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Choosing brain stimulation targets based on cingulate cortex functional connectivity has small but real consequences for #depression treatment. https://t.co/wylGY6XZMH https://t.co/TmceAAUcLf

Mar 8, 2023 · 1 like · 1 share · 11,606 followers View post →
Breathe In Courage, Breathe Out Fear
@ZenForceVets · X

Functional Connectivity Mapping for rTMS Target Selection in ... - Am J Psychiatry https://t.co/9oFY04LHUS

Mar 3, 2023 · 846 followers View post →
Dagur Bjarnason
@dagur79 · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 2, 2023 · 12 shares · 23 followers View post →
Klaus Schellhorn
@neuroconn · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 2, 2023 · 12 shares · 1,216 followers View post →
Jasmina is a PhD student
@jsmnpnv · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 2, 2023 · 12 shares · 587 followers View post →
Meiling Li-李美玲
@xiaoxiaoliu44 · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 2, 2023 · 12 shares · 205 followers View post →
Desmond Oathes
@DesmondOathes · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 12 shares · 2,059 followers View post →
Raymond Lam
@DrRaymondLam · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 12 shares · 2,122 followers View post →
Maximilian Lueckel
@mlueckel · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 12 shares · 398 followers View post →
Parsa Tadayon
@parsa_tad · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 12 shares · 131 followers View post →
Immanuel Elbau
@immanuel_elbau · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 12 shares · 217 followers View post →
Til Ole Bergmann
@tobergmann · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 12 shares · 3,674 followers View post →
Neurosys
@systems_neuro · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 12 shares · 405 followers View post →
Noah S Philip MD
@NoahSPhilipMD · X

RT @NinetLab: Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 12 shares · 1,979 followers View post →
NINET Lab
@NinetLab · X

Check out the latest from the THREE-D trial "FC Mapping for rTMS Target Selection in Depression" https://t.co/44V4xe4ORS

Mar 1, 2023 · 25 likes · 12 shares · 1,270 followers View post →
Noah S Philip MD
@NoahSPhilipMD · X

The parent piece, is found here. In brief, the sgACC/DLPC connectivity relationship appeared driven by large signal fluctuations that looked like respiratory artifact to the authors. And, contributing unfortunately little to clinical outcomes. https://t.co/thqYgEJJVW

Mar 1, 2023 · 3 likes · 1,979 followers View post →
Breathe In Courage, Breathe Out Fear
@ZenForceVets · X

Functional Connectivity Mapping for rTMS Target Selection in ... - Am J Psychiatry https://t.co/9oFY04LHUS

Mar 1, 2023 · 846 followers View post →
Functional Connectivity Mapping for rTMS Target Selection in ...
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... 10.1176/appi.ajp.20220306. Repetitive transcranial magnetic stimulation (rTMS) to the Precise effect size estimates are specifically important for left ...

Dec 21, 2025 View →
[Article] Functional Connectivity Mapping for rTMS Target Selection ...
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URL: https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.20220306 DOI: https://doi.org/10.1176/appi.ajp.20220306.

Oct 3, 2023 View →